National Institute of Allergy and Infectious Diseases; Notice of Closed Meetings, 4834 [2019-02686]
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Federal Register / Vol. 84, No. 33 / Tuesday, February 19, 2019 / Notices
carcinogenic potential of environmental
chemicals (including mixtures),
engineering safer products, and
designing more effective multi-target
therapeutics.
The hallmarks of cancer (1) and the
key characteristics of carcinogens (2)
offer two paradigms for organizing
information to better understand the
interactions between environmental
exposures and biological systems that
lead to cancer. The hallmarks of cancer
represent the biological traits of tumors
that allow for the unchecked growth of
cancer, while the key characteristics of
carcinogens begin with known human
carcinogens and identify the defining
properties of carcinogens. A series of
webinars prior to the workshop will
provide background on these
frameworks. Discussion at the workshop
will include recommended application
of the two frameworks, clarifying
terminology, the relationship between
the frameworks, and the available assays
for measuring effects associated with
each of the hallmarks and key
characteristics.
It is clear from biomonitoring studies
that humans are constantly exposed to
numerous structurally-diverse
chemicals. A recent nomination to NTP
was for development of a testing
strategy to better understand how
environmental chemicals might interact
with multiple cancer-relevant biological
pathways to elicit mixture effects that
would not be expected based on single
chemical considerations. An aim of the
workshop is to channel the collective
wisdom of cancer biologists,
toxicologists, and mixtures statisticians
to propose testing approaches designed
to evaluate hypotheses regarding the
joint action of chemicals that target
cancer pathways. This effort will
include discussion of cancer-specific
pathways and mechanisms, associated
technologies including organotypic and/
or mechanistically insightful tools,
preferred animal models, in silico/
computational approaches to link
relevant biological pathways, as well as
specific cancer types to use in
evaluating the hypotheses.
Meeting and Registration: This
meeting is open to the public, free of
charge, with attendance limited only by
the space available. The meeting will
consist of plenary sessions (webcast),
breakout discussion sessions, and a
poster session. The breakout sessions
and poster session will be open to the
public but will not be webcast.
Individuals who plan to attend in
person as observers or view the
proceedings via webcast should register
on the NTP website (https://
ntp.niehs.nih.gov/go/coc) by April 22,
VerDate Sep<11>2014
17:46 Feb 15, 2019
Jkt 247001
2019, to facilitate meeting planning.
Interested individuals are encouraged to
visit the web page to stay abreast of the
most current information about the
meeting.
Information for visitors to the US EPA
is available at https://www.epa.gov/
aboutepa/visiting-epa-headquarters.
Individuals with disabilities who need
accommodation to participate in this
event should contact Dr. Cynthia Rider
at phone: (984) 287–3175 or email:
cynthia.rider@nih.gov. TTY users
should contact the Federal TTY Relay
Service at 800–877–8339. Requests
should be made at least five business
days in advance of the event.
Meeting Materials: The preliminary
agenda and additional information are
available at https://ntp.niehs.nih.gov/
go/coc.
References
1. Hanahan D, Weinberg RA. Hallmarks of
cancer: The next generation. Cell.
2011;144(5):646–74. doi: 10.1016/
j.cell.2011.02.013. PubMed PMID:
21376230.
2. Smith MT, Guyton KZ, Gibbons CF, Fritz
JM, Portier CJ, Rusyn I, et al. Key
Characteristics of Carcinogens as a Basis
for Organizing Data on Mechanisms of
Carcinogenesis. Environmental health
perspectives. 2016;124(6):713–21. doi:
10.1289/ehp.1509912. PubMed PMID:
26600562; PubMed Central PMCID:
PMC4892922.
Brian R. Berridge,
Associate Director, National Toxicology
Program, National Institute of Environmental
Health Sciences.
[FR Doc. 2019–02684 Filed 2–15–19; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
National Institute of Allergy and
Infectious Diseases; Notice of Closed
Meetings
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended, notice is hereby given of the
following meetings.
The meetings will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
PO 00000
Frm 00072
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Name of Committee: Microbiology,
Infectious Diseases and AIDS Initial Review
Group; Acquired Immunodeficiency
Syndrome Research Review Committee.
Date: April 24, 2019.
Time: 8:00 a.m. to 6:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: Renaissance Arlington Capital View
Hotel, 2800 South Potomac Avenue,
Arlington, VA 22202.
Contact Person: Robert C. Unfer, Ph.D.,
Scientific Review Officer, Scientific Review
Program, Division of Extramural Activities,
Room 3F40A, National Institutes of Health,
NIAID, 5601 Fishers Lane, MSC 9834,
Bethesda, MD 20892–9834, (240) 669–5035,
robert.unfer@nih.gov.
Name of Committee: Microbiology,
Infectious Diseases and AIDS Initial Review
Group; Acquired Immunodeficiency
Syndrome Research Review Committee,
AIDSRRC Review Meeting.
Date: August 1–2, 2019.
