Board of Visitors for the National Fire Academy; Meeting, 59174-59175 [2021-23300]
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59174
Federal Register / Vol. 86, No. 204 / Tuesday, October 26, 2021 / Notices
Receptors Recognizing Mutated P53’’
[HHS Reference No. E–237–2017–2–IN–
10];
12. Japanese Patent Application No.
2020–517556 effective filing date of
September 17, 2018 entitled ‘‘T Cell
Receptors Recognizing Mutated P53’’
[HHS Reference No. E–237–2017–2–JP–
11];
13. Korean Patent Application No.
2020–7012344 effective filing date of
September 17, 2018 entitled ‘‘T Cell
Receptors Recognizing Mutated P53’’
[HHS Reference No. E–237–2017–2–KR–
12];
14. Mexican Application No. MX/a/
2020/003504, effective filing date of
September 17, 2018 entitled ‘‘T Cell
Receptors Recognizing Mutated P53’’
[HHS Reference No. E–237–2017–2–
MX–13];
15. New Zealand Patent Application
No. 763023 effective filing date of
September 17, 2018 entitled ‘‘T Cell
Receptors Recognizing Mutated P53’’
[HHS Reference No. E–237–2017–2–
NZ–14];
16. Singapore Patent Application No.
11202002636P effective filing date of
September 17, 2018 entitled ‘‘T Cell
Receptors Recognizing Mutated P53’’
[HHS Reference No. E–237–2017–2–SG–
15];
17. United States Patent Application
No. 16/651,242 effective filing date of
September 17, 2018 entitled ‘‘T Cell
Receptors Recognizing Mutated P53’’
[HHS Reference No. E–237–2017–2–US–
16];
18. Hong Kong Patent Application No.
62020021272.3 effective filing date of
September 17, 2018 entitled ‘‘T Cell
Receptors Recognizing Mutated P53’’
[HHS Reference No. E–237–2017–2–
HK–17];
19. United States Provisional Patent
Application No. 62/867,619, filed June
27, 2019 entitled ‘‘T Cell Receptors
Recognizing R175H or Y220C Mutation
in P53’’ [HHS Reference No. E–135–
2019–0–US–01];
20. PCT Application No. PCT/
US2020/039785, filed June 26, 2020
entitled ‘‘T Cell Receptors Recognizing
R175H or Y220C Mutation in P53’’
[HHS Reference No. E–135–2019–0–
PCT–02];
21. Taiwanese Application No.
109121744, filed June 26, 2020 entitled
‘‘T Cell Receptors Recognizing R175H or
Y220C Mutation in P53’’ [HHS
Reference No. E–135–2019–0–TW–03];
22. United States Provisional Patent
Application No. 63/074,747, filed
September 4, 2020 entitled ‘‘T Cell
Receptors Recognizing R273C or Y220C
Mutation in P53’’ [HHS Reference No.
E–173–2020–0–US–01];
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22:39 Oct 25, 2021
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23. PCT Patent Application No. PCT/
US2021/048786, filed September 2,
2021 entitled ‘‘T Cell Receptors
Recognizing R273C or Y220C Mutation
in P53’’ [HHS Reference No. E–173–
2020–0–PCT–02]; and
24. Taiwanese Patent Application No.
‘‘TBD’’, filed September 2, 2021 entitled
‘‘T Cell Receptors Recognizing R273C or
Y220C Mutation in P53’’ [HHS
Reference No. E–173–2020–0–TW–03].
The patent rights in these inventions
have been assigned and/or exclusively
licensed to the government of the
United States of America.
The prospective exclusive license
territory may be worldwide, and the
fields of use may be limited to the
following:
‘‘Autologous T cell therapy products
engineered by use of a CRISPR-nuclease
to express a therapeutic T cell receptor
claimed in the Licensed Patent Rights
for the treatment or prevention of cancer
in humans’’
‘‘Allogeneic T cell therapy products
engineered by use of a CRISPR-nuclease
to express a therapeutic T cell receptor
claimed in the Licensed Patent Rights
for the treatment or prevention of cancer
in humans’’
Specifically excluded from these
fields of use are:
1. Autologous, peripheral blood T cell
therapy products engineered by
transposon-mediated gene transfer for
the treatment of human cancers;
2. Autologous, peripheral blood T cell
therapy products engineered via
retrovirus and lentivirus-mediated gene
transfer for the treatment of human
cancer; and
3. Natural Killer T (NKT) cell therapy
products engineered via viral and nonviral means for the treatment of human
cancers. Wherein the NKT cell therapy
product contains at least 50% NKT
cells.
