National Institute of Allergy and Infectious Diseases; Notice of Closed Meetings, 4830-4831 [2019-02681]

Download as PDF 4830 Federal Register / Vol. 84, No. 33 / Tuesday, February 19, 2019 / Notices at least 10 business days prior to the meeting. Amy P. McNulty, Acting Director, Division of the Executive Secretariat. [FR Doc. 2019–02623 Filed 2–15–19; 8:45 am] BILLING CODE 4165–15–P DEPARTMENT OF HEALTH AND HUMAN SERVICES Office of the Secretary tkelley on DSKBCP9HB2PROD with NOTICES Office of Security & Strategic Information; Statement of Organization, Functions, and Delegations of Authority Part A, Office of the Secretary, Statement of Organization, Functions, and Delegations of Authority for the Department of Health and Human Services (HHS) is being amended at Part A, Chapter AB, Office of the Secretary, which was last amended at 82 FR 205, dated October 25, 2017. This notice changes the name of the Office of Security and Strategic Information to the Office of National Security. This notice does not revise the roles and authorities of the office or the Assistant Deputy Secretary for National Security, who serves as the Secretary’s Senior Intelligence Official. The changes are as follows: A. Under Chapter AB, Section AB.10 Organization, replace Office of Security and Strategic Information (ABE), with Office of National Security (ABE). B. Under Chapter AB, Section AB.20, Functions, replace the last paragraph, which begins with ‘‘Office of Security and Strategic Information (ABE),’’ with: Office of National Security (ABE). The Office of National Security (ONS) is headed by the Assistant Deputy Secretary for National Security, who reports directly to the Deputy Secretary and also serves as the Secretary’s Senior Intelligence Official on intelligence and counterintelligence issues. The Assistant Deputy Secretary for National Security has been delegated original classification authority by the Secretary. The Assistant Deputy Secretary for National Security manages the ONS.ONS’ vision is for HHS personnel to successfully accomplish missions worldwide in a security-informed manner and with the actionable intelligence needed, at the right time, for operational and policy decisions. ONS’ responsibilities include: Integrating intelligence and security information into HHS policy and operational decisions; assessing, anticipating, and warning of potential security threats to the Department and VerDate Sep<11>2014 17:46 Feb 15, 2019 Jkt 247001 our national security; and, providing policy guidance on and managing the OS implementation of the Department’s security, intelligence and counterintelligence programs. ONS’ programs include national security adjudication, classified national security information management, secure compartmented information facilities management, communications security, safeguarding and sharing of classified information, cyber threat intelligence, insider threat, and counterintelligence. In coordination with the Director of National Intelligence, ONS has been designated as a Federal Intelligence Coordinating Office and the Assistant Deputy Secretary for National Security serves as the HHS Federal Senior Intelligence Coordinator. ONS has responsibilities to establish implementing guidance, provide oversight, and manage the Department’s policy for the sharing, safeguarding, and coordinated exchange of information related to national or homeland security with other federal departments and agencies, including law enforcement organizations and the Intelligence Community, in compliance with HHS policies and applicable laws, regulations, and Executive Orders. C. Delegation of Authority. Pending further redelegation, directives or orders made by the Secretary or Deputy Secretary, all delegations and redelegations of authority made to officials and employees of affected organizational components will continue in them or their successors pending further redelegations, provided they are consistent with this reorganization. Dated: February 12, 2019. Eric D. Hargan, Deputy Secretary, Department of Health and Human Services. [FR Doc. 2019–02663 Filed 2–15–19; 8:45 am] BILLING CODE 4150–03–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Eye Institute; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended, notice is hereby given of the following meeting. The meeting will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose PO 00000 Frm 00068 Fmt 4703 Sfmt 4703 confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Eye Institute Special Emphasis Panel; R21 and R01 Data Analysis Applications. Date: March 19, 2019. Time: 8:00 a.m. to 5:00 p.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health, Rockledge 6700, 6700B Rockledge Drive, Bethesda, MD 20817 (Virtual Meeting). Contact Person: Brian Hoshaw, Ph.D., Scientific Review Officer, National Eye Institute, National Institutes of Health, Division of Extramural Research, 6700 B Rockledge Dr., Ste 3400, Rockville, MD 20892, 301–451–2020, hoshawb@ mail.nih.gov. (Catalogue of Federal Domestic Assistance Program Nos. 93.867, Vision Research, National Institutes of Health, HHS) Dated: February 12, 2019. Natasha M. Copeland, Program Analyst, Office of Federal Advisory Committee Policy. [FR Doc. 2019–02614 Filed 2–15–19; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute of Allergy and Infectious Diseases; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended, notice is hereby given of the following meetings. The meetings will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Institute of Allergy and Infectious Diseases Special Emphasis Panel; NIAID Investigator Initiated Program Project Applications (P01). Date: April 2–5, 2019. Time: 9:00 a.m. to 5:00 p.m. Agenda: To review and evaluate grant applications. E:\FR\FM\19FEN1.SGM 19FEN1 Federal Register / Vol. 84, No. 33 / Tuesday, February 19, 2019 / Notices Place: National Institutes of Health, 5601 Fishers Lane, Rockville, MD 20892 (Telephone Conference Call). Contact Person: Geetanjali Bansal, Ph.D., Scientific Reviewer Officer, Scientific Review Program, Division of Extramural Activities, Room 3G49, National Institutes of Health/ NIAID, 5601 Fishers Lane, MSC 9834, Bethesda, MD 20892–9834, (240) 669–5073, geetanjali.bansal@nih.gov. Name of Committee: National Institute of Allergy and Infectious Diseases Special Emphasis Panel; NIAID Investigator Initiated Program Project Applications (P01). Date: April 30–May 2, 2019. Time: 9:00 a.m. to 5:00 p.