Government-Owned Inventions; Availability for Licensing, 327-328 [2019-28358]

Download as PDF Federal Register / Vol. 85, No. 2 / Friday, January 3, 2020 / Notices jbell on DSKJLSW7X2PROD with NOTICES 6. European Patent No. 2836591, issued June 6, 2018, filed April 9, 2013 (HHS Ref. No. E–086–2012–2–EP–04); 7. US Patent No. 10407665, issued September 10, 2019, filed October 2, 2014 (HHS Ref. No. E–086–2012–2–US–05); 8. German Patent No. 2836591, issued June 6, 2018, filed April 9, 2013 (HHS Ref. No. E– 086–2012–2–DE–07); 9. French Patent No. 2836591, issued June 6, 2018, filed April 9, 2013 (HHS Ref. No. E– 086–2012–2–FR–08); 10. United Kingdom Patent No. 2836591, issued June 6, 2018, filed April 9, 2013 (HHS Ref. No. E–086–2012–2–GB–09); 11. US Patent Application No. 16/521,251, filed July 24, 2019 (HHS Ref. No. E–086– 2012–2–US–10); 12. Provisional Patent Application No. 61/ 086,991, filed August 7, 2008, now abandoned (HHS Ref. No. E–153–2008–0– US–01); 13. PCT Patent Application No. PCT/ US2009/052902, filed August 5, 2009, now abandoned (HHS Ref. No. E–153–2008–0– PCT–02); 14. Australian Patent No. 2009279676, issued July 30, 2015, filed August 5, 2009 (HHS Ref. No. E–153–2008–0–AU–03); 15. Canadian Patent No. 2732102, issued January 2, 2018, filed August 5, 2009 (HHS Ref. No. E–153–2008–0–CA–04); 16. European Patent No. 2340034, issued January 27, 2016, filed August 5, 2009 (HHS Ref. No. E–153–2008–0–EP–05); 17. US Patent No. 8951527, issued February 10, 2015, filed February 3, 2011 (HHS Ref. No. E–153–2008–0–US–06); 18. German Patent No. 602009036069.8, issued January 27, 2016, filed August 5, 2009 (HHS Ref. No. E–153–2008–0–DE–07); 19. French Patent No. 2340034, issued January 27, 2016, filed August 5, 2009 (HHS Ref. No. E–153–2008–0–FR–08); 20. United Kingdom Patent No. 2340034, issued January 27, 2016, filed August 5, 2009 (HHS Ref. No. E–153–2008–0–GB–09); 21. Provisional Patent Application No. 61/ 779,587, filed March 13, 2013, now abandoned (HHS Ref. No. E–296–2011–0– US–01); 22. PCT Patent Application No. PCT/ US2014/025989, filed March 13, 2014, now abandoned (HHS Ref. No. E–296–2011–0– PCT–02); 23. Australian Patent No. 2014244083, issued January 10, 2019, filed March 13, 2014, now abandoned (HHS Ref. No. E–296– 2011–0–AU–03); 24. Canadian Patent Application No. 2905418, filed March 13, 2014 (HHS Ref. No. E–296–2011–0–CA–04); 25. European Patent Application No. 14718255.4, filed March 13, 2014 (HHS Ref. No. E–296–2011–0–EP–05); 26. US Patent Application No. 14/775,428, filed September 11, 2015 (HHS Ref. No. E– 296–2011–0–US–06). The patent rights in these inventions have been assigned and/or exclusively licensed to the government of the United States of America. The prospective exclusive license territory may be worldwide, and the field of use may be limited to those previously VerDate Sep<11>2014 17:29 Jan 02, 2020 Jkt 250001 advertised in Federal Register notices 83 FR 22501 84 FR 1764, described in the supplementary information section above. This technology concerns CD47, originally named integrin-associated protein, which is a receptor for thrombospondin-1 (TSP1), a major component of platelet a-granules from which it is secreted on platelet activation. A number of important roles for CD47 have been defined in regulating the migration, proliferation, and survival of vascular cells, and in regulation of innate and adaptive immunity. Nitric Oxide (NO) plays an important role as a major intrinsic vasodilator, and it increases blood flow to tissues and organs. Disruption of this process leads to peripheral vascular disease, ischemic heart disease, stroke, diabetes and many more significant diseases. The inventors have discovered that TSP1 blocks the beneficial effects of NO and prevents it from dilating blood vessels and increasing blood flow to organs and tissues. Additionally, they discovered that this regulation requires TSP1 interaction with its cell receptor, CD47. These inventors have also found that blocking TSP1–CD47 interaction through the use of antisense morpholino oligonucleotides, peptides or antibodies have several therapeutic benefits including the treatment of cancer. This notice is made in accordance with 35 U.S.C. 209 and 37 CFR part 