Center for Scientific Review; Notice of Closed Meetings, 5246-5247 [2024-01574]

Download as PDF 5246 Federal Register / Vol. 89, No. 18 / Friday, January 26, 2024 / Notices Dated: January 23, 2024. Lauren K. Roth, Associate Commissioner for Policy. [FR Doc. 2024–01589 Filed 1–25–24; 8:45 am] BILLING CODE 4164–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES Meetings of the Presidential Advisory Council on Combating AntibioticResistant Bacteria Department of Health and Human Services, Office of the Secretary, Office of the Assistant Secretary for Health. ACTION: Notice. AGENCY: As stipulated by the Federal Advisory Committee Act, the Department of Health and Human Services (HHS) is hereby giving notice that a meeting is scheduled to be held for the Presidential Advisory Council on Combating Antibiotic-Resistant Bacteria (PACCARB). The meeting will be streamed live on hhs.gov/live. A preregistered public comment session will be held during the virtual meeting. Preregistration is required for members of the public who wish to present their comments live during the meeting. Individuals who wish to send in their written public comment should send an email to CARB@hhs.gov. Registration information is available on the website https://www.hhs.gov/paccarb and must be completed by February 15, 2024, for the February 22, 2024, Public Meeting. Additional information about registering for the meeting and providing public comment can be obtained at https:// www.hhs.gov/paccarb on the Upcoming Meetings page. DATES: The meeting is scheduled to be held on February 22, 2024, from 9 a.m. to 4 p.m. ET (times are tentative and subject to change). The confirmed times and agenda items for the meeting will be posted on the website for the PACCARB at https://www.hhs.gov/paccarb when this information becomes available. Preregistration for attending the meeting is strongly suggested and should be completed no later than February 15, 2024. SUMMARY: The virtual meeting can be accessed through a live webcast on the day of the meeting. Additional instructions regarding attending this meeting virtually will be posted at least one week prior to the meeting at: https:// www.hhs.gov/paccarb. FOR FURTHER INFORMATION CONTACT: Jomana Musmar, M.S., Ph.D., Designated Federal Officer, Presidential lotter on DSK11XQN23PROD with NOTICES1 ADDRESSES: VerDate Sep<11>2014 18:02 Jan 25, 2024 Jkt 262001 Advisory Council on Combating Antibiotic-Resistant Bacteria, Office of the Assistant Secretary for Health, U.S. Department of Health and Human Services, 1101 Wootton Parkway, Rockville, MD 20852. Phone: 202–746– 1512; Email: CARB@hhs.gov. SUPPLEMENTARY INFORMATION: The Presidential Advisory Council on Combating Antibiotic-Resistant Bacteria (PACCARB), established by Executive Order 13676, is continued by section 505 of Public Law 116–22, the Pandemic and All-Hazards Preparedness and Advancing Innovation Act of 2019 (PAHPAIA). Activities and duties of the PACCARB are governed by the provisions of the Federal Advisory Committee Act (FACA), Public Law 92– 463, as amended (5 U.S.C. app.), which sets forth standards for the formation and use of Federal advisory committees. The PACCARB shall advise and provide information and recommendations to the Secretary of Health and Human Services (Secretary) regarding programs and policies intended to reduce or combat antibioticresistant bacteria that may present a public health threat and improve capabilities to prevent, diagnose, mitigate, or treat such resistance. The PACCARB shall function solely for advisory purposes. Such advice, information, and recommendations may be related to improving: the effectiveness of antibiotics; research and advanced research on, and the development of, improved and innovative methods for combating or reducing antibiotic resistance, including new treatments, rapid point-of-care diagnostics, alternatives to antibiotics, including alternatives to animal antibiotics, and antimicrobial stewardship activities; surveillance of antibiotic-resistant bacterial infections, including publicly available and up-to-date information on resistance to antibiotics; education for health care providers and the public with respect to up-to-date information on antibiotic resistance and ways to reduce or combat such resistance to antibiotics related to humans and animals; methods to prevent or reduce the transmission of antibiotic-resistant bacterial infections; including stewardship programs; and coordination with respect to international efforts in order