California Code of Regulations
Title 27 - Environmental Protection
Division 4 - Office of Environmental Health Hazard Assessment
Chapter 1 - Safe Drinking Water and Toxic Enforcement Act of 1986
Article 8 - NO Observable Effect Levels
Section 25805 - Specific Regulatory Levels: Chemicals Causing Reproductive Toxicity
Current through Register 2024 Notice Reg. No. 38, September 20, 2024
(a) Exposure to a chemical at a level which does not exceed the level set forth in subsection (b) for such chemical has no observable effect assuming exposure at one thousand (1,000) times that level.
(b)
| Chemical Name | Level (micrograms/day) | ||
| Acrylamide | 140 | ||
| Atrazine | 100 (oral) | ||
| Avermectin B1 | 4.4 | ||
| Benzene | 24 (oral) | ||
| 49 (inhalation) | |||
| Bisphenol A (BPA) | 3 (dermal exposure from | ||
| solid materials) | |||
| Butyl Benzyl Phthalate (BBP) | 1,200 (oral) | ||
| Cadmium | 4.1 (oral) | ||
| Chlorpyrifos | 0.58 (oral and inhalation) | ||
| Chlorpyrifos | 7.2 (dermal) | ||
| Chromium (hexavalent compounds) | 8.2 (oral) | ||
| Cyanide Salts that readily dissociate in solution (expressed as cyanide) | 9.8 (oral) | ||
| 2,4-Diamino-6-chloro-s-triazine (DACT) | 100 (oral) | ||
| 2,4-D butyric acid (2,4-DB, 2,4-dichlorophenoxybutyric acid) | 910 | ||
| 1,2-Dibromo-3-chloropropane (DBCP) | 4.3 (inhalation) | ||
| 3.1 (oral) | |||
| Des-ethyl atrazine (DEA) | 100 (oral) | ||
| Des-isopropyl atrazine (DIA) | 100 (oral) | ||
| Di(n-butyl)phthalate (DBP) | 8.7 | ||
| Di(2-ethylhexyl)phthalate (DEHP), for intravenous exposures only | 4200 (adults) | ||
| 600 (infant boys, age 29 days-24 months) | |||
| 210 (neonatal infant boys, age 0-28 days) [Levels for male children and adolescents can be calculated by application of the default bodyweights specified in Title 27, California Code of Regulations, Section 25703(a)(8) to the procedure specified in Title 27, California Code of Regulations, Sections 25801 and 25803] | |||
| Di(2-ethylhexyl)phthalate (DEHP), for oral exposures only | 410 (adults) | ||
| 58 (infant boys, age 29 days-24 months) | |||
| 20 (neonatal infant boys, age 0-28 days) [Levels for male children and adolescents can be calculated by application of the default bodyweights specified in Title 27, California Code of Regulations, Section 25703(a)(8) to the procedure specified in Title 27, California Code of Regulations, Sections 25801 and 25803] | |||
| Di-n-hexyl phthalate (DnHP) | 2200 (oral) | ||
| Di-isodecyl phthalate (DIDP) | 2200 | ||
| m-Dinitrobenzene | 38 (oral) | ||
| Disodium cyanodithioimidocarbonate | 56 (oral) | ||
| [170 (oral) as 32% pesticidal formulation] | |||
| Ethyl dipropylthiocarbamate | 700 (oral and inhalation) | ||
| 6700 (dermal) | |||
| Ethylene glycol (ingested) | 8,700 (oral) | ||
| Ethylene glycol monoethyl ether (EGEE) | 750 (oral) | ||
| 960 (inhalation) | |||
| Ethylene glycol monoethyl ether acetate (EGEEA) | 1100 (oral) | ||
| 1400 (inhalation) | |||
| Ethylene glycol monomethyl ether | 63 (oral) | ||
| Ethylene glycol monomethyl ether acetate | 98 (oral) | ||
| Ethylene oxide | 20 | ||
| Hydramethylnon | 120 (oral) | ||
| Hydrogen cyanide | 10 (oral) | ||
| Lead | 0.5 | ||
| Linuron | 460 | ||
| Metham Sodium | 290 | ||
| Methanol | 47,000 (inhalation) | ||
| 23,000 (oral) | |||
| Methyl bromide as a structural fumigant | 810 (inhalation) | ||
| n-Hexane | 28,000 (oral) | ||
| 20,000 (inhalation) | |||
| N-Methylpyrrolidone | 3200 (inhalation) | ||
| 17000 (dermal) | |||
| Potassium dimethyldithiocarbamate | 720 | ||
| Potassium cyanide | 25 (oral) | ||
| Propazine | 100 (oral) | ||
| Quizalofop ethyl | 590 | ||
| Simazine | 100 (oral) | ||
| Sodium cyanide | 19 (oral) | ||
| Sodium dimethyldithiocarbamate | 23 (oral) [58 (oral) as 40% | ||
| pesticidal formulation] | |||
| Sulfur dioxide | 10000 | ||
| Thiophanate-methyl | 600 (oral) | ||
| Toluene | 7000 |
(c) Unless a specific level is otherwise provided in this section, an assessment by an agency of the state or federal government that is the substantial equivalent of the assessment described in subsection (a) of Section 25803, and establishes a maximum allowable dose level in the manner provided in paragraph (b)(1) of Section 25801, shall constitute the allowable dose level having no observable effect within the meaning of Section 25249.10(c) of the Act.
