National Toxicology Program; Notice of Public Meeting: Converging on Cancer Workshop, 4833-4834 [2019-02684]
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Federal Register / Vol. 84, No. 33 / Tuesday, February 19, 2019 / Notices
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
Center for Scientific Review; Notice of
Closed Meetings
tkelley on DSKBCP9HB2PROD with NOTICES
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended, notice is hereby given of the
following meetings.
The meetings will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: Center for Scientific
Review Special Emphasis Panel; PAR–18–
009: Academic-Industrial Partnerships
Research for Cancer Diagnosis and
Treatment.
Date: March 20, 2019.
Time: 1:00 p.m. to 5:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, 6701
Rockledge Drive, Bethesda, MD 20892
(Virtual Meeting).
Contact Person: Guo Feng Xu, Ph.D.,
Scientific Review Officer, Center for
Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 5122,
MSC 7854, Bethesda, MD 20892, 301–237–
9870, xuguofen@csr.nih.gov.
Name of Committee: Center for Scientific
Review Special Emphasis Panel; PAR:
Selected Topics in Transfusion Medicine.
Date: March 21–22, 2019.
Time: 10:00 a.m. to 6:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, 6701
Rockledge Drive, Bethesda, MD 20892
(Virtual Meeting).
Contact Person: Ai-Ping Zou, MD, Ph.D.,
Scientific Review Officer, Center for
Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 4118,
MSC 7814, Bethesda, MD 20892, 301–408–
9497, zouai@csr.nih.gov.
Name of Committee: Center for Scientific
Review Special Emphasis Panel; Member
Conflict: International and Cooperative
Projects 1.
Date: March 25, 2019.
Time: 12:00 p.m. to 3:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, 6701
Rockledge Drive, Bethesda, MD 20892
(Telephone Conference Call).
Contact Person: Brian H. Scott, Ph.D.,
Scientific Review Officer, National Institutes
of Health, Center for Scientific Review, 6701
VerDate Sep<11>2014
17:46 Feb 15, 2019
Jkt 247001
Rockledge Drive, Bethesda, MD 20892, 301–
827–7490, brianscott@mail.nih.gov.
Name of Committee: Center for Scientific
Review Special Emphasis Panel; Member
Conflict: AIDS and Related Research.
Date: March 28, 2019.
Time: 10:00 a.m. to 4:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, 6701
Rockledge Drive, Bethesda, MD 20892
(Virtual Meeting).
Contact Person: Shalanda A. Bynum,
Ph.D., Scientific Review Officer, Center for
Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 3206,
Bethesda, MD 20892, 301–755–4355,
bynumsa@csr.nih.gov.
Name of Committee: Center for Scientific
Review Special Emphasis Panel; Vascular
and Hematology AREA Application Review.
Date: April 5, 2019.
Time: 1:00 p.m. to 6:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, 6701
Rockledge Drive, Bethesda, MD 20892
(Telephone Conference Call).
Contact Person: Natalia Komissarova,
Ph.D., Scientific Review Officer, Center for
Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 5207,
MSC 7846, Bethesda, MD 20892, 301–435–
1206, komissar@mail.nih.gov.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.306, Comparative Medicine;
93.333, Clinical Research, 93.306, 93.333,
93.337, 93.393–93.396, 93.837–93.844,
93.846–93.878, 93.892, 93.893, National
Institutes of Health, HHS)
Dated: February 12, 2019.
Natasha M. Copeland,
Program Analyst, Office of Federal Advisory
Committee Policy.
[FR Doc. 2019–02612 Filed 2–15–19; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
National Toxicology Program; Notice
of Public Meeting: Converging on
Cancer Workshop
AGENCY:
National Institutes of Health,
HHS.
Notice of Public Meeting and
Registration Information.
