Significant New Use Rules on Certain Chemical Substances (22-4.5e), 49121-49144 [2024-12764]

Agencies

• ENVIRONMENTAL PROTECTION AGENCY

[Federal Register Volume 89, Number 113 (Tuesday, June 11, 2024)]
[Proposed Rules]
[Pages 49121-49144]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2024-12764]


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ENVIRONMENTAL PROTECTION AGENCY

40 CFR Part 721

[EPA-HQ-OPPT-2022-0771; FRL-11912-01-OCSPP]
RIN 2070-AB27


Significant New Use Rules on Certain Chemical Substances (22-
4.5e)

AGENCY: Environmental Protection Agency (EPA).

ACTION: Proposed rule.

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SUMMARY: EPA is proposing significant new use rules (SNURs) under the 
Toxic Substances Control Act (TSCA) for chemical substances that were 
the subject of premanufacture notices (PMNs) and are also subject to a 
TSCA Order. The SNURs require persons who intend to manufacture 
(defined by statute to include import) or process any of these chemical 
substances for an activity that is proposed as a significant new use by 
this rule to notify EPA at least 90 days before commencing that 
activity. The required notification initiates EPA's evaluation of the 
conditions of use for that chemical substance. In addition, the 
manufacture or processing for the significant new use may not commence 
until EPA has conducted a review of the required notification, made an 
appropriate determination regarding that notification, and taken such 
actions as required by that determination.

DATES: Comments must be received on or before July 11, 2024.

ADDRESSES: Submit your comments, identified by docket identification 
(ID) number EPA-HQ-OPPT-2022-0771, at https://www.regulations.gov. 
Follow the online instructions for submitting comments. Do not submit 
electronically any information you consider to be Confidential Business 
Information (CBI) or other information whose disclosure is restricted 
by statute. Additional instructions on commenting and visiting the 
docket, along with more information about dockets generally, is 
available at https://www.epa.gov/dockets.

FOR FURTHER INFORMATION CONTACT: 
    For technical information contact: William Wysong, New Chemicals 
Division (7405M), Office of Pollution Prevention and Toxics, 
Environmental Protection Agency, 1200 Pennsylvania Ave. NW, Washington, 
DC 20460-0001; telephone number: (202) 564-4163; email address: 
[email protected].
    For general information contact: The TSCA-Hotline, ABVI-Goodwill, 
422 South Clinton Ave., Rochester, NY 14620; telephone number: (202) 
554-1404; email address: [email protected].

SUPPLEMENTARY INFORMATION:

I. Executive Summary

A. What is the Agency's authority for taking this action?

    TSCA section 5(a)(2) (15 U.S.C. 2604(a)(2)) authorizes EPA to 
determine that a use of a chemical substance is a ``significant new 
use.'' EPA must make this determination by rule after considering all 
relevant factors, including the factors in TSCA section 5(a)(2) (see 
also the discussion in Unit II.).

B. What action is the Agency taking?

    EPA is proposing SNURs for the chemical substances discussed in 
Unit III. These SNURs, if finalized as proposed, would require persons 
who intend to manufacture or process any of these chemical substances 
for an activity that is designated as a significant new use to notify 
EPA at least 90 days before commencing that activity.

C. Does this action apply to me?

1. General Applicability
    This action applies to you if you manufacture, process, or use the 
chemical substances identified in Unit III. This may include entities 
in North American Industrial Classification System (NAICS) codes 325 
and 324110, e.g., chemical manufacturing and petroleum refineries.
2. Applicability to Importers and Exporters
    This action may also apply to certain entities through pre-existing 
import certification and export notification requirements under TSCA 
(https://www.epa.gov/tsca-import-export-requirements).
    Chemical importers are subject to TSCA section 13 (15 U.S.C. 2612), 
the requirements promulgated at 19 CFR 12.118 through 12.127 (see also 
19 CFR 127.28), and the EPA policy in support of import certification 
at 40 CFR part 707, subpart B. Chemical importers must certify that the 
shipment of the chemical substance complies with all applicable rules 
and orders under TSCA, including regulations issued under TSCA sections 
5, 6, 7 and Title IV.
    Pursuant to 40 CFR 721.20, any persons who export or intend to 
export a chemical substance that is the subject of this proposed rule 
on or after July 11, 2024 are subject to TSCA section 12(b) (15 U.S.C. 
2611(b)) and must comply with the export notification requirements in 
40 CFR part 707, subpart D.

D. What are the incremental economic impacts of this action?

    EPA has evaluated the potential costs of establishing SNUN 
reporting requirements for potential manufacturers (including 
importers) and processors of the chemical substances subject to these 
proposed SNURs. This analysis, which is available in the docket, is 
briefly summarized here.
1. Estimated Costs for SNUN Submissions
    If a SNUN is submitted, costs are an estimated $45,000 per SNUN 
submission for large business submitters and $14,500 for small business 
submitters. These estimates include the cost to prepare and submit the 
SNUN (including registration for EPA's Central Data Exchange (CDX)), 
and the payment of a user fee. Businesses that submit a SNUN would be 
subject to either a $37,000 user fee required by 40 CFR 
700.45(c)(2)(ii) and (d), or, if they are a small business as defined 
at 13 CFR 121.201, a reduced user fee of $6,480 (40 CFR 
700.45(c)(1)(ii) and (d)) per fiscal year 2022. The costs of submission 
for SNUNs will not be incurred by any company unless a company decides 
to pursue a significant new use as defined in these SNURs. 
Additionally, these estimates reflect the costs and fees as they are 
known at the time of this rulemaking.
2. Estimated Costs for Export Notifications
    EPA has also evaluated the potential costs associated with the 
export notification requirements under TSCA

[[Page 49122]]

section 12(b) and the implementing regulations at 40 CFR part 707, 
subpart D. For persons exporting a substance that is the subject of a 
SNUR, a one-time notice to EPA must be provided for the first export or 
intended export to a particular country. The total costs of export 
notification will vary by chemical, depending on the number of required 
notifications (i.e., the number of countries to which the chemical is 
exported). While EPA is unable to make any estimate of the likely 
number of export notifications for the chemical substances covered by 
these SNURs, as stated in the accompanying economic analysis, the 
estimated cost of the export notification requirement on a per unit 
basis is approximately $106.

E. What should I consider as I prepare my comments for EPA?

1. Submitting CBI
    Do not submit CBI to EPA through email or https://www.regulations.gov. If you wish to include CBI in your comment, please 
follow the applicable instructions at https://www.epa.gov/dockets/commenting-epa-dockets#rules and clearly mark the information that you 
claim to be CBI. Information so marked will not be disclosed except in 
accordance with procedures set forth in 40 CFR parts 2 and 703.
2. Tips for Preparing Your Comments
    When preparing and submitting your comments, see the commenting 
tips at https://www.epa.gov/dockets/commenting-epa-dockets.

II. Background

    This unit provides general information about SNURs. For additional 
information about EPA's new chemical program go to https://www.epa.gov/reviewing-new-chemicals-under-toxic-substances-control-act-tsca.

A. Significant New Use Determination Factors

    TSCA section 5(a)(2) states that EPA's determination that a use of 
a chemical substance is a significant new use must be made after 
consideration of all relevant factors, including:
     The projected volume of manufacturing and processing of a 
chemical substance.
     The extent to which a use changes the type or form of 
exposure of human beings or the environment to a chemical substance.
     The extent to which a use increases the magnitude and 
duration of exposure of human beings or the environment to a chemical 
substance.
     The reasonably anticipated manner and methods of 
manufacturing, processing, distribution in commerce, and disposal of a 
chemical substance.
    In determining what would constitute a significant new use for the 
chemical substances that are the subject of these SNURs, EPA considered 
relevant information about the toxicity of the chemical substances, and 
potential human exposures and environmental releases that may be 
associated with the substances, in the context of the four bulleted 
TSCA section 5(a)(2) factors listed in this unit and discussed in Unit 
III.
    These proposed SNURs include PMN substances that are subject to 
Orders issued under TSCA section 5(e)(1)(A), as required by the 
determinations made under TSCA section 5(a)(3)(B). The TSCA Orders 
require protective measures to limit exposures or otherwise mitigate 
the potential unreasonable risk. The proposed SNURs identify as 
significant new uses any manufacturing, processing, use, distribution 
in commerce, or disposal that does not conform to the restrictions 
imposed by the underlying TSCA Orders, consistent with TSCA section 
5(f)(4).

B. Rationale and Objectives of the SNURs

1. Rationale
    Under TSCA, no person may manufacture a new chemical substance or 
manufacture or process a chemical substance for a significant new use 
until EPA makes a determination as described in TSCA section 5(a) and 
takes any required action. The issuance of a SNUR is not a risk 
determination itself, only a notification requirement for ``significant 
new uses,'' so that the Agency has the opportunity to review the SNUN 
for the significant new use and make a TSCA section 5(a)(3) risk 
determination.
    During review of the PMNs submitted for these chemical substances, 
EPA concluded that regulation was warranted under TSCA section 5(e), 
pending the development of information sufficient to make reasoned 
evaluations of the health or environmental effects of these chemical 
substances. The basis for such findings is outlined in Unit IV. Based 
on these findings, TSCA Orders requiring the use of appropriate 
exposure controls were negotiated with the PMN submitters. As a general 
matter, EPA believes it is necessary to follow the TSCA Orders with a 
SNUR that identifies the absence of those protective measures as 
significant new uses to ensure that all manufacturers and processors--
not just the original submitter--are held to the same standard.
2. Objectives
    EPA is proposing these SNURs because the Agency wants:
     To identify as significant new uses any manufacturing, 
processing, use, distribution in commerce, or disposal that does not 
conform to the restrictions imposed by the underlying TSCA Orders, 
consistent with TSCA section 5(f)(4).
     To have an opportunity to review and evaluate data 
submitted in a SNUN before the submitter begins manufacturing or 
processing a listed chemical substance for the described significant 
new use.
     To be obligated to make a determination under TSCA section 
5(a)(3) regarding the use described in the SNUN, under the conditions 
of use. The Agency will either determine under TSCA section 5(a)(3)(C) 
that the significant new use is not likely to present an unreasonable 
risk, including an unreasonable risk to a potentially exposed or 
susceptible subpopulation identified as relevant by the Administrator 
under the conditions of use, or make a determination under TSCA section 
5(a)(3)(A) or (B) and take the required regulatory action associated 
with the determination, before manufacture or processing for the 
significant new use of the chemical substance can occur.
    Issuance of a proposed SNUR for a chemical substance does not 
signify that the chemical substance is listed on the TSCA Chemical 
Substance Inventory (TSCA Inventory). Guidance on how to determine if a 
chemical substance is on the TSCA Inventory is available at https://www.epa.gov/tsca-inventory.

C. Significant New Uses Claimed as CBI

    EPA is proposing to establish certain significant new uses which 
have been claimed as CBI subject to Agency confidentiality regulations 
at 40 CFR part 2 and 40 CFR part 720, subpart E. Absent a final 
determination or other disposition of the confidentiality claim under 
40 CFR part 2 procedures, EPA is required to keep this information 
confidential. EPA promulgated a procedure at 40 CFR 721.11 to deal with 
the situation where a specific significant new use is CBI.
    Under these procedures a manufacturer or processor may request EPA 
to determine whether a specific use would be a significant new use 
under the rule. The manufacturer or processor must show that it has a 
bona fide intent to manufacture or process the chemical substance and 
must identify the specific use for which it intends to manufacture or 
process the chemical substance. If

[[Page 49123]]

EPA concludes that the person has shown a bona fide intent to 
manufacture or process the chemical substance, EPA will tell the person 
whether the use identified in the bona fide submission would be a 
significant new use under the rule. Since most of the chemical 
identities of the chemical substances subject to these SNURs are also 
CBI, manufacturers and processors can combine the bona fide submission 
under the procedure in 40 CFR 721.11 into a single step.
    If EPA determines that the use identified in the bona fide 
submission would not be a significant new use, i.e., the use does not 
meet the criteria specified in the rule for a significant new use, that 
person can manufacture or process the chemical substance so long as the 
significant new use trigger is not met. In the case of a production 
volume trigger, this means that the aggregate annual production volume 
does not exceed that identified in the bona fide submission to EPA. 
Because of confidentiality concerns, EPA does not typically disclose 
the actual production volume that constitutes the use trigger. Thus, if 
the person later intends to exceed that volume, a new bona fide 
submission would be necessary to determine whether that higher volume 
would be a significant new use.

D. Applicability of General Provisions

    General provisions for SNURs appear in 40 CFR part 721, subpart A. 
These provisions describe persons subject to SNURs, recordkeeping 
requirements, exemptions to reporting requirements, and applicability 
of the rule to uses occurring before the effective date of the rule.
    Pursuant to 40 CFR 721.1(c), persons subject to SNURs must comply 
with the same requirements and EPA regulatory procedures as submitters 
of PMNs under TSCA section 5(a)(1)(A). In particular, these 
requirements include the information submission requirements of TSCA 
sections 5(b) and 5(d)(1), the exemptions authorized by TSCA sections 
5(h)(1), 5(h)(2), 5(h)(3), and 5(h)(5) and the regulations at 40 CFR 
part 720. In addition, provisions relating to user fees appear at 40 
CFR part 700.
    Once EPA receives a SNUN, EPA must either determine that the 
significant new use is not likely to present an unreasonable risk of 
injury under the conditions of use for the chemical substance or take 
such regulatory action as is associated with an alternative 
determination under TSCA section 5 before the manufacture (including 
import) or processing for the significant new use can commence. If EPA 
determines that the conditions of use of the chemical substance is not 
likely to present an unreasonable risk, EPA is required under TSCA 
section 5(g) to publish a statement of EPA's findings in the Federal 
Register.
    As discussed in Unit I.C.2., persons who export or intend to export 
a chemical substance identified in a proposed or final SNUR are subject 
to the export notification provisions of TSCA section 12(b), and 
persons who import a chemical substance identified in a final SNUR are 
subject to the TSCA section 13 import certification requirements. See 
also https://www.epa.gov/tsca-import-export-requirements.

E. Applicability of the Proposed SNURs to Uses Occurring Before the 
Effective Date of the Final Rule

    To establish a significant new use, EPA must determine that the use 
is not ongoing. The chemical substances subject to this proposed rule 
have undergone premanufacture review and received determinations under 
TSCA section 5(a)(3)(C). TSCA Orders have been issued for these 
chemical substances and the PMN submitters are required by the TSCA 
Orders to submit a SNUN before undertaking activities that would be 
designated as significant new uses in these SNURs. Additionally, the 
identities of many of the chemical substances subject to this proposed 
rule have been claimed as confidential per 40 CFR 720.85, further 
reducing the likelihood that another party would manufacture or process 
the substances for an activity that would be designated as a 
significant new use. Based on this, the Agency believes that it is 
highly unlikely that any of the significant new uses identified in Unit 
III. are ongoing.
    When the chemical substances identified in Unit III. are added to 
the TSCA Inventory, EPA recognizes that, before the rule is effective, 
other persons might engage in a use that has been identified as a 
significant new use. Persons who begin manufacture or processing of the 
chemical substances for a significant new use identified on or after 
the designated cutoff date specified in Unit III.A. would have to cease 
any such activity upon the effective date of the final rule. To resume 
their activities, these persons would have to first comply with all 
applicable SNUR notification requirements and EPA would have to take 
action under TSCA section 5 allowing manufacture or processing to 
proceed.