1. New section filed 2-24-88 as an emergency; operative 2-27-88 (Register 88, No. 11). A Certificate of Compliance must be transmitted to OAL within 120 days or emergency language will be repealed on 6-27-88.
2. New section refiled 6-27-88 as an emergency; operative 6-27-88 (Register 88, No. 27). A Certificate of Compliance must be transmitted to OAL within 120 days or emergency language will be repealed on 10-25-88.
3. New section refiled 10-17-88 as an emergency; operative 10-25-88 (Register 88, No. 44). A Certificate of Compliance must be transmitted to OAL within 120 days or emergency language will be repealed on 2-22-89.
4. New section refiled 2-21-89 as an emergency; operative 2-22-89 (Register 89, No. 10). A Certificate of Compliance must be transmitted to OAL within 120 days or emergency language will be repealed on 6-22-89.
5. Certificate of Compliance transmitted to OAL 6-9-89 and filed 7-10-89 (Register 89, No. 30).
6. Amendment of subsection (b) filed 4-9-92; operative 5-11-92 (Register 92, No. 15).
7. Amendment of subsection (b) filed 7-18-2002; operative 8-17-2002 (Register 2002, No. 29).
8. Amendment of section heading and subsection (c) filed 1-7-2003; operative 2-6-2003 (Register 2003, No. 2).
9. Amendment of subsection (b) filed 2-25-2003; operative 3-27-2003 (Register 2003, No. 9).
10. Amendment of section heading and subsection (b) filed 7-1-2003; operative 7-31-2003 (Register 2003, No. 27).
11. Amendment of section heading and subsection (b) filed 12-23-2004; operative 1-22-2005 (Register 2004, No. 52).
12. Amendment of subsection (b) filed 8-12-2005; operative 9-11-2005 (Register 2005, No. 32).
13. Amendment of subsection (b) filed 5-19-2006; operative 6-18-2006 (Register 2006, No. 20).
14. Amendment of subsection (b) filed 8-3-2006; operative 9-2-2006 (Register 2006, No. 31).
15. Amendment of subsection (b) filed 8-31-2007; operative 9-30-2007 (Register 2007, No. 35).
16. Change without regulatory effect renumbering title 22, section 12805 to title 27, section 25805, including amendment of subsection (c), filed 6-18-2008 pursuant to section 100, title 1, California Code of Regulations (Register 2008, No. 25).
17. Amendment of subsection (b) filed 6-23-2008; operative 7-23-2008 (Register 2008, No. 26).
18. Amendment subsection (b) filed 12-2-2008; operative 1-1-2009 (Register 2008, No. 49).
19. Amendment of subsection (b) filed 11-18-2010; operative 12-18-2010 (Register 2010, No. 47).
20. Amendment of subsection (b) filed 12-16-2010; operative 1-15-2011 (Register 2010, No. 51).
21. Amendment of subsection (b) filed 3-30-2011; operative 4-29-2011 (Register 2011, No. 13).
22. Amendment of subsection (b) filed 6-29-2011; operative 7-29-2011 (Register 2011, No. 26).
23. Amendment of subsection (b) filed 9-26-2011; operative 10-26-2011 (Register 2011, No. 39).
24. Amendment of subsection (b) filed 4-10-2013; operative 7-1-2013 (Register 2013, No. 15).
25. Amendment of subsection (b) filed 6-25-2013; operative 10-1-2013 (Register 2013, No. 26).
26. Amendment of subsection (b) filed 7-11-2013; operative 10-1-2013 (Register 2013, No. 28).
27. Amendment of subsection (b) filed 8-8-2013; operative 10-1-2013 (Register 2013, No. 32).
28. Amendment of subsection (b) filed 6-13-2016; operative 10-1-2016 (Register 2016, No. 25).
29. Change without regulatory effect amending subsection (b) filed 7-27-2016 pursuant to section 100, title 1, California Code of Regulations (Register 2016, No. 31).
30. Amendment of subsection (b) filed 4-4-2017; operative 7-1-2017 (Register 2017, No. 14).
31. Amendment of subsection (b) filed 5-3-2017; operative 7-1-2017 (Register 2017, No. 18).
32. Amendment of subsection (b) filed 7-17-2018; operative 10-1-2018 (Register 2018, No. 29).
33. Amendment of subsection (b) filed 3-11-2019; operative 7-1-2019 (Register 2019, No. 11).
34. Amendment of subsection (b) filed 6-24-2020; operative 10-1-2020 (Register 2020, No. 26).
Note: Authority cited: Section 25249.12, Health and Safety Code. Reference: Sections 25249.5, 25249.6, 25249.9, 25249.10 and 25249.11, Health and Safety Code.