Time: 10:00 a.m. to 6:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, 5601
Fishers Lane, Rockville, MD 20892,
(Telephone Conference Call).
Contact Person: Robert C. Unfer, Ph.D.,
Scientific Review Officer, Scientific Review
Program, Division of Extramural Activities,
Room 3F40A, National Institutes of Health,
NIAID, 5601 Fishers Lane, MSC 9834,
Bethesda, MD 20892–9834, (240) 669–5035,
robert.unfer@nih.gov.
Name of Committee: Microbiology,
Infectious Diseases and AIDS Initial Review
Group; Acquired Immunodeficiency
Syndrome Research Review Committee,
AIDSRRC Review Meeting.
Date: December 3–4, 2019.
Time: 10:00 a.m. to 6:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, 5601
Fishers Lane, Rockville, MD 20892,
(Telephone Conference Call).
Contact Person: Robert C. Unfer, Ph.D.,
Scientific Review Officer, Scientific Review
Program, Division of Extramural Activities,
Room 3F40A, National Institutes of Health,
NIAID, 5601 Fishers Lane, MSC 9834,
Bethesda, MD 20892–9834, (240) 669–5035,
robert.unfer@nih.gov.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.855, Allergy, Immunology,
and Transplantation Research; 93.856,
Microbiology and Infectious Diseases
Research, National Institutes of Health, HHS)
Dated: February 13, 2019.
Natasha M. Copeland,
Program Analyst, Office of Federal Advisory
Committee Policy.
[FR Doc. 2019–02686 Filed 2–15–19; 8:45 am]
BILLING CODE 4140–01–P
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]]>Agencies
[Federal Register Volume 84, Number 33 (Tuesday, February 19, 2019)]
[Notices]
[Page 4834]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2019-02686]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
National Institute of Allergy and Infectious Diseases; Notice of
Closed Meetings
Pursuant to section 10(d) of the Federal Advisory Committee Act, as
amended, notice is hereby given of the following meetings.
The meetings will be closed to the public in accordance with the
provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5
U.S.C., as amended. The grant applications and the discussions could
disclose confidential trade secrets or commercial property such as
patentable material, and personal information concerning individuals
associated with the grant applications, the disclosure of which would
constitute a clearly unwarranted invasion of personal privacy.
Name of Committee: Microbiology, Infectious Diseases and AIDS
Initial Review Group; Acquired Immunodeficiency Syndrome Research
Review Committee.
Date: April 24, 2019.
Time: 8:00 a.m. to 6:00 p.m.
Agenda: To review and evaluate grant applications.
Place: Renaissance Arlington Capital View Hotel, 2800 South
Potomac Avenue, Arlington, VA 22202.
Contact Person: Robert C. Unfer, Ph.D., Scientific Review
Officer, Scientific Review Program, Division of Extramural
Activities, Room 3F40A, National Institutes of Health, NIAID, 5601
Fishers Lane, MSC 9834, Bethesda, MD 20892-9834, (240) 669-5035,
robert.unfer@nih.gov.
Name of Committee: Microbiology, Infectious Diseases and AIDS
Initial Review Group; Acquired Immunodeficiency Syndrome Research
Review Committee, AIDSRRC Review Meeting.
Date: August 1-2, 2019.
Time: 10:00 a.m. to 6:00 p.m.
Agenda: To review and evaluate grant applications.
Place: National Institutes of Health, 5601 Fishers Lane,
Rockville, MD 20892, (Telephone Conference Call).
Contact Person: Robert C. Unfer, Ph.D., Scientific Review
Officer, Scientific Review Program, Division of Extramural
Activities, Room 3F40A, National Institutes of Health, NIAID, 5601
Fishers Lane, MSC 9834, Bethesda, MD 20892-9834, (240) 669-5035,
robert.unfer@nih.gov.
Name of Committee: Microbiology, Infectious Diseases and AIDS
Initial Review Group; Acquired Immunodeficiency Syndrome Research
Review Committee, AIDSRRC Review Meeting.
Date: December 3-4, 2019.
Time: 10:00 a.m. to 6:00 p.m.
Agenda: To review and evaluate grant applications.
Place: National Institutes of Health, 5601 Fishers Lane,
Rockville, MD 20892, (Telephone Conference Call).
Contact Person: Robert C. Unfer, Ph.D., Scientific Review
Officer, Scientific Review Program, Division of Extramural
Activities, Room 3F40A, National Institutes of Health, NIAID, 5601
Fishers Lane, MSC 9834, Bethesda, MD 20892-9834, (240) 669-5035,
robert.unfer@nih.gov.
(Catalogue of Federal Domestic Assistance Program Nos. 93.855,
Allergy, Immunology, and Transplantation Research; 93.856,
Microbiology and Infectious Diseases Research, National Institutes
of Health, HHS)
Dated: February 13, 2019.
Natasha M. Copeland,
Program Analyst, Office of Federal Advisory Committee Policy.
[FR Doc. 2019-02686 Filed 2-15-19; 8:45 am]
BILLING CODE 4140-01-P
