National Center for Advancing Translational Sciences; Notice of Closed Meeting, 58590 [2023-18490]
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58590
Federal Register / Vol. 88, No. 165 / Monday, August 28, 2023 / Notices
must provide for an annual External
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is conducted by an independent
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(EQRO). States must provide the EQRO
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Number: CMS–R–305 (OMB control
number: 0938–0786); Frequency:
Annually and one-time; Affected Public:
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governments; Number of Respondents:
698; Number of Responses: 10,249;
Total Annual Hours: 483,784. (For
policy questions regarding this
collection contact Carlye Burd at 720–
853–2780.)
Dated: August 23, 2023.
William N. Parham, III,
Director, Paperwork Reduction Staff, Office
of Strategic Operations and Regulatory
Affairs.
Name of Committee: National Center for
Advancing Translational Sciences Special
Emphasis Panel; NCATS SBIR Basket
Clinical Trials.
Date: September 21, 2023.
Time: 11:30 a.m. to 3:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health,
National Center for Advancing Translational
Sciences, 6701 Democracy Boulevard,
Bethesda, MD 20892 (Virtual Meeting).
Contact Person: Nakia C Brown, Ph.D.,
Scientific Review Officer, Office of Grants
Management and Scientific Review, National
Center for Advancing Translational Sciences,
National Institutes of Health, 6701
Democracy Boulevard, Room 1037, Bethesda,
MD 20892, (301) 827–3484, brownnac@
mail.nih.gov.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.859, Pharmacology,
Physiology, and Biological Chemistry
Research; 93.350, B—Cooperative
Agreements; 93.859, Biomedical Research
and Research Training, National Institutes of
Health, HHS)
Dated: August 23, 2023.
Melanie J. Pantoja,
Program Analyst, Office of Federal Advisory
Committee Policy.
[FR Doc. 2023–18490 Filed 8–25–23; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
Government-Owned Inventions;
Availability for Licensing
[FR Doc. 2023–18520 Filed 8–25–23; 8:45 am]
BILLING CODE 4120–01–P
AGENCY:
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
ACTION:
National Institutes of Health
SUMMARY:
National Center for Advancing
Translational Sciences; Notice of
Closed Meeting
lotter on DSK11XQN23PROD with NOTICES1
National Institutes of Health,
HHS.
Pursuant to section 1009 of the
Federal Advisory Committee Act, as
amended, notice is hereby given of the
following meeting.
The meeting will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
VerDate Sep<11>2014
15:55 Aug 25, 2023
Jkt 259001
Notice.
The invention listed below is
owned by an agency of the U.S.
Government and is available for
licensing to achieve expeditious
commercialization of results of
federally-funded research and
development.
FOR FURTHER INFORMATION CONTACT:
Licensing information may be obtained
by communicating with Vidita
Choudhry, Ph.D., Office of Technology
Transfer and Development, National
Heart, Lung, and Blood Institute, 31
Center Drive Room 4A29, MSC2479,
Bethesda, MD 20892–2479; telephone:
301–594–4095; email: vidita.choudhry@
nih.gov. A signed Confidential
Disclosure Agreement may be required
to receive any unpublished information.
SUPPLEMENTARY INFORMATION:
Technology description follows.
PO 00000
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Apparatus for Cryogenic-Electron
Microscopy Sample Preparation
Cryo-Electron Microscopy (cryo-EM)
is used to obtain high-resolution
structural images of macromolecular
structures. Samples must be purified
and loaded onto cryo-EM grids before
imaging. The ideal cryo-EM grid
consists of particles that are evenly and
richly distributed in a broad distribution
of orientations throughout the holes of
the support film. Current techniques to
prepare cryo-EM grids are performed
manually and require trial and error,
resulting in a bottleneck in cryo-EM
workflows.
Researchers have developed a device
and method for time-resolved
preparation of liquid samples for cryoEM experiments. In particular, the
mixing and dispensation of liquid
samples is achieved by electrical signals
that are transduced into specific
acoustic frequencies to mix the liquid
samples (low frequency) and then
dispense the mixture (high frequency)
in small, nanoliter volumes onto a cryoEM grid. This novel apparatus and
method provides more precise control
over liquid sample mixing and
dispensing, and improved dispensation
of the mixture onto the EM grid. Also,
the improved quality of captured images
of homogeneous macromolecular
structures is achieved due to a
uniformly mixed and dispensed sample
on the EM grid. This allows electrons to
be transmitted through the very thin
liquid film in the holes of the cryo-EM
grid to form an image.
Potential Commercial Applications
• Automation of cryo-EM
experiments aimed at Structure-based
Drug Design by examining
macromolecular structure and its
interactions with ligands.
• Kits with hardware and software
components to setup robotic automation
of cryo-EM sample preparation,
dispensation, plunging and storage.
Competitive Advantages
• Automated workflow eliminates the
guesswork out of cryo-EM sample
preparation.
• Increases sample prep success rate
and decreases the need to screen
repeated trials.
• Using acoustic-based, multiplesample mixing enables homogeneous
mixing and facilitates the observation of
transient molecular interactions with
high time resolution.
• Python code is available for
command and control of a robot that
manipulates the cryo-EM grid.
E:\FR\FM\28AUN1.SGM
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[Federal Register Volume 88, Number 165 (Monday, August 28, 2023)]
[Notices]
[Page 58590]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2023-18490]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
National Center for Advancing Translational Sciences; Notice of
Closed Meeting
Pursuant to section 1009 of the Federal Advisory Committee Act, as
amended, notice is hereby given of the following meeting.
The meeting will be closed to the public in accordance with the
provisions set forth in sections 552b(c)(4) and 552b(c)(6), title 5
U.S.C., as amended. The grant applications and the discussions could
disclose confidential trade secrets or commercial property such as
patentable material, and personal information concerning individuals
associated with the grant applications, the disclosure of which would
constitute a clearly unwarranted invasion of personal privacy.
Name of Committee: National Center for Advancing Translational
Sciences Special Emphasis Panel; NCATS SBIR Basket Clinical Trials.
Date: September 21, 2023.
Time: 11:30 a.m. to 3:00 p.m.
Agenda: To review and evaluate grant applications.
Place: National Institutes of Health, National Center for
Advancing Translational Sciences, 6701 Democracy Boulevard,
Bethesda, MD 20892 (Virtual Meeting).
Contact Person: Nakia C Brown, Ph.D., Scientific Review Officer,
Office of Grants Management and Scientific Review, National Center
for Advancing Translational Sciences, National Institutes of Health,
6701 Democracy Boulevard, Room 1037, Bethesda, MD 20892, (301) 827-
3484, [email protected].
(Catalogue of Federal Domestic Assistance Program Nos. 93.859,
Pharmacology, Physiology, and Biological Chemistry Research; 93.350,
B--Cooperative Agreements; 93.859, Biomedical Research and Research
Training, National Institutes of Health, HHS)
Dated: August 23, 2023.
Melanie J. Pantoja,
Program Analyst, Office of Federal Advisory Committee Policy.
[FR Doc. 2023-18490 Filed 8-25-23; 8:45 am]
BILLING CODE 4140-01-P