Intellectual Property Group A is
primarily directed to isolated T cell
receptors (TCRs) reactive to mutated
Kirsten rat sarcoma viral oncogene
homolog (KRAS), within the context of
several human leukocyte antigens
(HLAs). Mutated KRAS, which plays a
well-defined driver role in oncogenesis,
is expressed by a variety of human
cancers, including pancreatic, lung,
endometrial, ovarian and prostate. Due
to its restricted expression in
precancerous and cancerous cells, this
antigen may be targeted on mutant
KRAS-expressing tumors with minimal
normal tissue toxicity.
Intellectual Property Group B is
primarily directed to isolated TCRs
reactive to mutated tumor protein 53
(TP53 or P53), within the context of
several HLAs. P53 is the archetypal
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tumor suppressor gene and the most
frequently mutated gene in cancer.
Contemporary estimates suggest that
>50% of all tumors carry mutations in
P53. Because of its prevalence in cancer
and its restricted expression to
precancerous and cancerous cells, this
antigen may be targeted on mutant P53expressing tumors with minimal normal
tissue toxicity.
This Notice is made in accordance
with 35 U.S.C. 209 and 37 CFR part 404.
The prospective exclusive license will
be royalty bearing, and the prospective
exclusive license may be granted unless
within fifteen (15) days from the date of
this published Notice, the National
Cancer Institute receives written
evidence and argument that establishes
that the grant of the license would not
be consistent with the requirements of
35 U.S.C. 209 and 37 CFR part 404.
In response to this Notice, the public
may file comments or objections.
Comments and objections, other than
those in the form of a license
application, will not be treated
confidentially and may be made
publicly available.
License applications submitted in
response to this Notice will be
presumed to contain business
confidential information and any release
of information from these license
applications will be made only as
required and upon a request under the
Freedom of Information Act, 5 U.S.C.
552.
Dated: October 21, 2021.
Richard U. Rodriguez,
Associate Director, Technology Transfer
Center, National Cancer Institute.
[FR Doc. 2021–23289 Filed 10–25–21; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HOMELAND
SECURITY
Federal Emergency Management
Agency
[Docket ID FEMA–2008–0010]
Board of Visitors for the National Fire
Academy; Meeting
Federal Emergency
Management Agency, DHS.
ACTION: Committee management; notice
of open Federal Advisory Committee
meeting.
AGENCY:
The Board of Visitors for the
National Fire Academy (Board) will
meet virtually on Monday, December 6,
2021. The meeting will be open to the
public.
SUMMARY:
E:\FR\FM\26OCN1.SGM
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Federal Register / Vol. 86, No. 204 / Tuesday, October 26, 2021 / Notices
The meeting will take place on
Monday, December 6, 2021, 3:00 p.m. to
5:00 p.m. EST. Please note that the
meeting may close early if the Board has
completed its business.
ADDRESSES: Members of the public who
wish to participate in the virtual
conference should contact Deborah
Gartrell-Kemp as listed in the FOR
FURTHER INFORMATION CONTACT section
by close of business on November 22,
2021, to obtain the call-in number and
access code for the December 6th virtual
meeting. For more information on
services for individuals with disabilities
or to request special assistance, contact
Deborah Gartrell-Kemp as soon as
possible.
To facilitate public participation, we
are inviting public comment on the
issues to be considered by the Board as
listed in the SUPPLEMENTARY
INFORMATION section. Participants
seeking to have their comments
considered during the meeting should
submit them in advance or during the
public comment segment. Comments
submitted up to 30 days after the
meeting will be included in the public
record and may be considered at the
next meeting. Comments submitted in
advance must be identified by Docket ID
FEMA–2008–0010 and may be
submitted by one of the following
methods:
• Federal eRulemaking Portal: https://
www.regulations.gov. Follow the
instructions for submitting comments.
• Electronic Delivery: Email Deborah
Gartrell-Kemp at
Deborah.GartrellKemp@fema.dhs.gov no
later than December 1, 2021, for
consideration at the December 6, 2021
meeting.
Instructions: All submissions received
must include the words ‘‘Federal
Emergency Management Agency’’ and
the Docket ID for this action. Comments
received will be posted without
alteration at https://www.regulations.gov,
including any personal information
provided.
Docket: For access to the docket to
read background documents or
comments received by the National Fire
Academy Board of Visitors, go to https://
www.regulations.gov, click on
‘‘Advanced Search,’’ then enter
‘‘FEMA–2008–0010’’ in the ‘‘By Docket
ID’’ box, then select ‘‘FEMA’’ under ‘‘By
Agency,’’ and then click ‘‘Search.’’
