Genome in a Bottle Consortium-Work Plan Review Workshop, 43237-43238 [2012-18064]

Download as PDF Federal Register / Vol. 77, No. 142 / Tuesday, July 24, 2012 / Notices 8520, Gaithersburg, MD 20899, tel. (301) 975 5785, or terrell.vanderah@nist.gov. In addition, written comments may be sent via email to terrell.vanderah@nist.gov. SUPPLEMENTARY INFORMATION: I. Abstract This is a request to extend the expiration date of this currently approved information collection. The purpose of this collection is to gather information needed for the SURF (Summer Undergraduate Research Fellowship) Program. The information will be provided by student applicants and will be described in the Proposal Review Process and Evaluation Criteria sections of the Federal Register Notice for the SURF Program. The information will be used by the Program Directors and technical evaluators and is needed to determine eligible students, select students for the program using the Evaluation Criteria described in the Federal Register Notice, and place selected students in appropriate research projects that match their needs, interests, and academic preparation. The information includes: Student name, host institution, email address/ contact information, home address, class standing, first- and second-choice NIST laboratories they wish to apply to, academic major/minor, current overall GPA, need for housing and gender (for housing purposes only), availability dates, resume, personal statement of commitment and research interests, two letters of recommendation, academic transcripts, and ability to verify U.S. citizenship or permanent legal residency. II. Method of Collection sroberts on DSK5SPTVN1PROD with NOTICES III. Data OMB Control Number: 0693–0042. Form Number: None. Type of Review: Regular submission. Affected Public: Individuals or households. Estimated Number of Respondents: 300. Estimated Time per Response: 15 minutes. Estimated Total Annual Burden Hours: 75. Estimated Total Annual Respondent Cost Burden: $0. 21:06 Jul 23, 2012 Comments are invited on: (a) Whether the proposed collection of information is necessary for the proper performance of the functions of the agency, including whether the information shall have practical utility; (b) the accuracy of the agency’s estimate of the burden (including hours and cost) of the proposed collection of information; (c) ways to enhance the quality, utility, and clarity of the information to be collected; and (d) ways to minimize the burden of the collection of information on respondents, including through the use of automated collection techniques or other forms of information technology. Comments submitted in response to this notice will be summarized and/or included in the request for OMB approval of this information collection; they also will become a matter of public record. Dated: July 18, 2012. Gwellnar Banks, Management Analyst, Office of the Chief Information Officer. [FR Doc. 2012–17942 Filed 7–23–12; 8:45 am] BILLING CODE 3510–13–P DEPARTMENT OF COMMERCE National Institute of Standards and Technology Malcolm Baldrige National Quality Award Panel of Judges National Institute of Standards and Technology, Department of Commerce. ACTION: Notice of Closed Meeting. AGENCY: Pursuant to the Federal Advisory Committee Act, as amended, 5 U.S.C. app., notice is hereby given that the Panel of Judges of the Malcolm Baldrige National Quality Award will meet on Wednesday, August 29, 2012. The Panel of Judges is composed of twelve members prominent in the fields of quality, innovation, and performance management and appointed by the Secretary of Commerce, assembled to advise the Secretary of Commerce on the conduct of the Baldrige Award. The purpose of this meeting is to review applicant consensus scores and select applicants for site visit review. The applications under review by Judges contain trade secrets and proprietary commercial information submitted to the Government in confidence. DATES: The meeting will be held on Wednesday, August 29, 2012 from 8 a.m. until 5 p.m. Eastern time. The SUMMARY: The Student Application Information form will be available on the web; the collection is currently limited to paper form but can be submitted as hardcopy or scanned and submitted electronically. VerDate Mar<15>2010 IV. Request for Comments Jkt 226001 PO 00000 Frm 00010 Fmt 4703 Sfmt 4703 43237 entire meeting will be closed to the public. ADDRESSES: The meeting will be held at the