ACTION:
The National Toxicology
Program (NTP) announces a workshop
titled ‘‘Converging on Cancer’’ on April
29–30, 2019, to bring together
researchers working in the area of
cancer biology, assay development,
mixtures toxicology, in silico modeling,
and cancer risk assessment. The
objectives of the workshop are to
identify technologies and models that
can be used in a systems toxicology
SUMMARY:
PO 00000
Frm 00071
Fmt 4703
Sfmt 4703
4833
approach for cancer risk assessment.
Specific applications to understanding
the joint effects of multiple chemical
exposures will be discussed. The
workshop will consist of plenary
sessions (webcast), breakout discussion
sessions, and a poster session. This
workshop is open to the public.
Members of the public can register to
attend the workshop in person as
observers or view the plenary
proceedings via webcast.
DATES:
Meeting: April 29–30, 2019, begins at
9:00 a.m. to approximately 5:00 p.m.
Eastern Daylight Time (EDT).
Meeting Registration: Deadline is
April 22, 2019. Registration to view the
workshop via webcast is required.
ADDRESSES:
Meeting Location: William J. Clinton
East Building, U.S. Environmental
Protection Agency, 1201 Constitution
Ave. NW, Washington, DC 20460.
Meeting Web page: The preliminary
agenda and registration are at https://
ntp.niehs.nih.gov/go/coc.
Webcast: Plenary sessions of the
workshop will be webcast; the URL will
be provided to those who register for
viewing.
FOR FURTHER INFORMATION CONTACT: Dr.
Cynthia Rider, Toxicology Branch,
NIEHS, P.O. Box 12233, K2–12,
Research Triangle Park, NC 27709,
(telephone) 984–287–3175, Email:
cynthia.rider@nih.gov.
SUPPLEMENTARY INFORMATION:
Background: Cancer is a leading cause
of mortality worldwide. While the
defining feature of cancer is
uncontrolled division of abnormal cells,
it is a complex disease with varied
presentations (i.e., different etiologies
and target tissues) that involves
dysregulation of multiple
interconnected signaling pathways.
Diverse environmental factors have been
associated with the development and
progression of various cancer types. A
critical question in the field of
environmental health is how to harness
what is known about cancer biology and
associated environmental exposures to
improve public health outcomes. The
Converging on Cancer Workshop is
aimed at providing a clear path forward
for evaluating the interactions between
environmental exposures and cancer
biology using the latest tools in
toxicology and identifying knowledge
gaps that require research attention.
Potential applications of this
understanding include building a
framework for incorporating
mechanistic data into cancer risk
assessment, developing effective
screening tools to detect the
E:\FR\FM\19FEN1.SGM
19FEN1
tkelley on DSKBCP9HB2PROD with NOTICES
4834
Federal Register / Vol. 84, No. 33 / Tuesday, February 19, 2019 / Notices
carcinogenic potential of environmental
chemicals (including mixtures),
engineering safer products, and
designing more effective multi-target
therapeutics.
The hallmarks of cancer (1) and the
key characteristics of carcinogens (2)
offer two paradigms for organizing
information to better understand the
interactions between environmental
exposures and biological systems that
lead to cancer. The hallmarks of cancer
represent the biological traits of tumors
that allow for the unchecked growth of
cancer, while the key characteristics of
carcinogens begin with known human
carcinogens and identify the defining
properties of carcinogens. A series of
webinars prior to the workshop will
provide background on these
frameworks. Discussion at the workshop
will include recommended application
of the two frameworks, clarifying
terminology, the relationship between
the frameworks, and the available assays
for measuring effects associated with
each of the hallmarks and key
characteristics.