FOR FURTHER INFORMATION CONTACT:
Alternate Designated Federal Officer:
Stephen Dean, telephone (301) 447–
1271, email Stephen.Dean@
fema.dhs.gov.
Logistical Information: Deborah
Gartrell-Kemp, telephone (301) 447–
DATES:
VerDate Sep<11>2014
22:39 Oct 25, 2021
Jkt 256001
7230, email Deborah.GartrellKemp@
fema.dhs.gov.
The Board
will meet virtually on Monday,
December 6, 2021. The meeting will be
open to the public. Notice of this
meeting is given under the Federal
Advisory Committee Act, 5 U.S.C.
Appendix.
SUPPLEMENTARY INFORMATION:
The purpose of the Board is to review
annually the programs of the National
Fire Academy (Academy) and advise the
Administrator of the Federal Emergency
Management Agency (FEMA), through
the United States Fire Administrator, on
the operation of the Academy and any
improvements therein that the Board
deems appropriate. In carrying out its
responsibilities, the Board examines
Academy programs to determine
whether these programs further the
basic missions that are approved by the
Administrator of FEMA, examines the
physical plant of the Academy to
determine the adequacy of the
Academy’s facilities, and examines the
funding levels for Academy programs.
The Board submits a written annual
report through the United States Fire
Administrator to the Administrator of
FEMA. The report provides detailed
comments and recommendations
regarding the operation of the Academy.
Agenda
On Monday, December 6, 2021, there
will be five sessions, with deliberations
and voting at the end of each session as
necessary:
1. The Board will present their
Annual BOV report.
2. The Board will discuss United
States Fire Administration Data,
Research, Prevention and Response.
3. The Board will discuss deferred
maintenance and capital improvements
on the National Emergency Training
Center campus and Fiscal Year 2022
Budget Request/Budget Planning.
4. The Board will deliberate and vote
on recommendations on Academy
program activities to include
developments, deliveries, staffing,
admissions and strategic plan.
5. There will also be an update on the
Board of Visitors Subcommittee Groups
for the Professional Development
Initiative Update and the National Fire
Incident Report System.
There will be a 10-minute comment
period after each agenda item and each
speaker will be given no more than 2
minutes to speak. Please note that the
public comment period may end before
the time indicated following the last call
for comments. Contact Deborah Gartrell-
Frm 00064
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Kemp to register as a speaker. Meeting
materials will be posted at https://
www.usfa.fema.gov/training/nfa/about/
bov.html by December 1, 2021.
Eriks J. Gabliks,
Superintendent, National Fire Academy,
United States Fire Administration, Federal
Emergency Management Agency.
[FR Doc. 2021–23300 Filed 10–25–21; 8:45 am]
BILLING CODE 9111–74–P
Purpose of the Board
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DEPARTMENT OF HOMELAND
SECURITY
Federal Emergency Management
Agency
[Docket ID FEMA–2021–0002; Internal
Agency Docket No. FEMA–B–2175]
Changes in Flood Hazard
Determinations
Federal Emergency
Management Agency, DHS.
ACTION: Notice.
AGENCY:
This notice lists communities
where the addition or modification of
Base Flood Elevations (BFEs), base flood
depths, Special Flood Hazard Area
(SFHA) boundaries or zone
designations, or the regulatory floodway
(hereinafter referred to as flood hazard
determinations), as shown on the Flood
Insurance Rate Maps (FIRMs), and
where applicable, in the supporting
Flood Insurance Study (FIS) reports,
prepared by the Federal Emergency
Management Agency (FEMA) for each
community, is appropriate because of
new scientific or technical data. The
FIRM, and where applicable, portions of
the FIS report, have been revised to
reflect these flood hazard
determinations through issuance of a
Letter of Map Revision (LOMR), in
accordance with Federal Regulations.
The currently effective community
number is shown in the table below and
must be used for all new policies and
renewals.
SUMMARY:
These flood hazard
determinations will be finalized on the
dates listed in the table below and
revise the FIRM panels and FIS report
in effect prior to this determination for
the listed communities.
From the date of the second
publication of notification of these
changes in a newspaper of local
circulation, any person has 90 days in
which to request through the
community that the Deputy Associate
Administrator for Insurance and
Mitigation reconsider the changes. The
flood hazard determination information
DATES:
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Agencies
[Federal Register Volume 86, Number 204 (Tuesday, October 26, 2021)]
[Notices]
[Pages 59174-59175]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2021-23300]
=======================================================================
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DEPARTMENT OF HOMELAND SECURITY
Federal Emergency Management Agency
[Docket ID FEMA-2008-0010]
Board of Visitors for the National Fire Academy; Meeting
AGENCY: Federal Emergency Management Agency, DHS.
