Schedules of Controlled Substances: Placement of cyclopentyl fentanyl, isobutyryl fentanyl, para-chloroisobutyryl fentanyl, para-methoxybutyryl fentanyl, and valeryl fentanyl in Schedule I; Correction, 16667-16669 [2021-06596]
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16667
Rules and Regulations
Federal Register
Vol. 86, No. 60
Wednesday, March 31, 2021
This section of the FEDERAL REGISTER
contains regulatory documents having general
applicability and legal effect, most of which
are keyed to and codified in the Code of
Federal Regulations, which is published under
50 titles pursuant to 44 U.S.C. 1510.
The Code of Federal Regulations is sold by
the Superintendent of Documents.
DEPARTMENT OF JUSTICE
Drug Enforcement Administration
21 CFR Part 1308
[Docket No. DEA–565]
Schedules of Controlled Substances:
Placement of cyclopentyl fentanyl,
isobutyryl fentanyl, parachloroisobutyryl fentanyl, paramethoxybutyryl fentanyl, and valeryl
fentanyl in Schedule I; Correction
Drug Enforcement
Administration, Department of Justice.
ACTION: Final rule; correcting
amendment.
AGENCY:
The Drug Enforcement
Administration is correcting a final rule
that appeared in the Federal Register on
November 25, 2020. The document
issued an action placing five fentanylrelated substances (cyclopentyl fentanyl
(N-(1-phenethylpiperidin-4-yl)-Nphenylcyclopentanecarboxamide),
isobutyryl fentanyl (N-(1phenethylpiperidin-4-yl)-Nphenylisobutyramide), parachloroisobutyryl fentanyl (N-(4chlorophenyl)-N-(1-phenethylpiperidin4-yl)isobutyramide), paramethoxybutyryl fentanyl (N-(4methoxyphenyl)-N-(1phenethylpiperidin-4-yl)butyramide),
and valeryl fentanyl (N-(1phenethylpiperidin-4-yl)-Nphenylpentanamide), including their
jbell on DSKJLSW7X2PROD with RULES
SUMMARY:
isomers, esters, ethers, salts, and salts of
isomers, esters, and ethers, permanently
in schedule I of the Controlled
Substances Act, specifically to the
opiates list under DEA regulations. The
published document assigned incorrect
paragraph numbers to all five
substances, and inadvertently removed
four other substances from the listed
opiates.
DATES: Effective date: March 31, 2021.
FOR FURTHER INFORMATION CONTACT:
Terrence L. Boos, Drug and Chemical
Evaluation Section, Diversion Control
Division, Drug Enforcement
Administration; Telephone: (571) 362–
3249.
On
November 25, 2020, the Drug
Enforcement Administration (DEA)
permanently placed five fentanylrelated substances (cyclopentyl fentanyl
(N-(1-phenethylpiperidin-4-yl)-Nphenylcyclopentanecarboxamide),
isobutyryl fentanyl (N-(1phenethylpiperidin-4-yl)-Nphenylisobutyramide), parachloroisobutyryl fentanyl (N-(4chlorophenyl)-N-(1-phenethylpiperidin4-yl)isobutyramide), paramethoxybutyryl fentanyl (N-(4methoxyphenyl)-N-(1phenethylpiperidin-4-yl)butyramide),
and valeryl fentanyl (N-(1phenethylpiperidin-4-yl)-Nphenylpentanamide) in schedule I of the
Controlled Substances Act (CSA),
specifically to the opiates list under 21
CFR 1308.11(b). 85 FR 75231. The final
rule incorrectly assigned paragraph
numbers 22, 40, 56, and 59 under
paragraph (b) to cyclopentyl fentanyl,
isobutyryl fentanyl, parachloroisobutyryl fentanyl, and paramethoxybutyryl fentanyl, respectively,
overriding previously assigned
paragraph numbers for four listed
SUPPLEMENTARY INFORMATION:
opiates crotonyl fentanyl,
ketobemidone, para-fluorofentanyl, and
phenampromide (i.e., (b)(22), (40), (56),
and (59)). In addition, the final rule
incorrectly added valeryl fentanyl as a
new paragraph (b)(75) instead of (b)(76).
