Genome in a Bottle Consortium-Progress and Planning Workshop, 47674-47675 [2013-18934]

Download as PDF 47674 Federal Register / Vol. 78, No. 151 / Tuesday, August 6, 2013 / Notices DEPARTMENT OF COMMERCE National Institute of Standards and Technology Judges Panel of the Malcolm Baldrige National Quality Award National Institute of Standards and Technology, Department of Commerce. ACTION: Notice of closed meeting. AGENCY: The Judges Panel of the Malcolm Baldrige National Quality Award (Award) will meet in closed session on Wednesday, August 28, 2013, 9:00 a.m. to 3:30 p.m., Eastern time. The purpose of this meeting is to review the results of examiners’ scoring of written applications. Panel members will vote on which applicants merit site visits by examiners to verify the accuracy of quality improvements claimed by applicants. DATES: The meeting will convene on Wednesday, August 28, 2013, 9:00 a.m. to 3:30 p.m., Eastern time. The entire meeting will be closed to the public. ADDRESSES: The meeting will be held at the National Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg, Maryland 20899. FOR FURTHER INFORMATION CONTACT: Robert Fangmeyer, Acting Director, Baldrige Performance Excellence Program, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, telephone number (301) 975–4781, email robert.fangmeyer@nist.gov. SUPPLEMENTARY INFORMATION: SUMMARY: tkelley on DSK3SPTVN1PROD with NOTICES Authority: 15 U.S.C. 3711a(d)(1) and the Federal Advisory Committee Act, as amended, 5 U.S.C. App. 19:47 Aug 05, 2013 Jkt 229001 Dated: July 30, 2013. Phillip Singerman, Associate Director for Innovation & Industry Services. [FR Doc. 2013–18938 Filed 8–5–13; 8:45 am] BILLING CODE 3510–13–P DEPARTMENT OF COMMERCE National Institute of Standards and Technology Pursuant to the Federal Advisory Committee Act, as amended, 5 U.S.C. App., notice is hereby given that the Judges Panel of the Malcolm Baldrige National Quality Award will meet on Wednesday, August 28, 2013, 9:00 a.m. to 3:30 p.m., Eastern time. The Judges Panel is composed of twelve members, appointed by the Secretary of Commerce, chosen for their familiarity with quality improvement operations and competitiveness issues of manufacturing companies, services companies, small businesses, health care providers, and educational institutions. Members are also chosen who have broad experience in for-profit and nonprofit areas. The purpose of this meeting is to review the results of examiners’ scoring of written applications. Panel members will vote on which applicants merit site visits by examiners to verify the accuracy of VerDate Mar<15>2010 quality improvements claimed by applicants. The Senior Advisor to the Deputy Secretary performing the non-exclusive duties of the Chief Financial Officer and Assistant Secretary for Administration, with the concurrence of the General Counsel, formally determined on March 19, 2013, pursuant to Section 10(d) of the Federal Advisory Committee Act, as amended by Section 5(c) of the Government in Sunshine Act, Public Law 94–409, that the meeting of the Judges Panel may be closed in accordance with 5 U.S.C. 552b(c)(4) because the meeting is likely to disclose trade secrets and commercial or financial information obtained from a person which is privileged or confidential; and, 5 U.S.C. 552b(c)(9)(B) because for a government agency the meeting is likely to disclose information that could significantly frustrate implementation of a proposed agency action. The meeting, which involves examination of Award applicant data from U.S. companies and other organizations and a discussion of these data as compared to the Award criteria in order to select applicants for site visit review, conducted prior to recommending Award recipients, will be closed to the public. Genome in a Bottle Consortium— Progress and Planning Workshop National Institute of Standards & Technology (NIST), Commerce. ACTION: Notice of public workshop. AGENCY: NIST announces the Genome in a Bottle Consortium meeting to be held on Thursday and Friday, August 15 and 16, 2013. The Genome in a Bottle Consortium is developing the reference materials, reference methods, and reference data needed to assess confidence in human whole genome variant calls. A principal motivation for this consortium is to enable performance assessment of sequencing and science-based regulatory