National Cancer Institute; Notice of Meeting, 47629 [2018-20418]

Download as PDF Federal Register / Vol. 83, No. 183 / Thursday, September 20, 2018 / Notices order to facilitate their entry into the building. Contact Ann Ferrero using the information mentioned above by Thursday, October 18, 2018, 12:00 p.m. ET. All attendees are required to present government-issued identification prior to entry. The meeting will also be accessible via webcast. Instructions on how to access the meeting via webcast will be provided upon registration. Amy P. McNulty, Acting Director, Division of the Executive Secretariat. [FR Doc. 2018–20428 Filed 9–19–18; 8:45 am] BILLING CODE 4165–15–P Dated: September 14, 2018. Melanie J. Pantoja, Program Analyst, Office of Federal Advisory Committee Policy. DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health [FR Doc. 2018–20418 Filed 9–19–18; 8:45 am] National Cancer Institute; Notice of Meeting BILLING CODE 4140–01–P amozie on DSK3GDR082PROD with NOTICES1 Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended, notice is hereby given of a meeting of the National Cancer Institute Council of Research Advocates. The meeting will be open to the public, with attendance limited to space available. Individuals who plan to attend and need special assistance, such as sign language interpretation or other reasonable accommodations, should notify the Contact Person listed below in advance of the meeting. The open session will be videocast and can be accessed from the NIH Videocasting and Podcasting website (https:// videocast.nih.gov). Name of Committee: National Cancer Institute Council of Research Advocates. Date: October 19, 2018. Time: 9:00 a.m. to 4:30 p.m. Agenda: Welcome and Chairman’s Remarks, NCI Updates, Legislative Update, Budget Update, and Director’s Update. Place: National Institutes of Health, 35A Convent Drive, Building 35A, 640, Bethesda, MD 20892. Contact Person: Amy Williams, NCI Office of Advocacy Relations, National Cancer Institute, NIH, 31 Center Drive, Building 31, Room 10A28, Bethesda, MD 20892, 240–781– 3360 williaam@mail.nih.gov. Any interested person may file written comments with the committee by forwarding the statement to the Contact Person listed on this notice. The statement should include the name, address, telephone number and when applicable, the business or professional affiliation of the interested person. In the interest of security, NIH has instituted stringent procedures for entrance onto the NIH campus. All visitor vehicles, including taxicabs, hotel, and airport shuttles will be inspected before being allowed on campus. Visitors will be asked to show one form of identification (for example, a VerDate Sep<11>2014 18:01 Sep 19, 2018 Jkt 244001 government-issued photo ID, driver’s license, or passport) and to state the purpose of their visit. Information is also available on the Institute’s/Center’s home page: NCRA: https:// deainfo.nci.nih.gov/advisory/ncra/ncra.htm, where an agenda and any additional information for the meeting will be posted when available. (Catalogue of Federal Domestic Assistance Program Nos. 93.392, Cancer Construction; 93.393, Cancer Cause and Prevention Research; 93.394, Cancer Detection and Diagnosis Research; 93.395, Cancer Treatment Research; 93.396, Cancer Biology Research; 93.397, Cancer Centers Support; 93.398, Cancer Research Manpower; 93.399, Cancer Control, National Institutes of Health, HHS) DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Government-Owned Inventions; Availability for Licensing AGENCY: National Institutes of Health, HHS. ACTION: Notice. The invention listed below is owned by an agency of the U.S. Government and is available for licensing to achieve expeditious commercialization of results of federally-funded research and development. Foreign patent applications are filed on selected inventions to extend market coverage for companies and may also be available for licensing. FOR FURTHER INFORMATION CONTACT: Barry Buchbinder, Ph.D., 240–627– 3678; barry.buchbinder@nih.gov. Licensing information and copies of the U.S. patent application listed below may be obtained by communicating with the indicated licensing contact at the Technology Transfer and Intellectual Property Office, National Institute of Allergy and Infectious Diseases, 5601 Fishers Lane, Rockville, MD 20852; tel. 301–496–2644. A signed Confidential Disclosure Agreement will be required to receive copies of unpublished patent applications. SUPPLEMENTARY INFORMATION: Technology description follows. SUMMARY: Glycan-Masked Engineered Outer Domains of HIV-1 GP120 and Their Use Description of Technology: PO 00000 Frm 00030 Fmt 4703 Sfmt 4703 47629 The VRC01-class of potent, broadly neutralizing antibodies (bnAbs) targets the conserved CD4-binding site (CD4bs) of HIV-1 Env which has been a major target of HIV-vaccine design. The current best priming immunogen to engage the VRC01-class germline precursors is the eOD-GT8 60mer, which elicits VRC01-class precursors in multiple transgenic mouse models. However, a large proportion of the antibodies elicited by eOD-GT8 60mer are non-CD4bs or ‘‘off-target’’ antibodies, undermining its effectiveness in eliciting the VRC01class bnAb precursors. Researchers at the Vaccine Research Center (VRC) of the National Institute of Allergy and Infectious Diseases introduced multiple N-linked glycosylation sites to mask non-CD4bs regions of eOD-GT8 60mer to focus the antibody immune response to the CD4bs. Several glycan-masked mutants showed significantly decreased antibody binding to non-CD4bs ‘‘offtarget’’ epitopes while maintaining strong binding to CD4bs-specific bnAbs. Furthermore, in vivo studies showed that immunization with the best glycanmasked eOD-GT8 mutants resulted in significant increases in the elicitation of CD4bs-specific serum antibodies, CD4bs-specific B cells in the spleen, and VRC01-class precursors, compared to immunization with the parental eODGT8 immunogen. In conclusion, because of their improved antigenic and immunogenic profiles, glycan-masked eOD-GT8 60mer mutants may serve as improved priming immunogens to elicit VRC01-class bnAbs in humans. Potential Commercial Applications: • HIV-1 vaccine—the priming component in a prime-boost approach. Competitive Advantages: • Reduced off-target immunogenicity. • Improved efficacy in eliciting precursors for broadly neutralizing CD4bs antibodies. • Facilitates the development of VRC01-class bnAbs in humans. Development Stage: In vivo testing (rodents). Inventors: John R. Mascola (NIAID), Hongying Duan (NIAID), Xuejun Chen (NIAID), Cheng Cheng (NIAID) and Jeffrey C. Boyington (NIAID). Publications: Duan, H. et al., Glycan Masking Focuses Immune Responses to the HIV-1 CD4-Binding Site and Enhances Elicitation of VRC01-Class Precursor Antibodies. Immunity 49, 301 (2018). Intellectual Property: HHS Reference Number E–083–2017 includes U.S. Provisional Patent Application Number 62/476,397 filed 03/24/2017 and PCT E:\FR\FM\20SEN1.SGM 20SEN1