This document updates the numbering
of all listed opiates in paragraph (b), and
specifically corrects the paragraph
numbers for cyclopentyl fentanyl,
isobutyryl fentanyl, parachloroisobutyryl fentanyl, paramethoxybutyryl fentanyl, and valeryl
fentanyl, and reassigns paragraph
numbers for crotonyl fentanyl,
ketobemidone, para-fluorofentanyl, and
phenampromide. It bears emphasis that
DEA still considers the four substances
(crotonyl fentanyl, ketobemidone, parafluorofentanyl, and phenampromide) to
have been schedule I substances during
the time period from the issuance of the
November 25, 2020, final rule to this
correction, despite these inadvertent
numbering errors.1
List of Subjects in 21 CFR Part 1308
Administrative practice and
procedure, Drug traffic control,
Reporting and recordkeeping
requirements.
For the reasons set out above, 21 CFR
part 1308 is amended as follows:
PART 1308—SCHEDULES OF
CONTROLLED SUBSTANCES
1. The authority citation for 21 CFR
part 1308 continues to read as follows:
■
Authority: 21 U.S.C. 811, 812, 871(b),
956(b), unless otherwise noted.
2. In § 1308.11(b), revise the table to
read as follows:
■
§ 1308.11
*
Schedule I.
*
*
(b) * * *
*
*
(1) Acetyl-alpha-methylfentanyl (N-[1-(1-methyl-2-phenethyl)-4-piperidinyl]-N-phenylacetamide) ...................................................
(2) Acetylmethadol .....................................................................................................................................................................................
(3) Acetyl fentanyl (N-(1-phenethylpiperidin-4-yl)-N-phenylacetamide) ...............................................................................................
(4) Acryl fentanyl (N-(1-phenethylpiperidin-4-yl)-N-phenylacrylamide; also known as acryloylfentanyl) .........................................
(5) AH–7921 (3,4-dichloro-N-[(1-dimethylamino)cyclohexylmethyl]benzamide) ..................................................................................
(6) Allylprodine ..........................................................................................................................................................................................
(7) Alphacetylmethadol (except levo-alphacetylmethadol also known as levo-alpha-acetylmethadol, levomethadyl acetate, or
LAAM) .....................................................................................................................................................................................................
(8) Alphameprodine ...................................................................................................................................................................................
(9) Alphamethadol ......................................................................................................................................................................................
1 Under the CSA, a controlled substance may only
be removed from the schedules, or transferred to
another schedule, where DEA expressly does so by
a scheduling action issued in accordance with 21
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U.S.C. 811 and published in the Federal Register.
DEA took no such action with respect to crotonyl
fentanyl, ketobemidone, para-fluorofentanyl, and
phenampromide. Accordingly, the scheduling
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status of these four substances was never altered by
the final rule that appeared in the Federal Register
on November 25, 2020.
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Federal Register / Vol. 86, No. 60 / Wednesday, March 31, 2021 / Rules and Regulations
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(10) alpha-Methylfentanyl (N-[1-(alpha-methyl-beta-phenyl)ethyl-4-piperidyl]propionanilide; 1-(1-methyl-2-phenylethyl)-4-(Npropanilido)piperidine) ..........................................................................................................................................................................
(11) alpha-Methylthiofentanyl (N-[1-methyl-2-(2-thienyl)ethyl-4-piperidinyl]-N-phenylpropanamide) ..............................................
(12) Benzethidine .......................................................................................................................................................................................
(13) Betacetylmethadol ...............................................................................................................................................................................
(14) beta-Hydroxyfentanyl (N-[1-(2-hydroxy-2-phenethyl)-4-piperidinyl]-N-phenylpropanamide) ......................................................
(15) beta-Hydroxy-3-methylfentanyl (N-[1-(2-hydroxy-2-phenylethyl)-3-methyl-4-piperidinyl]-N-phenylpropanamide) ..................
(16) beta-Hydroxythiofentanyl (N-[1-[2-hydroxy-2-(thiophen-2-yl)ethyl]piperidin-4-yl]-N-phenylpropionamide) .............................
(17) Betameprodine ....................................................................................................................................................................................
(18) Betamethadol .......................................................................................................................................................................................
(19) Betaprodine .........................................................................................................................................................................................
(20) Butyryl fentanyl (N-(1-phenethylpiperidin-4-yl)-N-phenylbutyramide) .........................................................................................
(21) Clonitazene ..........................................................................................................................................................................................
(22) Crotonyl fentanyl ((E)-N-(1-phenethylpiperidin-4-yl)-N-phenylbut-2-enamide) .............................................................................
(23) Cyclopentyl fentanyl (N-(1-phenethylpiperidin-4-yl)-N-phenylcyclopentanecarboxamide) ..........................................................