ACTION: Committee management; notice of open Federal Advisory Committee
meeting.
-----------------------------------------------------------------------
SUMMARY: The Board of Visitors for the National Fire Academy (Board)
will meet virtually on Monday, December 6, 2021. The meeting will be
open to the public.
[[Page 59175]]
DATES: The meeting will take place on Monday, December 6, 2021, 3:00
p.m. to 5:00 p.m. EST. Please note that the meeting may close early if
the Board has completed its business.
ADDRESSES: Members of the public who wish to participate in the virtual
conference should contact Deborah Gartrell-Kemp as listed in the FOR
FURTHER INFORMATION CONTACT section by close of business on November
22, 2021, to obtain the call-in number and access code for the December
6th virtual meeting. For more information on services for individuals
with disabilities or to request special assistance, contact Deborah
Gartrell-Kemp as soon as possible.
To facilitate public participation, we are inviting public comment
on the issues to be considered by the Board as listed in the
SUPPLEMENTARY INFORMATION section. Participants seeking to have their
comments considered during the meeting should submit them in advance or
during the public comment segment. Comments submitted up to 30 days
after the meeting will be included in the public record and may be
considered at the next meeting. Comments submitted in advance must be
identified by Docket ID FEMA-2008-0010 and may be submitted by one of
the following methods:
Federal eRulemaking Portal: https://www.regulations.gov.
Follow the instructions for submitting comments.
Electronic Delivery: Email Deborah Gartrell-Kemp at
[email protected] no later than December 1, 2021, for
consideration at the December 6, 2021 meeting.
Instructions: All submissions received must include the words
``Federal Emergency Management Agency'' and the Docket ID for this
action. Comments received will be posted without alteration at https://www.regulations.gov, including any personal information provided.
Docket: For access to the docket to read background documents or
comments received by the National Fire Academy Board of Visitors, go to
https://www.regulations.gov, click on ``Advanced Search,'' then enter
``FEMA-2008-0010'' in the ``By Docket ID'' box, then select ``FEMA''
under ``By Agency,'' and then click ``Search.''
FOR FURTHER INFORMATION CONTACT:
Alternate Designated Federal Officer: Stephen Dean, telephone (301)
447-1271, email [email protected].
Logistical Information: Deborah Gartrell-Kemp, telephone (301) 447-
7230, email [email protected].
SUPPLEMENTARY INFORMATION: The Board will meet virtually on Monday,
December 6, 2021. The meeting will be open to the public. Notice of
this meeting is given under the Federal Advisory Committee Act, 5
U.S.C. Appendix.
Purpose of the Board
The purpose of the Board is to review annually the programs of the
National Fire Academy (Academy) and advise the Administrator of the
Federal Emergency Management Agency (FEMA), through the United States
Fire Administrator, on the operation of the Academy and any
improvements therein that the Board deems appropriate. In carrying out
its responsibilities, the Board examines Academy programs to determine
whether these programs further the basic missions that are approved by
the Administrator of FEMA, examines the physical plant of the Academy
to determine the adequacy of the Academy's facilities, and examines the
funding levels for Academy programs. The Board submits a written annual
report through the United States Fire Administrator to the
Administrator of FEMA. The report provides detailed comments and
recommendations regarding the operation of the Academy.
Agenda
On Monday, December 6, 2021, there will be five sessions, with
deliberations and voting at the end of each session as necessary:
1. The Board will present their Annual BOV report.
2. The Board will discuss United States Fire Administration Data,
Research, Prevention and Response.
3. The Board will discuss deferred maintenance and capital
improvements on the National Emergency Training Center campus and
Fiscal Year 2022 Budget Request/Budget Planning.
4. The Board will deliberate and vote on recommendations on Academy
program activities to include developments, deliveries, staffing,
admissions and strategic plan.
5. There will also be an update on the Board of Visitors
Subcommittee Groups for the Professional Development Initiative Update
and the National Fire Incident Report System.
There will be a 10-minute comment period after each agenda item and
each speaker will be given no more than 2 minutes to speak. Please note
that the public comment period may end before the time indicated
following the last call for comments. Contact Deborah Gartrell-Kemp to
register as a speaker. Meeting materials will be posted at https://www.usfa.fema.gov/training/nfa/about/bov.html by December 1, 2021.
Eriks J. Gabliks,
Superintendent, National Fire Academy, United States Fire
Administration, Federal Emergency Management Agency.
[FR Doc. 2021-23300 Filed 10-25-21; 8:45 am]
BILLING CODE 9111-74-P