It is clear from biomonitoring studies
that humans are constantly exposed to
numerous structurally-diverse
chemicals. A recent nomination to NTP
was for development of a testing
strategy to better understand how
environmental chemicals might interact
with multiple cancer-relevant biological
pathways to elicit mixture effects that
would not be expected based on single
chemical considerations. An aim of the
workshop is to channel the collective
wisdom of cancer biologists,
toxicologists, and mixtures statisticians
to propose testing approaches designed
to evaluate hypotheses regarding the
joint action of chemicals that target
cancer pathways. This effort will
include discussion of cancer-specific
pathways and mechanisms, associated
technologies including organotypic and/
or mechanistically insightful tools,
preferred animal models, in silico/
computational approaches to link
relevant biological pathways, as well as
specific cancer types to use in
evaluating the hypotheses.
Meeting and Registration: This
meeting is open to the public, free of
charge, with attendance limited only by
the space available. The meeting will
consist of plenary sessions (webcast),
breakout discussion sessions, and a
poster session. The breakout sessions
and poster session will be open to the
public but will not be webcast.
Individuals who plan to attend in
person as observers or view the
proceedings via webcast should register
on the NTP website (https://
ntp.niehs.nih.gov/go/coc) by April 22,
VerDate Sep<11>2014
17:46 Feb 15, 2019
Jkt 247001
2019, to facilitate meeting planning.
Interested individuals are encouraged to
visit the web page to stay abreast of the
most current information about the
meeting.
Information for visitors to the US EPA
is available at https://www.epa.gov/
aboutepa/visiting-epa-headquarters.
Individuals with disabilities who need
accommodation to participate in this
event should contact Dr. Cynthia Rider
at phone: (984) 287–3175 or email:
cynthia.rider@nih.gov. TTY users
should contact the Federal TTY Relay
Service at 800–877–8339. Requests
should be made at least five business
days in advance of the event.
Meeting Materials: The preliminary
agenda and additional information are
available at https://ntp.niehs.nih.gov/
go/coc.
References
1. Hanahan D, Weinberg RA. Hallmarks of
cancer: The next generation. Cell.
2011;144(5):646–74. doi: 10.1016/
j.cell.2011.02.013. PubMed PMID:
21376230.
2. Smith MT, Guyton KZ, Gibbons CF, Fritz
JM, Portier CJ, Rusyn I, et al. Key
Characteristics of Carcinogens as a Basis
for Organizing Data on Mechanisms of
Carcinogenesis. Environmental health
perspectives. 2016;124(6):713–21. doi:
10.1289/ehp.1509912. PubMed PMID:
26600562; PubMed Central PMCID:
PMC4892922.
Brian R. Berridge,
Associate Director, National Toxicology
Program, National Institute of Environmental
Health Sciences.
[FR Doc. 2019–02684 Filed 2–15–19; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
National Institute of Allergy and
Infectious Diseases; Notice of Closed
Meetings
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended, notice is hereby given of the
following meetings.
The meetings will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
PO 00000
Frm 00072
Fmt 4703
Sfmt 9990
Name of Committee: Microbiology,
Infectious Diseases and AIDS Initial Review
Group; Acquired Immunodeficiency
Syndrome Research Review Committee.
Date: April 24, 2019.
Time: 8:00 a.m. to 6:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: Renaissance Arlington Capital View
Hotel, 2800 South Potomac Avenue,
Arlington, VA 22202.
Contact Person: Robert C. Unfer, Ph.D.,
Scientific Review Officer, Scientific Review
Program, Division of Extramural Activities,
Room 3F40A, National Institutes of Health,
NIAID, 5601 Fishers Lane, MSC 9834,
Bethesda, MD 20892–9834, (240) 669–5035,
robert.unfer@nih.gov.
Name of Committee: Microbiology,
Infectious Diseases and AIDS Initial Review
Group; Acquired Immunodeficiency
Syndrome Research Review Committee,
AIDSRRC Review Meeting.
Date: August 1–2, 2019.
Time: 10:00 a.m. to 6:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, 5601
Fishers Lane, Rockville, MD 20892,
(Telephone Conference Call).