oversight of clinical sequencing. The purpose of this meeting is to update participants about progress of the consortium work, continue to get broad input from SUMMARY: PO 00000 Frm 00005 Fmt 4703 Sfmt 4703 individual stakeholders to update or refine the consortium work plan, continue to broadly solicit consortium membership from interested stakeholders, and invite members to participate in work plan implementation. DATES: The Genome in a Bottle Consortium meeting will be held on Thursday, August 15, 2013 from 9:30 a.m. to 5:30 p.m. Eastern Time and Friday, August 16, 2013 from 9:00 a.m. to 3:00 p.m. Eastern Time. Attendees must register by 5:00 p.m. Eastern Time on Thursday, August 8, 2013. ADDRESSES: The meeting will be held at the National Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg, MD 20899 in Room C103– C106, Building 215. Please note admittance instructions under the SUPPLEMENTARY INFORMATION section of this notice. FOR FURTHER INFORMATION CONTACT: For further information contact Justin Zook by email at jzook@nist.gov or by phone at (301) 975–4133 or Marc Salit by email at salit@nist.gov or by phone at (650) 350–2338. To register, go to: https:// www-s.nist.gov/CRS/. SUPPLEMENTARY INFORMATION: Clinical application of ultra high throughput sequencing (UHTS) for hereditary genetic diseases and oncology is rapidly growing. At present, there are no widely accepted genomic standards or quantitative performance metrics for confidence in variant calling. These standards and quantitative performance metrics are needed to achieve the confidence in measurement results expected for sound, reproducible research and regulated applications in the clinic. On April 13, 2012, NIST convened the workshop ‘‘Genome in a Bottle’’ to initiate a consortium to develop the reference materials, reference methods, and reference data needed to assess confidence in human whole genome variant calls. On August 16–17, 2012, NIST hosted the first large public meeting of the Genome in a Bottle Consortium, with about 100 participants from government, academic, and industry. A principal motivation for this consortium is to enable science-based regulatory oversight of clinical sequencing. At the August 2012 meeting, the consortium established work plans for four technical working groups with the following responsibilities: (1) Reference Material (RM) Selection and Design: select appropriate sources for whole genome RMs and identify or design synthetic DNA constructs that could be spiked-in to samples for measurement assurance. E:\FR\FM\06AUN1.SGM 06AUN1 Federal Register / Vol. 78, No. 151 / Tuesday, August 6, 2013 / Notices (2) Measurements for Reference Material Characterization: design and carry out experiments to characterize the RMs using multiple sequencing methods, other methods, and validation of selected variants using orthogonal technologies. (3) Bioinformatics, Data Integration, and Data Representation: develop methods to analyze and integrate the data for each RM, as well as select appropriate formats to represent the data. (4) Performance Metrics and Figures of Merit: develop useful performance metrics and figures of merit that can be obtained through measurement of the RMs. The products of these technical working groups will be a set of wellcharacterized whole genome and synthetic DNA RMs along with the methods (documentary standards) and reference data necessary for use of the RMs. These products will be designed to help enable translation of whole genome sequencing to regulated clinical applications. There is no cost for participating in the consortium. No proprietary information will be shared as part of the consortium, and all research results will be in the public domain. All visitors to the NIST site are required to pre-register to be admitted and present appropriate governmentissued photo ID to gain entry to NIST. Anyone wishing to attend this meeting must pre-register at https://wwws.nist.gov/CRS/ by 5:00 p.m. Eastern Time on Thursday, August 8, 2013, in order to attend. Dated: July 29, 2013. Willie E. May, Associate Director of Laboratory Programs. [FR Doc. 2013–18934 Filed 8–5–13; 8:45 am] BILLING CODE 3510–13–P DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648–XC794 Pacific Fishery Management Council; Public Meeting National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric Administration (NOAA), Commerce. ACTION: Notice of public meeting. tkelley on DSK3SPTVN1PROD with NOTICES AGENCY: The Pacific Fishery Management Council’s (Pacific Council) Ad Hoc Groundfish Electronic Monitoring Committee and Ad Hoc SUMMARY: VerDate Mar<15>2010 19:47 Aug 05, 2013 Jkt 229001 47675 Trawl Groundfish Electronic Monitoring Technical Advisory Committee (GEM Committees) will hold a work session, which is open to the public. Dated: August 1, 2013. Tracey L. Thompson, Acting Deputy Director, Office of Sustainable Fisheries, National Marine Fisheries Service. The meeting will be held August 20 and 21, 2013, from 8 a.m. until the earlier of 5 p.m. or when business for each day has been completed. [FR Doc. 2013–18941 Filed 8–5–13; 8:45 am] The meeting will be held at the Holiday Inn Portland Airport, Salon C Room, 8439 NE., Columbia Blvd. Portland, OR, 97220, telephone: 503– 256–5000. Council address: Pacific Council, 7700 NE., Ambassador Place, Suite 101, Portland, OR 97220–1384. DEPARTMENT OF DEFENSE DATES: ADDRESSES: FOR FURTHER INFORMATION CONTACT: Mr. Brett Wiedoff, Staff Officer, Pacific Council: (503) 820–2280. The primary purpose of the meeting is to discuss and develop potential alternatives for electronic monitoring (EM) for vessels participating in the West Coast groundfish trawl catch share program for consideration by the Pacific Council and to develop other recommendations as needed to further the Pacific Council process for considering EM. The GEM Committees were established by the Pacific Council at the June 2013 meeting in Garden Grove, California. No management actions will be decided at this meeting. The meeting will include review of the 2013 Trawl Catch Share Program EM Workshop Report and other reports to guide discussions. Although nonemergency issues not contained in the meeting agenda may come before the GEM committees for discussion, those issues may not be the subject of formal action during this meeting. The meeting will be restricted to those issues specifically listed in this notice and any issues arising after publication of this notice that require emergency action under section 305(c) of the MagnusonStevens Fishery Conservation and Management Act, provided the public has been notified of the GEM committees’ intent to take final action to address the emergency. A meeting report will be prepared by Pacific Council staff for consideration by the Pacific Council at its September 2013 meeting in Boise, Idaho. SUPPLEMENTARY INFORMATION: BILLING CODE 3510–22–P Office of the Secretary Meeting of the National Commission on the Structure of the Air Force; Cancellation of August 6, 2013 Meeting Director of Administration and Management, DoD. AGENCY: Notice of Advisory Committee Meeting; cancellation. ACTION: On Wednesday, July 31, 2013 (78 FR 46329), the Department of Defense published a notice announcing an August 6, 2013 meeting of the National Commission on the Structure of the Air Force. Under the provisions of the Federal Advisory Committee Act of 1972 (5 U.S.C., Appendix, as amended), and the Government in the Sunshine Act of 1976 (5 U.S.C. 552b, as amended), this notice announces that the National Commission on the Structure of the Air Force meeting scheduled for Tuesday, August 6, 2013 is hereby cancelled. Due to unforeseen circumstances arising from the furlough on civilian employee hours, the Chairman has re-evaluated the schedule to complete the Commission’s report by February 1, 2014. A more efficient agenda is planned, whereby the Chairman will combine the August 6, 2013 meeting with a future meeting. SUMMARY: Mrs. Marcia Moore, Designated Federal Officer, National Commission on the Structure of the Air Force, 1950 Defense Pentagon Room 3A874, Washington, DC 20301–1950. Email: dfoafstrucomm@osd.mil. Desk (703) 545–9113. Facsimile (703) 692–5625. FOR FURTHER INFORMATION CONTACT: Dated: August 1, 2013. Aaron Siegel, Alternate OSD Federal Register Liaison Officer, Department of Defense. Special Accommodations [FR Doc. 2013–18937 Filed 8–5–13; 8:45 am] This meeting is physically accessible to people with disabilities. Requests for sign language interpretation or other auxiliary aids should be directed to Mr. Kris Kleinschmidt at (503) 820–2280 at least five days prior to the meeting date. BILLING CODE 5001–06–P PO 00000 Frm 00006 Fmt 4703 Sfmt 9990 E:\FR\FM\06AUN1.SGM 06AUN1

