National Institute of Mental Health; Notice of Closed Meeting, 56027 [2023-17711]

Download as PDF Federal Register / Vol. 88, No. 158 / Thursday, August 17, 2023 / Notices ddrumheller on DSK120RN23PROD with NOTICES1 hallmark feature of type 2 diabetes mellitus (T2DM) is the accumulation of islet amyloid polypeptide fibrils in pancreatic islets. Such accumulations form amyloid plaques, referred to as islet amyloidosis. Amyloidosis due to aggregation of amyloid-b is key pathogenic event in AD, whereas aggregation of mature islet amyloid polypeptide (IAPP37) in human islet leads to b-cell dysfunction. Researchers at NIA used a bioinformatic approach to identify two novel islet amyloid polypeptide isoforms: IAPPb, encoding an elongated propeptide and nonaggregating IAPPg, which is processed to mature IAPP25 instead of IAPP37. They developed a quantitative selective reaction monitoring (SRM) proteomic assay to measure the isoform peptide levels in human clinical plasma and CSF from individuals with early AD and found that their levels were significantly reduced. Further, mature IAPP25 derived from IAPPg isoform inhibits fibrillation of IAPP and amyloid-b efficiently in vitro. Potential Commercial Applications: The novel IAPPb and IAPPg isoforms are potential peptidyl therapeutics to counteract with amyloid forming IAPP and amyloid-b in treatments of diabetes and Alzheimer’s disease and serve as blood-based biomarkers for Alzheimer’s disease. Competitive Advantages: • Peptide based anti-amyloid medicine. • Potential market applications for neurodegenerative diseases. Development Stage: Pre-clinical (in vivo validation). Publications: Liu, Q.-R., et al. Novel Hominid-Specific IAPP Isoforms: Potential Biomarkers of Early Alzheimer’s Disease and Inhibitors of Amyloid Formation. (PMID 36671553) at https://pubmed.ncbi.nlm.nih.gov/ 36671553/. Meng, Lanxia, et al. Islet amyloid polypeptide triggers a-synuclein pathology in Parkinson’s disease. (PMID 37150314) Dated: August 11, 2023. Richard U. Rodriguez, Associate Director, Technology Transfer Center, National Cancer Institute. [FR Doc. 2023–17673 Filed 8–16–23; 8:45 am] BILLING CODE 4140–01–P VerDate Sep<11>2014 21:36 Aug 16, 2023 Jkt 259001 DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome Research Institute; Notice of Closed Meeting Pursuant to section 1009 of the Federal Advisory Committee Act, as amended, notice is hereby given of the following meeting. The meeting will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research Institute Initial Review Group; Genome Research Study Section GNOM–G—CEGS. Date: November 2–3, 2023. Time: 10:00 a.m. to 3:00 p.m. Agenda: To review and evaluate grant applications. Place: National Human Genome Research Institute, National Institutes of Health, 6700B Rockledge Drive, Room 3180, Bethesda, MD 20892 (Virtual Meeting). Contact Person: Sarah Jo Wheelan, Ph.D., Scientific Review Officer, Scientific Review Branch, National Human Genome Research Institute, National Institutes of Health, 6700B Rockledge Drive, Room 3180, Bethesda, MD 20892, (301) 402–8823, wheelansj@nih.gov. (Catalogue of Federal Domestic Assistance Program Nos. 93.172, Human Genome Research, National Institutes of Health, HHS) Dated: August 14, 2023. Melanie J. Pantoja, Program Analyst, Office of Federal Advisory Committee Policy. 56027 552b(c)(6), title 5 U.S.C., as amended for the review, discussion, and evaluation of individual intramural programs and projects conducted by the National Institute Of Mental Health, including consideration of personnel qualifications and performance, and the competence of individual investigators, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: Board of Scientific Counselors; National Institute of Mental Health. Date: September 20–22, 2023. Time: September 20, 2023, 1:00 p.m. to 5:15 p.m. Agenda: To review and evaluate personnel qualifications and performance, and competence of individual investigators. Place: Porter Neuroscience Research Center, Building 35A, 35 Convent Drive, Bethesda, MD 20892. Time: September 21, 2023, 10:00 a.m. to 5:55 p.m. Agenda: To review and evaluate personnel qualifications and performance, and competence of individual investigators. Place: Porter Neuroscience Research Center, Building 35A, 35 Convent Drive, Bethesda, MD 20892. Time: September 22, 2023, 10:00 a.m. to 3:10 p.m. Agenda: To review and evaluate personnel qualifications and performance, and competence of individual investigators. Place: Porter Neuroscience Research Center, Building 35A, 35 Convent Drive, Bethesda, MD 20892. Contact Person: Jennifer E. Mehren, Ph.D., Scientific Advisor, Division of Intramural Research Programs, National Institute of Mental Health, NIH, 35A Convent Drive, Room GE 412, Bethesda, MD 20892–3747, 301–496–3501, mehrenj@mail.nih.gov. (Catalogue of Federal Domestic Assistance Program Nos. 93.242, Mental Health Research Grants, National Institutes of Health, HHS) [FR Doc. 2023–17713 Filed 8–16–23; 8:45 am] Dated: August 14, 2023. Melanie J. Pantoja, Program Analyst, Office of Federal Advisory Committee Policy. BILLING CODE 4140–01–P [FR Doc. 2023–17711 Filed 8–16–23; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute of Mental Health; Notice of Closed Meeting Pursuant to section 1009 of the Federal Advisory Committee Act, as amended, notice is hereby given of a meeting of the Board of Scientific Counselors, National Institute of Mental Health. The meeting will be closed to the public as indicated below in accordance with the provisions set forth in section PO 00000 Frm 00032 Fmt 4703 Sfmt 4703 DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Collaboration Opportunity To Develop a Vaccine Against Nicotine or Arecoline AGENCY: National Institutes of Health, HHS. ACTION: Notice. The Cancer Prevention Program of the National Cancer Institute (NCI) is seeking a partner in the private SUMMARY: E:\FR\FM\17AUN1.SGM 17AUN1

