Interagency Coordinating Committee on the Validation of Alternative Methods Communities of Practice Webinar on New Approach Methodologies To Assess (Developmental) Neurotoxicity; Notice of Public Webinar; Registration Information, 72609-72610 [2021-27692]

Download as PDF Federal Register / Vol. 86, No. 243 / Wednesday, December 22, 2021 / Notices Physiology, and Biological Chemistry Research; 93.350, B—Cooperative Agreements; 93.859, Biomedical Research and Research Training, National Institutes of Health, HHS) Dated: December 16, 2021. David W. Freeman, Program Analyst, Office of Federal Advisory Committee Policy. [FR Doc. 2021–27691 Filed 12–21–21; 8:45 am] BILLING CODE 4140–01–P National Institute of Environmental Health Sciences; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended, notice is hereby given of the following meeting. The meeting will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. khammond on DSKJM1Z7X2PROD with NOTICES BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES Interagency Coordinating Committee on the Validation of Alternative Methods Communities of Practice Webinar on New Approach Methodologies To Assess (Developmental) Neurotoxicity; Notice of Public Webinar; Registration Information National Institutes of Health Name of Committee: National Institute of Environmental Health Sciences Special Emphasis Panel; Mechanism for TimeSensitive Research Opportunities in Environmental Health Sciences (R21). Date: January 10, 2022. Time: 1:30 p.m. to 4:30 p.m. Agenda: To review and evaluate grant applications. Place: National Institute of Environmental Health Sciences, Keystone Building, 530 Davis Drive, Durham, NC 27709 (Virtual Meeting). Contact Person: Laura A. Thomas, Ph.D., Scientific Review Officer, Scientific Review Branch, Division of Extramural Research and Training, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, 984–287–3328, laura.thomas@ nih.gov. (Catalogue of Federal Domestic Assistance Program Nos. 93.115, Biometry and Risk Estimation—Health Risks from Environmental Exposures; 93.142, NIEHS Hazardous Waste Worker Health and Safety Training; 93.143, NIEHS Superfund Hazardous Substances—Basic Research and Education; 93.894, Resources and Manpower Development in the Environmental Health Sciences; 93.113, Biological Response to Environmental Health Hazards; 93.114, Applied Toxicological Research and Testing, National Institutes of Health, HHS) 17:55 Dec 21, 2021 [FR Doc. 2021–27690 Filed 12–21–21; 8:45 am] National Institutes of Health DEPARTMENT OF HEALTH AND HUMAN SERVICES VerDate Sep<11>2014 Dated: December 16, 2021. David W. Freeman, Program Analyst, Office of Federal Advisory Committee Policy. Jkt 256001 AGENCY: National Institutes of Health, HHS. ACTION: Notice. The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) announces a public webinar ‘‘New Approach Methodologies to Assess (Developmental) Neurotoxicity.’’ The webinar is organized on behalf of ICCVAM by the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM). Interested persons may participate via the web meeting platform. Time will be allotted for questions from the audience. Information about the webinar and registration are available at https:// ntp.niehs.nih.gov/go/commprac-2022. DATES: Webinar: January 25, 2022, 10:00 a.m. to approximately 11:30 a.m. EST. Registration for Webinar: January 4, 2022, until 11:30 a.m. EST January 25, 2022. Registration to view the webinar is required. ADDRESSES: Webinar web page: https:// ntp.niehs.nih.gov/go/commprac-2022. FOR FURTHER INFORMATION CONTACT: Dr. Nicole Kleinstreuer, Acting Director, NICEATM, email: nicole.kleinstreuer@ nih.gov, telephone: (984) 287–3150. SUPPLEMENTARY INFORMATION: Background: ICCVAM promotes the development and validation of toxicity testing methods that protect human health and the environment while replacing, reducing, or refining animal use. ICCVAM also provides guidance to test method developers and facilitates collaborations that promote the development of new test methods. To address these goals, ICCVAM will hold a Communities of Practice webinar on SUMMARY: PO 00000 Frm 00036 Fmt 4703 Sfmt 4703 72609 ‘‘New Approach Methodologies to Assess (Developmental) Neurotoxicity.’’ The nervous system has unique characteristics and can have different sensitivity to toxic substances compared to other organ systems. Effects of chemicals on the nervous system can be affected by concurrent exposures to other substances. During early life stages, exposure to neuroactive drugs and environmental toxins can interact and/or interfere with developmental processes of the brain, which can in turn result in structural and/or functional alterations. Traditional (developmental) neurotoxicity tests use mammals, but the high cost and low throughput of these tests make them impractical to use for all chemicals of potential concern. In addition, it is challenging to correlate the interpretation of animal data to complex human neurological effects. Therefore, interest is increasing in exploring human cell-based assays, computational systems, and other alternatives to traditional animal tests that can be used to predict chemical effects on the developing and adult nervous system. ‘‘New approach methodologies’’ (NAMs) refers to any non-animal technology or approach, or combination of these, that can be used to provide information on chemical hazard and risk assessment. This webinar will discuss NAMs that are being considered or developed for assessing potential effects of chemicals on the nervous system. Key insights and ongoing activities will be described in two presentations featuring speakers from U.S. federal research and regulatory agencies. The preliminary agenda and additional information about presentations will be posted at https:// ntp.niehs.nih.gov/go/commprac-2022 as available. Webinar and Registration: This webinar is open to the public with time scheduled for questions by participants following each presentation. Registration for the webinar is required and will be open from January 4, 2022, through 11:30 a.m. EST on January 25, 2022. Registration is available at https:// ntp.niehs.nih.gov/go/commprac-2022. Interested individuals are encouraged to visit this web page to stay abreast of the most current webinar information. Registrants