Agencies

[Federal Register Volume 78, Number 151 (Tuesday, August 6, 2013)]
[Notices]
[Pages 47674-47675]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 2013-18934]


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DEPARTMENT OF COMMERCE

National Institute of Standards and Technology


Genome in a Bottle Consortium--Progress and Planning Workshop

AGENCY: National Institute of Standards & Technology (NIST), Commerce.

ACTION: Notice of public workshop.

-----------------------------------------------------------------------

SUMMARY: NIST announces the Genome in a Bottle Consortium meeting to be 
held on Thursday and Friday, August 15 and 16, 2013. The Genome in a 
Bottle Consortium is developing the reference materials, reference 
methods, and reference data needed to assess confidence in human whole 
genome variant calls. A principal motivation for this consortium is to 
enable performance assessment of sequencing and science-based 
regulatory oversight of clinical sequencing. The purpose of this 
meeting is to update participants about progress of the consortium 
work, continue to get broad input from individual stakeholders to 
update or refine the consortium work plan, continue to broadly solicit 
consortium membership from interested stakeholders, and invite members 
to participate in work plan implementation.

DATES: The Genome in a Bottle Consortium meeting will be held on 
Thursday, August 15, 2013 from 9:30 a.m. to 5:30 p.m. Eastern Time and 
Friday, August 16, 2013 from 9:00 a.m. to 3:00 p.m. Eastern Time. 
Attendees must register by 5:00 p.m. Eastern Time on Thursday, August 
8, 2013.

ADDRESSES: The meeting will be held at the National Institute of 
Standards and Technology, 100 Bureau Drive, Gaithersburg, MD 20899 in 
Room C103-C106, Building 215. Please note admittance instructions under 
the SUPPLEMENTARY INFORMATION section of this notice.

FOR FURTHER INFORMATION CONTACT: For further information contact Justin 
Zook by email at jzook@nist.gov or by phone at (301) 975-4133 or Marc 
Salit by email at salit@nist.gov or by phone at (650) 350-2338. To 
register, go to: https://www-s.nist.gov/CRS/.

SUPPLEMENTARY INFORMATION: Clinical application of ultra high 
throughput sequencing (UHTS) for hereditary genetic diseases and 
oncology is rapidly growing. At present, there are no widely accepted 
genomic standards or quantitative performance metrics for confidence in 
variant calling. These standards and quantitative performance metrics 
are needed to achieve the confidence in measurement results expected 
for sound, reproducible research and regulated applications in the 
clinic. On April 13, 2012, NIST convened the workshop ``Genome in a 
Bottle'' to initiate a consortium to develop the reference materials, 
reference methods, and reference data needed to assess confidence in 
human whole genome variant calls. On August 16-17, 2012, NIST hosted 
the first large public meeting of the Genome in a Bottle Consortium, 
with about 100 participants from government, academic, and industry. A 
principal motivation for this consortium is to enable science-based 
regulatory oversight of clinical sequencing.
    At the August 2012 meeting, the consortium established work plans 
for four technical working groups with the following responsibilities:
    (1) Reference Material (RM) Selection and Design: select 
appropriate sources for whole genome RMs and identify or design 
synthetic DNA constructs that could be spiked-in to samples for 
measurement assurance.

[[Page 47675]]

    (2) Measurements for Reference Material Characterization: design 
and carry out experiments to characterize the RMs using multiple 
sequencing methods, other methods, and validation of selected variants 
using orthogonal technologies.
    (3) Bioinformatics, Data Integration, and Data Representation: 
develop methods to analyze and integrate the data for each RM, as well 
as select appropriate formats to represent the data.
    (4) Performance Metrics and Figures of Merit: develop useful 
performance metrics and figures of merit that can be obtained through 
measurement of the RMs.
    The products of these technical working groups will be a set of 
well-characterized whole genome and synthetic DNA RMs along with the 
methods (documentary standards) and reference data necessary for use of 
the RMs. These products will be designed to help enable translation of 
whole genome sequencing to regulated clinical applications.
    There is no cost for participating in the consortium. No 
proprietary information will be shared as part of the consortium, and 
all research results will be in the public domain.
    All visitors to the NIST site are required to pre-register to be 
admitted and present appropriate government-issued photo ID to gain 
entry to NIST. Anyone wishing to attend this meeting must pre-register 
at https://www-s.nist.gov/CRS/ by 5:00 p.m. Eastern Time on Thursday, 
August 8, 2013, in order to attend.

    Dated: July 29, 2013.
Willie E. May,
Associate Director of Laboratory Programs.
[FR Doc. 2013-18934 Filed 8-5-13; 8:45 am]
BILLING CODE 3510-13-P

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