National Institute of Standards and Technology, Administration Building, Gaithersburg, Maryland 20899. FOR FURTHER INFORMATION CONTACT: Dr. Harry Hertz, Director, Baldrige Performance Excellence Program, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, telephone number (301) 975– 2361. SUPPLEMENTARY INFORMATION: The Assistant Secretary for Administration, with the concurrence of the General Counsel, formally determined on April 5, 2012, that the meeting of the Judges Panel may be closed in accordance with 5 U.S.C. 552b(c)(4) because the meeting is likely to disclose trade secrets and commercial or financial information obtained from a person which is privileged or confidential and 5 U.S.C. 552b(c)(9)(B) because for a government agency the meetings are likely to disclose information that could significantly frustrate implementation of a proposed agency action. The meeting, which involves examination of Award applicant data from U.S. companies and other organizations and a discussion of these data as compared to the Award criteria in order to recommend organizations that will receive site visit reviews, may be closed to the public. Dated: July 18, 2012. Phillip A. Singerman, Associate Director for Innovation & Industry Services. [FR Doc. 2012–18068 Filed 7–23–12; 8:45 am] BILLING CODE 3510–13–P DEPARTMENT OF COMMERCE National Institute of Standards and Technology Genome in a Bottle Consortium—Work Plan Review Workshop National Institute of Standards & Technology (NIST), Commerce. ACTION: Notice of public workshop. AGENCY: NIST announces the Genome in a Bottle Consortium meeting to be held on Thursday and Friday, August 16 and 17, 2012. The Genome in a Bottle Consortium is planning to develop the reference materials, reference methods, and reference data needed to assess confidence in human whole genome variant calls. A principal motivation for this consortium is to enable performance assessment of sequencing and science-based regulatory oversight SUMMARY: E:\FR\FM\24JYN1.SGM 24JYN1 43238 Federal Register / Vol. 77, No. 142 / Tuesday, July 24, 2012 / Notices of clinical sequencing. The purpose of this meeting is to get broad input from stakeholders about the draft consortium work plan, broadly solicit consortium membership from interested stakeholders, and invite members to participate in work plan implementation. The Genome in a Bottle Consortium meeting will be held on Thursday and Friday, August 16 and 17, 2012. Attendees must register by 5 p.m. Eastern time on Thursday, August 9, 2012. DATES: The meeting will be held at the National Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg, MD 20899 in Room C103– C106, Building 215. Please note admittance instructions under the SUPPLEMENTARY INFORMATION section of this notice. FOR FURTHER INFORMATION CONTACT: For further information contact Justin Zook by email at jzook@nist.gov or by phone at (301) 975–4133 or Marc Salit by email at salit@nist.gov or by phone at (301) 975–3646. To register, go to: https:// www-s.nist.gov/CRS/. SUPPLEMENTARY INFORMATION: Clinical application of ultra high throughput sequencing (UHTS) for hereditary genetic diseases and oncology is rapidly growing. At present, there are no widely accepted genomic standards or quantitative performance metrics for confidence in variant calling. These standards and quantitative performance metrics are needed to achieve the confidence in measurement results expected for sound, reproducible research and regulated applications in the clinic. On April 13, 2012, NIST convened the workshop ‘‘Genome in a Bottle’’ to initiate a consortium to develop the reference materials, reference methods, and reference data needed to assess confidence in human whole genome variant calls. A principal motivation for this consortium is to enable science-based regulatory oversight of clinical sequencing. At present, we expect the consortium to have four working groups with the following responsibilities: (1) Reference Material (RM) Selection and Design: Select appropriate cell lines for whole genome RMs and design synthetic DNA constructs that could be spiked-in to samples. (2) Measurements for Reference Material Characterization: Design and carry out experiments to characterize the RMs using multiple sequencing methods, other methods, and validation of selected variants using orthogonal technologies. sroberts on DSK5SPTVN1PROD with NOTICES ADDRESSES: VerDate Mar<15>2010 21:06 Jul 23, 2012 Jkt 