Request for Information (RFI) on Assays and Approaches for Evaluating Chemical Effects on Cancer Pathways, 4831-4832 [2019-02683]
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Federal Register / Vol. 84, No. 33 / Tuesday, February 19, 2019 / Notices
Place: National Institutes of Health, 5601
Fishers Lane, Rockville, MD 20892
(Telephone Conference Call).
Contact Person: Geetanjali Bansal, Ph.D.,
Scientific Reviewer Officer, Scientific Review
Program, Division of Extramural Activities,
Room 3G49, National Institutes of Health/
NIAID, 5601 Fishers Lane, MSC 9834,
Bethesda, MD 20892–9834, (240) 669–5073,
geetanjali.bansal@nih.gov.
Name of Committee: National Institute of
Allergy and Infectious Diseases Special
Emphasis Panel; NIAID Investigator Initiated
Program Project Applications (P01).
Date: April 30–May 2, 2019.
Time: 9:00 a.m. to 5:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, 5601
Fishers Lane, Rockville, MD 20892
(Telephone Conference Call).
Contact Person: Geetanjali Bansal, Ph.D.,
Scientific Reviewer Officer, Scientific Review
Program, Division of Extramural Activities,
Room 3G49, National Institutes of Health/
NIAID, 5601 Fishers Lane, MSC 9834,
Bethesda, MD 20892–9834, (240) 669–5073,
geetanjali.bansal@nih.gov.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.855, Allergy, Immunology,
and Transplantation Research; 93.856,
Microbiology and Infectious Diseases
Research, National Institutes of Health, HHS)
Dated: February 13, 2019.
Natasha M. Copeland,
Program Analyst, Office of Federal Advisory
Committee Policy.
[FR Doc. 2019–02681 Filed 2–15–19; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
Request for Information (RFI) on
Assays and Approaches for Evaluating
Chemical Effects on Cancer Pathways
AGENCY:
National Institutes of Health,
HHS.
ACTION:
Request for information.
The National Toxicology
Program (NTP) at the National Institute
of Environmental Health Sciences is
seeking input on assays and approaches
for evaluating chemical effects on
cancer pathways, specifically, pathways
that map to the hallmarks of cancer and
key characteristics of carcinogens.
DATES: The National Toxicology
Program’s Request for Information is
open for public comment for a period of
60 days. Comments must be received by
April 22, 2019 to ensure consideration.
After the public comment period has
closed, the comments received by the
NTP will be used to inform the April
29–30th Workshop Converging on
Cancer (https://ntp.niehs.nih.gov/go/
tkelley on DSKBCP9HB2PROD with NOTICES
SUMMARY:
VerDate Sep<11>2014
17:46 Feb 15, 2019
Jkt 247001
coc). All responses to information
requested in this RFI are voluntary.
ADDRESSES: Submissions may be
electronically to https://
ntp.niehs.nih.gov/go/COC_RFI or by
mail to Cynthia Rider, Ph.D., National
Institute of Environmental Health
Sciences, 111 TW Alexander Drive, PO
Box 12233, MD:K2–12, Research
Triangle Park, NC 27709.
FOR FURTHER INFORMATION CONTACT:
Questions about this request for
information should be directed to FOR
FURTHER INFORMATION CONTACT:
Questions about this request for
information should be directed to
Cynthia Rider, Ph.D., National Institute
of Environmental Health Sciences, 111
TW Alexander Drive, PO Box 12233,
MD:K2–12, Research Triangle Park, NC
27709, cynthia.rider@nih.gov, 984–287–
3175.
SUPPLEMENTARY INFORMATION: Cancer is
a leading cause of mortality worldwide.
While the defining feature of cancer is
uncontrolled division of abnormal cells,
it is a complex disease with varied
presentations (i.e., different etiologies
and target tissues) that involves
dysregulation of multiple
interconnected signaling pathways.
Diverse environmental factors have been
associated with the development and
progression of various cancer types. A
critical question in the field of
environmental health is how to harness
what is known about cancer biology and
associated environmental exposures to
improve public health outcomes. This
Request for Information is in support of
the Converging on Cancer Workshop,
which is aimed at providing a clear path
forward for evaluating the interactions
between environmental exposures and
cancer biology using the latest tools in
toxicology and identifying knowledge
gaps that require research attention.
Potential applications of this
understanding include building a
framework for incorporating
mechanistic data into cancer risk
assessment, developing efficient and
reliable screening tools to detect the
carcinogenic potential of environmental
chemicals (including mixtures),
engineering safer products, and
designing more effective multi-target
therapeutics.