F. Important Information About SNUN Submissions

1. SNUN Submissions
    SNUNs must be submitted on EPA Form No. 7710-25, generated using e-
PMN software, and submitted to the Agency in accordance with the 
procedures set forth in 40 CFR 720.40 and 721.25. E-PMN software is 
available at https://www.epa.gov/reviewing-new-chemicals-under-toxic-substances-control-act-tsca.
2. Development and Submission of Information
    EPA recognizes that TSCA section 5 does not require development of 
any particular new information (e.g., generating test data) before 
submission of a SNUN. There is an exception: If a person is required to 
submit information for a chemical substance pursuant to a rule, order 
or consent agreement under TSCA section 4, then TSCA section 5(b)(1)(A) 
requires such information to be submitted to EPA at the time of 
submission of the SNUN.
    In the absence of a rule, TSCA Order, or consent agreement under 
TSCA section 4 covering the chemical substance, persons are required 
only to submit information in their possession or control and to 
describe any other information known to or reasonably ascertainable by 
them (see 40 CFR 720.50). However, upon review of PMNs and SNUNs, the 
Agency has the authority to require appropriate testing. To assist with 
EPA's analysis of the SNUN, submitters are encouraged, but not 
required, to provide the potentially useful information identified for 
the chemical substance in Unit III.C.
    EPA strongly encourages persons, before performing any testing, to 
consult with the Agency pertaining to protocol selection. Furthermore, 
pursuant to TSCA section 4(h), which pertains to reduction of testing 
in vertebrate animals, EPA encourages consultation with the Agency on 
the use of alternative test methods and strategies (also called New 
Approach Methodologies, or NAMs), if available, to generate the 
recommended test data. EPA encourages dialog with Agency 
representatives to help determine how best the submitter can meet both 
the data needs and the objective of TSCA section 4(h). For more 
information on alternative test methods and strategies to reduce 
vertebrate animal testing, visit https://www.epa.gov/assessing-and-managing-chemicals-under-tsca/alternative-test-methods-and-strategies-reduce.
    The potentially useful information described in Unit III.C. for 
these

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chemical substances may not be the only means of providing information 
to evaluate the chemical substance associated with the significant new 
uses. However, submitting a SNUN without any information may increase 
the likelihood that EPA will take action under TSCA sections 5(e) or 
5(f). EPA recommends that potential SNUN submitters contact EPA early 
enough so that they will be able to conduct the appropriate tests to 
provide useful information with their SNUN submission.
    SNUN submitters should be aware that EPA will be better able to 
evaluate SNUNs which provide detailed information on the following:
     Human exposure and environmental release that may result 
from the significant new use of the chemical substances.

III. Chemical Substances Subject to These Proposed SNURs

A. What is the designated cutoff date for ongoing uses?

    EPA designates June 11, 2024, as the cutoff date for determining 
whether the new use is ongoing. This designation is explained in more 
detail in Unit II.E.

B. What information is provided for each chemical substance?

    For each chemical substance identified in Unit III.C., EPA provides 
the following information:
     PMN number (the proposed CFR citation assigned in the 
regulatory text section of this document).
     Chemical name (generic name, if the specific name is 
claimed as CBI).
     Chemical Abstracts Service Registry Number (CASRN) (if 
assigned for non-confidential chemical identities).
     Basis for the action or, as applicable, the effective date 
of and basis for the TSCA Order.
     Potentially useful information.
    The regulatory text section of the proposed rule specifies the 
activities designated as significant new uses. Certain new uses, 
including production volume limits and other uses designated in the 
proposed rules, may be claimed as CBI.
    These proposed rules include PMN substances that are subject to 
orders issued under TSCA section 5(e)(1)(A), as required by the 
determinations made under TSCA section 5(a)(3)(B). Those TSCA Orders 
require protective measures to limit exposures or otherwise mitigate 
the potential unreasonable risk. The proposed SNURs identify as 
significant new uses any manufacturing, processing, use, distribution 
in commerce, or disposal that does not conform to the restrictions 
imposed by the underlying TSCA Orders, consistent with TSCA section 
5(f)(4).
    Where EPA determined that the PMN substance may present an 
unreasonable risk of injury to human health via inhalation exposure, 
the underlying TSCA Order usually requires that potentially exposed 
employees wear specified respirators unless actual measurements of the 
workplace air show that air-borne concentrations of the PMN substance 
are below a New Chemical Exposure Limit (NCEL). The comprehensive NCELs 
provisions in TSCA Orders include requirements addressing performance 
criteria for sampling and analytical methods, periodic monitoring, 
respiratory protection, and recordkeeping. No comparable NCEL 
provisions for SNURs currently exist in 40 CFR part 721, subpart B. 
Therefore, for these cases, the individual SNURs in 40 CFR part 721, 
subpart E, will state that persons subject to the SNUR who wish to 
pursue NCELs as an alternative to the 40 CFR 721.63 respirator 
requirements may request to do so under 40 CFR 721.30. EPA expects that 
persons whose 40 CFR 721.30 requests to use the NCELs approach for 
SNURs are approved by EPA, will be required to comply with NCELs 
provisions that are comparable to those contained in the corresponding 
TSCA Order.

C. Which chemical substances are subject to this proposed rule?

    The substances subject to the proposed rules in this document are 
as follows:
PMN Number: P-18-398 (40 CFR 721.11860)
    Chemical Name: 1,2-Ethanediamine, N-(1-methylethyl)-N-[2-[(1-
methylethyl)amino]ethyl]-.
    CASRN: 10507-06-9.
    Effective Date of TSCA Order: April 13, 2022.
    Basis for TSCA Order: The PMN states that the use will be as an 
intermediate. Based on comparison to analogous substances, EPA has 
identified concerns for acute toxicity, skin sensitization, eyes, skin, 
and respiratory tract corrosion, and systemic, reproductive, and 
developmental effects. Based on comparison to analogous aliphatic 
amines, EPA predicts that toxicity to aquatic organisms may occur at 
concentrations that exceed 210 ppb. The Order was issued under TSCA 
sections 5(a)(3)(B)(ii)(I) and 5(e)(1)(A)(ii)(I), based on a finding 
that in the absence of sufficient information to permit a reasoned 
evaluation, the substance may present an unreasonable risk of injury to 
human health or the environment. To protect against these risks, the 
Order requires:
     Use of personal protective equipment where there is a 
potential for dermal exposure;
     Use of a NIOSH-certified full facepiece gas/vapor 
respirator with an APF of at least 50 where there is a potential for 
inhalation exposure;
     Establishment of a hazard communication program, including 
human health precautionary statements on each label and in the SDS; and
     No use of the PMN substance other than for the 
confidential use allowed in the Order.
    The proposed SNUR would designate as a ``significant new use'' the 
absence of these protective measures.
    Potentially Useful Information: EPA has determined that certain 
information may be potentially useful in support of a request by the 
PMN submitter to modify the Order, or if a manufacturer or processor is 
considering submitting a SNUN for a significant new use that will be 
designated by this SNUR. EPA has determined that the results of aquatic 
toxicity and skin sensitization testing may be potentially useful to 
characterize the health and environmental effects of the PMN substance. 
Although the Order does not require these tests, the Order's 
restrictions remain in effect until the Order is modified or revoked by 
EPA based on submission of this or other relevant information.
PMN Number: P-19-49 (40 CFR 721.11861)
    Chemical Name: Fatty acids, polymers with substituted 
carbomonocycles, dialkanolamine, alkyl substituted alkanediamine and 
halo-substituted heteromonocycle, formates (salts) (generic).
    CASRN: Not available.
    Effective Date of Modified TSCA Order: May 19, 2022.
    Basis for TSCA Order: The PMN states that the generic (non-
confidential) use will be as an isolated intermediate coating resin. 
Based on the amine content and the surfactant properties of the PMN 
substance, EPA has identified concerns for irritation to all tissues. 
Based on formic acid, EPA has also identified concerns for 
neurotoxicity, blood toxicity, and developmental toxicity. Based on 
test data on the PMN substance, EPA predicts that toxicity to aquatic 
organisms may occur at concentrations that exceed 114 ppb. EPA issued 
an Order under TSCA sections 5(a)(3)(B)(ii)(I) and 5(e)(1)(A)(ii)(I), 
based on a finding that in the absence of sufficient information

[[Page 49125]]

to permit a reasoned evaluation, the substance may present an 
unreasonable risk of injury to human health or the environment. The 
Order, effective October 27, 2020, required the submitter of P-19-49 to 
submit to EPA the results of certain toxicity testing before any 
manufacturing (which includes import), processing, or use of the PMN 
substance. On September 17, 2021, the PMN submitter provided the 
results of three environmental toxicity studies in accordance with the 
requirements of the Order. EPA reviewed those studies and determined 
the studies to be valid. EPA subsequently modified the terms of the 
Order to mitigate any unreasonable risks to human health and the 
environment and issued a modified Order, effective May 19, 2022. To 
protect against these potential risks, the modified Order requires:
     Use of personal protective equipment where there is a 
potential for dermal exposure;
     Establishment of a hazard communication program, including 
human health precautionary statements on each label and in the SDS;
     No manufacture or processing of the PMN substance in a 
manner that generates a vapor, mist, or aerosol;
     No use of the PMN substance in a manner that generates a 
vapor, mist, or aerosol that results in inhalation to industrial or 
commercial workers;
     No manufacture the PMN substance to contain the 
confidential residual identified in the Order at greater than 0.1%; and
     No release of the PMN substance resulting in surface water 
concentrations that exceed 114 ppb.
    The proposed SNUR would designate as a ``significant new use'' the 
absence of these protective measures.
    Potentially Useful Information: EPA has determined that certain 
information may be potentially useful in support of a request by the 
PMN submitter to modify the Order, or if a manufacturer or processor is 
considering submitting a SNUN for a significant new use that will be 
designated by this SNUR. EPA has determined that the results of skin 
irritation, eye irritation, developmental/reproductive toxicity, 
pulmonary effects, and neurotoxicity testing may be potentially useful 
to characterize the health effects of the PMN substance. Although the 
Order does not require these tests, the Order's restrictions remain in 
effect until the Order is modified or revoked by EPA based on 
submission of this or other relevant information.
PMN Number: P-19-160 (40 CFR 721.11862)
    Chemical Name: Alkanesulfonic acid, 2-[(2-aminoethyl)heteroatom-
substituted]-, sodium salt (1:1), polymer with .alpha.-[2,2-
bis(hydroxymethyl)butyl]-.omega.-methoxypoly(oxy-1,2-ethanediyl) and 
1,1'-methylenebis[4-isocyanatocyclohexane], acrylic acid-
dipenthaerythritol reaction products- and polypropylene glycol ether 
with pentaerythritol (4:1) triacrylate-blocked (generic).
    CASRN: Not available.
    Effective Date of TSCA Order: July 27, 2022.
    Basis for TSCA Order: The PMN states that the use will be as a 
component of a UV curable printing ink. Based on analogue data and 
information provided in the SDS, EPA has identified concerns for skin 
irritation and dermal and respiratory sensitization. Based on analogue 
data and data on a component of the PMN substance, EPA has identified 
concerns for eye irritation/corrosion and genotoxicity. Based on 
analogue data, EPA has also identified concerns for systemic toxicity, 
developmental toxicity, and neurotoxicity. Based on comparison to 
analogous polyanionic polymers, EPA predicts that the PMN substance has 
low environmental hazard. The Order was issued under TSCA sections 
5(a)(3)(B)(ii)(I) and 5(e)(1)(A)(ii)(I), based on a finding that in the 
absence of sufficient information to permit a reasoned evaluation, the 
substance may present an unreasonable risk of injury to human health or 
the environment. To protect against these risks, the Order requires:
     Use of personal protective equipment where there is a 
potential for dermal exposure;
     Establishment of a hazard communication program, including 
human health precautionary statements on each label and in the SDS;
     No use of the PMN substance in a consumer product;
     No manufacture, processing, or use of the PMN substance in 
any manner that results in inhalation exposure; and
     No release of the PMN substance resulting in surface water 
concentrations that exceed 302 ppb.
    The proposed SNUR would designate as a ``significant new use'' the 
absence of these protective measures.
    Potentially Useful Information: EPA has determined that certain 
information may be potentially useful in support of a request by the 
PMN submitter to modify the Order, or if a manufacturer or processor is 
considering submitting a SNUN for a significant new use that will be 
designated by this SNUR. EPA has determined that the results of 
specific target organ toxicity, pulmonary effects, reproductive 
toxicity (developmental effects), skin sensitization, skin irritation, 
eye damage, carcinogenicity, and genetic toxicity testing may be 
potentially useful to characterize the health effects of the PMN 
substance. Although the Order does not require these tests, the Order's 
restrictions remain in effect until the Order is modified or revoked by 
EPA based on submission of this or other relevant information.
PMN Number: P-20-101 (40 CFR 721.11863)
    Chemical Name: Alkanoic acid, hydroxy-(hydroxyalkyl)-alkyl-, 
polymer with .alpha.-[(hydroxyalkyl)alkyl]-.omega.-alkoxypoly(oxy-
alkanediyl), (haloalkyl)oxiane polymer (alkylalkylidene)bis[hydroxy-
carbomonocycle] alkenoate and isocyanate-alkyl-carbomonocycle, 
hydroxyalkyl acrylate-blocked (generic).
    CASRN: Not available.
    Effective Date of TSCA Order: July 27, 2022.
    Basis for TSCA Order: The PMN states that the use will be as a 
coating resin. Based on structural alerts and test data for an analogue 
and feedstock component, EPA has identified concerns for skin, eye, and 
respiratory tract irritation; skin and respiratory sensitization; acute 
neurotoxicity; and systemic and reproductive effects. Based on test 
data for a metabolite of the PMN substance, as well as analogues of the 
LMW fraction, EPA has identified concerns for eye and respiratory tract 
irritation; skin sensitization; portal-of-entry effects; and systemic, 
reproductive, and developmental effects. Based on hazard data for an 
analogous chemical and comparison to analogous polyanionic polymers 
(and monomers), EPA predicts that the substance has moderate 
environmental toxicity. The Order was issued under TSCA sections 
5(a)(3)(B)(ii)(I) and 5(e)(1)(A)(ii)(I), based on a finding that in the 
absence of sufficient information to permit a reasoned evaluation, the 
substance may present an unreasonable risk of injury to human health or 
the environment. To protect against these risks, the Order requires:
     Use of personal protective equipment where there is a 
potential for dermal exposure;
     Use of a NIOSH-certified combination particulate and gas/
vapor respirator with an APF of at least 50 where there is a potential 
for inhalation exposure;

[[Page 49126]]