will receive instructions on how to access and participate in the webinar in the email confirming their registration. Background Information on ICCVAM and NICEATM: ICCVAM is an interagency committee composed of representatives from 17 federal regulatory and research agencies that require, use, generate, or disseminate E:\FR\FM\22DEN1.SGM 22DEN1 72610 Federal Register / Vol. 86, No. 243 / Wednesday, December 22, 2021 / Notices toxicological and safety testing information. ICCVAM conducts technical evaluations of new, revised, and alternative safety testing methods and integrated testing strategies with regulatory applicability. ICCVAM also promotes the scientific validation and regulatory acceptance of testing methods that more accurately assess the safety and hazards of chemicals and products and replace, reduce, or refine animal use. The ICCVAM Authorization Act of 2000 (42 U.S.C. 285l–3) establishes ICCVAM as a permanent interagency committee of the National Institute of Environmental Health Sciences and provides the authority for ICCVAM involvement in activities relevant to the development of alternative test methods. Additional information about ICCVAM can be found at https:// ntp.niehs.nih.gov/go/iccvam. NICEATM administers ICCVAM, provides support for ICCVAM-related activities, and conducts and publishes analyses and evaluations of data from new, revised, and alternative testing approaches. NICEATM and ICCVAM work collaboratively to evaluate new and improved testing approaches applicable to the needs of U.S. federal agencies. NICEATM and ICCVAM welcome the public nomination of new, revised, and alternative test methods and strategies for validation studies and technical evaluations. Additional information about NICEATM can be found at https://ntp.niehs.nih.gov/go/ niceatm. Dated: December 16, 2021. Brian R. Berridge, Associate Director, National Toxicology Program. DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health khammond on DSKJM1Z7X2PROD with NOTICES National Center for Advancing Translational Sciences; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended, notice is hereby given of the following meeting. The meeting will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, Jkt 256001 Name of Committee: National Center for Advancing Translational Sciences Special Emphasis Panel; National Center for Advancing Translational Sciences Special Emphasis Panel. Date: February 23, 2022. Time: 10:00 a.m. to 5:00 p.m. Agenda: To review and evaluate grant applications. Place: National Center for Advancing Translational Sciences, National Institutes of Health, 6701 Democracy Boulevard, Room 1037, Bethesda, MD 20892 (Virtual Meeting). Contact Person: Carol (Chang-Sook) Kim, Ph.D., Scientific Review Administrator, Office of Grants Management and Scientific Review, National Center for Advancing Translational Sciences, National Institutes of Health, 6701 Democracy Boulevard, Room 1037, Bethesda, MD 20892 (301) 827–7940, carolko@mail.nih.gov. (Catalogue of Federal Domestic Assistance Program Nos. 93.859, Pharmacology, Physiology, and Biological Chemistry Research; 93.350, B—Cooperative Agreements; 93.859, Biomedical Research and Research Training, National Institutes of Health, HHS) Name of Committee: National Advisory Neurological Disorders and Stroke Council. Date: February 2–3, 2022. Open: February 2, 2022, 1:00 p.m. to 6:00 p.m. Agenda: Report by the Director, NINDS; Report by the Director, Division of Extramural Activities; and Administrative and Program Developments. Open session will be videocast from this link: https://videocast.nih.gov/. Closed: February 3, 2022, 1:00 p.m. to 5:30 p.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health, Neuroscience Center, 6001 Executive Blvd., Rockville, MD 20852 (Virtual Meeting). Contact Person: Robert Finkelstein, Ph.D., Director of Extramural Research, National Institute of Neurological Disorders and Stroke, NIH, 6001 Executive Blvd., Suite 3309, MSC 9531, Rockville, MD 20852, (301) 496–9248, finkelsr@ninds.nih.gov. Any interested person may file written comments with the committee by forwarding the statement to the Contact Person listed on this notice at least 10 days in advance of the meeting. The statement should include the name, address, telephone number and when applicable, the business or professional affiliation of the interested person. Information is also available on the Institute’s/Center’s home page: www.ninds.nih.gov, where an agenda and any additional information for the meeting will be posted when available. (Catalogue of Federal Domestic Assistance Program Nos. 93.853, Clinical Research Related to Neurological Disorders; 93.854, Biological Basis Research in the Neurosciences, National Institutes of Health, HHS) Dated: December 16, 2021. David W. Freeman, Program Analyst, Office of Federal Advisory Committee Policy. [FR Doc. 2021–27689 Filed 12–21–21; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institute of Neurological Disorders and Stroke Notice of Meeting BILLING CODE 4140–01–P 17:55 Dec 21, 2021 and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. National Institutes of Health [FR Doc. 2021–27692 Filed 12–21–21; 8:45 am] VerDate Sep<11>2014 and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended, notice is hereby given of a meeting of the National Advisory Neurological Disorders and Stroke Council. The meeting will be open to the public. Individuals who plan to participate and need special assistance, such as sign language interpretation or other reasonable accommodations, should notify the Contact Person listed below in advance of the meeting. The meeting will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, PO 00000 Frm 00037 Fmt 4703 Sfmt 4703 Dated: December 16, 2021. Tyeshia M. Roberson-Curtis, Program Analyst, Office of Federal Advisory Committee Policy. [FR Doc. 2021–27724 Filed 12–21–21; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HOMELAND SECURITY U.S. Customs and Border Protection Automated Commercial Environment (ACE) Export Manifest for Air Cargo Test: Extension of Test U.S. Customs and Border Protection; Department of Homeland Security. ACTION: General notice. AGENCY: This notice announces that U.S. Customs and Border Protection SUMMARY: E:\FR\FM\22DEN1.SGM 22DEN1