(24) Cyclopropyl fentanyl (N-(1-phenethylpiperidin-4-yl)-N-phenylcyclopropanecarboxamide) .........................................................
(25) Dextromoramide ..................................................................................................................................................................................
(26) Diampromide .......................................................................................................................................................................................
(27) Diethylthiambutene ............................................................................................................................................................................
(28) Difenoxin .............................................................................................................................................................................................
(29) Dimenoxadol .......................................................................................................................................................................................
(30) Dimepheptanol ....................................................................................................................................................................................
(31) Dimethylthiambutene .........................................................................................................................................................................
(32) Dioxaphetyl butyrate ..........................................................................................................................................................................
(33) Dipipanone ..........................................................................................................................................................................................
(34) Ethylmethylthiambutene ....................................................................................................................................................................
(35) Etonitazene ..........................................................................................................................................................................................
(36) Etoxeridine ..........................................................................................................................................................................................
(37) 4-Fluoroisobutyryl fentanyl (N-(4-fluorophenyl)-N-(1-phenethylpiperidin-4-yl)isobutyramide; also known as parafluoroisobutyryl fentanyl) .......................................................................................................................................................................
(38) Furanyl fentanyl (N-(1-phenethylpiperidin-4-yl)-N-phenylfuran-2-carboxamide) .........................................................................
(39) Furethidine ..........................................................................................................................................................................................
(40) Hydroxypethidine ...............................................................................................................................................................................
(41) Isobutyryl fentanyl (N-(1-phenethylpiperidin-4-yl)-N-phenylisobutyramide) ................................................................................
(42) Ketobemidone .....................................................................................................................................................................................
(43) Levomoramide .....................................................................................................................................................................................
(44) Levophenacylmorphan .......................................................................................................................................................................
(45) Methoxyacetyl fentanyl (2-methoxy-N-(1-phenethylpiperidin-4-yl)-N-phenylacetamide) .............................................................
(46) 3-Methylfentanyl (N-[3-methyl-1-(2-phenylethyl)-4-piperidyl]-N-phenylpropanamide) ................................................................
(47) 3-Methylthiofentanyl (N-[3-methyl-1-(2-thienylethyl)-4-piperidinyl]-N-phenylpropanamide) .....................................................
(48) Morpheridine ......................................................................................................................................................................................
(49) MPPP (1-methyl-4-phenyl-4-propionoxypiperidine) ........................................................................................................................
(50) MT–45 (1-cyclohexyl-4-(1,2-diphenylethyl)piperazine) ...................................................................................................................
(51) Noracymethadol ..................................................................................................................................................................................
(52) Norlevorphanol ...................................................................................................................................................................................
(53) Normethadone .....................................................................................................................................................................................
(54) Norpipanone ........................................................................................................................................................................................
(55) Ocfentanil (N-(2-fluorophenyl)-2-methoxy-N-(1-phenethylpiperidin-4-yl)acetamide) ...................................................................
(56) ortho-Fluorofentanyl (N-(2-fluorophenyl)-N-(1-phenethylpiperidin-4-yl)propionamide); also known as 2-fluorofentanyl) .......
(57) para-Chloroisobutyryl fentanyl (N-(4-chlorophenyl)-N-(1-phenethylpiperidin-4-yl)isobutyramide) ............................................
(58) para-Fluorobutyryl fentanyl (N-(4-fluorophenyl)-N-(1-phenethylpiperidin-4-yl)butyramide) ......................................................
(59) para-Fluorofentanyl (N-(4-fluorophenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]propanamide) ........................................................
(60) para-Methoxybutyryl fentanyl (N-(4-methoxyphenyl)-N-(1-phenethylpiperidin-4-yl)butyramide) ..............................................
(61) PEPAP (1-(2-phenylethyl)-4-phenyl-4-acetoxypiperidine) ...............................................................................................................
(62) Phenadoxone .......................................................................................................................................................................................
(63) Phenampromide ..................................................................................................................................................................................
(64) Phenomorphan ....................................................................................................................................................................................
(65) Phenoperidine .....................................................................................................................................................................................
(66) Piritramide ...........................................................................................................................................................................................
(67) Proheptazine ........................................................................................................................................................................................
(68) Properidine ..........................................................................................................................................................................................
(69) Propiram ..............................................................................................................................................................................................
(70) Racemoramide .....................................................................................................................................................................................
