Wisconsin Administrative Code
Department of Natural Resources
NR 200-299 - Environmental Protection Wisconsin Pollutant Discharge Elimination System
Chapter NR 237 - Pharmaceutical manufacturing
Section NR 237.08 - Effluent limitations representing the degree of effluent reduction attainable by the application of the best practicable control technology currently available

Universal Citation: WI Admin Code § NR 237.08

Current through August 26, 2024

(1) EXISTING SOURCE. Except as provided in 40 CFR 125.30 to 125.32, any existing source subject to this chapter shall achieve the effluent limitations set forth in subs. (2), (3) and (4) representing the degree of effluent reduction attainable by the application of BPT.

(2) BIOLOGICAL OXYGEN DEMAND AND CHEMICAL OXYGEN DEMAND.

(a) Except as provided in par. (c), the limitation for the daily average mass of BOD5 and COD for any calendar month shall be calculated by multiplying the long term daily average raw waste load by a variability factor and the difference between 1 and the required fractional reduction as given in the following table:

Table 1

Pharmaceutical Manufacturing

BPT Effluent Limitations
Pollutant or pollutant property	Variability factor	Required fractional reduction
BOD5	3.0	0.9
COD	2.2	0.74

(b) The limitations for BOD5 and COD shall be expressed in mass per unit time.

(c) Extraction operations and mixing, compounding, and formulation operations are not required to reduce the maximum 30-day average BOD5 concentration to less than 45 mg/l or reduce the maximum 30-day average COD concentration to less than 220 mg/l.

(d)

1. For fermentation operations, calculation of raw waste loads of BOD5 and COD shall exclude any waste load associated with separable mycelia and solvents in those waste loads, except that residual amounts of solvents remaining after solvent recovery, separate disposal, or reuse may be included in the raw waste load. Removal, disposal, and reuse includes physical separation and removal of separable mycelia, recovery of solvents from waste streams, incineration of concentrated solvent waste streams, incineration of tar still bottoms, and broth concentration for disposal other than to the treatment system.

2. For extraction, chemical synthesis, and mixing, compounding, and formulation operations, calculation of raw waste loads of BOD5 and COD shall exclude any waste load associated with solvents in those waste loads, except that residual amounts of solvents remaining after solvent recovery, separate disposal, or reuse may be included in the raw waste load. Removal, disposal, and reuse includes recovery of solvents from waste streams and incineration of concentrated solvent waste streams and incineration of tar still bottoms.

(3) TOTAL SUSPENDED SOLIDS. The TSS BPT effluent limitation shall be calculated by multiplying the BOD5 limitation, as calculated in sub. (2), by 1.7.

(4) CYANIDE AND PH. The following limitations for cyanide and pH apply:

Table 2

Pharmaceutical Manufacturing

BPT Effluent Limitations
milligrams per liter
Pollutant or pollutant property	Maximum for any 1 day	Average of daily values for 30 consecutive days
Cyanide (1)	33.5	9.4
pH	(2)	(2)

(1) This applies only to those plants using or generating cyanide and to discharges not resulting from research.

(2) Within the range of 6.0 to 9.0.

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