     Establishment of a hazard communication program, including 
human health precautionary statements on each label and in the SDS;
     No manufacture or processing of the PMN substance with 
greater than 20% (by weight) oligomer content below 1,000 daltons 
(i.e., low molecular weight species);
     No processing or use of the PMN substance for manual spray 
application;
     No processing of the PMN substance for use in a consumer 
product; and
     No use of the PMN substance in a consumer product.
    The proposed SNUR would designate as a ``significant new use'' the 
absence of these protective measures.
    Potentially Useful Information: EPA has determined that certain 
information may be potentially useful in support of a request by the 
PMN submitter to modify the Order, or if a manufacturer or processor is 
considering submitting a SNUN for a significant new use that will be 
designated by this SNUR. EPA has determined that the results of 
specific target organ toxicity testing may be potentially useful to 
characterize the health effects of the PMN substance. Although the 
Order does not require this test, the Order's restrictions remain in 
effect until the Order is modified or revoked by EPA based on 
submission of this or other relevant information.
PMN Number: P-20-182 (40 CFR 721.11864)
    Chemical Name: 1,4-Benzenedicarboxylic acid, bis[2-(2-
butoxyethoxy)ethyl] ester (9CI).
    CASRN: 90430-63-0.
    Effective Date of TSCA Order: April 21, 2022.
    Basis for TSCA Order: The PMN states that the generic (non-
confidential) use will be as a plasticizer for PVC formulations. Based 
on the structural alert for ethylene glycol ethers, EPA has identified 
concerns for neurotoxicity, kidney effects, immunotoxicity, and blood 
effects. Based on test data on the PMN substance, EPA has identified 
concerns for skin sensitization and mutagenicity. Based on test data 
for an analogue, EPA has identified concerns for skin sensitization. 
Based on test data on potential metabolites, EPA has also identified 
concerns for acute toxicity (mortality), lung toxicity, systemic 
effects, and developmental effects. Based on test data on the PMN 
substance and comparison to analogous chemical substances, EPA predicts 
that toxicity to aquatic organisms may occur at concentrations that 
exceed 4 ppb. The Order was issued under TSCA sections 
5(a)(3)(B)(ii)(I) and 5(e)(1)(A)(ii)(I), based on a finding that in the 
absence of sufficient information to permit a reasoned evaluation, the 
substance may present an unreasonable risk of injury to human health or 
the environment. To protect against these risks, the Order requires:
     Use of personal protective equipment where there is a 
potential for dermal exposure;
     Use of a NIOSH-certified particulate respirator with an 
APF of at least 1,000 where there is a potential for inhalation 
exposure, or compliance with an NCEL of 0.01 mg/m\3\ as an 8-hour time-
weighted average to prevent inhalation exposure;
     No release of the PMN substance resulting in surface water 
concentrations that exceed 4 ppb; and
     Establishment of a hazard communication program, including 
human health precautionary statements on each label and in the SDS.
    The proposed SNUR would designate as a ``significant new use'' the 
absence of these protective measures.
    Potentially Useful Information: EPA has determined that certain 
information may be potentially useful in support of a request by the 
PMN submitter to modify the Order, or if a manufacturer or processor is 
considering submitting a SNUN for a significant new use that will be 
designated by this SNUR. EPA has determined that the results of 
metabolism or pharmacokinetics, skin sensitization, reproductive 
toxicity, developmental toxicity, immunotoxicity, neurotoxicity, 
specific target organ toxicity, and aquatic toxicity testing may be 
potentially useful to characterize the health and environmental effects 
of the PMN substance. Although the Order does not require these tests, 
the Order's restrictions remain in effect until the Order is modified 
or revoked by EPA based on submission of this or other relevant 
information.
PMN Number: P-21-56 (40 CFR 721.11865)
    Chemical Name: Isocyanic acid, polyalkylenepolyarylene ester, 
polymer with alkyl-hydroxyalkyl-alkanediol, alkoxyalcohol and 
alkoxylalkoxyalcohol-blocked (generic).
    CASRN: Not available.
    Effective Date of TSCA Order: May 11, 2022.
    Basis for TSCA Order: The PMN states that the generic (non-
confidential) use will be as a component of coatings. Based on data on 
an analogous chemical substance, EPA has identified concerns for acute 
neurotoxicity and skin sensitization. The Order was issued under TSCA 
sections 5(a)(3)(B)(ii)(I) and 5(e)(1)(A)(ii)(I), based on a finding 
that in the absence of sufficient information to permit a reasoned 
evaluation, the substance may present an unreasonable risk of injury to 
human health or the environment. To protect against these risks, the 
Order requires:
     Use of personal protective equipment where there is a 
potential for dermal exposure;
     Use of a NIOSH-certified particulate, gas/vapor, or 
combination particulate and gas/vapor (as appropriate to the 
conditions) respirator with an APF of at least 50, or 1,000 if spray 
applied, where there is a potential for inhalation exposure;
     No manufacture of the PMN substance beyond 24 months 
without submittal to EPA of the results of certain testing described in 
the Testing section of the Order;
     Establishment of a hazard communication program, including 
human health precautionary statements on each label and in the SDS; and
     No use of the PMN substance in a consumer product.
    The proposed SNUR would designate as a ``significant new use'' the 
absence of these protective measures.
    Potentially Useful Information: EPA has determined that certain 
information may be potentially useful in support of a request by the 
PMN submitter to modify the Order, or if a manufacturer or processor is 
considering submitting a SNUN for a significant new use that will be 
designated by this SNUR. EPA has determined that the results of 
neurotoxicity and acute toxicity testing may be potentially useful to 
characterize the health effects of the PMN substance. Although the 
Order does not require these tests, the Order's restrictions remain in 
effect until the Order is modified or revoked by EPA based on 
submission of this or other relevant information. In addition, the 
submitter has agreed not to exceed the time limit specified in the 
Order without performing the required testing outlined in the Testing 
section of the Order.
PMN Numbers: P-21-58 (40 CFR 721.11866), P-21-60 (40 CFR 721.11867), 
and P-21-61 (40 CFR 721.11868)
    Chemical Names: Substituted alkanoic acid, compound with 
aminoalkylalkyl-aminoalkylalkoxy-polyoxyalkylalkanediyl, polymer with 
haloalkyl-epoxide and alkylalkylidene-cycloarylalcohol (generic) (P-21-
58); Bisphenol A epichlorohydrin polymer with alkylpolyalkene-
polyarylene-hydroxypolyoxyalkyldiyl reaction products with 
alkylalkylidenealkylalkylidene-

[[Page 49127]]

aminoalkyl-alkanepolyamine and alkylaminoalkanol (generic) (P-21-60); 
and Sulfur based acid, compds. with modified bisphenol A-
epichlorohydrin-polyalkylene polyol ether with bisphenol A polymer-N-
dialkylalkylidene-N- (dialkylalklyidene)aminoalkyl-alkanepolyamine-
alkylaminoalkanol reaction products (generic) (P-21-61).
    CASRNs: Not available.
    Effective Date of TSCA Order: May 9, 2022.
    Basis for TSCA Order: The PMNs state that the generic (non-
confidential) use will be as a component in coatings (P-21-58 and P-21-
61) and as an isolated intermediate (P-21-60). Based on the surfactant-
like properties of P-21-58, EPA has identified concerns for lung 
effects and irritation to the skin, eyes, and respiratory tract. Based 
on data for an analogue of the lower molecular weight fraction of P-21-
58, EPA has also identified concerns for neurotoxicity, cardiovascular 
effects, and systemic effects. Based on a structural alert for 
aliphatic amines and data for the expected hydrolysis product, EPA has 
identified concerns for irritation to the skin, eyes, and respiratory 
tract; neurotoxicity; mortality; systemic effects; developmental 
effects; and carcinogenicity for P-21-60 and P-21-61. Based on 
comparison to analogous polycationic polymers, EPA predicts that 
toxicity to aquatic organisms may occur at concentrations that exceed 
50 ppb for P-21-58. Based on comparison to analogous aliphatic amines 
and polycationic polymers, EPA predicts that toxicity to aquatic 
organisms may occur at concentrations that exceed 11 ppb for P-21-60. 
Based on comparison to analogous aliphatic amines, EPA predicts that 
toxicity to aquatic organisms may occur at concentrations that exceed 
11 ppb for P-21-61. The Order was issued under TSCA sections 
5(a)(3)(B)(ii)(I) and 5(e)(1)(A)(ii)(I), based on a finding that in the 
absence of sufficient information to permit a reasoned evaluation, the 
substances may present an unreasonable risk of injury to human health 
or the environment. To protect against these risks, the Order requires:
     Use of personal protective equipment where there is a 
potential for dermal exposure;
     Establishment of a hazard communication program, including 
human health precautionary statements on each label and in the SDS;
     No manufacture, processing, or use the PMN substances in 
any manner that results in inhalation exposure;
     No use of the PMN substances in a consumer product;
     No release of P-21-58 resulting in surface water 
concentrations that exceed 50 ppb;
     No release of P-21-60, or any waste stream containing P-
21-60, into water; and
     No release of P-21-61 resulting in surface water 
concentrations that exceed 11 ppb.
    The proposed SNUR would designate as a ``significant new use'' the 
absence of these protective measures.
    Potentially Useful Information: EPA has determined that certain 
information may be potentially useful in support of a request by the 
PMN submitter to modify the Order, or if a manufacturer or processor is 
considering submitting a SNUN for a significant new use that will be 
designated by this SNUR. EPA has determined that the results of 
specific target organ toxicity, neurotoxicity, skin irritation, and 
aquatic toxicity testing may be potentially useful to characterize the 
health and environmental effects of the PMN substances. EPA has also 
determined that the results of eye irritation, pulmonary effects, 
developmental toxicity, and carcinogenicity testing may be potentially 
useful to characterize the health effects of P-21-60 and P-21-61. 
Although the Order does not require these tests, the Order's 
restrictions remain in effect until the Order is modified or revoked by 
EPA based on submission of this or other relevant information.
PMN Number: P-21-66 (40 CFR 721.11869)
    Chemical Name: 1,2-Alkanediol, 3-aryloxy, mono phosphate ester 
(generic).
    CASRN: Not available.
    Effective Date of TSCA Order: June 10, 2022.
    Basis for TSCA Order: The PMN states that the use will be as a 
blended or standalone epoxy curative (hardener) and foaming agent when 
blended with certain ingredients. Based on information provided in the 
SDS and the low pH of the PMN substance when neat, EPA has identified 
concerns for skin, eye, and respiratory tract corrosion. Based on 
release of the free phosphate, EPA has also identified concerns for 
blood effects and irritation to the skin, eyes, and respiratory tract. 
Based on analogue data and the structural alert for phosphate esters, 
EPA has identified concerns for acute toxicity, acute neurotoxicity, 
corrosion to skin and eyes, and delayed neurotoxicity. Based on test 
data for an analogue of the hydrolysis product, EPA has also identified 
concerns for acute toxicity, eye irritation, systemic effects, and 
developmental effects. Based on comparison to an analogous chemical 
substance, EPA predicts that toxicity to aquatic organisms may occur at 
concentrations that exceed 3 ppb. The Order was issued under TSCA 
sections 5(a)(3)(B)(ii)(I) and 5(e)(1)(A)(ii)(I), based on a finding 
that in the absence of sufficient information to permit a reasoned 
evaluation, the substance may present an unreasonable risk of injury to 
human health or the environment. To protect against these risks, the 
Order requires:
     Use of personal protective equipment where there is a 
potential for dermal exposure;
     Establishment of a hazard communication program, including 
human health precautionary statements on each label and in the SDS;
     No use of the PMN substance in a consumer product;
     No use of the PMN substance other than as an epoxy 
curative;
     No manufacture, processing, or use of the PMN substance in 
any manner that results in inhalation exposure or that results in 
fugitive air emissions; and
     No release of the PMN substance, or any waste stream 
containing the PMN substance, into water.
    The proposed SNUR would designate as a ``significant new use'' the 
absence of these protective measures.
    Potentially Useful Information: EPA has determined that certain 
information may be potentially useful in support of a request by the 
PMN submitter to modify the Order, or if a manufacturer or processor is 
considering submitting a SNUN for a significant new use that will be 
designated by this SNUR. EPA has determined that the results of acute 
toxicity, eye irritation/corrosion, skin corrosion, specific target 
organ toxicity, pulmonary effects, developmental toxicity, 
neurotoxicity, and aquatic toxicity testing may be potentially useful 
to characterize the health and environmental effects of the PMN 
substance. Although the Order does not require these tests, the Order's 
restrictions remain in effect until the Order is modified or revoked by 
EPA based on submission of this or other relevant information.
PMN Number: P-21-68 (40 CFR 721.11870)
    Chemical Name: Metalloxanes, alkyl, alkyl group-terminated, 
reaction products with dihalo-dialkylalkylaryl-alkyl-polycyclic-
ylidene(dialkylsilylene)-dialkylalkylaryl-alkylalkyl-polycyclic-

[[Page 49128]]

ylidene, metal oxide and nonmetallic oxide (generic).
    CASRN: Not available.
    Effective Date of TSCA Order: June 27, 2022.
    Basis for TSCA Order: The PMN states that the generic (non-
confidential) use will be as a polymerization catalyst. Based on the 
reactivity of the PMN substance and the release of hydrochloric acid, 
EPA has identified concerns for an acute handling hazard; irritation 
and corrosion to the skin, eyes, and respiratory tract; and lung 
overload (if respirable, poorly soluble particulates are inhaled). 
Based on analogue data, EPA has identified concerns for irritation to 
skin, eyes, and respiratory tract; lung effects; serious eye damage and 
ocular corrosion; portal-of-entry effects; mutagenicity; acute 
neurotoxicity; systemic effects; reproductive/developmental effects; 
and dermal and respiratory sensitization. The Order was issued under 
TSCA sections 5(a)(3)(B)(ii)(I) and 5(e)(1)(A)(ii)(I), based on a 
finding that in the absence of sufficient information to permit a 
reasoned evaluation, the substance may present an unreasonable risk of 
injury to human health or the environment. To protect against these 
risks, the Order requires:
     Use of personal protective equipment where there is a 
potential for dermal exposure;
     Establishment of a hazard communication program, including 
human health precautionary statements on each label and in the SDS;
     No manufacture, processing, or use of the PMN substance 
other than in an enclosed process;
     No manufacture, processing, or use of the PMN substance in 
any manner that results in inhalation or dermal exposure to the PMN 
substance; and
     No release of the PMN substance resulting in surface water 
concentrations that exceed 50 ppb.
    The proposed SNUR would designate as a ``significant new use'' the 
absence of these protective measures.
    Potentially Useful Information: EPA has determined that certain 
information may be potentially useful in support of a request by the 
PMN submitter to modify the Order, or if a manufacturer or processor is 
considering submitting a SNUN for a significant new use that will be 
designated by this SNUR. EPA has determined that the results of acute 
toxicity, skin sensitization, skin corrosion, specific target organ 
toxicity, pulmonary effects, reproductive toxicity, and mutagenicity 
testing may be potentially useful to characterize the health effects of 
the PMN substance. Although the Order does not require these tests, the 
Order's restrictions remain in effect until the Order is modified or 
revoked by EPA based on submission of this or other relevant 
information.
PMN Number: P-21-83 (40 CFR 721.11871)
    Chemical Name: Alkenoic acid, reaction products with 
pentaerythritol, polymers with diisocyanatoalkane and heteromonocyle 
homopolymer esters with alkanoic acid-pentaerythritol reaction products 
(generic).
    CASRN: Not available.
    Effective Date of TSCA Order: June 6, 2022.
    Basis for TSCA Order: The PMN states that the use will be as a UV 
curable resin. Based on information provided in the SDS and a 
structural alert for acrylates, EPA has identified concerns for 
irritation to the skin, eyes, and respiratory tract. Based on a 
structural alert for acrylates for the low molecular weight fraction, 
OECD QSAR Toolbox results for the feedstock present as a residual, and 
information provided in the SDS, EPA has also identified concerns for 
skin and respiratory sensitization. Based on multifunctional reactive 
groups, EPA has identified respiratory sensitization. Based on test 
data for the feedstock residual, EPA has identified concerns for skin 
irritation, clinical signs, systemic effects, and irritation in the GI 
tract. Based on comparison to analogous acrylates/methacrylates and 
esters, EPA predicts that toxicity to aquatic organisms may occur at 
concentrations that exceed 1 ppb. The Order was issued under TSCA 
sections 5(a)(3)(B)(ii)(I) and 5(e)(1)(A)(ii)(I), based on a finding 
that in the absence of sufficient information to permit a reasoned 
evaluation, the substance may present an unreasonable risk of injury to 
human health or the environment. To protect against these risks, the 
Order requires:
     Use of personal protective equipment where there is a 
potential for dermal exposure;
     Use of a NIOSH-certified Combination Particulate and Gas/
Vapor respirator with an APF of 1,000 where there is a potential for 
inhalation exposure;
     Establishment of a hazard communication program, including 
human health precautionary statements on each label and in the SDS;
     No use of the PMN substance in a consumer product; and
     No release of the PMN substance resulting in surface water 
concentrations that exceed 1 ppb.
    The proposed SNUR would designate as a ``significant new use'' the 
absence of these protective measures.
    Potentially Useful Information: EPA has determined that certain 
information may be potentially useful in support of a request by the 
PMN submitter to modify the Order, or if a manufacturer or processor is 
considering submitting a SNUN for a significant new use that will be 
designated by this SNUR. EPA has determined that the results of skin 
irritation, eye damage, specific target organ toxicity, and skin 
sensitization testing may be potentially useful to characterize the 
health effects of the PMN substance. Although the Order does not 
require these tests, the Order's restrictions remain in effect until 
the Order is modified or revoked by EPA based on submission of this or 
other relevant information.
PMN Number: P-21-84 (40 CFR 721.11872)
    Chemical Name: Carbopolycycle octa-alkene, halo (generic).
    CASRN: Not available.
    Effective Date of TSCA Order: May 27, 2022.
    Basis for TSCA Order: The PMN states that the generic (non-
confidential) use will be as a chemical intermediate. Based on test 
data for an analogue, EPA has identified concerns for severe 
irritation/corrosion to the skin, eyes, and respiratory tract, acute 
toxicity, and mutagenicity. Based on OECD Toolbox results, EPA has also 
identified concerns for skin sensitization. Based on comparison to 
analogous benzyl halides, EPA predicts that toxicity to aquatic 
organisms may occur at concentrations that exceed 7 ppb. The Order was 
issued under TSCA sections 5(a)(3)(B)(ii)(I) and 5(e)(1)(A)(ii)(I), 
based on a finding that in the absence of sufficient information to 
permit a reasoned evaluation, the substance may present an unreasonable 
risk of injury to human health or the environment. To protect against 
these risks, the Order requires:
     Use of personal protective equipment where there is a 
potential for dermal exposure;
     Use of a NIOSH-certified Gas/Vapor respirator with an APF 
of at least 50 where there is a potential for inhalation exposure;
     No release of the PMN substance resulting in surface water 
concentrations that exceed 7 ppb; and
     Establishment of a hazard communication program, including 
human health precautionary statements on each label and in the SDS.