(71) Tetrahydrofuranyl fentanyl (N-(1-phenethylpiperidin-4-yl)-N-phenyltetrahydrofuran-2-carboxamide) .......................................
(72) Thiofentanyl (N-phenyl-N-[1-(2-thienyl)ethyl-4-piperidinyl]propanamide) ...................................................................................
(73) Tilidine ................................................................................................................................................................................................
(74) Trimeperidine .....................................................................................................................................................................................
(75) U–47700 (3,4-dichloro-N-[2-(dimethylamino)cyclohexyl]-N-methylbenzamide) ............................................................................
(76) Valeryl fentanyl (N-(1-phenethylpiperidin-4-yl)-N-phenylpentanamide) .......................................................................................
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Federal Register / Vol. 86, No. 60 / Wednesday, March 31, 2021 / Rules and Regulations
*
*
*
*
effective date of that rule, if the effective
date is earlier than April 16, 2022.
FOR FURTHER INFORMATION CONTACT:
Terrence L. Boos, Drug and Chemical
Evaluation Section, Drug Enforcement
Administration; Telephone: (571) 362–
3249.
*
D. Christopher Evans,
Acting Administrator.
[FR Doc. 2021–06596 Filed 3–30–21; 8:45 am]
BILLING CODE 4410–09–P
DEPARTMENT OF JUSTICE
SUPPLEMENTARY INFORMATION:
Drug Enforcement Administration
Background and Legal Authority
21 CFR Part 1308
[Docket No. DEA–491]
Schedules of Controlled Substances:
Extension of Temporary Placement of
5F–EDMB–PINACA, 5F–MDMB–PICA,
FUB–AKB48, 5F–CUMYL–PINACA and
FUB–144 in Schedule I of the
Controlled Substances Act
Drug Enforcement
Administration, Department of Justice.
ACTION: Temporary rule; temporary
scheduling order; extension.
AGENCY:
The Acting Administrator of
the Drug Enforcement Administration is
issuing this order to extend the
temporary schedule I status of ethyl 2(1-(5-fluoropentyl)-1H-indazole-3carboxamido)-3,3-dimethylbutanoate
(trivial name: 5F–EDMB–PINACA);
methyl 2-(1-(5-fluoropentyl)-1H-indole3-carboxamido)-3,3-dimethylbutanoate
(trivial name: 5F–MDMB–PICA); N(adamantan-1-yl)-1-(4-fluorobenzyl)-1Hindazole-3-carboxamide (trivial names:
FUB–AKB48; FUB–APINACA; AKB48
N-(4-fluorobenzyl)); 1-(5-fluoropentyl)N-(2-phenylpropan-2-yl)-1H-indazole-3carboxamide (trivial names: 5F–
CUMYL–PINACA; SGT–25); and (1-(4fluorobenzyl)-1H-indol-3-yl)(2,2,3,3tetramethylcyclopropyl)methanone
(trivial name: FUB–144), and their
optical, positional, and geometric
isomers, salts, and salts of isomers. The
schedule I status of 5F–EDMB–PINACA,
5F–MDMB–PICA, FUB–AKB48, 5F–
CUMYL–PINACA and FUB–144
currently is in effect until April 16,
2021. This temporary order will extend
the temporary scheduling of 5F–EDMB–
PINACA, 5F–MDMB–PICA, FUB–
AKB48, 5F–CUMYL–PINACA and FUB–
144 for one year or until the permanent
scheduling action for these substances is
completed, whichever occurs first.
DATES: This order, which extends the
temporary scheduling order that DEA
previously issued for these substances
(84 FR 15505, April 16, 2019), is
effective April 16, 2021, and expires on
April 16, 2022. If DEA publishes a final
rule making this scheduling action
permanent, this order will expire on the
jbell on DSKJLSW7X2PROD with RULES
SUMMARY:
VerDate Sep<11>2014
15:38 Mar 30, 2021
Jkt 253001
On April 16, 2019, the former Acting
Administrator of the Drug Enforcement
Administration (DEA) published a
temporary scheduling order in the
Federal Register (84 FR 15505) placing
ethyl 2-(1-(5-fluoropentyl)-1H-indazole3-carboxamido)-3,3-dimethylbutanoate
(trivial name: 5F–EDMB–PINACA);
methyl 2-(1-(5-fluoropentyl)-1H-indole3-carboxamido)-3,3-dimethylbutanoate
(trivial name: 5F–MDMB–PICA); N(adamantan-1-yl)-1-(4-fluorobenzyl)-1Hindazole-3-carboxamide (trivial names:
FUB–AKB48; FUB–APINACA; AKB48
N-(4-fluorobenzyl)); 1-(5-fluoropentyl)N-(2-phenylpropan-2-yl)-1H-indazole-3carboxamide (trivial names: 5F–
CUMYL–PINACA; SGT–25); and (1-(4fluorobenzyl)-1H-indol-3-yl)(2,2,3,3tetramethylcyclopropyl)methanone
(trivial name: FUB–144) in schedule I of
the Controlled Substances Act (CSA)
pursuant to the temporary scheduling
provisions of 21 U.S.C. 811(h). That
order was effective on the date of
publication, and was based on findings
by the former Acting Administrator of
DEA that the temporary scheduling of
these substances was necessary to avoid
an imminent hazard to the public safety
pursuant to subsection (h)(1).