Contact Person: Robert C. Unfer, Ph.D.,
Scientific Review Officer, Scientific Review
Program, Division of Extramural Activities,
Room 3F40A, National Institutes of Health,
NIAID, 5601 Fishers Lane, MSC 9834,
Bethesda, MD 20892–9834, (240) 669–5035,
robert.unfer@nih.gov.
Name of Committee: Microbiology,
Infectious Diseases and AIDS Initial Review
Group; Acquired Immunodeficiency
Syndrome Research Review Committee,
AIDSRRC Review Meeting.
Date: December 3–4, 2019.
Time: 10:00 a.m. to 6:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, 5601
Fishers Lane, Rockville, MD 20892,
(Telephone Conference Call).
Contact Person: Robert C. Unfer, Ph.D.,
Scientific Review Officer, Scientific Review
Program, Division of Extramural Activities,
Room 3F40A, National Institutes of Health,
NIAID, 5601 Fishers Lane, MSC 9834,
Bethesda, MD 20892–9834, (240) 669–5035,
robert.unfer@nih.gov.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.855, Allergy, Immunology,
and Transplantation Research; 93.856,
Microbiology and Infectious Diseases
Research, National Institutes of Health, HHS)
Dated: February 13, 2019.
Natasha M. Copeland,
Program Analyst, Office of Federal Advisory
Committee Policy.
[FR Doc. 2019–02686 Filed 2–15–19; 8:45 am]
BILLING CODE 4140–01–P
E:\FR\FM\19FEN1.SGM
19FEN1
Agencies
[Federal Register Volume 84, Number 33 (Tuesday, February 19, 2019)]
[Notices]
[Pages 4833-4834]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2019-02684]
-----------------------------------------------------------------------
DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
National Toxicology Program; Notice of Public Meeting: Converging
on Cancer Workshop
AGENCY: National Institutes of Health, HHS.
ACTION: Notice of Public Meeting and Registration Information.
-----------------------------------------------------------------------
SUMMARY: The National Toxicology Program (NTP) announces a workshop
titled ``Converging on Cancer'' on April 29-30, 2019, to bring together
researchers working in the area of cancer biology, assay development,
mixtures toxicology, in silico modeling, and cancer risk assessment.
The objectives of the workshop are to identify technologies and models
that can be used in a systems toxicology approach for cancer risk
assessment. Specific applications to understanding the joint effects of
multiple chemical exposures will be discussed. The workshop will
consist of plenary sessions (webcast), breakout discussion sessions,
and a poster session. This workshop is open to the public. Members of
the public can register to attend the workshop in person as observers
or view the plenary proceedings via webcast.
DATES:
Meeting: April 29-30, 2019, begins at 9:00 a.m. to approximately
5:00 p.m. Eastern Daylight Time (EDT).
Meeting Registration: Deadline is April 22, 2019. Registration to
view the workshop via webcast is required.
ADDRESSES:
Meeting Location: William J. Clinton East Building, U.S.
Environmental Protection Agency, 1201 Constitution Ave. NW, Washington,
DC 20460.
Meeting Web page: The preliminary agenda and registration are at
https://ntp.niehs.nih.gov/go/coc.
Webcast: Plenary sessions of the workshop will be webcast; the URL
will be provided to those who register for viewing.
FOR FURTHER INFORMATION CONTACT: Dr. Cynthia Rider, Toxicology Branch,
NIEHS, P.O. Box 12233, K2-12, Research Triangle Park, NC 27709,
(telephone) 984-287-3175, Email: cynthia.rider@nih.gov.
SUPPLEMENTARY INFORMATION:
Background: Cancer is a leading cause of mortality worldwide. While
the defining feature of cancer is uncontrolled division of abnormal
cells, it is a complex disease with varied presentations (i.e.,
different etiologies and target tissues) that involves dysregulation of
multiple interconnected signaling pathways. Diverse environmental
factors have been associated with the development and progression of
various cancer types. A critical question in the field of environmental
health is how to harness what is known about cancer biology and
associated environmental exposures to improve public health outcomes.