Agencies

[Federal Register Volume 83, Number 183 (Thursday, September 20, 2018)]
[Notices]
[Page 47629]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2018-20418]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


National Cancer Institute; Notice of Meeting

    Pursuant to section 10(d) of the Federal Advisory Committee Act, as 
amended, notice is hereby given of a meeting of the National Cancer 
Institute Council of Research Advocates.
    The meeting will be open to the public, with attendance limited to 
space available. Individuals who plan to attend and need special 
assistance, such as sign language interpretation or other reasonable 
accommodations, should notify the Contact Person listed below in 
advance of the meeting. The open session will be videocast and can be 
accessed from the NIH Videocasting and Podcasting website (https://videocast.nih.gov).

    Name of Committee: National Cancer Institute Council of Research 
Advocates.
    Date: October 19, 2018.
    Time: 9:00 a.m. to 4:30 p.m.
    Agenda: Welcome and Chairman's Remarks, NCI Updates, Legislative 
Update, Budget Update, and Director's Update.
    Place: National Institutes of Health, 35A Convent Drive, 
Building 35A, 640, Bethesda, MD 20892.
    Contact Person: Amy Williams, NCI Office of Advocacy Relations, 
National Cancer Institute, NIH, 31 Center Drive, Building 31, Room 
10A28, Bethesda, MD 20892, 240-781-3360 [email protected].

    Any interested person may file written comments with the 
committee by forwarding the statement to the Contact Person listed 
on this notice. The statement should include the name, address, 
telephone number and when applicable, the business or professional 
affiliation of the interested person.
    In the interest of security, NIH has instituted stringent 
procedures for entrance onto the NIH campus. All visitor vehicles, 
including taxicabs, hotel, and airport shuttles will be inspected 
before being allowed on campus. Visitors will be asked to show one 
form of identification (for example, a government-issued photo ID, 
driver's license, or passport) and to state the purpose of their 
visit.
    Information is also available on the Institute's/Center's home 
page: NCRA: https://deainfo.nci.nih.gov/advisory/ncra/ncra.htm, where 
an agenda and any additional information for the meeting will be 
posted when available.

(Catalogue of Federal Domestic Assistance Program Nos. 93.392, 
Cancer Construction; 93.393, Cancer Cause and Prevention Research; 
93.394, Cancer Detection and Diagnosis Research; 93.395, Cancer 
Treatment Research; 93.396, Cancer Biology Research; 93.397, Cancer 
Centers Support; 93.398, Cancer Research Manpower; 93.399, Cancer 
Control, National Institutes of Health, HHS)

    Dated: September 14, 2018.
Melanie J. Pantoja,
Program Analyst, Office of Federal Advisory Committee Policy.
[FR Doc. 2018-20418 Filed 9-19-18; 8:45 am]
 BILLING CODE 4140-01-P

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