[[Page 49129]]

    The proposed SNUR would designate as a ``significant new use'' the 
absence of these protective measures.
    Potentially Useful Information: EPA has determined that certain 
information may be potentially useful in support of a request by the 
PMN submitter to modify the Order, or if a manufacturer or processor is 
considering submitting a SNUN for a significant new use that will be 
designated by this SNUR. EPA has determined that the results of acute 
toxicity, specific target organ toxicity, skin corrosion, eye damage, 
skin sensitization, genetic toxicity, and aquatic toxicity testing may 
be potentially useful to characterize the health and environmental 
effects of the PMN substance. Although the Order does not require these 
tests, the Order's restrictions remain in effect until the Order is 
modified or revoked by EPA based on submission of this or other 
relevant information.
PMN Number: P-21-92 (40 CFR 721.11873)
    Chemical Name: 2-Propenoic acid, (polyhydro-1,3-dioxo-2H-isoindol-
2-yl)alkyl ester (generic).
    CASRN: Not available.
    Effective Date of TSCA Order: April 5, 2022.
    Basis for TSCA Order: The PMN states that the uses of the PMN 
substance will be for thermoset composites, 3D printing, and industrial 
coatings. Based on test data for the PMN substance, EPA has identified 
concerns for skin irritation. Based on information provided in the SDS, 
EPA has also identified concerns for skin irritation and eye 
irritation. Based on test data for a hydrolysis product, EPA has 
identified concerns for developmental, body weight, and portal-of-entry 
(inhalation and oral) effects. Based on test data for an analogue, EPA 
has also identified concerns for clinical signs, skin irritation, eye 
irritation, and developmental, body weight, and lung effects. Based on 
test data for an analogue, EPA identified concerns for portal-of-entry 
(inhalation) and liver effects. Based on comparison to analogous 
acrylates/methacrylates and imides, EPA predicts that toxicity to 
aquatic organisms may occur at concentrations that exceed 13 ppb. The 
Order was issued under TSCA sections 5(a)(3)(B)(ii)(I) and 
5(e)(1)(A)(ii)(I), based on a finding that in the absence of sufficient 
information to permit a reasoned evaluation, the substance may present 
an unreasonable risk of injury to human health or the environment. To 
protect against these risks, the Order requires:
     Use of personal protective equipment where there is a 
potential for dermal exposure;
     Use of a NIOSH-certified combination particulate and gas/
vapor respirator with an APF of at least 10 to prevent inhalation 
exposure where there is a potential for inhalation exposure;
     Disposal of the PMN substance only by incineration or by 
RCRA Subtitle C landfill;
     Establishment of a hazard communication program, including 
human health precautionary statements on each label and in the SDS;
     No use of the PMN substance in a consumer product;
     No use of the PMN substance where the concentration of the 
PMN substance exceeds 40% in formulation when inhalation exposure is 
expected; and
     No release of the PMN substance, or any waste stream 
containing the PMN substance, into water.
    The proposed SNUR designates as a ``significant new use'' the 
absence of these protective measures.
    Potentially Useful Information: EPA has determined that certain 
information may be potentially useful in support of a request by the 
PMN submitter to modify the Order, or if a manufacturer or processor is 
considering submitting a SNUN for a significant new use that would be 
designated by this SNUR. EPA has determined that the results of 
developmental toxicity, specific target organ toxicity, pulmonary 
effects, and aquatic toxicity testing may be potentially useful to 
characterize the environmental and human health effects of the PMN 
substance. Although the Order does not require these tests, the Order's 
restrictions remain in effect until the Order is modified or revoked by 
EPA based on submission of this or other relevant information.
PMN Number: P-21-102 (40 CFR 721.11874)
    Chemical Name: Heteromonocycle, polymer, [2-[(1-oxo-2-propen-1-
yl)oxy]alkyl]ester (generic).
    CASRN: Not available.
    Effective Date of TSCA Order: May 20, 2022.
    Basis for TSCA Order: The PMN states that the generic (non-
confidential) use will be as a raw material for industrial additive 
manufacturing, UV-curable inks, coatings and adhesives. Based on TSCA 
New Chemical Category document for acrylates, EPA has identified 
concerns for skin sensitization and irritation to the skin, eyes, and 
respiratory tract. Based on test data for an analogue of the low 
molecular weight fraction, EPA has also identified concerns for 
systemic and developmental effects. Based on comparison to analogous 
acrylates/methacrylates and esters, EPA predicts that toxicity to 
aquatic organisms may occur at concentrations that exceed 337 ppb. The 
Order was issued under TSCA sections 5(a)(3)(B)(ii)(I) and 
5(e)(1)(A)(ii)(I), based on a finding that in the absence of sufficient 
information to permit a reasoned evaluation, the substance may present 
an unreasonable risk of injury to human health or the environment. To 
protect against these risks, the Order requires:
     Use of personal protective equipment where there is a 
potential for dermal exposure;
     Use of a NIOSH-certified Combination Particulate and Gas/
Vapor respirator with an APF of at least 10 where there is a potential 
for inhalation exposure;
     No use of the PMN substance in a consumer product;
     No release of the PMN substance resulting in surface water 
concentrations that exceed 337 ppb; and
     Establishment of a hazard communication program, including 
human health precautionary statements on each label and in the SDS.
    The proposed SNUR would designate as a ``significant new use'' the 
absence of these protective measures.
    Potentially Useful Information: EPA has determined that certain 
information may be potentially useful in support of a request by the 
PMN submitter to modify the Order, or if a manufacturer or processor is 
considering submitting a SNUN for a significant new use that will be 
designated by this SNUR. EPA has determined that the results of skin 
irritation, skin sensitization, eye damage, developmental toxicity, 
specific target organ toxicity, and aquatic toxicity testing may be 
potentially useful to characterize the health and environmental effects 
of the PMN substance. Although the Order does not require these tests, 
the Order's restrictions remain in effect until the Order is modified 
or revoked by EPA based on submission of this or other relevant 
information.

[[Page 49130]]

PMN Numbers: P-21-109 (40 CFR 721.11875), P-21-110 (40 CFR 721.11876), 
P-21-111 (40 CFR 721.11877), P-21-112 (40 CFR 721.11878), P-21-113 (40 
CFR 721.11879), P-21-114 (40 CFR 721.11880), P-21-116 (40 CFR 
721.11881), P-21-117 (40 CFR 721.11882), P-21-118 (40 CFR 721.11883), 
P-21-119 (40 CFR 721.11884), P-21-121 (40 CFR 721.11885), P-21-122 (40 
CFR 721.11886), and P-21-123 (40 CFR 721.11887)
    Chemical Names: Hydrocarbons linear and branched, light alkylate 
(generic) (P-21-109), Hydrocarbons linear and branched, light catalytic 
cracked (generic) (P-21-110), Hydrocarbons linear and branched, heavy 
catalytic cracked (generic) (P-21-111), Hydrocarbons linear and 
branched, light hydrocracked (generic) (P-21-112), Hydrocarbons linear 
and branched, isomerization (generic) (P-21-113), Hydrocarbons linear 
and branched, heavy catalytic reformed (generic) (P-21-114), 
Hydrocarbons linear and branched, hydrotreated light (generic) (P-21-
116), Hydrocarbons linear and branched, hydrotreated light paraffinic 
(generic) (P-21-117), Hydrocarbons linear and branched, light catalytic 
cracked (generic) (P-21-118), Hydrocarbons linear and branched, heavy 
hydrocracked (generic) (P-21-119), Hydrocarbons linear and branched, 
heavy catalytic cracked (generic) (P-21-121), Hydrocarbons linear and 
branched, heavy hydrocracked (generic) (P-21-122), and Hydrocarbons 
linear and branched, light hydrocracked (generic) (P-21-123).
    CASRNs: Not available.
    Effective Date of TSCA Order: July 14, 2022.
    Basis for TSCA Order: The PMNs state that the generic (non-
confidential) use will be as a component in fuels (P-21-109, P-21-110, 
P-21-111, P-21-112, P-21-113, P-21-114, P-21-116, P-21-117, P-21-121, 
and P-21-123) or as a chemical intermediate (P-21-118, P-21-119, and P-
21-122). Based on available information on compositionally analogous 
mixtures and on constituents of the PMN substances, EPA has identified 
concerns for skin and eye irritation, acute toxicity, systemic toxicity 
(neurotoxicity, body weight effects, and liver, kidney, blood, spleen, 
and other organ effects), reproductive and developmental toxicity, oral 
and inhalation portal entry effects, genetic toxicity, and 
carcinogenicity. Based on the chemical composition (petroleum) of the 
PMN substances, EPA has also identified concerns for hydrocarbon 
pneumonia/aspiration hazard. EPA assumes that respiratory tract 
irritation is possible from exposure to the PMN substances. Based on 
comparison to analogous chemical substances and data on constituents of 
the PMN substances, EPA predicts that toxicity to aquatic organisms may 
occur at concentrations that exceed 0.3 ppb. The Order was issued under 
TSCA sections 5(a)(3)(B)(ii)(I) and 5(e)(1)(A)(ii)(I), based on a 
finding that in the absence of sufficient information to permit a 
reasoned evaluation, the substances may present an unreasonable risk of 
injury to human health or the environment. To protect against these 
risks, the Order requires:
     No manufacture, processing, or use of the PMN substances 
other than for processing and use as a fuel, fuel additive, fuel 
blending stock, or refinery feedstock (including, but not limited to 
cracking, coking, hydroprocessing, distillation, or deasphalting) 
subject to 40 CFR parts 79 or 1090;
     Use of personal protective equipment where there is a 
potential for dermal exposure; and
     Establishment of a hazard communication program.
    The proposed SNUR would designate as a ``significant new use'' the 
absence of these protective measures.
    Potentially Useful Information: EPA has determined that certain 
information may be potentially useful in support of a request by the 
PMN submitter to modify the Order, or if a manufacturer or processor is 
considering submitting a SNUN for a significant new use that will be 
designated by this SNUR. EPA has determined that the results of skin 
irritation, eye irritation, respiratory depression/irritation, 
hydrocarbon developmental toxicity, systemic toxicity, genetic 
toxicity, and aquatic toxicity testing may be potentially useful to 
characterize the health and environmental effects of the PMN 
substances. Additionally, the results of consumer inhalation exposure 
testing/monitoring at gas stations may be potentially useful to 
characterize the degree of exposure to the PMN substances. Although the 
Order does not require these tests, the Order's restrictions remain in 
effect until the Order is modified or revoked by EPA based on 
submission of this or other relevant information.
PMN Number: P-21-197 (40 CFR 721.11888)
    Chemical Name: Imidazole-carboxylic acid, substituted (generic).
    CASRN: Not available.
    Effective Date of TSCA Order: June 20, 2022.
    Basis for TSCA Order: The PMN states that the use will be as an 
additive for use in battery electrolyte formulations. Based on analogue 
data, EPA has identified concerns for acute neurotoxicity and skin 
sensitization. Based on test data for potential metabolites, EPA has 
also identified concerns for acute toxicity, skin corrosion, eye 
irritation, and systemic, respiratory tract, reproductive, and 
developmental effects. Based on acute hazard data for an analogous 
chemical substance, EPA predicts that toxicity to aquatic organisms may 
occur at concentrations that exceed 380 ppb. The Order was issued under 
TSCA sections 5(a)(3)(B)(ii)(I) and 5(e)(1)(A)(ii)(I), based on a 
finding that in the absence of sufficient information to permit a 
reasoned evaluation, the substance may present an unreasonable risk of 
injury to human health or the environment. To protect against these 
risks, the Order requires:
     Use of personal protective equipment where there is a 
potential for dermal exposure;
     Use of a NIOSH-certified Combination Particulate and Gas/
Vapor respirator with an APF of 50 where there is a potential for 
inhalation exposure;
     Establishment of a hazard communication program, including 
human health precautionary statements on each label and in the SDS;
     No domestic manufacture of the PMN substance (i.e., import 
only);
     No processing or use of the PMN substance other than in an 
enclosed process, except that sampling and equipment cleaning 
operations need not occur in an enclosed process; and
     No disposal of the PMN substance or waste streams 
containing the PMN substance other than by incineration with 99.9% 
efficiency.
    The proposed SNUR would designate as a ``significant new use'' the 
absence of these protective measures.
    Potentially Useful Information: EPA has determined that certain 
information may be potentially useful in support of a request by the 
PMN submitter to modify the Order, or if a manufacturer or processor is 
considering submitting a SNUN for a significant new use that will be 
designated by this SNUR. EPA has determined that the results of aquatic 
toxicity, acute toxicity, metabolism/pharmacokinetics, specific target 
organ toxicity, skin corrosion, eye damage, skin sensitization, 
pulmonary effects, reproductive toxicity, and developmental toxicity 
testing may be potentially useful to characterize the

[[Page 49131]]

health and environmental effects of the PMN substance. Although the 
Order does not require these tests, the Order's restrictions remain in 
effect until the Order is modified or revoked by EPA based on 
submission of this or other relevant information.
PMN Numbers: P-21-216 (40 CFR 721.11889) and P-21-217 (40 CFR 
721.11890)
    Chemical Names: Multi-walled carbon nanotubes (generic) (P-21-216 
and P-21-217).
    CASRNs: Not available.
    Effective Date of TSCA Order: May 31, 2022.
    Basis for TSCA Order: The PMNs state that the generic (non-
confidential) use will be as an additive in electrode materials and 
plastics (P-21-216) or as an additive in electrode materials and 
thermoplastics, and a component in electrodes (P-21-217). Based on 
comparison to analogous carbon-based nanomaterials, EPA has identified 
concerns for lung toxicity, lung fibrosis, lung cancer, pleural 
toxicity (inflammation), pleural fibrosis, and pleural cancer 
(mesothelioma). Based on hazard data for a residual and test data for 
multi-walled carbon nanotube analogues, EPA has also identified 
concerns acute neurotoxicity, skin and respiratory sensitization, 
reproductive and developmental toxicity, lung effects, systemic 
effects, immunotoxicity, eye and skin irritation, mutagenicity, 
genotoxicity, and carcinogenicity. EPA was unable to estimate the 
environmental hazard of the PMN substances. The Order was issued under 
TSCA sections 5(a)(3)(B)(ii)(I) and 5(e)(1)(A)(ii)(I), based on a 
finding that in the absence of sufficient information to permit a 
reasoned evaluation, the substances may present an unreasonable risk of 
injury to human health or the environment. To protect against these 
risks, the Order requires:
     Use of personal protective equipment where there is a 
potential for dermal exposure;
     Use of a NIOSH-certified particulate respirator with an 
APF of at least 1,000 if the capture and reduction rate is at least 
99.5% but not 99.975% or greater, or an APF of at least 50 if the 
capture and reduction rate is at least 99.975%, where there is a 
potential for inhalation exposure;
     No domestic manufacture of the PMN substances (i.e., 
import only);
     No manufacture of the PMN substances to contain the 
confidential impurity listed in the Order at greater than 1% (by 
weight);
     No use of the PMN substances other than for the 
confidential use allowed in the Order;
     No processing or use of the PMN substances other than in 
application methods that do not generate a vapor, mist, dust, or 
aerosol unless such application method occurs in an enclosed process;
     No disposal of the PMN substances or waste streams 
containing the PMN substances other than by landfill or incineration;
     No release of the PMN substances directly, either by point 
(stack) or non-point (fugitive) sources, to air;
     No release of the PMN substances, or any waste stream 
containing the PMN substances, into water; and
     Establishment of a hazard communication program, including 
human health precautionary statements on each label and in the SDS.
    The proposed SNUR would designate as a ``significant new use'' the 
absence of these protective measures.
    Potentially Useful Information: EPA has determined that certain 
information may be potentially useful in support of a request by the 
PMN submitter to modify the Order, or if a manufacturer or processor is 
considering submitting a SNUN for a significant new use that will be 
designated by this SNUR. EPA has determined that the results of 
carcinogenicity, eye irritation, skin irritation, genetic toxicity, 
developmental toxicity, and aquatic toxicity testing may be potentially 
useful to characterize the health and environmental effects of the PMN 
substances. Although the Order does not require these tests, the 
Order's restrictions remain in effect until the Order is modified or 
revoked by EPA based on submission of this or other relevant 
information.

IV. Statutory and Executive Order Reviews

    Additional information about these statutes and Executive orders 
can be found at https://www.epa.gov/laws-regulations-and-executive-orders.

A. Executive Order 12866: Regulatory Planning and Review and Executive 
Order 14094: Modernizing Regulatory Review

    This action proposes to establish SNURs for new chemical substances 
that were the subject of PMNs. The Office of Management and Budget 
(OMB) has exempted these types of actions from review under Executive 
Order 12866 (58 FR 51735, October 4, 1993), as amended by Executive 
Order 14094 (88 FR 21879, April 11, 2023).