404. The prospective exclusive license will be royalty bearing, and the prospective exclusive license may be granted unless within fifteen (15) days from the date of this published notice, the National Cancer Institute receives written evidence and argument that establishes that the grant of the license would not be consistent with the requirements of 35 U.S.C. 209 and 37 CFR part 404. In response to this Notice, the public may file comments or objections. Comments and objections, other than those in the form of a license application, will not be treated confidentially, and may be made publicly available. License applications submitted in response to this Notice will be presumed to contain business confidential information and any release of information in these license applications will be made only as required and upon a request under the Freedom of Information Act, 5 U.S.C. 552. PO 00000 Frm 00031 Fmt 4703 Sfmt 4703 327 Dated: December 20, 2019. Richard U. Rodriguez, Associate Director, Technology Transfer Center, National Cancer Institute. [FR Doc. 2019–28355 Filed 1–2–20; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Government-Owned Inventions; Availability for Licensing National Institutes of Health. Notice. AGENCY: ACTION: The invention listed below is owned by an agency of the U.S. Government and is available for licensing to achieve expeditious commercialization of results of federally-funded research and development. FOR FURTHER INFORMATION CONTACT: Licensing information may be obtained by communicating with Vidita Choudhry, Ph.D., National Heart, Lung, and Blood, Office of Technology Transfer and Development, 31 Center Drive, Room 4A29, MSC2479, Bethesda, MD 20892–2479; telephone: 301–594– 4095; email: vidita.choudhry@nih.gov. A signed Confidential Disclosure Agreement may be required to receive any unpublished information. SUPPLEMENTARY INFORMATION: Technology description follows. SUMMARY: Therapeutic and Diagnostic Targets for Severe RSV Infection Respiratory Syncytial Virus (RSV) infects nearly all children by their second birthday. RSV usually causes mild respiratory illness, however, a subset of patients experience severe infection that require hospitalization. Successful host defense against viral pathogens requires rapid recognition of the virus and activation of both innate and adaptive immunity. Toll-Like Receptors (TLRs) are responsible for mounting an innate immune response and genetic variations within TLRs modulate severity of infection. Researchers at NIEHS have identified a single nucleotide polymorphism (SNP) in TLR8 that is associated with RSV disease severity. The SNP is p53responsive allele, indicating that p53, a master cell cycle regulator, can strongly influence TLR8 mediated immune responses. Identification of this SNP can inform diagnosis and prognosis of RSV disease and serve as a therapeutic target for severe RSV infection. Potential Commercial Applications: E:\FR\FM\03JAN1.SGM 03JAN1 328 Federal Register / Vol. 85, No. 2 / Friday, January 3, 2020 / Notices • Development of therapeutics against severe RSV infection • Diagnostic biomarker Competitive Advantages: • Enhance the innate immune response to respiratory infection • Improve clinical trial outcome in patients with TLR8 mediated RSV infection Development Stage: • Early stage • In vitro data available Inventors: Michael Resnick (NIEHS), Daniel Menendez (NIEHS), Steven Kleeberger (NIEHS), and Fernando Polack (Infant Foundation). Intellectual Property: HHS Reference No. E–072–2019–0; US Application No. 62/881,656. Licensing Contact: Vidita Choudhry, Ph.D.; 301–594–4095; vidita.choudhry@ nih.gov. This notice is made in accordance with 35 U.S.C. 209 and 37 CFR part 404. Dated: December 26, 2019. Vidita Choudhry, Technology Development Specialist, National Heart, Lung, and Blood Institute, Office of Technology Transfer and Development. [FR Doc. 2019–28358 Filed 1–2–20; 8:45 am] BILLING CODE 4140–01–P Place: Residence Inn Bethesda, 7335 Wisconsin Avenue, Bethesda, MD 20814. Contact Person: Helen Huang, Ph.D., Scientific Review Officer, Scientific Review Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20817, 301–435–8380, helen.huang@nih.gov. Name of Committee: National Institute