Government-Owned Inventions; Availability for Licensing, 61958-61959 [2020-21710]

Download as PDF 61958 Federal Register / Vol. 85, No. 191 / Thursday, October 1, 2020 / Notices as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. jbell on DSKJLSW7X2PROD with NOTICES Name of Committee: National Heart, Lung, and Blood Advisory Council. Date: October 27, 2020. Closed: 10:00 a.m. to 12:00 p.m. Agenda: To Review and Evaluate Grant Applications and/or Proposals. Place: NIH, Bethesda, MD (Virtual Meeting). Open: 12:30 p.m. to 5:00 p.m. Agenda: To Discuss Program Policies and Issues. Place: NIH, Bethesda, MD (Virtual Meeting). Virtual Access: The meeting will be videocast and can be accessed from the NIH Videocast. https://www.nhlbi.nih.gov/about/ advisory-and-peer-review-committees/ advisory-council. Please note, the link to the videocast meeting will be posted within a week of the meeting date. Contact Person: Laura K. Moen, Ph.D., Director, Division of Extramural Research Activities, National Heart, Lung, and Blood Institute, National Institutes of Health, 6705 Rockledge Drive, Room 206–Q, Bethesda, MD 20892, 301–827–5517, moenl@mail.nih.gov. Any interested person may file written comments with the committee by forwarding the statement to the Contact Person listed on this notice. The statement should include the name, address, telephone number and when applicable, the business or professional affiliation of the interested person. Any member of the public may submit written comments no later than 15 days after the meeting. Information is also available on the Institute’s/Center’s home page: www.nhlbi.nih.gov/meetings/nhlbac/ index.htm, where an agenda and any additional information for the meeting will be posted when available. (Catalogue of Federal Domestic Assistance Program Nos. 93.233, National Center for Sleep Disorders Research; 93.837, Heart and Vascular Diseases Research; 93.838, Lung Diseases Research; 93.839, Blood Diseases and Resources Research, National Institutes of Health, HHS) Dated: September 25, 2020. Ronald J. Livingston, Jr., Program Analyst, Office of Federal Advisory Committee Policy. [FR Doc. 2020–21673 Filed 9–30–20; 8:45 am] 22:13 Sep 30, 2020 National Institutes of Health National Human Genome Research Institute; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended, notice is hereby given of the following meeting. The meeting will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research Institute Special Emphasis Panel; Advancing Genomic Medicine Research. Date: December 1, 2020. Time: 2:00 p.m. to 5:00 p.m. Agenda: To review and evaluate grant applications. Place: National Human Genome Research Institute, National Institutes of Health, 6700B Rockledge Drive, Suite 300, Bethesda, MD 20892 (Virtual Meeting). Contact Person: Barbara J. Thomas, Ph.D., Scientific Review Officer, Scientific Review Branch, National Human Genome Research Institute, National Institutes of Health, 6700B Rockledge Drive, Suite 300, Bethesda, MD 20892–9306, 301–402–0838, barbara.thomas@nih.gov. (Catalogue of Federal Domestic Assistance Program Nos. 93.172, Human Genome Research, National Institutes of Health, HHS) Dated: September 25, 2020. Melanie J. Pantoja, Program Analyst, Office of Federal Advisory Committee Policy. [FR Doc. 2020–21674 Filed 9–30–20; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Government-Owned Inventions; Availability for Licensing AGENCY: National Institutes of Health, HHS. ACTION: Notice. The inventions listed below are owned by an agency of the U.S. Government and are available for licensing in the U.S. to achieve SUMMARY: BILLING CODE 4140–01–P VerDate Sep<11>2014 DEPARTMENT OF HEALTH AND HUMAN SERVICES Jkt 253001 PO 00000 Frm 00040 Fmt 4703 Sfmt 4703 expeditious commercialization of results of federally-funded research and development. FOR FURTHER INFORMATION CONTACT: Licensing information may be obtained by emailing Brian W. Bailey, Ph.D., bbailey@mail.nih.gov, the indicated licensing contact at the National Heart, Lung, and Blood, Office of Technology Transfer and Development Office of Technology Transfer, 31 Center Drive, Room 4A29, MSC2479, Bethesda, MD 20892–2479; telephone: 301–402–5579. A signed Confidential Disclosure Agreement may be required to receive any unpublished information. SUPPLEMENTARY INFORMATION: Technology description follows. Methods To Produce Very Long-Chain Fatty Acids (VLCFA) Available for licensing and commercial development are patent rights covering methods for synthetically producing highly pure, polyunsaturated very long-chain fatty acids (C20–C40) that are highly scalable, do not require toxic mercury, and are applicable to the synthesis of highly deuterated (≤90%), partially deuterated, and non-deuterated lipids. VLCFAs, while present in very small concentrations in living organisms, nonetheless play vital roles in certain biological processes. The present invention addresses an unmet need for VLCFAs for experimental and therapeutic uses that is currently inadequately met through labor intensive and time consuming extractions from natural sources or technically difficult overexpression in cell cultures, which give very small yields. This invention also includes a method for treating and preventing macular degeneration using VLCFAs. This technology is available for licensing for commercial development in accordance with 35 U.S.C. 209 and 37 CFR part 404. Potential Commercial Applications: • Synthesis of very-long chain fatty acids for in vitro and in vivo research purposes • Synthesis of very-long chain fatty acids for therapeutic purposes • Treatment and prevention of macular degeneration, inflammatory disorders and other disorders and conditions associated with very long-chain fatty acid deficiencies Development Stage: • Preclinical • Mouse data Inventors: Rolf Swenson (NHLBI), Zhen-Dan Shi (NHLBI), Zhi-Hong Yang (NHLBI) and Alan Remaley (NHLBI). E:\FR\FM\01OCN1.SGM 01OCN1 Federal Register / Vol. 85, No. 191 / Thursday, October 1, 2020 / Notices Intellectual Property: HHS Reference No. E–126–2020–0–US–01 ; U.S Patent Application 63/072,519 filed August 31, 2020. Licensing Contact: Brian W. Bailey, Ph.D.; 301–594–4094; bbailey@ mail.nih.gov. Dated: September 25, 2020. National Heart, Lung, and Blood Institute, Office of Technology Transfer and Development. Potential Commercial Applications Development of EMP2 inhibitor for treatment of neutrophil-dependent lung disorders, such as: [FR Doc. 2020–21710 Filed 9–30–20; 8:45 am] BILLING CODE 4140–01–P • • • • • DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Government-Owned Inventions; Availability for Licensing AGENCY: National Institutes of Health, HHS. ACTION: Notice. The inventions listed below are owned by an agency of the U.S. Government and are available for licensing to achieve expeditious commercialization of results of federally-funded research and development. FOR FURTHER INFORMATION CONTACT: Licensing information may be obtained by communicating with Vidita Choudhry, Ph.D., National Heart, Lung, and Blood, Office of Technology Transfer and Development, 31 Center Drive, Room 4A29, MSC2479, Bethesda, MD 20892–2479; telephone: 301–594– 4095; email: vidita.choudhry@nih.gov. A signed Confidential Disclosure Agreement may be required to receive any unpublished information. SUPPLEMENTARY INFORMATION: Technology description follows. jbell on DSKJLSW7X2PROD with NOTICES SUMMARY: Reducing Bloodstream Neutrophils as a Treatment for Lung Infection and Inflammation During lung infection, bloodstream neutrophils (PMNs) responding to infection travel to the airspace lumen. Although successful arrival of microbicidal PMNs to the airspace is essential for host defense against inhaled pathogens, excessive accumulation of PMNs in the lung contributes to the pathogenesis of several prevalent lung disorders, including acute lung injury, bronchiectasis, and chronic obstructive pulmonary disease (COPD). Unfortunately, there is no treatment for controlling PMN accumulation in the lung. The subject invention describes epithelial membrane protein 2 (EMP2) VerDate Sep<11>2014 22:13 Sep 30, 2020 Jkt 253001 as a lung epithelial protein that regulates PMN entry into the inflamed airspace. EMP2 knockout mice have reduced PMN accumulation and exhibit increased survival during bacterial infection. Inhibition of EMP2 can potentially reduce intra airway PMN accumulation and provide a specific treatment for various lung disorders. Acute lung injury pneumonia (bacterial, viral, fungal) bronchiectasis COPD and asthma radiation- or chemotherapeuticinduced pneumonitis • idiopathic or induced interstitial lung disease • bronchopulmonary dysplasia • lung transplant rejection Competitive Advantages • EMP2 can selectively target PMN accumulation in the lung, rather than broadly affecting PMN trafficking through all tissues. Development Stage • Early stage • In vitro and in vivo (animal) data available Inventors: Michael Brian Fessler (NIEHS), Carmen J. Williams (NIEHS), and Wan-Chi Lin (NIEHS). Intellectual Property: HHS Reference No. E–125–2018–0; U.S Provisional Patent Application 62/664,805 filed April 30, 2018, International Patent Application PCT/US2019/29801 filed on April 30, 2019. Publications: Lin WC, Gowdy KM, Madenspacher JH, et al. Epithelial membrane protein 2 governs transepithelial migration of neutrophils into the airspace. J Clin Invest. 2020;130(1):157–170. Licensing Contact: Vidita Choudhry, Ph.D.; 301–594–4095; vidita.choudhry@ nih.gov. This notice is made in accordance with 35 U.S.C. 209 and 37 CFR part 404. Dated: September 28, 2020. Vidita Choudhry, Technology Development Specialist, National Heart, Lung, and Blood Institute, Office of Technology Transfer and Development. [FR Doc. 2020–21709 Filed 9–30–20; 8:45 am] BILLING CODE 4140–01–P PO 00000 Frm 00041 Fmt 4703 Sfmt 4703 61959 DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Prospective Grant of an Exclusive Patent License: Allogeneic Therapy Using an Armored Payload and Chimeric Antigen Receptors Targeting GPC3 AGENCY: National Institutes of Health, HHS. ACTION: Notice. The National Cancer Institute, an institute of the National Institutes of Health, Department of Health and Human Services, is contemplating the grant of an Exclusive Patent License to practice the inventions embodied in the Patents and Patent Applications listed in the Supplementary Information section of this notice to Senti Biosciences, Inc. (‘‘Senti’’) located in South San Francisco, CA. DATES: Only written comments and/or complete applications for a license which are received by the National Cancer Institute’s Technology Transfer Center on or before October 16, 2020 will be considered. ADDRESSES: Requests for copies of the patent application, inquiries, and comments relating to the contemplated an Exclusive Patent License should be directed to: David A Lambertson, Ph.D., Senior Technology Transfer Manager at Telephone at 240–276–5530 or Email at david.lambertson@nih.gov. SUPPLEMENTARY INFORMATION: SUMMARY: Intellectual Property The following represents the intellectual property to be licensed under the prospective agreement: (A) U.S. Provisional Patent Application 61/654,232 entitled ‘‘Highaffinity Monoclonal Antibodies To Glypican-3 And Use Thereof’’ [HHS Ref. E–136–2012–0–US–01], PCT Patent Application PCT/US2013/043633 entitled ‘‘High-affinity Monoclonal Antibodies To Glypican-3 And Use Thereof’’ [HHS Ref. E–136–2012–0– PCT–02], Chinese Patent 104520331 entitled ‘‘High-affinity Monoclonal Antibodies To Glypican-3 And Use Thereof’’ [HHS Ref. E–136–2012–0–CN– 03], Japanese Patent 6494507 entitled ‘‘High-affinity Monoclonal Antibodies To Glypican-3 And Use Thereof’’ [HHS Ref. E–136–2012–0–JP–04], South Korean Patent Application 10–2014– 7037046 entitled ‘‘High-affinity Monoclonal Antibodies To Glypican-3 And Use Thereof’’ [HHS Ref. E–136– 2012–0–KR–05], Singapore Patent 11201407972R entitled ‘‘High-affinity E:\FR\FM\01OCN1.SGM 01OCN1