B. Paperwork Reduction Act (PRA)

    According to the PRA (44 U.S.C. 3501 et seq.), an agency may not 
conduct or sponsor, and a person is not required to respond to a 
collection of information that requires OMB approval under PRA, unless 
it has been approved by OMB and displays a currently valid OMB control 
number. The OMB control numbers for EPA's regulations in title 40 of 
the CFR, after appearing in the Federal Register, are listed in 40 CFR 
part 9, and included on the related collection instrument or form, if 
applicable.
    The information collection requirements related to SNURs have 
already been approved by OMB pursuant to PRA under OMB control number 
2070-0038 (EPA ICR No. 1188). This action does not impose any burden 
requiring additional OMB approval. If an entity were to submit a SNUN 
to the Agency, the annual burden is estimated to average between 30 and 
170 hours per submission. This burden estimate includes the time needed 
to review instructions, search existing data sources, gather and 
maintain the data needed, and complete, review, and submit the required 
SNUN.
    EPA always welcomes your feedback on the burden estimates. Send any 
comments about the accuracy of the burden estimate, and any suggested 
methods for improving the collection instruments or instruction or 
minimizing respondent burden, including through the use of automated 
collection techniques.

C. Regulatory Flexibility Act (RFA)

    I certify that this action will not have a significant economic 
impact on a substantial number of small entities under the RFA (5 
U.S.C. 601 et seq.). The requirement to submit a SNUN applies to any 
person (including small or large entities) who intends to engage in any 
activity described in the final rule as a ``significant new use.'' 
Because these uses are ``new,'' based on all information currently 
available to EPA, EPA has concluded that no small or large entities 
presently engage in such activities.
    A SNUR requires that any person who intends to engage in such 
activity in the future must first notify EPA by submitting a SNUN. 
Although some small entities may decide to pursue a significant new use 
in the future, EPA cannot presently determine how many, if any, there 
may be. However, EPA's experience to date is that, in response to the 
promulgation of SNURs covering over 1,000 chemicals, the Agency 
receives only a small number of notices

[[Page 49132]]

per year. For example, the number of SNUNs received was 16 in Federal 
Fiscal Year (FY) FY2018, five in FY2019, seven in FY2020, 13 in FY2021, 
11 in FY2022, and 15 in FY 2023, and only a fraction of these 
submissions were from small businesses.
    In addition, the Agency currently offers relief to qualifying small 
businesses by reducing the SNUN submission fee from $37,000 to $6,480. 
This lower fee reduces the total reporting and recordkeeping cost of 
submitting a SNUN to about $14,500 per SNUN submission for qualifying 
small firms. Therefore, the potential economic impacts of complying 
with these proposed SNURs are not expected to be significant or 
adversely impact a substantial number of small entities. In a SNUR that 
published in the Federal Register of June 2, 1997 (62 FR 29684) (FRL-
5597-1), the Agency presented its general determination that SNURs are 
not expected to have a significant economic impact on a substantial 
number of small entities, which was provided to the Chief Counsel for 
Advocacy of the Small Business Administration.

D. Unfunded Mandates Reform Act (UMRA)

    This action does not contain an unfunded mandate of $100 million or 
more in any one year (in 1995 dollars) as described in UMRA, 2 U.S.C. 
1531-1538, and does not significantly or uniquely affect small 
governments. Based on EPA's experience with proposing and finalizing 
SNURs, State, local, and Tribal governments have not been impacted by 
SNURs. In addition, the estimated costs of this action to the private 
sector do not exceed $183 million or more in any one year (the 1995 
dollars are adjusted to 2023 dollars for inflation using the GDP 
implicit price deflator). The estimated costs for this action are 
discussed in Unit I.D.

E. Executive Order 13132: Federalism

    This action will not have federalism implications as specified in 
Executive Order 13132 (64 FR 43255, August 10, 1999), because it is not 
expected to have a substantial direct effect on States, on the 
relationship between the national government and the States, or on the 
distribution of power and responsibilities among the various levels of 
government. Accordingly, the requirements of Executive Order 13132 do 
not apply to this action.

F. Executive Order 13175: Consultation and Coordination With Indian 
Tribal Governments

    This action will not have Tribal implications as specified in 
Executive Order 13175 (65 FR 67249, November 9, 2000), because it is 
not expected to have substantial direct effects on Indian Tribes, 
significantly or uniquely affect the communities of Indian Tribal 
governments and does not involve or impose any requirements that affect 
Indian Tribes. Accordingly, the requirements of Executive Order 13175 
do not apply to this action.

G. Executive Order 13045: Protection of Children From Environmental 
Health Risks and Safety Risks

    This action is not subject to Executive Order 13045 (62 FR 19885, 
April 23, 1997), because it does not concern an environmental health or 
safety risk. Since this action does not concern human health, EPA's 
2021 Policy on Children's Health also does not apply. Although the 
establishment of these SNURs do not address an existing children's 
environmental health concern because the chemical uses involved are not 
ongoing uses, SNURs require that persons notify EPA at least 90 days 
before commencing manufacture (defined by statute to include import) or 
processing of any of these chemical substances for an activity that is 
designated as a significant new use by this rulemaking. This 
notification allows EPA to assess the conditions of use to identify 
potential risks and take appropriate actions before the activities 
commence.

H. Executive Order 13211: Actions Concerning Regulations That 
Significantly Affect Energy Supply, Distribution, or Use

    This action is not a ``significant energy action'' as defined in 
Executive Order 13211 (66 FR 28355, May 22, 2001), because it is not 
likely to have a significant adverse effect on the supply, 
distribution, or use of energy.

I. National Technology Transfer and Advancement Act (NTTAA)

    This action does not involve any technical standards subject to 
NTTAA section 12(d) (15 U.S.C. 272 note).

J. Executive Order 12898: Federal Actions To Address Environmental 
Justice in Minority Populations and Low-Income Populations and 
Executive Order 14096: Revitalizing Our Nation's Commitment to 
Environmental Justice for All

    This action does not concern human health or environmental 
conditions and therefore cannot be evaluated with respect to the 
potential for disproportionate impacts on non-white and low-income 
populations in accordance with Executive Order 12898 (59 FR 7629, 
February 16, 1994) and Executive Order 14096 (88 FR 25251, April 26, 
2023). Although this action does not concern human health or 
environmental conditions, the premanufacture notifications required by 
these SNURs allow EPA to assess the conditions of use to identify 
potential disproportionate risks and take appropriate actions before 
the activities commence.

List of Subjects in 40 CFR Part 721

    Environmental protection, Chemicals, Hazardous substances, 
Reporting and recordkeeping requirements.

    Dated: June 6, 2024.
Mary Elissa Reaves,
Director, Office of Pollution Prevention and Toxics.

    Therefore, for the reasons stated in the preamble, EPA proposes to 
amend 40 CFR chapter 1 as follows:

PART 721--SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES

0
1. The authority citation for part 721 continues to read as follows:

    Authority: 15 U.S.C. 2604, 2607, and 2625(c)

0
2. Add Sec. Sec.  721.11860 through 721.11890 to subpart E to read as 
follows:

Subpart E--Significant New Uses for Specific Chemical Substances

Sec.
* * * * *
721.11860 1,2-Ethanediamine, N-(1-methylethyl)-N-[2-[(1-
methylethyl)amino]ethyl]-.
721.11861 Fatty acids, polymers with substituted carbomonocycles, 
dialkanolamine, alkyl substituted alkanediamine and halo-substituted 
heteromonocycle, formates (salts) (generic).
721.11862 Alkanesulfonic acid, 2-[(2-aminoethyl)heteroatom-
substituted]-, sodium salt (1:1), polymer with .alpha.-[2,2-
bis(hydroxymethyl)butyl]-.omega.-methoxypoly(oxy-1,2-ethanediyl) and 
1,1'-methylenebis[4-isocyanatocyclohexane], acrylic acid-
dipenthaerythritol reaction products- and polypropylene glycol ether 
with pentaerythritol (4:1) triacrylate-blocked (generic).
721.11863 Alkanoic acid, hydroxy-(hydroxyalkyl)-alkyl-, polymer with 
.alpha.-[(hydroxyalkyl)alkyl]-.omega.-alkoxypoly(oxy-alkanediyl), 
(haloalkyl)oxiane polymer (alkylalkylidene)bis[hydroxy-

[[Page 49133]]

carbomonocycle] alkenoate and isocyanate-alkyl-carbomonocycle, 
hydroxyalkyl acrylate-blocked (generic).
721.11864 1,4-Benzenedicarboxylic acid, bis[2-(2-butoxyethoxy)ethyl] 
ester (9CI).
721.11865 Isocyanic acid, polyalkylenepolyarylene ester, polymer 
with alkyl-hydroxyalkyl-alkanediol, alkoxyalcohol and 
alkoxylalkoxyalcohol-blocked (generic).
721.11866 Substituted alkanoic acid, compound with aminoalkylalkyl-
aminoalkylalkoxy-polyoxyalkylalkanediyl, polymer with haloalkyl-
epoxide and alkylalkylidene-cycloarylalcohol (generic).
721.11867 Bisphenol A epichlorohydrin polymer with alkylpolyalkene-
polyarylene-hydroxypolyoxyalkyldiyl reaction products with 
alkylalkylidenealkylalkylidene-aminoalkyl-alkanepolyamine and 
alkylaminoalkanol (generic).
721.11868 Sulfur based acid, compds. with modified bisphenol A-
epichlorohydrin-polyalkylene polyol ether with bisphenol A polymer-
N-dialkylalkylidene-N- (dialkylalklyidene)aminoalkyl-
alkanepolyamine-alkylaminoalkanol reaction products (generic).
721.118691 2-Alkanediol, 3-aryloxy, mono phosphate ester (generic).
721.11870 Metalloxanes, alkyl, alkyl group-terminated, reaction 
products with dihalo-dialkylalkylaryl-alkyl-polycyclic-
ylidene(dialkylsilylene)-dialkylalkylaryl-alkylalkyl-polycyclic-
ylidene, metal oxide and nonmetallic oxide (generic).
721.11871 Alkenoic acid, reaction products with pentaerythritol, 
polymers with diisocyanatoalkane and heteromonocyle homopolymer 
esters with alkanoic acid-pentaerythritol reaction products 
(generic).
721.11872 Carbopolycycle octa-alkene, halo (generic).
721.11873 2-Propenoic acid, (polyhydro-1,3-dioxo-2H-isoindol-2-
yl)alkyl ester (generic).
721.11874 Heteromonocycle, polymer, [2-[(1-oxo-2-propen-1-
yl)oxy]alkyl]ester (generic).
721.11875 Hydrocarbons linear and branched, light alkylate 
(generic).
721.11876 Hydrocarbons linear and branched, light catalytic cracked 
(generic).
721.11877 Hydrocarbons linear and branched, heavy catalytic cracked 
(generic).
721.11878 Hydrocarbons linear and branched, light hydrocracked 
(generic).
721.11879 Hydrocarbons linear and branched, isomerization (generic).
721.11880 Hydrocarbons linear and branched, heavy catalytic reformed 
(generic).
721.11881 Hydrocarbons linear and branched, hydrotreated light 
(generic).
721.11882 Hydrocarbons linear and branched, hydrotreated light 
paraffinic (generic).
721.11883 Hydrocarbons linear and branched, light catalytic cracked 
(generic).
721.11884 Hydrocarbons linear and branched, heavy hydrocracked 
(generic).
721.11885 Hydrocarbons linear and branched, heavy catalytic cracked 
(generic).
721.11886 Hydrocarbons linear and branched, heavy hydrocracked 
(generic).
721.11887 Hydrocarbons linear and branched, light hydrocracked 
(generic).
721.11888 Imidazole-carboxylic acid, substituted (generic).
721.11889 Multi-walled carbon nanotubes (generic).
721.11890 Multi-walled carbon nanotubes (generic).
* * * * *


Sec.  721.11860  1,2-Ethanediamine, N-(1-methylethyl)-N-[2-[(1-
methylethyl)amino]ethyl]-.

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified as 1,2-ethanediamine, 
N-(1-methylethyl)-N-[2-[(1-methylethyl)amino]ethyl]- (PMN P-18-398; 
CASRN 10507-06-9) is subject to reporting under this section for the 
significant new uses described in paragraph (a)(2) of this section.
    (2) The significant new uses are: (i) Protection in the workplace. 
Requirements as specified in Sec.  721.63(a)(1), (3) through (5), and 
(c). When determining which persons are reasonably likely to be exposed 
as required for Sec.  721.63(a)(1) and (4), engineering control 
measures (e.g., enclosure or confinement of the operation, general and 
local ventilation) or administrative control measures (e.g., workplace 
policies and procedures) shall be considered and implemented to prevent 
exposure, where feasible. For purposes of Sec.  721.63(a)(5), 
respirators must provide a National Institute for Occupational Safety 
and Health (NIOSH) assigned protection factor (APF) of at least 50.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), and (g)(1), (3) and (5). For purposes of 
Sec.  721.72(g)(1), this substance may cause: acute toxicity; specific 
target organ toxicity; reproductive toxicity; skin corrosion; serious 
eye damage; skin sensitization. For purposes of Sec.  721.72(g)(3), 
this substance may be: toxic to aquatic life. Alternative hazard and 
warning statements that meet the criteria of the Globally Harmonized 
System and OSHA Hazard Communication Standard may be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(k).
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i) are applicable to manufacturers, importers, and 
processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.11861  Fatty acids, polymers with substituted 
carbomonocycles, dialkanolamine, alkyl substituted alkanediamine and 
halo-substituted heteromonocycle, formates (salts) (generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as fatty 
acids, polymers with substituted carbomonocycles, dialkanolamine, alkyl 
substituted alkanediamine and halo-substituted heteromonocycle, 
formates (salts) (PMN P-19-49) is subject to reporting under this 
section for the significant new uses described in paragraph (a)(2) of 
this section. The requirements of this section do not apply to 
quantities of the substance after they have been completely reacted 
(cured).
    (2) The significant new uses are: (i) Protection in the workplace. 
Requirements as specified in Sec.  721.63(a)(1) and (3), (b), and (c). 
When determining which persons are reasonably likely to be exposed as 
required for Sec.  721.63(a)(1), engineering control measures (e.g., 
enclosure or confinement of the operation, general and local 
ventilation) or administrative control measures (e.g., workplace 
policies and procedures) shall be considered and implemented to prevent 
exposure, where feasible. For purposes of Sec.  721.63(b), the 
concentration is set at 1%.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (f), and (g)(1), (3) and (5). For purposes of Sec.  
721.72(e), the concentration is set at 1%. For purposes of Sec.  
721.72(g)(1), this substance may cause: skin irritation; eye 
irritation; reproductive toxicity; specific organ toxicity. For 
purposes of Sec.  721.72(g)(3), this substance may be: toxic to aquatic 
life. Alternative hazard and warning statements that meet the criteria 
of the Globally Harmonized System and OSHA Hazard Communication 
Standard may be used.
    (iii) Industrial, commercial, and consumer activities. It is a 
significant new use to manufacture or process the substance in any 
manner that generates a vapor, mist, or aerosol. It is a significant 
new use to use the substance in any manner that generates a vapor, 
mist, or aerosol that results in inhalation to industrial or commercial 
workers. It