Agencies

[Federal Register Volume 86, Number 243 (Wednesday, December 22, 2021)]
[Notices]
[Pages 72609-72610]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2021-27692]


-----------------------------------------------------------------------

DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Interagency Coordinating Committee on the Validation of 
Alternative Methods Communities of Practice Webinar on New Approach 
Methodologies To Assess (Developmental) Neurotoxicity; Notice of Public 
Webinar; Registration Information

AGENCY: National Institutes of Health, HHS.

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: The Interagency Coordinating Committee on the Validation of 
Alternative Methods (ICCVAM) announces a public webinar ``New Approach 
Methodologies to Assess (Developmental) Neurotoxicity.'' The webinar is 
organized on behalf of ICCVAM by the National Toxicology Program 
Interagency Center for the Evaluation of Alternative Toxicological 
Methods (NICEATM). Interested persons may participate via the web 
meeting platform. Time will be allotted for questions from the 
audience. Information about the webinar and registration are available 
at https://ntp.niehs.nih.gov/go/commprac-2022.

DATES: 
    Webinar: January 25, 2022, 10:00 a.m. to approximately 11:30 a.m. 
EST.
    Registration for Webinar: January 4, 2022, until 11:30 a.m. EST 
January 25, 2022.
    Registration to view the webinar is required.