226001 (3) Bioinformatics, Data Integration, and Data Representation: Develop methods to analyze and integrate the data for each RM, as well as select appropriate formats to represent the data. (4) Performance Metrics and Figures of Merit: Develop useful performance metrics and figures of merit that can be obtained through measurement of the RMs. The products of these working groups will be a set of well-characterized whole genome and synthetic DNA RMs along with the methods (documentary standards) and reference data necessary for use of the RMs. These products will be designed to help enable translation of whole genome sequencing to regulated clinical applications. There is no cost for participating in the consortium. No proprietary information will be shared as part of the consortium, and all research results will be in the public domain. All visitors to the NIST site are required to pre-register to be admitted and have appropriate governmentissued photo ID to gain entry to NIST. Anyone wishing to attend this meeting must register at https://www-s.nist.gov/ CRS/by 5 p.m. Eastern time on Thursday, August 9, 2012, in order to attend. Dated: July 18, 2012. Willie E. May, Associate Director for Laboratory Programs. [FR Doc. 2012–18064 Filed 7–23–12; 8:45 am] BILLING CODE 3510–13–P DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648–XZ14 Takes of Marine Mammals Incidental to Specified Activities; Navy Training Conducted at the Silver Strand Training Complex, San Diego Bay National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric Administration (NOAA), Commerce. ACTION: Notice of issuance of an incidental harassment authorization. AGENCY: In accordance with provisions of the Marine Mammal Protection Act (MMPA) as amended, notification is hereby given that an Incidental Harassment Authorization (IHA) has been issued to the U.S. Navy (Navy) to take marine mammals, by harassment, incidental to conducting training exercises at the Silver Strand Training SUMMARY: PO 00000 Frm 00011 Fmt 4703 Sfmt 4703 Complex (SSTC) in the vicinity of San Diego Bay, California. DATES: This authorization is effective from July 18, 2012, until July 17, 2013. ADDRESSES: A copy of the application, IHA, and/or a list of references used in this document may be obtained by writing to P. Michael Payne, Chief, Permits and Conservation Division, Office of Protected Resources, National Marine Fisheries Service, 1315 EastWest Highway, Silver Spring, MD 20910–3225. FOR FURTHER INFORMATION CONTACT: Shane Guan, NMFS, (301) 427–8401, or Monica DeAngelis, NMFS, (562) 980– 3232. SUPPLEMENTARY INFORMATION: Background Sections 101(a)(5)(A) and (D) of the MMPA (16 U.S.C. 1361 et seq.) direct the Secretary of Commerce (Secretary) to allow, upon request, the incidental, but not intentional taking of small numbers of marine mammals by U.S. citizens who engage in a specified activity (other than commercial fishing) if certain findings are made and regulations are issued or, if the taking is limited to harassment, notice of a proposed authorization is provided to the public for review. Authorization for incidental takings shall be granted if NMFS finds that the taking will have a negligible impact on the species or stock(s), will not have an unmitigable adverse impact on the availability of the species or stock(s) for subsistence uses (where relevant), and if the permissible methods of taking and requirements pertaining to the mitigation, monitoring and reporting of such taking are set forth. NMFS has defined ‘‘negligible impact’’ in 50 CFR 216.103 as: ‘‘* * * an impact resulting from the specified activity that cannot be reasonably expected to, and is not reasonably likely to, adversely affect the species or stock through effects on annual rates of recruitment or survival.’’ The National Defense Authorization Act of 2004 (NDAA) (Public Law 108– 136) removed the ‘‘small numbers’’ and ‘‘specified geographical region’’ limitations and amended the definition of ‘‘harassment’’ as it applies to a ‘‘military readiness activity’’ to read as follows (Section 3(18)(B) of the MMPA): (i) Any act that injures or has the significant potential to injure a marine mammal or marine mammal stock in the wild [Level A Harassment]; or (ii) any act that disturbs or is likely to disturb a marine mammal or marine mammal stock in the wild by causing disruption of natural behavioral patterns, including, but not limited to, E:\FR\FM\24JYN1.SGM 24JYN1