to inform and advance the United States capabilities to combat antibiotic resistance. The February 22, 2024, meeting will serve as a critical platform for key international stakeholders, and nongovernment organizations, to share their latest strategies and progress in tackling PO 00000 Frm 00047 Fmt 4703 Sfmt 4703 the global threat of antimicrobial resistance. The focus will be on both showcasing successful international and regional initiatives and identifying areas for enhanced collaboration and knowledge exchange. The meeting agenda will be posted on the PACCARB website at https://www.hhs.gov/paccarb when it has been finalized. All agenda items are tentative and subject to change. Instructions regarding attending the meeting virtually will be posted at least one week prior to the meeting at: https://www.hhs.gov/paccarb. Members of the public will have the opportunity to provide comments virtually during the February meeting by pre-registering online at https:// www.hhs.gov/paccarb; pre-registration is required for participation in this session with limited spots available. Written public comments can also be emailed to CARB@hhs.gov by midnight February 15, 2024, and should be limited to no more than one page. All public comments received prior to February 15, 2024, will be provided to the PACCARB members. Dated: January 10, 2024. Jomana F. Musmar, Designated Federal Officer, Presidential Advisory Council on Combating AntibioticResistant Bacteria, Office of the Assistant Secretary for Health. [FR Doc. 2024–01545 Filed 1–25–24; 8:45 am] BILLING CODE 4150–44–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review; Notice of Closed Meetings Pursuant to section 1009 of the Federal Advisory Committee Act, as amended, notice is hereby given of the following meetings. The meetings will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: Center for Scientific Review Special Emphasis Panel; Member Conflict: Biological Chemistry and Macromolecular Biophysics. Date: February 21, 2024. Time: 10:00 a.m. to 6:00 p.m. E:\FR\FM\26JAN1.SGM 26JAN1 lotter on DSK11XQN23PROD with NOTICES1 Federal Register / Vol. 89, No. 18 / Friday, January 26, 2024 / Notices Agenda: To review and evaluate grant applications. Place: National Institutes of Health, Rockledge II, 6701 Rockledge Drive, Bethesda, MD 20892 (Virtual Meeting). Contact Person: Vandana Kumari, Ph.D., Scientific Review Officer, Center for Scientific Review, 6701 Rockledge Drive, Bethesda, MD 20892, (301) 496–3290, vandana.kumari@nih.gov. Name of Committee: Center for Scientific Review Special Emphasis Panel; Collaborative R01—Clinical Studies of Mental Illness. Date: February 21, 2024. Time: 11:00 a.m. to 8:00 p.m. Agenda: To review and evaluate grant applications. Place: Embassy Suites at the Chevy Chase Pavilion, 4300 Military Road, NW Washington, DC 20015. Contact Person: Allison Kurti, Ph.D., Scientific Review Officer, Center for Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Room 1007J, Bethesda, MD 20892, (301) 594–1814, kurtian@csr.nih.gov. Name of Committee: Oncology 2— Translational Clinical Integrated Review Group; Cancer Prevention Study Section. Date: February 22–23, 2024. Time: 8:00 a.m. to 7:00 p.m. Agenda: To review and evaluate grant applications. Place: Canopy by Hilton, 940 Rose Avenue, North Bethesda, MD 20852. Contact Person: Byung Min Chung, Ph.D., Scientific Review Officer, Center for Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892, (301) 496–4056, justin.chung@ nih.gov. Name of Committee: Biology of Development and Aging Integrated Review Group; Advancing Therapeutics A Study Section. Date: February 22–23, 2024. Time: 8:00 a.m. to 8:00 p.m. Agenda: To review and evaluate grant applications. Place: The Watergate, 2650 Virginia Avenue NW, Washington, DC 20037, Contact Person: Maureen Shuh, Ph.D., Scientific Review Officer, Center for Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892, (301) 480–4097, maureen.shuh@ nih.gov. Name of Committee: Brain Disorders and Clinical Neuroscience Integrated Review Group; Clinical Neuroimmunology and Brain Tumors Study Section Date: February 22–23, 2024. Time: 8:00 a.m. to 8:00 p.