ADDRESSES: Webinar web page: https://ntp.niehs.nih.gov/go/commprac-2022.

FOR FURTHER INFORMATION CONTACT: Dr. Nicole Kleinstreuer, Acting 
Director, NICEATM, email: [email protected], telephone: (984) 
287-3150.

SUPPLEMENTARY INFORMATION: 
    Background: ICCVAM promotes the development and validation of 
toxicity testing methods that protect human health and the environment 
while replacing, reducing, or refining animal use. ICCVAM also provides 
guidance to test method developers and facilitates collaborations that 
promote the development of new test methods. To address these goals, 
ICCVAM will hold a Communities of Practice webinar on ``New Approach 
Methodologies to Assess (Developmental) Neurotoxicity.''
    The nervous system has unique characteristics and can have 
different sensitivity to toxic substances compared to other organ 
systems. Effects of chemicals on the nervous system can be affected by 
concurrent exposures to other substances. During early life stages, 
exposure to neuroactive drugs and environmental toxins can interact 
and/or interfere with developmental processes of the brain, which can 
in turn result in structural and/or functional alterations. Traditional 
(developmental) neurotoxicity tests use mammals, but the high cost and 
low throughput of these tests make them impractical to use for all 
chemicals of potential concern. In addition, it is challenging to 
correlate the interpretation of animal data to complex human 
neurological effects. Therefore, interest is increasing in exploring 
human cell-based assays, computational systems, and other alternatives 
to traditional animal tests that can be used to predict chemical 
effects on the developing and adult nervous system.
    ``New approach methodologies'' (NAMs) refers to any non-animal 
technology or approach, or combination of these, that can be used to 
provide information on chemical hazard and risk assessment. This 
webinar will discuss NAMs that are being considered or developed for 
assessing potential effects of chemicals on the nervous system. Key 
insights and ongoing activities will be described in two presentations 
featuring speakers from U.S. federal research and regulatory agencies. 
The preliminary agenda and additional information about presentations 
will be posted at https://ntp.niehs.nih.gov/go/commprac-2022 as 
available.
    Webinar and Registration: This webinar is open to the public with 
time scheduled for questions by participants following each 
presentation. Registration for the webinar is required and will be open 
from January 4, 2022, through 11:30 a.m. EST on January 25, 2022. 
Registration is available at https://ntp.niehs.nih.gov/go/commprac-2022. Interested individuals are encouraged to visit this web page to 
stay abreast of the most current webinar information. Registrants will 
receive instructions on how to access and participate in the webinar in 
the email confirming their registration.
    Background Information on ICCVAM and NICEATM: ICCVAM is an 
interagency committee composed of representatives from 17 federal 
regulatory and research agencies that require, use, generate, or 
disseminate

[[Page 72610]]

toxicological and safety testing information. ICCVAM conducts technical 
evaluations of new, revised, and alternative safety testing methods and 
integrated testing strategies with regulatory applicability. ICCVAM 
also promotes the scientific validation and regulatory acceptance of 
testing methods that more accurately assess the safety and hazards of 
chemicals and products and replace, reduce, or refine animal use.
    The ICCVAM Authorization Act of 2000 (42 U.S.C. 285l-3) establishes 
ICCVAM as a permanent interagency committee of the National Institute 
of Environmental Health Sciences and provides the authority for ICCVAM 
involvement in activities relevant to the development of alternative 
test methods. Additional information about ICCVAM can be found at 
https://ntp.niehs.nih.gov/go/iccvam.
    NICEATM administers ICCVAM, provides support for ICCVAM-related 
activities, and conducts and publishes analyses and evaluations of data 
from new, revised, and alternative testing approaches. NICEATM and 
ICCVAM work collaboratively to evaluate new and improved testing 
approaches applicable to the needs of U.S. federal agencies. NICEATM 
and ICCVAM welcome the public nomination of new, revised, and 
alternative test methods and strategies for validation studies and 
technical evaluations. Additional information about NICEATM can be 
found at https://ntp.niehs.nih.gov/go/niceatm.

    Dated: December 16, 2021.
Brian R. Berridge,
Associate Director, National Toxicology Program.
[FR Doc. 2021-27692 Filed 12-21-21; 8:45 am]
BILLING CODE 4140-01-P

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