Subsection (h)(2) requires that the
temporary control of these substances
expire two years from the effective date
of the scheduling order, i.e., on April 16,
2021. However, this same subsection
also provides that during the pendency
of proceedings under 21 U.S.C. 811(a)(1)
with respect to the substance, the
temporary scheduling 1 of that substance
may be extended for up to one year.
Proceedings for the scheduling of a
substance under 21 U.S.C. 811(a) may
be initiated by the Attorney General
(delegated to the Administrator of DEA
pursuant to 28 CFR 0.100) on his own
motion, at the request of the Secretary
of Health and Human Services (HHS),2
1 Though DEA has used the term ‘‘final order’’
with respect to temporary scheduling orders in the
past, this notice adheres to the statutory language
of 21 U.S.C. 811(h), which refers to a ‘‘temporary
scheduling order.’’ No substantive change is
intended.
2 The Secretary of HHS has delegated to the
Assistant Secretary for Health of HHS the authority
to make domestic drug scheduling
recommendations.
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16669
or on the petition of any interested
party.
The Acting Administrator of DEA, on
his own motion, has initiated
proceedings under 21 U.S.C. 811(a)(1) to
permanently schedule 5F–EDMB–
PINACA, 5F–MDMB–PICA, FUB–
AKB48, 5F–CUMYL–PINACA and FUB–
144. DEA is simultaneously publishing
a notice of proposed rulemaking for the
placement of 5F–EDMB–PINACA, 5F–
MDMB–PICA, FUB–AKB48, 5F–
CUMYL–PINACA and FUB–144 in
schedule I elsewhere in this issue of the
Federal Register. If that proposed rule is
finalized, DEA will publish a final rule
in the Federal Register to make
permanent the schedule I status of these
substances.
Pursuant to 21 U.S.C. 811(h)(2), the
Acting Administrator orders that the
temporary scheduling of 5F–EDMB–
PINACA, 5F–MDMB–PICA, FUB–
AKB48, 5F–CUMYL–PINACA and FUB–
144, and their optical, positional, and
geometric isomers, salts, and salts of
isomers, be extended for one year, or
until the permanent scheduling
proceeding is completed, whichever
occurs first.
Regulatory Matters
The CSA provides for an expedited
temporary scheduling action where the
Attorney General, as delegated to the
Administrator of DEA, may, by order,
place a substance in schedule I if such
action is necessary to avoid an
imminent hazard to the public safety. 21
U.S.C. 811(h). That same subsection also
provides that the temporary scheduling
of a substance shall expire at the end of
two years from the date of the issuance
of such temporary scheduling order,
except that the Attorney General may,
during the pendency of proceedings
under 21 U.S.C. 811(a)(1) to
permanently schedule the substance,
extend the temporary scheduling for up
to one year.
To the extent that subsection 811(h)
directs that temporary scheduling
actions be issued by order and sets forth
the procedures by which such orders are
to be issued and extended, DEA believes
that the notice and comment
requirements of section 553 of the
Administrative Procedure Act, 5 U.S.C.
553, do not apply to this extension of
the temporary scheduling action. The
specific language chosen by Congress
indicates an intention for DEA to
proceed through the issuance of an
order instead of proceeding by
rulemaking. Given that Congress
specifically requires the Attorney
General to follow rulemaking
procedures for other kinds of scheduling
actions, see 21 U.S.C. 811(a), it is
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]]>Agencies
[Federal Register Volume 86, Number 60 (Wednesday, March 31, 2021)]
[Rules and Regulations]
[Pages 16667-16669]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2021-06596]
========================================================================
Rules and Regulations
Federal Register
________________________________________________________________________
This section of the FEDERAL REGISTER contains regulatory documents
having general applicability and legal effect, most of which are keyed
to and codified in the Code of Federal Regulations, which is published
under 50 titles pursuant to 44 U.S.C. 1510.