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[Federal Register Volume 77, Number 142 (Tuesday, July 24, 2012)]
[Notices]
[Pages 43237-43238]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 2012-18064]


-----------------------------------------------------------------------

DEPARTMENT OF COMMERCE

National Institute of Standards and Technology


Genome in a Bottle Consortium--Work Plan Review Workshop

AGENCY: National Institute of Standards & Technology (NIST), Commerce.

ACTION: Notice of public workshop.

-----------------------------------------------------------------------

SUMMARY: NIST announces the Genome in a Bottle Consortium meeting to be 
held on Thursday and Friday, August 16 and 17, 2012. The Genome in a 
Bottle Consortium is planning to develop the reference materials, 
reference methods, and reference data needed to assess confidence in 
human whole genome variant calls. A principal motivation for this 
consortium is to enable performance assessment of sequencing and 
science-based regulatory oversight

[[Page 43238]]

of clinical sequencing. The purpose of this meeting is to get broad 
input from stakeholders about the draft consortium work plan, broadly 
solicit consortium membership from interested stakeholders, and invite 
members to participate in work plan implementation.

DATES: The Genome in a Bottle Consortium meeting will be held on 
Thursday and Friday, August 16 and 17, 2012. Attendees must register by 
5 p.m. Eastern time on Thursday, August 9, 2012.

ADDRESSES: The meeting will be held at the National Institute of 
Standards and Technology, 100 Bureau Drive, Gaithersburg, MD 20899 in 
Room C103-C106, Building 215. Please note admittance instructions under 
the SUPPLEMENTARY INFORMATION section of this notice.

FOR FURTHER INFORMATION CONTACT: For further information contact Justin 
Zook by email at jzook@nist.gov or by phone at (301) 975-4133 or Marc 
Salit by email at salit@nist.gov or by phone at (301) 975-3646. To 
register, go to: https://www-s.nist.gov/CRS/.

SUPPLEMENTARY INFORMATION: Clinical application of ultra high 
throughput sequencing (UHTS) for hereditary genetic diseases and 
oncology is rapidly growing. At present, there are no widely accepted 
genomic standards or quantitative performance metrics for confidence in 
variant calling. These standards and quantitative performance metrics 
are needed to achieve the confidence in measurement results expected 
for sound, reproducible research and regulated applications in the 
clinic. On April 13, 2012, NIST convened the workshop ``Genome in a 
Bottle'' to initiate a consortium to develop the reference materials, 
reference methods, and reference data needed to assess confidence in 
human whole genome variant calls. A principal motivation for this 
consortium is to enable science-based regulatory oversight of clinical 
sequencing.
    At present, we expect the consortium to have four working groups 
with the following responsibilities:
    (1) Reference Material (RM) Selection and Design: Select 
appropriate cell lines for whole genome RMs and design synthetic DNA 
constructs that could be spiked-in to samples.
    (2) Measurements for Reference Material Characterization: Design 
and carry out experiments to characterize the RMs using multiple 
sequencing methods, other methods, and validation of selected variants 
using orthogonal technologies.
    (3) Bioinformatics, Data Integration, and Data Representation: 
Develop methods to analyze and integrate the data for each RM, as well 
as select appropriate formats to represent the data.
    (4) Performance Metrics and Figures of Merit: Develop useful 
performance metrics and figures of merit that can be obtained through 
measurement of the RMs.
    The products of these working groups will be a set of well-
characterized whole genome and synthetic DNA RMs along with the methods 
(documentary standards) and reference data necessary for use of the 
RMs. These products will be designed to help enable translation of 
whole genome sequencing to regulated clinical applications.
    There is no cost for participating in the consortium. No 
proprietary information will be shared as part of the consortium, and 
all research results will be in the public domain.
    All visitors to the NIST site are required to pre-register to be 
admitted and have appropriate government-issued photo ID to gain entry 
to NIST. Anyone wishing to attend this meeting must register at https://www-s.nist.gov/CRS/by 5 p.m. Eastern time on Thursday, August 9, 2012, 
in order to attend.

    Dated: July 18, 2012.
Willie E. May,
Associate Director for Laboratory Programs.
[FR Doc. 2012-18064 Filed 7-23-12; 8:45 am]
BILLING CODE 3510-13-P
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