of Child Health and Human Development Initial Review Group; Function, Integration, and Rehabilitation Sciences Subcommittee. Date: February 26, 2020. Time: 8:00 a.m. to 5:00 p.m. Agenda: To review and evaluate grant applications. Place: Residence Inn Bethesda, 7335 Wisconsin Avenue, Bethesda, MD 20814. Contact Person: Helen Huang, Ph.D., Scientific Review Officer, Scientific Review Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20817, 301–435–8380, helen.huang@nih.gov. (Catalogue of Federal Domestic Assistance Program Nos. 93.864, Population Research; 93.865, Research for Mothers and Children; 93.929, Center for Medical Rehabilitation Research; 93.209, Contraception and Infertility Loan Repayment Program, National Institutes of Health, HHS) Dated: December 27, 2019. Ronald J. Livingston, Jr., Program Analyst, Office of Federal Advisory Committee Policy. [FR Doc. 2019–28359 Filed 1–2–20; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES Dated: December 27, 2019. Ronald J. Livingston, Jr., Program Analyst, Office of Federal Advisory Committee Policy. [FR Doc. 2019–28357 Filed 1–2–20; 8:45 am] DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health jbell on DSKJLSW7X2PROD with NOTICES Place: National Institutes of Health, Rockledge II, 6701 Rockledge Drive, Bethesda, MD 20892 (Telephone Conference Call). Contact Person: Ileana Hancu, Ph.D., Scientific Review Officer, Center for Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Room 5116, Bethesda, MD 20817, 301–402–3911, ileana.hancu@nih.gov. Name of Committee: Center for Scientific Review Special Emphasis Panel; PAR Panel: Secondary Analyses of Existing Datasets in Heart, Lung and Blood Diseases and Sleep Disorders. Date: January 28, 2020. Time: 11:00 a.m. to 6:00 p.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health, Rockledge II, 6701 Rockledge Drive, Bethesda, MD 20892 (Virtual Meeting). Contact Person: Heidi B. Friedman, Ph.D., Scientific Review Officer, Center for Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Room 1012A, MSC 7770, Bethesda, MD 20892, 301–379– 5632, hfriedman@csr.nih.gov. (Catalogue of Federal Domestic Assistance Program Nos. 93.306, Comparative Medicine; 93.333, Clinical Research, 93.306, 93.333, 93.337, 93.393–93.396, 93.837–93.844, 93.846–93.878, 93.892, 93.893, National Institutes of Health, HHS) BILLING CODE 4140–01–P Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meetings National Institutes of Health DEPARTMENT OF HEALTH AND HUMAN SERVICES Center for Scientific Review; Notice of Closed Meetings National Institutes of Health Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended, notice is hereby given of the following meetings. The meetings will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended, notice is hereby given of the following meetings. The meetings will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Institute of Child Health and Human Development Initial Review Group; Reproduction, Andrology, and Gynecology Subcommittee. Date: February 21, 2020. Time: 8:00 a.m. to 5:00 p.m. Agenda: To review and evaluate grant applications. Name of Committee: Center for Scientific Review Special Emphasis Panel; Early Phase Clinical Trials in Imaging and Image-Guided Interventions (R01 Clinical Trial Required). Date: January 28, 2020. Time: 10:00 a.m. to 1:00 p.m. Agenda: To review and evaluate grant applications. VerDate Sep<11>2014 17:29 Jan 02, 2020 Jkt 250001 PO 00000 Frm 00032 Fmt 4703 Sfmt 4703 Prospective Grant of an Exclusive Patent License: Development and Commercialization of CD19/CD22 Chimeric Antigen Receptor (CAR) Therapies for the Treatment of B-Cell Malignancies AGENCY: National Institutes of Health, HHS. ACTION: Notice. The National Cancer Institute, an institute of the National Institutes of Health, Department of Health and Human Services, is contemplating the grant of an Exclusive Patent License to practice the inventions embodied in the Patents and Patent Applications listed in the Supplementary Information section of this Notice to CJ Healthcare, (‘‘CJ’’), located in Seoul, Republic of Korea. DATES: Only written comments and/or applications for a license which are received by the National Cancer SUMMARY: E:\FR\FM\03JAN1.SGM 03JAN1