The Code of Federal Regulations is sold by the Superintendent of Documents.
========================================================================
Federal Register / Vol. 86, No. 60 / Wednesday, March 31, 2021 /
Rules and Regulations
[[Page 16667]]
DEPARTMENT OF JUSTICE
Drug Enforcement Administration
21 CFR Part 1308
[Docket No. DEA-565]
Schedules of Controlled Substances: Placement of cyclopentyl
fentanyl, isobutyryl fentanyl, para-chloroisobutyryl fentanyl, para-
methoxybutyryl fentanyl, and valeryl fentanyl in Schedule I; Correction
AGENCY: Drug Enforcement Administration, Department of Justice.
ACTION: Final rule; correcting amendment.
-----------------------------------------------------------------------
SUMMARY: The Drug Enforcement Administration is correcting a final rule
that appeared in the Federal Register on November 25, 2020. The
document issued an action placing five fentanyl-related substances
(cyclopentyl fentanyl (N-(1-phenethylpiperidin-4-yl)-N-
phenylcyclopentanecarboxamide), isobutyryl fentanyl (N-(1-
phenethylpiperidin-4-yl)-N-phenylisobutyramide), para-chloroisobutyryl
fentanyl (N-(4-chlorophenyl)-N-(1-phenethylpiperidin-4-
yl)isobutyramide), para-methoxybutyryl fentanyl (N-(4-methoxyphenyl)-N-
(1-phenethylpiperidin-4-yl)butyramide), and valeryl fentanyl (N-(1-
phenethylpiperidin-4-yl)-N-phenylpentanamide), including their isomers,
esters, ethers, salts, and salts of isomers, esters, and ethers,
permanently in schedule I of the Controlled Substances Act,
specifically to the opiates list under DEA regulations. The published
document assigned incorrect paragraph numbers to all five substances,
and inadvertently removed four other substances from the listed
opiates.
DATES: Effective date: March 31, 2021.
FOR FURTHER INFORMATION CONTACT: Terrence L. Boos, Drug and Chemical
Evaluation Section, Diversion Control Division, Drug Enforcement
Administration; Telephone: (571) 362-3249.
SUPPLEMENTARY INFORMATION: On November 25, 2020, the Drug Enforcement
Administration (DEA) permanently placed five fentanyl-related
substances (cyclopentyl fentanyl (N-(1-phenethylpiperidin-4-yl)-N-
phenylcyclopentanecarboxamide), isobutyryl fentanyl (N-(1-
phenethylpiperidin-4-yl)-N-phenylisobutyramide), para-chloroisobutyryl
fentanyl (N-(4-chlorophenyl)-N-(1-phenethylpiperidin-4-
yl)isobutyramide), para-methoxybutyryl fentanyl (N-(4-methoxyphenyl)-N-
(1-phenethylpiperidin-4-yl)butyramide), and valeryl fentanyl (N-(1-
phenethylpiperidin-4-yl)-N-phenylpentanamide) in schedule I of the
Controlled Substances Act (CSA), specifically to the opiates list under
21 CFR 1308.11(b). 85 FR 75231. The final rule incorrectly assigned
paragraph numbers 22, 40, 56, and 59 under paragraph (b) to cyclopentyl
fentanyl, isobutyryl fentanyl, para-chloroisobutyryl fentanyl, and
para-methoxybutyryl fentanyl, respectively, overriding previously
assigned paragraph numbers for four listed opiates crotonyl fentanyl,
ketobemidone, para-fluorofentanyl, and phenampromide (i.e., (b)(22),
(40), (56), and (59)). In addition, the final rule incorrectly added
valeryl fentanyl as a new paragraph (b)(75) instead of (b)(76). This
document updates the numbering of all listed opiates in paragraph (b),
and specifically corrects the paragraph numbers for cyclopentyl
fentanyl, isobutyryl fentanyl, para-chloroisobutyryl fentanyl, para-
methoxybutyryl fentanyl, and valeryl fentanyl, and reassigns paragraph
numbers for crotonyl fentanyl, ketobemidone, para-fluorofentanyl, and
phenampromide. It bears emphasis that DEA still considers the four
substances (crotonyl fentanyl, ketobemidone, para-fluorofentanyl, and
phenampromide) to have been schedule I substances during the time
period from the issuance of the November 25, 2020, final rule to this
correction, despite these inadvertent numbering errors.\1\
---------------------------------------------------------------------------
\1\ Under the CSA, a controlled substance may only be removed
from the schedules, or transferred to another schedule, where DEA
expressly does so by a scheduling action issued in accordance with
21 U.S.C. 811 and published in the Federal Register. DEA took no
such action with respect to crotonyl fentanyl, ketobemidone, para-
fluorofentanyl, and phenampromide. Accordingly, the scheduling
status of these four substances was never altered by the final rule
that appeared in the Federal Register on November 25, 2020.