[[Page 49134]]

is a significant new use to manufacture the substance to contain the 
confidential residual identified in the TSCA Order for this substance 
at greater than 0.1%.
    (iv) Release to Water. Requirements as specified in Sec.  
721.90(a)(4), (b)(4), and (c)(4), where N=114.
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i) and (k) are applicable to manufacturers, 
importers, and processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.11862  Alkanesulfonic acid, 2-[(2-aminoethyl)heteroatom-
substituted]-, sodium salt (1:1), polymer with .alpha.-[2,2-
bis(hydroxymethyl)butyl]-.omega.-methoxypoly(oxy-1,2-ethanediyl) and 
1,1'-methylenebis[4-isocyanatocyclohexane], acrylic acid-
dipenthaerythritol reaction products- and polypropylene glycol ether 
with pentaerythritol (4:1) triacrylate-blocked (generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as 
alkanesulfonic acid, 2-[(2-aminoethyl)heteroatom-substituted]-, sodium 
salt (1:1), polymer with .alpha.-[2,2-bis(hydroxymethyl)butyl]-.omega.-
methoxypoly(oxy-1,2-ethanediyl) and 1,1'-methylenebis[4-
isocyanatocyclohexane], acrylic acid-dipenthaerythritol reaction 
products- and polypropylene glycol ether with pentaerythritol (4:1) 
triacrylate-blocked (PMN P-19-160) is subject to reporting under this 
section for the significant new uses described in paragraph (a)(2) of 
this section.
    (2) The significant new uses are: (i) Protection in the workplace. 
Requirements as specified in Sec.  721.63(a)(1) and (3), and (c). When 
determining which persons are reasonably likely to be exposed as 
required for Sec.  721.63(a)(1), engineering control measures (e.g., 
enclosure or confinement of the operation, general and local 
ventilation) or administrative control measures (e.g., workplace 
policies and procedures) shall be considered and implemented to prevent 
exposure, where feasible.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), and (g)(1) and (5). For purposes of Sec.  
721.72(g)(1), this substance may cause: skin irritation; eye 
irritation; serious eye damage; skin sensitization; respiratory 
sensitization; reproductive toxicity; specific organ toxicity. 
Alternative hazard and warning statements that meet the criteria of the 
Globally Harmonized System and OSHA Hazard Communication Standard may 
be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(o). It is a significant new use to 
manufacture, process, or use the substance in any manner that results 
in inhalation exposure.
    (iv) Release to Water. Requirements as specified in Sec.  
721.90(a)(4), (b)(4), and (c)(4), where N=302.
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i), and (k) are applicable to manufacturers, 
importers, and processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.11863  Alkanoic acid, hydroxy-(hydroxyalkyl)-alkyl-, polymer 
with .alpha.-[(hydroxyalkyl)alkyl]-.omega.-alkoxypoly(oxy-alkanediyl), 
(haloalkyl)oxiane polymer (alkylalkylidene)bis[hydroxy-carbomonocycle] 
alkenoate and isocyanate-alkyl-carbomonocycle, hydroxyalkyl acrylate-
blocked (generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance generically identified as 
alkanoic acid, hydroxy-(hydroxyalkyl)-alkyl-, polymer with .alpha.-
[(hydroxyalkyl)alkyl]-.omega.-alkoxypoly(oxy-alkanediyl), 
(haloalkyl)oxiane polymer (alkylalkylidene)bis[hydroxy-carbomonocycle] 
alkenoate and isocyanate-alkyl-carbomonocycle, hydroxyalkyl acrylate-
blocked (PMN P-20-101) is subject to reporting under this section for 
the significant new uses described in paragraph (a)(2) of this section. 
The requirements of this section do not apply to quantities of the 
substance after they have been completely cured.
    (2) The significant new uses are: (i) Protection in the workplace. 
Requirements as specified in Sec.  721.63(a)(1), (3) through (5), and 
(c). When determining which persons are reasonably likely to be exposed 
as required for Sec.  721.63(a)(1) and (4), engineering control 
measures (e.g., enclosure or confinement of the operation, general and 
local ventilation) or administrative control measures (e.g., workplace 
policies and procedures) shall be considered and implemented to prevent 
exposure, where feasible. For purposes of Sec.  721.63(a)(5), 
respirators must provide a National Institute for Occupational Safety 
and Health (NIOSH) assigned protection factor (APF) of at least 50.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), and (g)(1), (3) and (5). For purposes of 
Sec.  721.72(g)(1), this substance may cause: acute toxicity; skin 
irritation; eye irritation; respiratory sensitization; skin 
sensitization; reproductive toxicity; specific target organ toxicity. 
For purposes of Sec.  721.72(g)(3), this substance may be: toxic to 
aquatic life. Alternative hazard and warning statements that meet the 
criteria of the Globally Harmonized System and OSHA Hazard 
Communication Standard may be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(o). It is a significant new use to 
manufacture or process the substance with greater than 20% (by weight) 
oligomer content below 1,000 daltons (i.e., low molecular weight 
species). It is a significant new use to use the substance in a manual 
spray application.
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i) are applicable to manufacturers, importers, and 
processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.11864  1,4-Benzenedicarboxylic acid, bis[2-(2-
butoxyethoxy)ethyl] ester (9CI).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified as 1,4-
benzenedicarboxylic acid, bis[2-(2-butoxyethoxy)ethyl] ester (9CI) (PMN 
P-20-182; CASRN 90430-63-0) is subject to reporting under this section 
for the significant new uses described in paragraph (a)(2) of this 
section. The requirements of this section do not apply to quantities of 
the substance after they have been completely reacted (cured).
    (2) The significant new uses are: (i) Protection in the workplace. 
Requirements as specified in Sec.  721.63(a)(1), (3) through (5), and 
(c). When determining which persons are reasonably likely to be exposed 
as required for Sec.  721.63(a)(1) and (4), engineering control 
measures (e.g., enclosure or confinement of the

[[Page 49135]]

operation, general and local ventilation) or administrative control 
measures (e.g., workplace policies and procedures) shall be considered 
and implemented to prevent exposure, where feasible. For purposes of 
Sec.  721.63(a)(5), respirators must provide a National Institute for 
Occupational Safety and Health (NIOSH) assigned protection factor (APF) 
of at least 1,000.
    (A) As an alternative to the respirator requirements in paragraph 
(a)(2)(i) of this section, a manufacturer or processor may choose to 
follow the new chemical exposure limit (NCEL) provision listed in the 
TSCA section 5(e) Order for this substance. The NCEL is 0.01 mg/m\3\ as 
an 8-hour time weighted average. Persons who wish to pursue NCELs as an 
alternative to Sec.  721.63 respirator requirements may request to do 
so under Sec.  721.30. Persons whose Sec.  721.30 requests to use the 
NCELs approach are approved by EPA will be required to follow NCELs 
provisions comparable to those contained in the corresponding TSCA 
section 5(e) Order.
    (B) [Reserved]
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), and (g)(1), (3) and (5). For purposes of 
Sec.  721.72(g)(1), this substance may cause: skin sensitization; 
reproductive toxicity; specific target organ toxicity. For purposes of 
Sec.  721.72(g)(3), this substance may be: toxic to aquatic life. 
Alternative hazard and warning statements that meet the criteria of the 
Globally Harmonized System and OSHA Hazard Communication Standard may 
be used.
    (iii) Release to water. Requirements as specified in Sec.  
721.90(a)(4), (b)(4), and (c)(4), where N=4.
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (h), and (k) are applicable to manufacturers, 
importers, and processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.11865  Isocyanic acid, polyalkylenepolyarylene ester, polymer 
with alkyl-hydroxyalkyl-alkanediol, alkoxyalcohol and 
alkoxylalkoxyalcohol-blocked (generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as 
isocyanic acid, polyalkylenepolyarylene ester, polymer with alkyl-
hydroxyalkyl-alkanediol, alkoxyalcohol and alkoxylalkoxyalcohol-blocked 
(PMN P-21-56) is subject to reporting under this section for the 
significant new uses described in paragraph (a)(2) of this section. The 
requirements of this section do not apply to quantities of the 
substance after they have been completely reacted (cured).
    (2) The significant new uses are: (i) Protection in the workplace. 
Requirements as specified in Sec.  721.63(a)(1), (3) through (5), and 
(c). When determining which persons are reasonably likely to be exposed 
as required for Sec.  721.63(a)(1) and (4), engineering control 
measures (e.g., enclosure or confinement of the operation, general and 
local ventilation) or administrative control measures (e.g., workplace 
policies and procedures) shall be considered and implemented to prevent 
exposure, where feasible. For purposes of Sec.  721.63(a)(5), 
respirators must provide a National Institute for Occupational Safety 
and Health (NIOSH) assigned protection factor (APF) of at least 50 or 
1,000 if spray applied.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), and (g)(1) and (5). For purposes of Sec.  
721.72(g)(1), this substance may cause: acute toxicity; skin 
sensitization. Alternative hazard and warning statements that meet the 
criteria of the Globally Harmonized System and OSHA Hazard 
Communication Standard may be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(o). It is a significant new use to 
manufacture the substance beyond 24 months.
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i) are applicable to manufacturers, importers, and 
processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.11866  Substituted alkanoic acid, compound with 
aminoalkylalkyl-aminoalkylalkoxy-polyoxyalkylalkanediyl, polymer with 
haloalkyl-epoxide and alkylalkylidene-cycloarylalcohol (generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as 
substituted alkanoic acid, compound with aminoalkylalkyl-
aminoalkylalkoxy-polyoxyalkylalkanediyl, polymer with haloalkyl-epoxide 
and alkylalkylidene-cycloarylalcohol (PMN P-21-58) is subject to 
reporting under this section for the significant new uses described in 
paragraph (a)(2) of this section. The requirements of this section do 
not apply to quantities of the substance after they have been 
completely reacted (cured).
    (2) The significant new uses are: (i) Protection in the workplace. 
Requirements as specified in Sec.  721.63(a)(1) and (3), (b), and (c). 
When determining which persons are reasonably likely to be exposed as 
required for Sec.  721.63(a)(1), engineering control measures (e.g., 
enclosure or confinement of the operation, general and local 
ventilation) or administrative control measures (e.g., workplace 
policies and procedures) shall be considered and implemented to prevent 
exposure, where feasible. For purposes of Sec.  721.63(b), the 
concentration is set at 1%.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (f), and (g)(1), (3) and (5). For purposes of Sec.  
721.72(e), the concentration is set at 1%. For purposes of Sec.  
721.72(g)(1), this substance may cause: skin irritation; eye 
irritation; specific target organ toxicity. For purposes of Sec.  
721.72(g)(3), this substance may be: toxic to aquatic life. Alternative 
hazard and warning statements that meet the criteria of the Globally 
Harmonized System and OSHA Hazard Communication Standard may be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(o). It is a significant new use to 
manufacture, process, or use the substance in any manner that results 
in inhalation exposure.
    (iv) Release to water. Requirements as specified in Sec.  
721.90(a)(4), (b)(4), and (c)(4), where N=50.
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i), and (k) are applicable to manufacturers, 
importers, and processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.

[[Page 49136]]

Sec.  721.11867  Bisphenol A epichlorohydrin polymer with 
alkylpolyalkene-polyarylene-hydroxypolyoxyalkyldiyl reaction products 
with alkylalkylidenealkylalkylidene-aminoalkyl-alkanepolyamine and 
alkylaminoalkanol (generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as 
bisphenol A epichlorohydrin polymer with alkylpolyalkene-polyarylene-
hydroxypolyoxyalkyldiyl reaction products with 
alkylalkylidenealkylalkylidene-aminoalkyl-alkanepolyamine and 
alkylaminoalkanol (PMN P-21-60) is subject to reporting under this 
section for the significant new uses described in paragraph (a)(2) of 
this section. The requirements of this section do not apply to 
quantities of the substance after they have been completely reacted 
(cured).
    (2) The significant new uses are: (i) Protection in the workplace. 
Requirements as specified in Sec.  721.63(a)(1) and (3), (b), and (c). 
When determining which persons are reasonably likely to be exposed as 
required for Sec.  721.63(a)(1), engineering control measures (e.g., 
enclosure or confinement of the operation, general and local 
ventilation) or administrative control measures (e.g., workplace 
policies and procedures) shall be considered and implemented to prevent 
exposure, where feasible. For purposes of Sec.  721.63(b), the 
concentration is set at 0.1%.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (f), and (g)(1), (3) and (5). For purposes of Sec.  
721.72(e), the concentration is set at 0.1%. For purposes of Sec.  
721.72(g)(1), this substance may cause: skin irritation; eye 
irritation; carcinogenicity; reproductive toxicity; specific target 
organ toxicity. For purposes of Sec.  721.72(g)(3), this substance may 
be: toxic to aquatic life. Alternative hazard and warning statements 
that meet the criteria of the Globally Harmonized System and OSHA 
Hazard Communication Standard may be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(o). It is a significant new use to 
manufacture, process, or use the substance in any manner that results 
in inhalation exposure.
    (iv) Release to water. Requirements as specified in Sec.  
721.90(a)(1), (b)(1), and (c)(1).
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i), and (k) are applicable to manufacturers, 
importers, and processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.11868  Sulfur based acid, compds. with modified bisphenol A-
epichlorohydrin-polyalkylene polyol ether with bisphenol A polymer-N-
dialkylalkylidene-N- (dialkylalklyidene)aminoalkyl-alkanepolyamine-
alkylaminoalkanol reaction products (generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as sulfur 
based acid, compds. with modified bisphenol A-epichlorohydrin-
polyalkylene polyol ether with bisphenol A polymer-N-dialkylalkylidene-
N- (dialkylalklyidene)aminoalkyl-alkanepolyamine-alkylaminoalkanol 
reaction products (PMN P-21-61) is subject to reporting under this 
section for the significant new uses described in paragraph (a)(2) of 
this section. The requirements of this section do not apply to 
quantities of the substance after they have been completely reacted 
(cured).
    (2) The significant new uses are: (i) Protection in the workplace. 
Requirements as specified in Sec.  721.63(a)(1) and (3), (b), and (c). 
When determining which persons are reasonably likely to be exposed as 
required for Sec.  721.63(a)(1), engineering control measures (e.g., 
enclosure or confinement of the operation, general and local 
ventilation) or administrative control measures (e.g., workplace 
policies and procedures) shall be considered and implemented to prevent 
exposure, where feasible. For purposes of Sec.  721.63(b), the 
concentration is set at 0.1%.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (f), and (g)(1), (3) and (5). For purposes of Sec.  
721.72(e), the concentration is set at 0.1%. For purposes of Sec.  
721.72(g)(1), this substance may cause: skin irritation; eye 
irritation; carcinogenicity; reproductive toxicity; specific target 
organ toxicity. For purposes of Sec.  721.72(g)(3), this substance may 
be: toxic to aquatic life. Alternative hazard and warning statements 
that meet the criteria of the Globally Harmonized System and OSHA 
Hazard Communication Standard may be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(o). It is a significant new use to 
manufacture, process, or use the substance in any manner that results 
in inhalation exposure.
    (iv) Release to water. Requirements as specified in Sec.  
721.90(a)(4), (b)(4), and (c)(4), where N=11.
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i), and (k) are applicable to manufacturers, 
importers, and processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.11869  1,2-Alkanediol, 3-aryloxy, mono phosphate ester 
(generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as 1,2-
alkanediol, 3-aryloxy, mono phosphate ester (PMN P-21-66) is subject to 
reporting under this section for the significant new uses described in 
paragraph (a)(2) of this section. The requirements of this section do 
not apply to quantities of the substance after they have been 
completely destroyed.
    (2) The significant new uses are:
    (i) Protection in the workplace. Requirements as specified in Sec.  
721.63(a)(1) and (3), (b), and (c). When determining which persons are 
reasonably likely to be exposed as required for Sec.  721.63(a)(1), 
engineering control measures (e.g., enclosure or confinement of the 
operation, general and local ventilation) or administrative control 
measures (e.g., workplace policies and procedures) shall be considered 
and implemented to prevent exposure, where feasible. For purposes of 
Sec.  721.63(b), the concentration is set at 1.0%.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (f), and (g)(1), (3) and (5). For the purposes of 
Sec.  721.72(e), the concentration is set at 1.0%. For purposes of 
Sec.  721.72(g)(1), this substance may cause: acute toxicity; skin 
corrosion; skin irritation; serious eye damage; eye irritation; 
reproductive toxicity; specific target organ toxicity. For purposes of 
Sec.  721.72(g)(3), this substance may be: toxic to aquatic life. 
Alternative hazard and warning statements that meet the criteria of the 
Globally Harmonized System and OSHA

[[Page 49137]]