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892 (Virtual Meeting). Contact Person: Aleksey G Kazantsev, Ph.D., Scientific Review Officer, Center for Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Room 5201, Bethesda, MD 20817, 301–435–1042, aleksey.kazantsev@nih.gov. VerDate Sep<11>2014 18:02 Jan 25, 2024 Jkt 262001 Name of Committee: Biological Chemistry and Macromolecular Biophysics Integrated Review Group; Macromolecular Structure and Function B Study Section. Date: February 22–23, 2024. Time: 8:30 a.m. to 5:00 p.m. Agenda: To review and evaluate grant applications. Place: Hyatt Regency, Bethesda One, Bethesda Metro Center, Bethesda, MD 20814. Contact Person: Alexei A Yeliseev, Ph.D., Scientific Review Officer, Center for Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892, (301) 443–0552, yeliseeva@ mail.nih.gov. Name of Committee: Biobehavioral and Behavioral Processes Integrated Review Group; Adult Psychopathology and Disorders of Aging Study Section. Date: February 22–23, 2024. Time: 9:00 a.m. to 8:00 p.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health, Rockledge II, 6701 Rockledge Drive, Bethesda, MD 20892 (Virtual Meeting). Contact Person: Benjamin G Shapero, Ph.D., Scientific Review Officer, Center for Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Room 3182, MSC 7848, Bethesda, MD 20892, (301) 402– 4786, shaperobg@mail.nih.gov. Name of Committee: Vascular and Hematology Integrated Review Group; Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section. Date: February 22–23, 2024. Time: 9:00 a.m. to 9:00 p.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health, Rockledge II, 6701 Rockledge Drive, Bethesda, MD 20892 (Virtual Meeting). Contact Person: Vivian Tang, Ph.D., Scientific Review Officer, Center for Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892, (301) 594–6208 tangvw@csr.nih.gov. Name of Committee: Infectious Diseases and Immunology B Integrated Review Group; Hypersensitivity, Autoimmune, and Immunemediated Diseases Study Section Date: February 22–23, 2024. Time: 9:00 a.m. to 8:00 p.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health, Rockledge II, 6701 Rockledge Drive, Bethesda, MD 20892 (Virtual Meeting). Contact Person: Xinrui Li, Ph.D., Scientific Review Officer, Center for Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892, (301) 594–2084, xinrui.li@nih.gov. Name of Committee: Genes, Genomes, and Genetics Integrated Review Group; Molecular Genetics Study Section. Date: February 22–23, 2024. Time: 9:00 a.m. to 8:00 p.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health, Rockledge II, 6701 Rockledge Drive, Bethesda, MD 20892 (Virtual Meeting). PO 00000 Frm 00048 Fmt 4703 Sfmt 9990 5247 Contact Person: Altaf Ahmad Dar, Ph.D., Scientific Review Officer, Center for Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892, (301) 827–2680, altaf.dar@nih.gov. Name of Committee: Risk, Prevention and Health Behavior Integrated Review Group; Social Psychology, Personality and Interpersonal Processes Study Section Date: February 22–23, 2024. Time: 9:30 a.m. to 8:00 p.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health, Rockledge II, 6701 Rockledge Drive, Bethesda, MD 20892 (Virtual Meeting). Contact Person: Shahrzad Mavandadi, Ph.D., Scientific Review Officer, Center for Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892, (301) 496–4792, shahrzad.mavandadi@nih.gov. Name of Committee: Infectious Diseases and Immunology B Integrated Review Group; Immunity and Host Defense Study Section. Date: February 22–23, 2024. Time: 9:30 a.m. to 7:00 p.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health, Rockledge II, 6701 Rockledge Drive, Bethesda, MD 20892 (Virtual Meeting). Contact Person: Alok Mulky, Ph.D., Scientific Review Officer, Center for Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Room 4203, Bethesda, MD 20892, (301) 435–3566, mulkya@mail.nih.gov. Name of Committee: Center for Scientific Review Special Emphasis Panel; Collaborative Applications: Clinical Studies of Mental Illness. Date: February 22, 2024. Time: 3:00 p.m. to 8:00 p.m. Agenda: To review and evaluate grant applications.. Place: National Institutes of Health, Rockledge II, 6701 Rockledge Drive, Bethesda, MD 20892 (Virtual Meeting). Contact Person: Benjamin G Shapero, Ph.D., Scientific Review Officer, Center for Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Room 3182, MSC 7848, Bethesda, MD 20892, (301) 402– 4786, shaperobg@mail.nih.gov. Catalogue of Federal Domestic Assistance Program Nos. 93.306, Comparative Medicine; 93.333, Clinical Research, 93.306, 93.333, 93.337, 93.393–93.396, 93.837–93.844, 93.846–93.878, 93.892, 93.893, National Institutes of Health, HHS) Dated: January 23, 2024. Lauren A. Fleck, Program Analyst, Office of Federal Advisory Committee Policy. [FR Doc. 2024–01574 Filed 1–25–24; 8:45 am] BILLING CODE 4140–01–P E:\FR\FM\26JAN1.SGM 26JAN1