---------------------------------------------------------------------------
List of Subjects in 21 CFR Part 1308
Administrative practice and procedure, Drug traffic control,
Reporting and recordkeeping requirements.
For the reasons set out above, 21 CFR part 1308 is amended as
follows:
PART 1308--SCHEDULES OF CONTROLLED SUBSTANCES
0
1. The authority citation for 21 CFR part 1308 continues to read as
follows:
Authority: 21 U.S.C. 811, 812, 871(b), 956(b), unless otherwise
noted.
0
2. In Sec. 1308.11(b), revise the table to read as follows:
Sec. 1308.11 Schedule I.
* * * * *
(b) * * *
(1) Acetyl-alpha-methylfentanyl (N-[1-(1-methyl-2-phenethyl)- 9815
4-piperidinyl]-N-phenylacetamide)...........................
(2) Acetylmethadol........................................... 9601
(3) Acetyl fentanyl (N-(1-phenethylpiperidin-4-yl)-N- 9821
phenylacetamide)............................................
(4) Acryl fentanyl (N-(1-phenethylpiperidin-4-yl)-N- 9811
phenylacrylamide; also known as acryloylfentanyl)...........
(5) AH-7921 (3,4-dichloro-N-[(1- 9551
dimethylamino)cyclohexylmethyl]benzamide)...................
(6) Allylprodine............................................. 9602
(7) Alphacetylmethadol (except levo-alphacetylmethadol also 9603
known as levo-alpha-acetylmethadol, levomethadyl acetate, or
LAAM).......................................................
(8) Alphameprodine........................................... 9604
(9) Alphamethadol............................................ 9605
[[Page 16668]]
(10) alpha-Methylfentanyl (N-[1-(alpha-methyl-beta- 9814
phenyl)ethyl-4-piperidyl]propionanilide; 1-(1-methyl-2-
phenylethyl)-4-(N-propanilido)piperidine)...................
(11) alpha-Methylthiofentanyl (N-[1-methyl-2-(2-thienyl)ethyl- 9832
4-piperidinyl]-N-phenylpropanamide).........................
(12) Benzethidine............................................ 9606
(13) Betacetylmethadol....................................... 9607
(14) beta-Hydroxyfentanyl (N-[1-(2-hydroxy-2-phenethyl)-4- 9830
piperidinyl]-N-phenylpropanamide)...........................
(15) beta-Hydroxy-3-methylfentanyl (N-[1-(2-hydroxy-2- 9831
phenylethyl)-3-methyl-4-piperidinyl]-N-phenylpropanamide)...
(16) beta-Hydroxythiofentanyl (N-[1-[2-hydroxy-2-(thiophen-2- 9836
yl)ethyl]piperidin-4-yl]-N-phenylpropionamide)..............
(17) Betameprodine........................................... 9608
(18) Betamethadol............................................ 9609
(19) Betaprodine............................................. 9611
(20) Butyryl fentanyl (N-(1-phenethylpiperidin-4-yl)-N- 9822
phenylbutyramide)...........................................
(21) Clonitazene............................................. 9612
(22) Crotonyl fentanyl ((E)-N-(1-phenethylpiperidin-4-yl)-N- 9844
phenylbut-2-enamide)........................................
(23) Cyclopentyl fentanyl (N-(1-phenethylpiperidin-4-yl)-N- 9847
phenylcyclopentanecarboxamide)..............................
(24) Cyclopropyl fentanyl (N-(1-phenethylpiperidin-4-yl)-N- 9845
phenylcyclopropanecarboxamide)..............................