Hazard Communication Standard may be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(o). It is a significant new use to 
manufacture, process, or use the substance in any manner that results 
in inhalation exposure or that results in fugitive air emissions. It is 
a significant new use to use the substance other than as an epoxy 
curative.
    (iv) Release to water. Requirements as specified in Sec.  
721.90(a)(1), (b)(1), and (c)(1).
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i), and (k) are applicable to manufacturers, 
importers, and processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.11870  Metalloxanes, alkyl, alkyl group-terminated, reaction 
products with dihalo-dialkylalkylaryl-alkyl-polycyclic-
ylidene(dialkylsilylene)-dialkylalkylaryl-alkylalkyl-polycyclic-
ylidene, metal oxide and nonmetallic oxide (generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as 
metalloxanes, alkyl, alkyl group-terminated, reaction products with 
dihalo-dialkylalkylaryl-alkyl-polycyclic-ylidene(dialkylsilylene)-
dialkylalkylaryl-alkylalkyl-polycyclic-ylidene, metal oxide and 
nonmetallic oxide (PMN P-21-68) is subject to reporting under this 
section for the significant new uses described in paragraph (a)(2) of 
this section.
    (2) The significant new uses are: (i) Protection in the workplace. 
Requirements as specified in Sec.  721.63(a)(1) and (3), and (c). When 
determining which persons are reasonably likely to be exposed as 
required for Sec.  721.63(a)(1), engineering control measures (e.g., 
enclosure or confinement of the operation, general and local 
ventilation) or administrative control measures (e.g., workplace 
policies and procedures) shall be considered and implemented to prevent 
exposure, where feasible.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), and (g)(1) and (5). For purposes of Sec.  
721.72(g)(1), this substance may cause: acute toxicity; skin corrosion; 
skin irritation; serious eye damage; eye irritation; respiratory 
sensitization; skin sensitization; germ cell mutagenicity; reproductive 
toxicity; specific target organ toxicity. Alternative hazard and 
warning statements that meet the criteria of the Globally Harmonized 
System and OSHA Hazard Communication Standard may be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(a) through (c). It is a significant new 
use to manufacture, process, or use the substance in any manner that 
results in inhalation or dermal exposure.
    (iv) Release to water. Requirements as specified in Sec.  
721.90(a)(4), (b)(4), and (c)(4), where N=50.
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i), and (k) are applicable to manufacturers, 
importers, and processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.11871  Alkenoic acid, reaction products with pentaerythritol, 
polymers with diisocyanatoalkane and heteromonocyle homopolymer esters 
with alkanoic acid-pentaerythritol reaction products (generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as 
alkenoic acid, reaction products with pentaerythritol, polymers with 
diisocyanatoalkane and heteromonocyle homopolymer esters with alkanoic 
acid-pentaerythritol reaction products (PMN P-21-83) is subject to 
reporting under this section for the significant new uses described in 
paragraph (a)(2) of this section. The requirements of this section do 
not apply to quantities of the substance after they have been 
completely reacted (cured).
    (2) The significant new uses are: (i) Protection in the workplace. 
Requirements as specified in Sec.  721.63(a)(1), (3) through (5), and 
(c). When determining which persons are reasonably likely to be exposed 
as required for Sec.  721.63(a)(1) and (4), engineering control 
measures (e.g., enclosure or confinement of the operation, general and 
local ventilation) or administrative control measures (e.g., workplace 
policies and procedures) shall be considered and implemented to prevent 
exposure, where feasible. For purposes of Sec.  721.63(a)(5), 
respirators must provide a National Institute for Occupational Safety 
and Health (NIOSH) assigned protection factor (APF) of at least 1,000.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), and (g)(1), (3) and (5). For purposes of 
Sec.  721.72(g)(1), this substance may cause: skin irritation; eye 
irritation; respiratory sensitization; skin sensitization; specific 
target organ toxicity. For purposes of Sec.  721.72(g)(3), this 
substance may be: toxic to aquatic life. Alternative hazard and warning 
statements that meet the criteria of the Globally Harmonized System and 
OSHA Hazard Communication Standard may be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(o).
    (iv) Release to water. Requirements as specified in Sec.  
721.90(a)(4), (b)(4), and (c)(4), where N=1.
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i), and (k) are applicable to manufacturers, 
importers, and processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.11872  Carbopolycycle octa-alkene, halo (generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as 
carbopolycycle octa-alkene, halo (PMN P-21-84) is subject to reporting 
under this section for the significant new uses described in paragraph 
(a)(2) of this section.
    (2) The significant new uses are: (i) Protection in the workplace. 
Requirements as specified in Sec.  721.63(a)(1), (3) through (5), and 
(c). When determining which persons are reasonably likely to be exposed 
as required for Sec.  721.63(a)(1) and (4), engineering control 
measures (e.g., enclosure or confinement of the operation, general and 
local ventilation) or administrative control measures (e.g., workplace 
policies and procedures) shall be considered and implemented to prevent 
exposure, where feasible. For purposes of Sec.  721.63(a)(5), 
respirators must provide a National Institute for Occupational Safety 
and Health (NIOSH) assigned protection factor (APF) of at least 50.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a)

[[Page 49138]]

through (d), (f), and (g)(1), (3) and (5). For purposes of Sec.  
721.72(g)(1), this substance may cause: acute toxicity; skin corrosion; 
serious eye damage; skin sensitization; genetic toxicity. For purposes 
of Sec.  721.72(g)(3), this substance may be: toxic to aquatic life. 
Alternative hazard and warning statements that meet the criteria of the 
Globally Harmonized System and OSHA Hazard Communication Standard may 
be used.
    (iii) Release to water. Requirements as specified in Sec.  
721.90(a)(4), (b)(4), and (c)(4), where N=7.
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (h), and (k) are applicable to manufacturers, 
importers, and processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.11873  2-Propenoic acid, (polyhydro-1,3-dioxo-2H-isoindol-2-
yl)alkyl ester (generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as 2-
propenoic acid, (polyhydro-1,3-dioxo-2H-isoindol-2-yl)alkyl ester (PMN 
P-21-92) is subject to reporting under this section for the significant 
new uses described in paragraph (a)(2) of this section. The 
requirements of this section do not apply to quantities of the PMN 
substance after they have been completely reacted (cured).
    (2) The significant new uses are: (i) Protection in the workplace. 
Requirements as specified in Sec.  721.63(a)(1), (3) through (5), (b), 
and (c). When determining which persons are reasonably likely to be 
exposed as required for Sec.  721.63(a)(1) and (a)(4), engineering 
control measures (e.g., enclosure or confinement of the operation, 
general and local ventilation) or administrative control measures 
(e.g., workplace policies and procedures) shall be considered and 
implemented to prevent exposure, where feasible. For purposes of Sec.  
721.63(b), the concentration is set at 1.0%. For purposes of Sec.  
721.63(a)(5), respirators must provide a National Institute for 
Occupational Safety and Health (NIOSH) assigned protection factor (APF) 
of at least 10.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (f), and (g)(1) and (3). For purposes of Sec.  
721.72(g)(1), this substance may cause: skin irritation; eye 
irritation; specific target organ toxicity; reproductive toxicity. For 
purposes of Sec.  721.72(g)(3), this substance may be: toxic to aquatic 
life. For purposes of Sec.  721.72(e), the concentration is set at 
1.0%. Alternative hazard and warning statements that meet the criteria 
of the Globally Harmonized System and OSHA Hazard Communication 
Standard may be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(o). It is a significant new use to use the 
substance at a concentration of greater than 40% in formulation when 
inhalation exposure is expected.
    (iv) Disposal. It is a significant new use to dispose of the 
substance or waste streams containing the substance other than by 
incineration or RCRA subtitle C landfill.
    (v) Release to water. Requirements as specified in Sec.  
721.90(a)(1), (b)(1), and (c)(1).
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (k) are applicable to manufacturers, importers, and 
processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.11874  Heteromonocycle, polymer, [2-[(1-oxo-2-propen-1-
yl)oxy]alkyl]ester (generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as 
heteromonocycle, polymer, [2-[(1-oxo-2-propen-1-yl)oxy]alkyl]ester (PMN 
P-21-102) is subject to reporting under this section for the 
significant new uses described in paragraph (a)(2) of this section. The 
requirements of this section do not apply to quantities of the 
substance after they have been completely reacted (cured).
    (2) The significant new uses are: (i) Protection in the workplace. 
Requirements as specified in Sec.  721.63(a)(1), (3) through (5), and 
(c). When determining which persons are reasonably likely to be exposed 
as required for Sec.  721.63(a)(1) and (4), engineering control 
measures (e.g., enclosure or confinement of the operation, general and 
local ventilation) or administrative control measures (e.g., workplace 
policies and procedures) shall be considered and implemented to prevent 
exposure, where feasible. For purposes of Sec.  721.63(a)(5), 
respirators must provide a National Institute for Occupational Safety 
and Health (NIOSH) assigned protection factor (APF) of at least 10.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), and (g)(1), (3) and (5). For purposes of 
Sec.  721.72(g)(1), this substance may cause: skin irritation; eye 
irritation; specific target organ toxicity; developmental toxicity; 
skin sensitization. For purposes of Sec.  721.72(g)(3), this substance 
may be: toxic to aquatic life. Alternative hazard and warning 
statements that meet the criteria of the Globally Harmonized System and 
OSHA Hazard Communication Standard may be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(o).
    (iv) Release to water. Requirements as specified in Sec.  
721.90(a)(4), (b)(4), and (c)(4), where N=337.
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i), and (k) are applicable to manufacturers, 
importers, and processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.11875  Hydrocarbons linear and branched, light alkylate 
(generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as 
hydrocarbons linear and branched, light alkylate (PMN P-21-109) is 
subject to reporting under this section for the significant new uses 
described in paragraph (a)(2) of this section. The requirements of this 
section do not apply to quantities of the substance after they have 
been incorporated into a fuel, fuel additive, fuel blending stock, or 
used as a refinery feedstock (including, but not limited to cracking, 
coking, hydroprocessing, distillation, or deasphalting).
    (2) The significant new uses are: (i) Protection in the workplace. 
Requirements as specified in Sec.  721.63(a)(1) and (3), (b) and (c). 
When determining which persons are reasonably likely to be exposed as 
required for Sec.  721.63(a)(1), engineering control measures (e.g., 
enclosure or confinement of the operation, general and local 
ventilation) or administrative

[[Page 49139]]

control measures (e.g., workplace policies and procedures) shall be 
considered and implemented to prevent exposure, where feasible. For 
purposes of Sec.  721.63(b), the concentration is set at 0.1%.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a).
    (iii) Industrial, commercial, and consumer activities. It is a 
significant new use to manufacture, process, or use the substance other 
than for processing and use as a fuel, fuel additive, fuel blending 
stock, or refinery feedstock (including, but not limited to cracking, 
coking, hydroprocessing, distillation, or deasphalting) subject to 40 
CFR parts 79 or 1090.
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i) are applicable to manufacturers, importers, and 
processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.11876  Hydrocarbons linear and branched, light catalytic 
cracked (generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as 
hydrocarbons linear and branched, light catalytic cracked (PMN P-21-
110) is subject to reporting under this section for the significant new 
uses described in paragraph (a)(2) of this section. The requirements of 
this section do not apply to quantities of the substance after they 
have been incorporated into a fuel, fuel additive, fuel blending stock, 
or used as a refinery feedstock (including, but not limited to 
cracking, coking, hydroprocessing, distillation, or deasphalting).
    (2) The significant new uses are: (i) Protection in the workplace. 
Requirements as specified in Sec.  721.63(a)(1) and (3), (b) and (c). 
When determining which persons are reasonably likely to be exposed as 
required for Sec.  721.63(a)(1), engineering control measures (e.g., 
enclosure or confinement of the operation, general and local 
ventilation) or administrative control measures (e.g., workplace 
policies and procedures) shall be considered and implemented to prevent 
exposure, where feasible. For purposes of Sec.  721.63(b), the 
concentration is set at 0.1%.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a).
    (iii) Industrial, commercial, and consumer activities. It is a 
significant new use to manufacture, process, or use the substance other 
than for processing and use as a fuel, fuel additive, fuel blending 
stock, or refinery feedstock (including, but not limited to cracking, 
coking, hydroprocessing, distillation, or deasphalting) subject to 40 
CFR parts 79 or 1090.
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i) are applicable to manufacturers, importers, and 
processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.11877  Hydrocarbons linear and branched, heavy catalytic 
cracked (generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as 
hydrocarbons linear and branched, heavy catalytic cracked (PMN P-21-
111) is subject to reporting under this section for the significant new 
uses described in paragraph (a)(2) of this section. The requirements of 
this section do not apply to quantities of the substance after they 
have been incorporated into a fuel, fuel additive, fuel blending stock, 
or used as a refinery feedstock (including, but not limited to 
cracking, coking, hydroprocessing, distillation, or deasphalting).
    (2) The significant new uses are: (i) Protection in the workplace. 
Requirements as specified in Sec.  721.63(a)(1) and (3), (b) and (c). 
When determining which persons are reasonably likely to be exposed as 
required for Sec.  721.63(a)(1), engineering control measures (e.g., 
enclosure or confinement of the operation, general and local 
ventilation) or administrative control measures (e.g., workplace 
policies and procedures) shall be considered and implemented to prevent 
exposure, where feasible. For purposes of Sec.  721.63(b), the 
concentration is set at 0.1%.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a).
    (iii) Industrial, commercial, and consumer activities. It is a 
significant new use to manufacture, process, or use the substance other 
than for processing and use as a fuel, fuel additive, fuel blending 
stock, or refinery feedstock (including, but not limited to cracking, 
coking, hydroprocessing, distillation, or deasphalting) subject to 40 
CFR parts 79 or 1090.
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i) are applicable to manufacturers, importers, and 
processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.11878  Hydrocarbons linear and branched, light hydrocracked 
(generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as 
hydrocarbons linear and branched, light hydrocracked (PMN P-21-112) is 
subject to reporting under this section for the significant new uses 
described in paragraph (a)(2) of this section. The requirements of this 
section do not apply to quantities of the substance after they have 
been incorporated into a fuel, fuel additive, fuel blending stock, or 
used as a refinery feedstock (including, but not limited to cracking, 
coking, hydroprocessing, distillation, or deasphalting).
    (2) The significant new uses are: (i) Protection in the workplace. 
Requirements as specified in Sec.  721.63(a)(1) and (3), (b) and (c). 
When determining which persons are reasonably likely to be exposed as 
required for Sec.  721.63(a)(1), engineering control measures (e.g., 
enclosure or confinement of the operation, general and local 
ventilation) or administrative control measures (e.g., workplace 
policies and procedures) shall be considered and implemented to prevent 
exposure, where feasible. For purposes of Sec.  721.63(b), the 
concentration is set at 0.1%.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a).
    (iii) Industrial, commercial, and consumer activities. It is a 
significant new use to manufacture, process, or use the substance other 
than for processing and use as a fuel, fuel additive, fuel blending 
stock, or refinery feedstock (including, but not limited to cracking, 
coking, hydroprocessing, distillation, or deasphalting) subject to 40 
CFR parts 79 or 1090.
    (b) Specific requirements. The provisions of subpart A of this part

[[Page 49140]]

apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through(i), are applicable to manufacturers, importers, and 
processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.11879  Hydrocarbons linear and branched, isomerization 
(generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as 
hydrocarbons linear and branched, isomerization (PMN P-21-113) is 
subject to reporting under this section for the significant new uses 
described in paragraph (a)(2) of this section. The requirements of this 
section do not apply to quantities of the substance after they have 
been incorporated into a fuel, fuel additive, fuel blending stock, or 
used as a refinery feedstock (including, but not limited to cracking, 
coking, hydroprocessing, distillation, or deasphalting).
    (2) The significant new uses are: (i) Protection in the workplace. 
Requirements as specified in Sec.  721.63(a)(1) and (3), (b) and (c). 
When determining which persons are reasonably likely to be exposed as 
required for Sec.  721.63(a)(1), engineering control measures (e.g., 
enclosure or confinement of the operation, general and local 
ventilation) or administrative control measures (e.g., workplace 
policies and procedures) shall be considered and implemented to prevent 
exposure, where feasible. For purposes of Sec.  721.63(b), the 
concentration is set at 0.1%.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a).
    (iii) Industrial, commercial, and consumer activities. It is a 
significant new use to manufacture, process, or use the substance other 
than for processing and use as a fuel, fuel additive, fuel blending 
stock, or refinery feedstock (including, but not limited to cracking, 
coking, hydroprocessing, distillation, or deasphalting) subject to 40 
CFR parts 79 or 1090.
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i), are applicable to manufacturers, importers, and 
processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.11880  Hydrocarbons linear and branched, heavy catalytic 
reformed (generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as 
hydrocarbons linear and branched, heavy catalytic reformed (PMN P-21-
114) is subject to reporting under this section for the significant new 
uses described in paragraph (a)(2) of this section. The requirements of 
this section do not apply to quantities of the substance after they 
have been incorporated into a fuel, fuel additive, fuel blending stock, 
or used as a refinery feedstock (including, but not limited to 
cracking, coking, hydroprocessing, distillation, or deasphalting).
    (2) The significant new uses are: (i) Protection in the workplace. 
Requirements as specified in Sec.  721.63(a)(1) and (3), (b) and (c). 
When determining which persons are reasonably likely to be exposed as 
required for Sec.  721.63(a)(1), engineering control measures (e.g., 
enclosure or confinement of the operation, general and local 
ventilation) or administrative control measures (e.g., workplace 
policies and procedures) shall be considered and implemented to prevent 
exposure, where feasible. For purposes of Sec.  721.63(b), the 
concentration is set at 0.1%.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a).
    (iii) Industrial, commercial, and consumer activities. It is a 
significant new use to manufacture, process, or use the substance other 
than for processing and use as a fuel, fuel additive, fuel blending 
stock, or refinery feedstock (including, but not limited to cracking, 
coking, hydroprocessing, distillation, or deasphalting) subject to 40 
CFR parts 79 or 1090.
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i), are applicable to manufacturers, importers, and 
processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.11881  Hydrocarbons linear and branched, hydrotreated light 
(generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as 
hydrocarbons linear and branched, hydrotreated light (PMN P-21-116) is 
subject to reporting under this section for the significant new uses 
described in paragraph (a)(2) of this section. The requirements of this 
section do not apply to quantities of the substance after they have 
been incorporated into a fuel, fuel additive, fuel blending stock, or 
used as a refinery feedstock (including, but not limited to cracking, 
coking, hydroprocessing, distillation, or deasphalting).
    (2) The significant new uses are: (i) Protection in the workplace. 
Requirements as specified in Sec.  721.63(a)(1) and (3), (b) and (c). 
When determining which persons are reasonably likely to be exposed as 
required for Sec.  721.63(a)(1), engineering control measures (e.g., 
enclosure or confinement of the operation, general and local 
ventilation) or administrative control measures (e.g., workplace 
policies and procedures) shall be considered and implemented to prevent 
exposure, where feasible. For purposes of Sec.  721.63(b), the 
concentration is set at 0.1%.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a).
    (iii) Industrial, commercial, and consumer activities. It is a 
significant new use to manufacture, process, or use the substance other 
than for processing and use as a fuel, fuel additive, fuel blending 
stock, or refinery feedstock (including, but not limited to cracking, 
coking, hydroprocessing, distillation, or deasphalting) subject to 40 
CFR parts 79 or 1090.
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i), are applicable to manufacturers, importers, and 
processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.11882  Hydrocarbons linear and branched, hydrotreated light 
paraffinic (generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as 
hydrocarbons linear and branched, hydrotreated light paraffinic