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health, 5601 Fishers Lane, Rockville, MD 20892 (Telephone Conference Call). Contact Person: Geetanjali Bansal, Ph.D., Scientific Reviewer Officer, Scientific Review Program, Division of Extramural Activities, Room 3G49, National Institutes of Health/ NIAID, 5601 Fishers Lane, MSC 9834, Bethesda, MD 20892–9834, (240) 669–5073, geetanjali.bansal@nih.gov. (Catalogue of Federal Domestic Assistance Program Nos. 93.855, Allergy, Immunology, and Transplantation Research; 93.856, Microbiology and Infectious Diseases Research, National Institutes of Health, HHS) Dated: February 13, 2019. Natasha M. Copeland, Program Analyst, Office of Federal Advisory Committee Policy. [FR Doc. 2019–02681 Filed 2–15–19; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Request for Information (RFI) on Assays and Approaches for Evaluating Chemical Effects on Cancer Pathways AGENCY: National Institutes of Health, HHS. ACTION: Request for information. The National Toxicology Program (NTP) at the National Institute of Environmental Health Sciences is seeking input on assays and approaches for evaluating chemical effects on cancer pathways, specifically, pathways that map to the hallmarks of cancer and key characteristics of carcinogens. DATES: The National Toxicology Program’s Request for Information is open for public comment for a period of 60 days. Comments must be received by April 22, 2019 to ensure consideration. After the public comment period has closed, the comments received by the NTP will be used to inform the April 29–30th Workshop Converging on Cancer (https://ntp.niehs.nih.gov/go/ tkelley on DSKBCP9HB2PROD with NOTICES SUMMARY: VerDate Sep<11>2014 17:46 Feb 15, 2019 Jkt 247001 coc). All responses to information requested in this RFI are voluntary. ADDRESSES: Submissions may be electronically to https:// ntp.niehs.nih.gov/go/COC_RFI or by mail to Cynthia Rider, Ph.D., National Institute of Environmental Health Sciences, 111 TW Alexander Drive, PO Box 12233, MD:K2–12, Research Triangle Park, NC 27709. FOR FURTHER INFORMATION CONTACT: Questions about this request for information should be directed to FOR FURTHER INFORMATION CONTACT: Questions about this request for information should be directed to Cynthia Rider, Ph.D., National Institute of Environmental Health Sciences, 111 TW Alexander Drive, PO Box 12233, MD:K2–12, Research Triangle Park, NC 27709, cynthia.rider@nih.gov, 984–287– 3175. SUPPLEMENTARY INFORMATION: Cancer is a leading cause of mortality worldwide. While the defining feature of cancer is uncontrolled division of abnormal cells, it is a complex disease with varied presentations (i.e., different etiologies and target tissues) that involves dysregulation of multiple interconnected signaling pathways. Diverse environmental factors have been associated with the development and progression of various cancer types. A critical question in the field of environmental health is how to harness what is known about cancer biology and associated environmental exposures to improve public health outcomes. This Request for Information is in support of the Converging on Cancer Workshop, which is aimed at providing a clear path forward for evaluating the interactions between environmental exposures and cancer biology using the latest tools in toxicology and identifying knowledge gaps that require research attention. Potential applications of this understanding include building a framework for incorporating mechanistic data into cancer risk assessment, developing efficient and reliable screening tools to detect the carcinogenic potential of environmental chemicals (including mixtures), engineering safer products, and designing more effective multi-target therapeutics. The hallmarks of cancer (1) and key characteristics of carcinogens (2) offer two paradigms for organizing information to better understand the interactions between environmental exposures and biological systems that lead to cancer. The hallmarks of cancer represent the biological traits of tumors that allow for the unchecked growth of cancer, while the key characteristics PO 00000 Frm 00069 Fmt 4703 Sfmt 4703 4831 framework begins with known human carcinogens and identifies their defining properties. It is clear from biomonitoring studies that we are constantly exposed to numerous structurally-diverse chemicals. A recent nomination to NTP was for development of a testing strategy to better understand how environmental chemicals might interact with multiple cancer-relevant biological pathways to elicit mixture effects that would not be expected based on single chemical considerations. This RFI is intended to generate input that will facilitate new testing approaches designed to evaluate these hypotheses in a cancer context. Responses to the RFI should provide information on technologies targeting cancer-specific pathways and mechanisms, including organotypic and/or mechanistically insightful tools, preferred animal models, and in silico/ computational approaches to link relevant pathways, as well as cancer types for use in evaluating hypotheses regarding the joint action of chemicals that target cancer pathways. Information requested: The NTP requests information regarding assays and approaches to measure the key biological mechanisms/pathways associated with chemical carcinogenesis. Responses to any or all of the questions below are invited from interested individuals/groups, including, but not limited to, the environmental health research community, health professionals, educators, policy makers, industry, and the public. • Systematic review approaches to transparently identify and evaluate mechanistic information on the carcinogenic properties of chemicals and chemical mixtures. • Assays associated with the biological mechanisms/pathways described by the hallmarks of cancer and the key characteristics of carcinogens. • Assays that integrate across multiple cancer-related pathways (e.g., organotypic microphysiological systems, mechanistic animal models). • Modeling approaches to assess the joint effects of multiple chemicals on carcinogenic potential. • Feedback on critical pathways and mechanisms to target when developing novel carcinogenicity testing strategies. • Feedback on cancer types conducive to exploring chemical interaction hypotheses. • Environmental chemicals known to affect key biological mechanisms/ pathways leading to cancer and which key biological mechanisms/pathways are affected by these chemicals. E:\FR\FM\19FEN1.SGM 19FEN1