Agencies

[Federal Register Volume 89, Number 18 (Friday, January 26, 2024)]
[Notices]
[Pages 5246-5247]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2024-01574]


-----------------------------------------------------------------------

DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Center for Scientific Review; Notice of Closed Meetings

    Pursuant to section 1009 of the Federal Advisory Committee Act, as 
amended, notice is hereby given of the following meetings.
    The meetings will be closed to the public in accordance with the 
provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 
U.S.C., as amended. The grant applications and the discussions could 
disclose confidential trade secrets or commercial property such as 
patentable material, and personal information concerning individuals 
associated with the grant applications, the disclosure of which would 
constitute a clearly unwarranted invasion of personal privacy.

    Name of Committee: Center for Scientific Review Special Emphasis 
Panel; Member Conflict: Biological Chemistry and Macromolecular 
Biophysics.
    Date: February 21, 2024.
    Time: 10:00 a.m. to 6:00 p.m.

[[Page 5247]]

    Agenda: To review and evaluate grant applications.
    Place: National Institutes of Health, Rockledge II, 6701 
Rockledge Drive, Bethesda, MD 20892 (Virtual Meeting).
    Contact Person: Vandana Kumari, Ph.D., Scientific Review 
Officer, Center for Scientific Review, 6701 Rockledge Drive, 
Bethesda, MD 20892, (301) 496-3290, [email protected].

    Name of Committee: Center for Scientific Review Special Emphasis 
Panel; Collaborative R01--Clinical Studies of Mental Illness.
    Date: February 21, 2024.
    Time: 11:00 a.m. to 8:00 p.m.
    Agenda: To review and evaluate grant applications.
    Place: Embassy Suites at the Chevy Chase Pavilion, 4300 Military 
Road, NW Washington, DC 20015.
    Contact Person: Allison Kurti, Ph.D., Scientific Review Officer, 
Center for Scientific Review, National Institutes of Health, 6701 
Rockledge Drive, Room 1007J, Bethesda, MD 20892, (301) 594-1814, 
[email protected].