The hallmarks of cancer (1) and key
characteristics of carcinogens (2) offer
two paradigms for organizing
information to better understand the
interactions between environmental
exposures and biological systems that
lead to cancer. The hallmarks of cancer
represent the biological traits of tumors
that allow for the unchecked growth of
cancer, while the key characteristics
PO 00000
Frm 00069
Fmt 4703
Sfmt 4703
4831
framework begins with known human
carcinogens and identifies their defining
properties. It is clear from
biomonitoring studies that we are
constantly exposed to numerous
structurally-diverse chemicals. A recent
nomination to NTP was for
development of a testing strategy to
better understand how environmental
chemicals might interact with multiple
cancer-relevant biological pathways to
elicit mixture effects that would not be
expected based on single chemical
considerations. This RFI is intended to
generate input that will facilitate new
testing approaches designed to evaluate
these hypotheses in a cancer context.
Responses to the RFI should provide
information on technologies targeting
cancer-specific pathways and
mechanisms, including organotypic
and/or mechanistically insightful tools,
preferred animal models, and in silico/
computational approaches to link
relevant pathways, as well as cancer
types for use in evaluating hypotheses
regarding the joint action of chemicals
that target cancer pathways.
Information requested: The NTP
requests information regarding assays
and approaches to measure the key
biological mechanisms/pathways
associated with chemical
carcinogenesis. Responses to any or all
of the questions below are invited from
interested individuals/groups,
including, but not limited to, the
environmental health research
community, health professionals,
educators, policy makers, industry, and
the public.
• Systematic review approaches to
transparently identify and evaluate
mechanistic information on the
carcinogenic properties of chemicals
and chemical mixtures.
• Assays associated with the
biological mechanisms/pathways
described by the hallmarks of cancer
and the key characteristics of
carcinogens.
• Assays that integrate across
multiple cancer-related pathways (e.g.,
organotypic microphysiological
systems, mechanistic animal models).
• Modeling approaches to assess the
joint effects of multiple chemicals on
carcinogenic potential.
• Feedback on critical pathways and
mechanisms to target when developing
novel carcinogenicity testing strategies.
• Feedback on cancer types
conducive to exploring chemical
interaction hypotheses.
• Environmental chemicals known to
affect key biological mechanisms/
pathways leading to cancer and which
key biological mechanisms/pathways
are affected by these chemicals.
E:\FR\FM\19FEN1.SGM
19FEN1
4832
Federal Register / Vol. 84, No. 33 / Tuesday, February 19, 2019 / Notices
• Types of scientific data (e.g.,
mechanistic, epidemiological) needed to
address underlying knowledge gaps of
chemical exposures leading to
carcinogenesis.
• New technologies and innovative
research approaches that could be
leveraged to address these underlying
knowledge gaps.
References
1. Hanahan D, Weinberg RA. Hallmarks of
cancer: the next generation. Cell.
2011;144(5):646–74. doi: 10.1016/
j.cell.2011.02.013. PubMed PMID:
21376230.
2. Smith MT, Guyton KZ, Gibbons CF, Fritz
JM, Portier CJ, Rusyn I, et al. Key
Characteristics of Carcinogens as a Basis
for Organizing Data on Mechanisms of
Carcinogenesis. Environmental health
perspectives. 2016;124(6):713–21. doi:
10.1289/ehp.1509912. PubMed PMID:
26600562; PubMed Central PMCID:
PMC4892922.
Dated: February 13, 2019.
Natasha M. Copeland,
Program Analyst, Office of Federal Advisory
Committee Policy.
[FR Doc. 2019–02682 Filed 2–15–19; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
Brian R. Berridge,
Associate Director, National Toxicology
Program, National Institute of Environmental
Health Sciences.
National Institute on Deafness and
Other Communication Disorders;
Notice of Closed Meeting
[FR Doc. 2019–02683 Filed 2–15–19; 8:45 am]
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended, notice is hereby given of the
following meeting.
The meeting will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
BILLING CODE 4140–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
National Institute of Allergy and
Infectious Diseases; Notice of Closed
Meeting
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended, notice is hereby given of the
following meeting.
The meeting will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
tkelley on DSKBCP9HB2PROD with NOTICES
Review Program, Division of Extramural
Activities, Room # 3G41B, National Institutes
of Health/NIAID, 5601 Fishers Lane, MSC
9823, Bethesda, MD 20892–9823, (240) 669–
5068, zhuqing.li@nih.gov.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.855, Allergy, Immunology,
and Transplantation Research; 93.856,
Microbiology and Infectious Diseases
Research, National Institutes of Health, HHS)
Name of Committee: National Institute of
Allergy and Infectious Diseases Special
Emphasis Panel, NIAID Investigator Initiated
Program Project Applications (P01).