Agencies

[Federal Register Volume 88, Number 158 (Thursday, August 17, 2023)]
[Notices]
[Page 56027]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2023-17711]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


National Institute of Mental Health; Notice of Closed Meeting

    Pursuant to section 1009 of the Federal Advisory Committee Act, as 
amended, notice is hereby given of a meeting of the Board of Scientific 
Counselors, National Institute of Mental Health.
    The meeting will be closed to the public as indicated below in 
accordance with the provisions set forth in section 552b(c)(6), title 5 
U.S.C., as amended for the review, discussion, and evaluation of 
individual intramural programs and projects conducted by the National 
Institute Of Mental Health, including consideration of personnel 
qualifications and performance, and the competence of individual 
investigators, the disclosure of which would constitute a clearly 
unwarranted invasion of personal privacy.

    Name of Committee: Board of Scientific Counselors; National 
Institute of Mental Health.
    Date: September 20-22, 2023.
    Time: September 20, 2023, 1:00 p.m. to 5:15 p.m.
    Agenda: To review and evaluate personnel qualifications and 
performance, and competence of individual investigators.
    Place: Porter Neuroscience Research Center, Building 35A, 35 
Convent Drive, Bethesda, MD 20892.
    Time: September 21, 2023, 10:00 a.m. to 5:55 p.m.
    Agenda: To review and evaluate personnel qualifications and 
performance, and competence of individual investigators.
    Place: Porter Neuroscience Research Center, Building 35A, 35 
Convent Drive, Bethesda, MD 20892.
    Time: September 22, 2023, 10:00 a.m. to 3:10 p.m.
    Agenda: To review and evaluate personnel qualifications and 
performance, and competence of individual investigators.
    Place: Porter Neuroscience Research Center, Building 35A, 35 
Convent Drive, Bethesda, MD 20892.
    Contact Person: Jennifer E. Mehren, Ph.D., Scientific Advisor, 
Division of Intramural Research Programs, National Institute of 
Mental Health, NIH, 35A Convent Drive, Room GE 412, Bethesda, MD 
20892-3747, 301-496-3501, [email protected].

(Catalogue of Federal Domestic Assistance Program Nos. 93.242, 
Mental Health Research Grants, National Institutes of Health, HHS)

    Dated: August 14, 2023.
Melanie J. Pantoja,
Program Analyst, Office of Federal Advisory Committee Policy.
[FR Doc. 2023-17711 Filed 8-16-23; 8:45 am]
BILLING CODE 4140-01-P

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