    Name of Committee: Oncology 2--Translational Clinical Integrated 
Review Group; Cancer Prevention Study Section.
    Date: February 22-23, 2024.
    Time: 8:00 a.m. to 7:00 p.m.
    Agenda: To review and evaluate grant applications.
    Place: Canopy by Hilton, 940 Rose Avenue, North Bethesda, MD 
20852.
    Contact Person: Byung Min Chung, Ph.D., Scientific Review 
Officer, Center for Scientific Review, National Institutes of 
Health, 6701 Rockledge Drive, Bethesda, MD 20892, (301) 496-4056, 
[email protected].

    Name of Committee: Biology of Development and Aging Integrated 
Review Group; Advancing Therapeutics A Study Section.
    Date: February 22-23, 2024.
    Time: 8:00 a.m. to 8:00 p.m.
    Agenda: To review and evaluate grant applications.
    Place: The Watergate, 2650 Virginia Avenue NW, Washington, DC 
20037,
    Contact Person: Maureen Shuh, Ph.D., Scientific Review Officer, 
Center for Scientific Review, National Institutes of Health, 6701 
Rockledge Drive, Bethesda, MD 20892, (301) 480-4097, 
[email protected].

    Name of Committee: Brain Disorders and Clinical Neuroscience 
Integrated Review Group; Clinical Neuroimmunology and Brain Tumors 
Study Section
    Date: February 22-23, 2024.
    Time: 8:00 a.m. to 8:00 p.m.
    Agenda: To review and evaluate grant applications.
    Place: National Institutes of Health, 6701 Rockledge Drive, 
Bethesda, MD 20892 (Virtual Meeting).
    Contact Person: Aleksey G Kazantsev, Ph.D., Scientific Review 
Officer, Center for Scientific Review, National Institutes of 
Health, 6701 Rockledge Drive, Room 5201, Bethesda, MD 20817, 301-
435-1042, [email protected].

    Name of Committee: Biological Chemistry and Macromolecular 
Biophysics Integrated Review Group; Macromolecular Structure and 
Function B Study Section.
    Date: February 22-23, 2024.
    Time: 8:30 a.m. to 5:00 p.m.
    Agenda: To review and evaluate grant applications.
    Place: Hyatt Regency, Bethesda One, Bethesda Metro Center, 
Bethesda, MD 20814.
    Contact Person: Alexei A Yeliseev, Ph.D., Scientific Review 
Officer, Center for Scientific Review, National Institutes of 
Health, 6701 Rockledge Drive, Bethesda, MD 20892, (301) 443-0552, 
[email protected].

    Name of Committee: Biobehavioral and Behavioral Processes 
Integrated Review Group; Adult Psychopathology and Disorders of 
Aging Study Section.
    Date: February 22-23, 2024.
    Time: 9:00 a.m. to 8:00 p.m.
    Agenda: To review and evaluate grant applications.
    Place: National Institutes of Health, Rockledge II, 6701 
Rockledge Drive, Bethesda, MD 20892 (Virtual Meeting).
    Contact Person: Benjamin G Shapero, Ph.D., Scientific Review 
Officer, Center for Scientific Review, National Institutes of 
Health, 6701 Rockledge Drive, Room 3182, MSC 7848, Bethesda, MD 
20892, (301) 402-4786, [email protected].

    Name of Committee: Vascular and Hematology Integrated Review 
Group; Hemostasis, Thrombosis, Blood Cells and Transfusion Study 
Section.
    Date: February 22-23, 2024.
    Time: 9:00 a.m. to 9:00 p.m.
    Agenda: To review and evaluate grant applications.
    Place: National Institutes of Health, Rockledge II, 6701 
Rockledge Drive, Bethesda, MD 20892 (Virtual Meeting).
    Contact Person: Vivian Tang, Ph.D., Scientific Review Officer, 
Center for Scientific Review, National Institutes of Health, 6701 
Rockledge Drive, Bethesda, MD 20892, (301) 594-6208 
[email protected].