[[Page 49141]]

(PMN P-21-117) is subject to reporting under this section for the 
significant new uses described in paragraph (a)(2) of this section. The 
requirements of this section do not apply to quantities of the 
substance after they have been incorporated into a fuel, fuel additive, 
fuel blending stock, or used as a refinery feedstock (including, but 
not limited to cracking, coking, hydroprocessing, distillation, or 
deasphalting).
    (2) The significant new uses are: (i) Protection in the workplace. 
Requirements as specified in Sec.  721.63(a)(1) and (3), (b) and (c). 
When determining which persons are reasonably likely to be exposed as 
required for Sec.  721.63(a)(1), engineering control measures (e.g., 
enclosure or confinement of the operation, general and local 
ventilation) or administrative control measures (e.g., workplace 
policies and procedures) shall be considered and implemented to prevent 
exposure, where feasible. For purposes of Sec.  721.63(b), the 
concentration is set at 0.1%.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a).
    (iii) Industrial, commercial, and consumer activities. It is a 
significant new use to manufacture, process, or use the substance other 
than for processing and use as a fuel, fuel additive, fuel blending 
stock, or refinery feedstock (including, but not limited to cracking, 
coking, hydroprocessing, distillation, or deasphalting) subject to 40 
CFR parts 79 or 1090.
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i), are applicable to manufacturers, importers, and 
processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.11883  Hydrocarbons linear and branched, light catalytic 
cracked (generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance generically identified as 
hydrocarbons linear and branched, light catalytic cracked (PMN P-21-
118) is subject to reporting under this section for the significant new 
uses described in paragraph (a)(2) of this section. The requirements of 
this section do not apply to quantities of the substance after they 
have been incorporated into a fuel, fuel additive, fuel blending stock, 
or used as a refinery feedstock (including, but not limited to 
cracking, coking, hydroprocessing, distillation, or deasphalting).
    (2) The significant new uses are: (i) Protection in the workplace. 
Requirements as specified in Sec.  721.63(a)(1) and (3), (b) and (c). 
When determining which persons are reasonably likely to be exposed as 
required for Sec.  721.63(a)(1), engineering control measures (e.g., 
enclosure or confinement of the operation, general and local 
ventilation) or administrative control measures (e.g., workplace 
policies and procedures) shall be considered and implemented to prevent 
exposure, where feasible. For purposes of Sec.  721.63(b), the 
concentration is set at 0.1%.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a).
    (iii) Industrial, commercial, and consumer activities. It is a 
significant new use to manufacture, process, or use the substance other 
than for processing and use as a fuel, fuel additive, fuel blending 
stock, or refinery feedstock (including, but not limited to cracking, 
coking, hydroprocessing, distillation, or deasphalting) subject to 40 
CFR parts 79 or 1090.
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i), are applicable to manufacturers, importers, and 
processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.11884  Hydrocarbons linear and branched, heavy hydrocracked 
(generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as 
hydrocarbons linear and branched, heavy hydrocracked (PMN P-21-119) is 
subject to reporting under this section for the significant new uses 
described in paragraph (a)(2) of this section. The requirements of this 
section do not apply to quantities of the substance after they have 
been incorporated into a fuel, fuel additive, fuel blending stock, or 
used as a refinery feedstock (including, but not limited to cracking, 
coking, hydroprocessing, distillation, or deasphalting).
    (2) The significant new uses are: (i) Protection in the workplace. 
Requirements as specified in Sec.  721.63(a)(1) and (3), (b) and (c). 
When determining which persons are reasonably likely to be exposed as 
required for Sec.  721.63(a)(1), engineering control measures (e.g., 
enclosure or confinement of the operation, general and local 
ventilation) or administrative control measures (e.g., workplace 
policies and procedures) shall be considered and implemented to prevent 
exposure, where feasible. For purposes of Sec.  721.63(b), the 
concentration is set at 0.1%.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a).
    (iii) Industrial, commercial, and consumer activities. It is a 
significant new use to manufacture, process, or use the substance other 
than for processing and use as a fuel, fuel additive, fuel blending 
stock, or refinery feedstock (including, but not limited to cracking, 
coking, hydroprocessing, distillation, or deasphalting) subject to 40 
CFR parts 79 or 1090.
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i), are applicable to manufacturers, importers, and 
processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.11885  Hydrocarbons linear and branched, heavy catalytic 
cracked (generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as 
hydrocarbons linear and branched, heavy catalytic cracked (PMN P-21-
121) is subject to reporting under this section for the significant new 
uses described in paragraph (a)(2) of this section. The requirements of 
this section do not apply to quantities of the substance after they 
have been incorporated into a fuel, fuel additive, fuel blending stock, 
or used as a refinery feedstock (including, but not limited to 
cracking, coking, hydroprocessing, distillation, or deasphalting).
    (2) The significant new uses are: (i) Protection in the workplace. 
Requirements as specified in Sec.  721.63(a)(1) and (3), (b) and (c). 
When determining which persons are reasonably likely to be exposed as 
required for Sec.  721.63(a)(1), engineering control measures (e.g., 
enclosure or confinement of the operation, general and local 
ventilation) or administrative control measures (e.g., workplace 
policies and procedures) shall be considered and implemented to prevent

[[Page 49142]]

exposure, where feasible. For purposes of Sec.  721.63(b), the 
concentration is set at 0.1%.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a).
    (iii) Industrial, commercial, and consumer activities. It is a 
significant new use to manufacture, process, or use the substance other 
than for processing and use as a fuel, fuel additive, fuel blending 
stock, or refinery feedstock (including, but not limited to cracking, 
coking, hydroprocessing, distillation, or deasphalting) subject to 40 
CFR parts 79 or 1090.
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i), are applicable to manufacturers, importers, and 
processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.11886  Hydrocarbons linear and branched, heavy hydrocracked 
(generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as 
hydrocarbons linear and branched, heavy hydrocracked (PMN P-21-122) is 
subject to reporting under this section for the significant new uses 
described in paragraph (a)(2) of this section. The requirements of this 
section do not apply to quantities of the substance after they have 
been incorporated into a fuel, fuel additive, fuel blending stock, or 
used as a refinery feedstock (including, but not limited to cracking, 
coking, hydroprocessing, distillation, or deasphalting).
    (2) The significant new uses are: (i) Protection in the workplace. 
Requirements as specified in Sec.  721.63(a)(1) and (3), (b) and (c). 
When determining which persons are reasonably likely to be exposed as 
required for Sec.  721.63(a)(1), engineering control measures (e.g., 
enclosure or confinement of the operation, general and local 
ventilation) or administrative control measures (e.g., workplace 
policies and procedures) shall be considered and implemented to prevent 
exposure, where feasible. For purposes of Sec.  721.63(b), the 
concentration is set at 0.1%.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a).
    (iii) Industrial, commercial, and consumer activities. It is a 
significant new use to manufacture, process, or use the substance other 
than for processing and use as a fuel, fuel additive, fuel blending 
stock, or refinery feedstock (including, but not limited to cracking, 
coking, hydroprocessing, distillation, or deasphalting) subject to 40 
CFR parts 79 or 1090.
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i), are applicable to manufacturers, importers, and 
processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.11887  Hydrocarbons linear and branched, light hydrocracked 
(generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as 
hydrocarbons linear and branched, light hydrocracked (PMN P-21-123) is 
subject to reporting under this section for the significant new uses 
described in paragraph (a)(2) of this section. The requirements of this 
section do not apply to quantities of the substance after they have 
been incorporated into a fuel, fuel additive, fuel blending stock, or 
used as a refinery feedstock (including, but not limited to cracking, 
coking, hydroprocessing, distillation, or deasphalting).
    (2) The significant new uses are: (i) Protection in the workplace. 
Requirements as specified in Sec.  721.63(a)(1) and (3), (b) and (c). 
When determining which persons are reasonably likely to be exposed as 
required for Sec.  721.63(a)(1), engineering control measures (e.g., 
enclosure or confinement of the operation, general and local 
ventilation) or administrative control measures (e.g., workplace 
policies and procedures) shall be considered and implemented to prevent 
exposure, where feasible. For purposes of Sec.  721.63(b), the 
concentration is set at 0.1%.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a).
    (iii) Industrial, commercial, and consumer activities. It is a 
significant new use to manufacture, process, or use the substance other 
than for processing and use as a fuel, fuel additive, fuel blending 
stock, or refinery feedstock (including, but not limited to cracking, 
coking, hydroprocessing, distillation, or deasphalting) subject to 40 
CFR parts 79 or 1090.
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i), are applicable to manufacturers, importers, and 
processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.11888  Imidazole-carboxylic acid, substituted (generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as 
imidazole-carboxylic acid, substituted (P-21-197) is subject to 
reporting under this section for the significant new uses described in 
paragraph (a)(2) of this section. The requirements of this section do 
not apply to quantities of the substance after they have been 
incorporated into an article.
    (2) The significant new uses are: (i) Protection in the workplace. 
Requirements as specified in Sec.  721.63(a)(1) and (3) through (5), 
and (c). When determining which persons are reasonably likely to be 
exposed as required for Sec.  721.63(a)(1) and (4), engineering control 
measures (e.g., enclosure or confinement of the operation, general and 
local ventilation) or administrative control measures (e.g., workplace 
policies and procedures) shall be considered and implemented to prevent 
exposure, where feasible. For purposes of Sec.  721.63(a)(5), 
respirators must provide a National Institute for Occupational Safety 
and Health (NIOSH) assigned protection factor (APF) of at least 50.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), and (g)(1), (3) and (5). For purposes of 
Sec.  721.72(g)(1), this substance may cause: acute toxicity; skin 
corrosion; eye irritation; serious eye damage; skin sensitization; 
reproductive toxicity; specific target organ toxicity. For purposes of 
Sec.  721.72(g)(3) this substance may be: toxic to aquatic life. 
Alternative hazard and warning statements that meet the criteria of the 
Globally Harmonized System and OSHA Hazard Communication Standard may 
be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(f). It is a significant new use to process 
or use the substance other than in an enclosed process, except that 
sampling and equipment

[[Page 49143]]

cleaning operations need not occur in an enclosed process.
    (iv) Disposal. It is a significant new use to dispose of the 
substance or waste streams containing the substance other than by 
incineration with 99.9% efficiency.
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (j) are applicable to manufacturers, importers, and 
processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.11889  Multi-walled carbon nanotubes (generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as multi-
walled carbon nanotubes (PMN P-21-216) is subject to reporting under 
this section for the significant new uses described in paragraph (a)(2) 
of this section. The requirements of this section do not apply to 
quantities of the substance after they have been completely reacted 
(cured), entrained in a polymer, or incorporated into an article.
    (2) The significant new uses are: (i) Protection in the workplace. 
Requirements as specified in Sec.  721.63(a)(1), (3) through (5), and 
(c). When determining which persons are reasonably likely to be exposed 
as required for Sec.  721.63(a)(1) and (4), engineering control 
measures (e.g., enclosure or confinement of the operation, general and 
local ventilation) or administrative control measures (e.g., workplace 
policies and procedures) shall be considered and implemented to prevent 
exposure, where feasible. For purposes of Sec.  721.63(a)(5), 
respirators must provide a National Institute for Occupational Safety 
and Health (NIOSH) assigned protection factor (APF) of at least 1,000 
if the capture and reduction rate is at least 99.5% but not 99.975% or 
greater, or at least 50 if the capture and reduction rate is at least 
99.975%.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), and (g)(1), (3) and (5). For purposes of 
Sec.  721.72(g)(1), this substance may cause: eye irritation; skin 
irritation; respiratory sensitization; skin sensitization; genetic 
toxicity; reproductive toxicity; carcinogenicity; specific target organ 
toxicity. For purposes of Sec.  721.72(g)(3), this substance may be: 
toxic to aquatic life. Alternative hazard and warning statements that 
meet the criteria of the Globally Harmonized System and OSHA Hazard 
Communication Standard may be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(f). It is a significant new use to 
manufacture the substance to contain the confidential impurity listed 
in the Order at greater than 1% (by weight). It is a significant new 
use to process or use the substance other than for the confidential use 
allowed in the Order. It is a significant new use to process or use the 
substance other than in application methods that do not generate a 
vapor, mist, dust, or aerosol, unless such application method occurs in 
an enclosed process.
    (iv) Disposal. Requirements as specified in Sec.  721.85 (a)(1) and 
(2), (b)(1) and (2), and (c)(1) and (2). It is a significant new use to 
release the substance directly, whether by point (stack) or non-point 
(fugitive) sources, to air.
    (v) Release to water. Requirements as specified in Sec.  
721.90(a)(1), (b)(1), and (c)(1).
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (k) are applicable to manufacturers, importers, and 
processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.11890  Multi-walled carbon nanotubes (generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as multi-
walled carbon nanotubes (PMN P-21-217) is subject to reporting under 
this section for the significant new uses described in paragraph (a)(2) 
of this section. The requirements of this section do not apply to 
quantities of the substance after they have been completely reacted 
(cured), entrained in a polymer, or incorporated into an article.
    (2) The significant new uses are:
    (i) Protection in the workplace. Requirements as specified in Sec.  
721.63(a)(1), (3) through (5), and (c). When determining which persons 
are reasonably likely to be exposed as required for Sec.  721.63(a)(1) 
and (4), engineering control measures (e.g., enclosure or confinement 
of the operation, general and local ventilation) or administrative 
control measures (e.g., workplace policies and procedures) shall be 
considered and implemented to prevent exposure, where feasible. For 
purposes of Sec.  721.63(a)(5), respirators must provide a National 
Institute for Occupational Safety and Health (NIOSH) assigned 
protection factor (APF) of at least 1,000 if the capture and reduction 
rate is at least 99.5% but not 99.975% or greater or of at least 50 if 
the capture and reduction rate is at least 99.975%.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), and (g)(1), (3) and (5). For purposes of 
Sec.  721.72(g)(1), this substance may cause: eye irritation; skin 
irritation; respiratory sensitization; skin sensitization; genetic 
toxicity; reproductive toxicity; carcinogenicity; specific target organ 
toxicity. For purposes of Sec.  721.72(g)(3), this substance may be: 
toxic to aquatic life. Alternative hazard and warning statements that 
meet the criteria of the Globally Harmonized System and OSHA Hazard 
Communication Standard may be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(f). It is a significant new use to 
manufacture the substance to contain the confidential impurity listed 
in the Order at greater than 1% (by weight). It is a significant new 
use to process or use the substance other than for the confidential use 
allowed in the Order. It is a significant new use to process or use the 
substance other than in application methods that do not generate a 
vapor, mist, dust, or aerosol, unless such application method occurs in 
an enclosed process.
    (iv) Disposal. Requirements as specified in Sec.  721.85 (a)(1) and 
(2), (b)(1) and (2), and (c)(1) and (2). It is a significant new use to 
release the substance directly, either by point (stack) or non-point 
(fugitive) sources, to air.

[[Page 49144]]

    (v) Release to water. Requirements as specified in Sec.  
721.90(a)(1), (b)(1), and (c)(1).
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (k) are applicable to manufacturers, importers, and 
processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.
* * * * *
[FR Doc. 2024-12764 Filed 6-10-24; 8:45 am]
BILLING CODE 6560-50-P