(25) Dextromoramide.......................................... 9613
(26) Diampromide............................................. 9615
(27) Diethylthiambutene...................................... 9616
(28) Difenoxin............................................... 9168
(29) Dimenoxadol............................................. 9617
(30) Dimepheptanol........................................... 9618
(31) Dimethylthiambutene..................................... 9619
(32) Dioxaphetyl butyrate.................................... 9621
(33) Dipipanone.............................................. 9622
(34) Ethylmethylthiambutene.................................. 9623
(35) Etonitazene............................................. 9624
(36) Etoxeridine............................................. 9625
(37) 4-Fluoroisobutyryl fentanyl (N-(4-fluorophenyl)-N-(1- 9824
phenethylpiperidin-4-yl)isobutyramide; also known as para-
fluoroisobutyryl fentanyl)..................................
(38) Furanyl fentanyl (N-(1-phenethylpiperidin-4-yl)-N- 9834
phenylfuran-2-carboxamide)..................................
(39) Furethidine............................................. 9626
(40) Hydroxypethidine........................................ 9627
(41) Isobutyryl fentanyl (N-(1-phenethylpiperidin-4-yl)-N- 9827
phenylisobutyramide)........................................
(42) Ketobemidone............................................ 9628
(43) Levomoramide............................................ 9629
(44) Levophenacylmorphan..................................... 9631
(45) Methoxyacetyl fentanyl (2-methoxy-N-(1- 9825
phenethylpiperidin-4-yl)-N-phenylacetamide).................
(46) 3-Methylfentanyl (N-[3-methyl-1-(2-phenylethyl)-4- 9813
piperidyl]-N-phenylpropanamide).............................
(47) 3-Methylthiofentanyl (N-[3-methyl-1-(2-thienylethyl)-4- 9833
piperidinyl]-N-phenylpropanamide)...........................
(48) Morpheridine............................................ 9632
(49) MPPP (1-methyl-4-phenyl-4-propionoxypiperidine)......... 9661
(50) MT-45 (1-cyclohexyl-4-(1,2-diphenylethyl)piperazine).... 9560
(51) Noracymethadol.......................................... 9633
(52) Norlevorphanol.......................................... 9634
(53) Normethadone............................................ 9635
(54) Norpipanone............................................. 9636
(55) Ocfentanil (N-(2-fluorophenyl)-2-methoxy-N-(1- 9838
phenethylpiperidin-4-yl)acetamide)..........................
(56) ortho-Fluorofentanyl (N-(2-fluorophenyl)-N-(1- 9816
phenethylpiperidin-4-yl)propionamide); also known as 2-
fluorofentanyl).............................................
(57) para-Chloroisobutyryl fentanyl (N-(4-chlorophenyl)-N-(1- 9826
phenethylpiperidin-4-yl)isobutyramide)......................
(58) para-Fluorobutyryl fentanyl (N-(4-fluorophenyl)-N-(1- 9823
phenethylpiperidin-4-yl)butyramide).........................
(59) para-Fluorofentanyl (N-(4-fluorophenyl)-N-[1-(2- 9812
phenylethyl)-4-piperidinyl]propanamide).....................
(60) para-Methoxybutyryl fentanyl (N-(4-methoxyphenyl)-N-(1- 9837
phenethylpiperidin-4-yl)butyramide).........................
(61) PEPAP (1-(2-phenylethyl)-4-phenyl-4-acetoxypiperidine).. 9663
(62) Phenadoxone............................................. 9637
(63) Phenampromide........................................... 9638
(64) Phenomorphan............................................ 9647
(65) Phenoperidine........................................... 9641
(66) Piritramide............................................. 9642
(67) Proheptazine............................................ 9643
(68) Properidine............................................. 9644
(69) Propiram................................................ 9649
(70) Racemoramide............................................ 9645
(71) Tetrahydrofuranyl fentanyl (N-(1-phenethylpiperidin-4- 9843
yl)-N-phenyltetrahydrofuran-2-carboxamide)..................
(72) Thiofentanyl (N-phenyl-N-[1-(2-thienyl)ethyl-4- 9835
piperidinyl]propanamide)....................................
(73) Tilidine................................................ 9750
(74) Trimeperidine........................................... 9646
(75) U-47700 (3,4-dichloro-N-[2-(dimethylamino)cyclohexyl]-N- 9547
methylbenzamide)............................................
(76) Valeryl fentanyl (N-(1-phenethylpiperidin-4-yl)-N- 9840
phenylpentanamide)..........................................
[[Page 16669]]
* * * * *
D. Christopher Evans,
Acting Administrator.
[FR Doc. 2021-06596 Filed 3-30-21; 8:45 am]
BILLING CODE 4410-09-P