Date: May 1, 2019.
Time: 1:00 p.m. to 4:30 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, 5601
Fishers Lane, Rockville, MD 20892
(Telephone Conference Call).
Contact Person: Zhuqing (Charlie) Li,
Ph.D., Scientific Review Officer, Scientific
VerDate Sep<11>2014
17:46 Feb 15, 2019
Jkt 247001
Name of Committee: National Institute on
Deafness and Other Communication
Disorders Special Emphasis Panel; NIDCD
Loan Repayment Review.
Date: March 25, 2019.
Time: 8:30 a.m. to 10:30 a.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health,
Neuroscience Center Building (NSC), 6001
Executive Boulevard, Rockville, MD 20852
(Telephone Conference Call).
Contact Person: Sheo Singh, Ph.D.,
Scientific Review Officer, Scientific Review
Branch, Division of Extramural Activities,
6001 Executive Blvd., Room 8351, Bethesda,
MD 20892, 301–496–8683, singhs@
nidcd.nih.gov.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.173, Biological Research
Related to Deafness and Communicative
Disorders, National Institutes of Health, HHS)
PO 00000
Frm 00070
Fmt 4703
Sfmt 9990
Dated: February 12, 2019.
Sylvia L. Neal,
Program Analyst, Office of Federal Advisory
Committee Policy.
[FR Doc. 2019–02613 Filed 2–15–19; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
National Institute of Diabetes and
Digestive and Kidney Diseases; Notice
of Closed Meeting
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended, notice is hereby given of the
following meeting.
The meeting will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: National Institute of
Diabetes and Digestive and Kidney Diseases
Special Emphasis Panel; Clinical Trials in
Urology.
Date: March 27, 2019.
Time: 2:00 p.m. to 3:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, Two
Democracy Plaza, 6707 Democracy
Boulevard, Bethesda, MD 20892 (Telephone
Conference Call).
Contact Person: Elena Sanovich, Ph.D.,
Scientific Review Officer, Review Branch,
DEA, NIDDK, National Institutes of Health,
Room 7351, 6707 Democracy Boulevard,
Bethesda, MD 20892–2542, 301–594–8886,
sanoviche@mail.nih.gov.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.847, Diabetes,
Endocrinology and Metabolic Research;
93.848, Digestive Diseases and Nutrition
Research; 93.849, Kidney Diseases, Urology
and Hematology Research, National Institutes
of Health, HHS)
Dated: February 12, 2019.
Melanie J. Pantoja,
Program Analyst, Office of Federal Advisory
Committee Policy.
[FR Doc. 2019–02615 Filed 2–15–19; 8:45 am]
BILLING CODE 4140–01–P
E:\FR\FM\19FEN1.SGM
19FEN1
Agencies
[Federal Register Volume 84, Number 33 (Tuesday, February 19, 2019)]
[Notices]
[Pages 4831-4832]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2019-02683]
-----------------------------------------------------------------------
DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
Request for Information (RFI) on Assays and Approaches for
Evaluating Chemical Effects on Cancer Pathways
AGENCY: National Institutes of Health, HHS.
ACTION: Request for information.
-----------------------------------------------------------------------
SUMMARY: The National Toxicology Program (NTP) at the National
Institute of Environmental Health Sciences is seeking input on assays
and approaches for evaluating chemical effects on cancer pathways,
specifically, pathways that map to the hallmarks of cancer and key
characteristics of carcinogens.
DATES: The National Toxicology Program's Request for Information is
open for public comment for a period of 60 days. Comments must be
received by April 22, 2019 to ensure consideration. After the public
comment period has closed, the comments received by the NTP will be
used to inform the April 29-30th Workshop Converging on Cancer (https://ntp.niehs.nih.gov/go/coc). All responses to information requested in
this RFI are voluntary.
ADDRESSES: Submissions may be electronically to https://ntp.niehs.nih.gov/go/COC_RFI or by mail to Cynthia Rider, Ph.D.,
National Institute of Environmental Health Sciences, 111 TW Alexander
Drive, PO Box 12233, MD:K2-12, Research Triangle Park, NC 27709.