Agencies

[Federal Register Volume 85, Number 2 (Friday, January 3, 2020)]
[Notices]
[Pages 327-328]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2019-28358]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Government-Owned Inventions; Availability for Licensing

AGENCY: National Institutes of Health.

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: The invention listed below is owned by an agency of the U.S. 
Government and is available for licensing to achieve expeditious 
commercialization of results of federally-funded research and 
development.

FOR FURTHER INFORMATION CONTACT: Licensing information may be obtained 
by communicating with Vidita Choudhry, Ph.D., National Heart, Lung, and 
Blood, Office of Technology Transfer and Development, 31 Center Drive, 
Room 4A29, MSC2479, Bethesda, MD 20892-2479; telephone: 301-594-4095; 
email: [email protected]. A signed Confidential Disclosure 
Agreement may be required to receive any unpublished information.

SUPPLEMENTARY INFORMATION: Technology description follows.

Therapeutic and Diagnostic Targets for Severe RSV Infection

    Respiratory Syncytial Virus (RSV) infects nearly all children by 
their second birthday. RSV usually causes mild respiratory illness, 
however, a subset of patients experience severe infection that require 
hospitalization. Successful host defense against viral pathogens 
requires rapid recognition of the virus and activation of both innate 
and adaptive immunity. Toll-Like Receptors (TLRs) are responsible for 
mounting an innate immune response and genetic variations within TLRs 
modulate severity of infection. Researchers at NIEHS have identified a 
single nucleotide polymorphism (SNP) in TLR8 that is associated with 
RSV disease severity. The SNP is p53-responsive allele, indicating that 
p53, a master cell cycle regulator, can strongly influence TLR8 
mediated immune responses. Identification of this SNP can inform 
diagnosis and prognosis of RSV disease and serve as a therapeutic 
target for severe RSV infection.

    Potential Commercial Applications:


[[Page 328]]


 Development of therapeutics against severe RSV infection
 Diagnostic biomarker

    Competitive Advantages:

 Enhance the innate immune response to respiratory infection
 Improve clinical trial outcome in patients with TLR8 mediated 
RSV infection

    Development Stage:

 Early stage
 In vitro data available

    Inventors: Michael Resnick (NIEHS), Daniel Menendez (NIEHS), Steven 
Kleeberger (NIEHS), and Fernando Polack (Infant Foundation).
    Intellectual Property: HHS Reference No. E-072-2019-0; US 
Application No. 62/881,656.
    Licensing Contact: Vidita Choudhry, Ph.D.; 301-594-4095; 
[email protected]. This notice is made in accordance with 35 
U.S.C. 209 and 37 CFR part 404.

    Dated: December 26, 2019.
Vidita Choudhry,
Technology Development Specialist, National Heart, Lung, and Blood 
Institute, Office of Technology Transfer and Development.
[FR Doc. 2019-28358 Filed 1-2-20; 8:45 am]
 BILLING CODE 4140-01-P
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