    Name of Committee: Infectious Diseases and Immunology B 
Integrated Review Group; Hypersensitivity, Autoimmune, and Immune-
mediated Diseases Study Section
    Date: February 22-23, 2024.
    Time: 9:00 a.m. to 8:00 p.m.
    Agenda: To review and evaluate grant applications.
    Place: National Institutes of Health, Rockledge II, 6701 
Rockledge Drive, Bethesda, MD 20892 (Virtual Meeting).
    Contact Person: Xinrui Li, Ph.D., Scientific Review Officer, 
Center for Scientific Review, National Institutes of Health, 6701 
Rockledge Drive, Bethesda, MD 20892, (301) 594-2084, 
[email protected].

    Name of Committee: Genes, Genomes, and Genetics Integrated 
Review Group; Molecular Genetics Study Section.
    Date: February 22-23, 2024.
    Time: 9:00 a.m. to 8:00 p.m.
    Agenda: To review and evaluate grant applications.
    Place: National Institutes of Health, Rockledge II, 6701 
Rockledge Drive, Bethesda, MD 20892 (Virtual Meeting).
    Contact Person: Altaf Ahmad Dar, Ph.D., Scientific Review 
Officer, Center for Scientific Review, National Institutes of 
Health, 6701 Rockledge Drive, Bethesda, MD 20892, (301) 827-2680, 
[email protected].

    Name of Committee: Risk, Prevention and Health Behavior 
Integrated Review Group; Social Psychology, Personality and 
Interpersonal Processes Study Section
    Date: February 22-23, 2024.
    Time: 9:30 a.m. to 8:00 p.m.
    Agenda: To review and evaluate grant applications.
    Place: National Institutes of Health, Rockledge II, 6701 
Rockledge Drive, Bethesda, MD 20892 (Virtual Meeting).
    Contact Person: Shahrzad Mavandadi, Ph.D., Scientific Review 
Officer, Center for Scientific Review, National Institutes of 
Health, 6701 Rockledge Drive, Bethesda, MD 20892, (301) 496-4792, 
[email protected].

    Name of Committee: Infectious Diseases and Immunology B 
Integrated Review Group; Immunity and Host Defense Study Section.
    Date: February 22-23, 2024.
    Time: 9:30 a.m. to 7:00 p.m.
    Agenda: To review and evaluate grant applications.
    Place: National Institutes of Health, Rockledge II, 6701 
Rockledge Drive, Bethesda, MD 20892 (Virtual Meeting).
    Contact Person: Alok Mulky, Ph.D., Scientific Review Officer, 
Center for Scientific Review, National Institutes of Health, 6701 
Rockledge Drive, Room 4203, Bethesda, MD 20892, (301) 435-3566, 
[email protected].

    Name of Committee: Center for Scientific Review Special Emphasis 
Panel; Collaborative Applications: Clinical Studies of Mental 
Illness.
    Date: February 22, 2024.
    Time: 3:00 p.m. to 8:00 p.m.
    Agenda: To review and evaluate grant applications..
    Place: National Institutes of Health, Rockledge II, 6701 
Rockledge Drive, Bethesda, MD 20892 (Virtual Meeting).
    Contact Person: Benjamin G Shapero, Ph.D., Scientific Review 
Officer, Center for Scientific Review, National Institutes of 
Health, 6701 Rockledge Drive, Room 3182, MSC 7848, Bethesda, MD 
20892, (301) 402-4786, [email protected].

Catalogue of Federal Domestic Assistance Program Nos. 93.306, 
Comparative Medicine; 93.333, Clinical Research, 93.306, 93.333, 
93.337, 93.393-93.396, 93.837-93.844, 93.846-93.878, 93.892, 93.893, 
National Institutes of Health, HHS)

    Dated: January 23, 2024.
Lauren A. Fleck,
Program Analyst, Office of Federal Advisory Committee Policy.
[FR Doc. 2024-01574 Filed 1-25-24; 8:45 am]
BILLING CODE 4140-01-P


This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.