Agencies

[Federal Register Volume 85, Number 191 (Thursday, October 1, 2020)]
[Notices]
[Pages 61958-61959]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2020-21710]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Government-Owned Inventions; Availability for Licensing

AGENCY: National Institutes of Health, HHS.

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: The inventions listed below are owned by an agency of the U.S. 
Government and are available for licensing in the U.S. to achieve 
expeditious commercialization of results of federally-funded research 
and development.

FOR FURTHER INFORMATION CONTACT: Licensing information may be obtained 
by emailing Brian W. Bailey, Ph.D., [email protected], the indicated 
licensing contact at the National Heart, Lung, and Blood, Office of 
Technology Transfer and Development Office of Technology Transfer, 31 
Center Drive, Room 4A29, MSC2479, Bethesda, MD 20892-2479; telephone: 
301-402-5579. A signed Confidential Disclosure Agreement may be 
required to receive any unpublished information.

SUPPLEMENTARY INFORMATION: Technology description follows.

Methods To Produce Very Long-Chain Fatty Acids (VLCFA)

    Available for licensing and commercial development are patent 
rights covering methods for synthetically producing highly pure, 
polyunsaturated very long-chain fatty acids (C20-C40) that are highly 
scalable, do not require toxic mercury, and are applicable to the 
synthesis of highly deuterated (>90%), partially deuterated, and non-
deuterated lipids. VLCFAs, while present in very small concentrations 
in living organisms, nonetheless play vital roles in certain biological 
processes. The present invention addresses an unmet need for VLCFAs for 
experimental and therapeutic uses that is currently inadequately met 
through labor intensive and time consuming extractions from natural 
sources or technically difficult overexpression in cell cultures, which 
give very small yields. This invention also includes a method for 
treating and preventing macular degeneration using VLCFAs.
    This technology is available for licensing for commercial 
development in accordance with 35 U.S.C. 209 and 37 CFR part 404.
    Potential Commercial Applications:

 Synthesis of very-long chain fatty acids for in vitro and in 
vivo research purposes
 Synthesis of very-long chain fatty acids for therapeutic 
purposes
 Treatment and prevention of macular degeneration, inflammatory 
disorders and other disorders and conditions associated with very long-
chain fatty acid deficiencies

    Development Stage:

 Preclinical
 Mouse data

    Inventors: Rolf Swenson (NHLBI), Zhen-Dan Shi (NHLBI), Zhi-Hong 
Yang (NHLBI) and Alan Remaley (NHLBI).

[[Page 61959]]

    Intellectual Property: HHS Reference No. E-126-2020-0-US-01 ; U.S 
Patent Application 63/072,519 filed August 31, 2020.
    Licensing Contact: Brian W. Bailey, Ph.D.; 301-594-4094; 
[email protected].

    Dated: September 25, 2020.
National Heart, Lung, and Blood Institute, Office of Technology 
Transfer and Development.
[FR Doc. 2020-21710 Filed 9-30-20; 8:45 am]
BILLING CODE 4140-01-P
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