FOR FURTHER INFORMATION CONTACT: Questions about this request for
information should be directed to FOR FURTHER INFORMATION CONTACT:
Questions about this request for information should be directed to
Cynthia Rider, Ph.D., National Institute of Environmental Health
Sciences, 111 TW Alexander Drive, PO Box 12233, MD:K2-12, Research
Triangle Park, NC 27709, cynthia.rider@nih.gov, 984-287-3175.
SUPPLEMENTARY INFORMATION: Cancer is a leading cause of mortality
worldwide. While the defining feature of cancer is uncontrolled
division of abnormal cells, it is a complex disease with varied
presentations (i.e., different etiologies and target tissues) that
involves dysregulation of multiple interconnected signaling pathways.
Diverse environmental factors have been associated with the development
and progression of various cancer types. A critical question in the
field of environmental health is how to harness what is known about
cancer biology and associated environmental exposures to improve public
health outcomes. This Request for Information is in support of the
Converging on Cancer Workshop, which is aimed at providing a clear path
forward for evaluating the interactions between environmental exposures
and cancer biology using the latest tools in toxicology and identifying
knowledge gaps that require research attention. Potential applications
of this understanding include building a framework for incorporating
mechanistic data into cancer risk assessment, developing efficient and
reliable screening tools to detect the carcinogenic potential of
environmental chemicals (including mixtures), engineering safer
products, and designing more effective multi-target therapeutics.
The hallmarks of cancer (1) and key characteristics of carcinogens
(2) offer two paradigms for organizing information to better understand
the interactions between environmental exposures and biological systems
that lead to cancer. The hallmarks of cancer represent the biological
traits of tumors that allow for the unchecked growth of cancer, while
the key characteristics framework begins with known human carcinogens
and identifies their defining properties. It is clear from
biomonitoring studies that we are constantly exposed to numerous
structurally-diverse chemicals. A recent nomination to NTP was for
development of a testing strategy to better understand how
environmental chemicals might interact with multiple cancer-relevant
biological pathways to elicit mixture effects that would not be
expected based on single chemical considerations. This RFI is intended
to generate input that will facilitate new testing approaches designed
to evaluate these hypotheses in a cancer context. Responses to the RFI
should provide information on technologies targeting cancer-specific
pathways and mechanisms, including organotypic and/or mechanistically
insightful tools, preferred animal models, and in silico/computational
approaches to link relevant pathways, as well as cancer types for use
in evaluating hypotheses regarding the joint action of chemicals that
target cancer pathways.
Information requested: The NTP requests information regarding
assays and approaches to measure the key biological mechanisms/pathways
associated with chemical carcinogenesis. Responses to any or all of the
questions below are invited from interested individuals/groups,
including, but not limited to, the environmental health research
community, health professionals, educators, policy makers, industry,
and the public.
Systematic review approaches to transparently identify and
evaluate mechanistic information on the carcinogenic properties of
chemicals and chemical mixtures.
Assays associated with the biological mechanisms/pathways
described by the hallmarks of cancer and the key characteristics of
carcinogens.
Assays that integrate across multiple cancer-related
pathways (e.g., organotypic microphysiological systems, mechanistic
animal models).
Modeling approaches to assess the joint effects of
multiple chemicals on carcinogenic potential.
Feedback on critical pathways and mechanisms to target
when developing novel carcinogenicity testing strategies.
Feedback on cancer types conducive to exploring chemical
interaction hypotheses.
Environmental chemicals known to affect key biological
mechanisms/pathways leading to cancer and which key biological
mechanisms/pathways are affected by these chemicals.
[[Page 4832]]
Types of scientific data (e.g., mechanistic,
epidemiological) needed to address underlying knowledge gaps of
chemical exposures leading to carcinogenesis.
New technologies and innovative research approaches that
could be leveraged to address these underlying knowledge gaps.
References
1. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation.
Cell. 2011;144(5):646-74. doi: 10.1016/j.cell.2011.02.013. PubMed
PMID: 21376230.
2. Smith MT, Guyton KZ, Gibbons CF, Fritz JM, Portier CJ, Rusyn I,
et al. Key Characteristics of Carcinogens as a Basis for Organizing
Data on Mechanisms of Carcinogenesis. Environmental health
perspectives. 2016;124(6):713-21. doi: 10.1289/ehp.1509912. PubMed
PMID: 26600562; PubMed Central PMCID: PMC4892922.
Brian R. Berridge,
Associate Director, National Toxicology Program, National Institute of
Environmental Health Sciences.
[FR Doc. 2019-02683 Filed 2-15-19; 8:45 am]
BILLING CODE 4140-01-P