Agencies

[Federal Register Volume 84, Number 33 (Tuesday, February 19, 2019)]
[Notices]
[Pages 4830-4831]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2019-02681]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


National Institute of Allergy and Infectious Diseases; Notice of 
Closed Meetings

    Pursuant to section 10(d) of the Federal Advisory Committee Act, as 
amended, notice is hereby given of the following meetings.
    The meetings will be closed to the public in accordance with the 
provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 
U.S.C., as amended. The grant applications and the discussions could 
disclose confidential trade secrets or commercial property such as 
patentable material, and personal information concerning individuals 
associated with the grant applications, the disclosure of which would 
constitute a clearly unwarranted invasion of personal privacy.

    Name of Committee: National Institute of Allergy and Infectious 
Diseases Special Emphasis Panel; NIAID Investigator Initiated 
Program Project Applications (P01).
    Date: April 2-5, 2019.
    Time: 9:00 a.m. to 5:00 p.m.
    Agenda: To review and evaluate grant applications.

[[Page 4831]]

    Place: National Institutes of Health, 5601 Fishers Lane, 
Rockville, MD 20892 (Telephone Conference Call).
    Contact Person: Geetanjali Bansal, Ph.D., Scientific Reviewer 
Officer, Scientific Review Program, Division of Extramural 
Activities, Room 3G49, National Institutes of Health/NIAID, 5601 
Fishers Lane, MSC 9834, Bethesda, MD 20892-9834, (240) 669-5073, 
geetanjali.bansal@nih.gov.

    Name of Committee: National Institute of Allergy and Infectious 
Diseases Special Emphasis Panel; NIAID Investigator Initiated 
Program Project Applications (P01).
    Date: April 30-May 2, 2019.
    Time: 9:00 a.m. to 5:00 p.m.
    Agenda: To review and evaluate grant applications.
    Place: National Institutes of Health, 5601 Fishers Lane, 
Rockville, MD 20892 (Telephone Conference Call).
    Contact Person: Geetanjali Bansal, Ph.D., Scientific Reviewer 
Officer, Scientific Review Program, Division of Extramural 
Activities, Room 3G49, National Institutes of Health/NIAID, 5601 
Fishers Lane, MSC 9834, Bethesda, MD 20892-9834, (240) 669-5073, 
geetanjali.bansal@nih.gov.

(Catalogue of Federal Domestic Assistance Program Nos. 93.855, 
Allergy, Immunology, and Transplantation Research; 93.856, 
Microbiology and Infectious Diseases Research, National Institutes 
of Health, HHS)

    Dated: February 13, 2019.
Natasha M. Copeland,
Program Analyst, Office of Federal Advisory Committee Policy.
[FR Doc. 2019-02681 Filed 2-15-19; 8:45 am]
BILLING CODE 4140-01-P
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