The Converging on Cancer Workshop is aimed at providing a clear path
forward for evaluating the interactions between environmental exposures
and cancer biology using the latest tools in toxicology and identifying
knowledge gaps that require research attention. Potential applications
of this understanding include building a framework for incorporating
mechanistic data into cancer risk assessment, developing effective
screening tools to detect the
[[Page 4834]]
carcinogenic potential of environmental chemicals (including mixtures),
engineering safer products, and designing more effective multi-target
therapeutics.
The hallmarks of cancer (1) and the key characteristics of
carcinogens (2) offer two paradigms for organizing information to
better understand the interactions between environmental exposures and
biological systems that lead to cancer. The hallmarks of cancer
represent the biological traits of tumors that allow for the unchecked
growth of cancer, while the key characteristics of carcinogens begin
with known human carcinogens and identify the defining properties of
carcinogens. A series of webinars prior to the workshop will provide
background on these frameworks. Discussion at the workshop will include
recommended application of the two frameworks, clarifying terminology,
the relationship between the frameworks, and the available assays for
measuring effects associated with each of the hallmarks and key
characteristics.
It is clear from biomonitoring studies that humans are constantly
exposed to numerous structurally-diverse chemicals. A recent nomination
to NTP was for development of a testing strategy to better understand
how environmental chemicals might interact with multiple cancer-
relevant biological pathways to elicit mixture effects that would not
be expected based on single chemical considerations. An aim of the
workshop is to channel the collective wisdom of cancer biologists,
toxicologists, and mixtures statisticians to propose testing approaches
designed to evaluate hypotheses regarding the joint action of chemicals
that target cancer pathways. This effort will include discussion of
cancer-specific pathways and mechanisms, associated technologies
including organotypic and/or mechanistically insightful tools,
preferred animal models, in silico/computational approaches to link
relevant biological pathways, as well as specific cancer types to use
in evaluating the hypotheses.
Meeting and Registration: This meeting is open to the public, free
of charge, with attendance limited only by the space available. The
meeting will consist of plenary sessions (webcast), breakout discussion
sessions, and a poster session. The breakout sessions and poster
session will be open to the public but will not be webcast. Individuals
who plan to attend in person as observers or view the proceedings via
webcast should register on the NTP website (https://ntp.niehs.nih.gov/go/coc) by April 22, 2019, to facilitate meeting planning. Interested
individuals are encouraged to visit the web page to stay abreast of the
most current information about the meeting.
Information for visitors to the US EPA is available at https://www.epa.gov/aboutepa/visiting-epa-headquarters. Individuals with
disabilities who need accommodation to participate in this event should
contact Dr. Cynthia Rider at phone: (984) 287-3175 or email:
cynthia.rider@nih.gov. TTY users should contact the Federal TTY Relay
Service at 800-877-8339. Requests should be made at least five business
days in advance of the event.
Meeting Materials: The preliminary agenda and additional
information are available at https://ntp.niehs.nih.gov/go/coc.
References
1. Hanahan D, Weinberg RA. Hallmarks of cancer: The next generation.
Cell. 2011;144(5):646-74. doi: 10.1016/j.cell.2011.02.013. PubMed
PMID: 21376230.
2. Smith MT, Guyton KZ, Gibbons CF, Fritz JM, Portier CJ, Rusyn I,
et al. Key Characteristics of Carcinogens as a Basis for Organizing
Data on Mechanisms of Carcinogenesis. Environmental health
perspectives. 2016;124(6):713-21. doi: 10.1289/ehp.1509912. PubMed
PMID: 26600562; PubMed Central PMCID: PMC4892922.
Brian R. Berridge,
Associate Director, National Toxicology Program, National Institute of
Environmental Health Sciences.
[FR Doc. 2019-02684 Filed 2-15-19; 8:45 am]
BILLING CODE 4140-01-P