Government-Owned Inventions; Availability for Licensing, 29127-29128 [2018-13416]

Download as PDF Federal Register / Vol. 83, No. 121 / Friday, June 22, 2018 / Notices Enhancement Award; 93.936, NIH Acquired Immunodeficiency Syndrome Research Loan Repayment Program; 93.187, Undergraduate Scholarship Program for Individuals from Disadvantaged Backgrounds, National Institutes of Health, HHS) Dated: June 19, 2018. Natasha M. Copeland, Program Analyst, Office of Federal Advisory Committee Policy. [FR Doc. 2018–13419 Filed 6–21–18; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Prospective Grant of an Exclusive Patent License: Methods of Modulating Erythropoiesis With Arginine Vasopressin Receptor 1B Molecules AGENCY: National Institutes of Health, HHS. ACTION: Notice. The National Institute of Dental and Craniofacial Research, an institute of the National Institutes of Health, Department of Health and Human Services, is contemplating the grant of an Exclusive Patent License to practice the inventions embodied in the Patent Applications listed in the Supplementary Information section of this notice to ERYTHRYx Therapeutics, located in Los Angeles, California. DATES: Only written comments and/or applications for a license which are received by the Office of Technology Transfer and Innovation Access, National Institute of Dental and Craniofacial Research on or before July 9, 2018 will be considered. ADDRESSES: Requests for copies of the patent application, inquiries, and comments relating to the contemplated an Exclusive Patent License should be directed to: Yun Mei, Technology Transfer and Patent Specialist, Office of Technology Transfer and Innovation Access, National Institute of Dental and Craniofacial Research, National Institutes of Health, BLDG 1 DEM, RM667, 6701 Democracy Blvd., Bethesda, MD 20817; Telephone: (301) 827–4639; Facsimile: (301) 496–1005; Email: yun.mei@nih.gov. SUPPLEMENTARY INFORMATION: daltland on DSKBBV9HB2PROD with NOTICES SUMMARY: Intellectual Property 1. U.S. Provisional Patent Application No. 61/885,258, filed October 1, 2013 and entitled ‘‘Methods of Modulating Erythropoiesis with Arginine Vasopressin Receptor 1B Molecules’’ VerDate Sep<11>2014 17:16 Jun 21, 2018 Jkt 244001 (HHS Reference No. E–619–2013–0–US– 01); 2. PCT Application No. PCT/US2014/ 058613, filed October 1, 2014 and entitled ‘‘Methods of Modulating Erythropoiesis with Arginine Vasopressin Receptor 1B Molecules’’ (HHS Reference No. E–619–2013–0– PCT–02); 3. U.S. Patent Application No. 15/ 022,531, filed March 16, 2016 and entitled ‘‘Methods of Modulating Erythropoiesis with Arginine Vasopressin Receptor 1B Molecules’’ (HHS Reference No. E–619–2013–0–US– 03); The patent rights in these inventions have been assigned and/or exclusively licensed to the government of the United States of America. The prospective exclusive license territory may be the United States and the field of use may be limited to ‘‘Use of arginine vasopressin receptor 1B agonists to treat anemia caused by (i) chronic renal failure on dialysis, (ii) receiving myelosuppressive chemotherapy, or (iii) lacking antidiuretic hormone.’’ The subject technology is a method of using arginine vasopressin receptor 1B (AVPR1B) agonists to increase the number of red blood cells to treat anemia. The inventors discovered that hematopoietic stem cells express AVPR1B receptor, and these receptors play a key role in promoting hematopoietic stem and progenitor cell proliferation. The number of red blood cells and their precursors significantly increased on day 2 following vasopressin administration, an onset time much faster than erythropoietin (EPO), which is commonly used to stimulate red blood cell production for anemia treatment. EPO takes about a week to manifest its clinical effects. The AVPR1B agonists can be used to jumpstart the hematopoietic system and erythropoietin can be used to sustain the effect. The subject technology is a repurposing of an existing drug, vasopressin, an AVPR1B agonist, also called antidiuretic hormone. It is a nineamino acid peptide secreted from the posterior pituitary and used to treat patients with central diabetes insipidus, an uncommon disorder that causes an imbalance of water in the body. This imbalance leads to excretion of large amount of urine (polyuria) and intense thirst even after drinking fluids (polydipsia). This notice is made in accordance with 35 U.S.C. 209 and 37 CFR part 404. The prospective exclusive license will be royalty bearing, and the prospective exclusive license may be granted unless PO 00000 Frm 00040 Fmt 4703 Sfmt 4703 29127 within fifteen (15) days from the date of this published notice, the National Institute of Dental and Craniofacial Research receives written evidence and argument that establishes that the grant of the license would not be consistent with the requirements of 35 U.S.C. 209 and 37 CFR part 404. In response to this Notice, the public may file comments or objections. Comments and objections, other than those in the form of a license application, will not be treated confidentially, and may be made publicly available. License applications submitted in response to this Notice will be presumed to contain business confidential information and any release of information in these license applications will be made only as required and upon a request under the Freedom of Information Act, 5 U.S.C. 552. Dated: June 19, 2018. David W. Bradley, Director, Office of Technology Transfer and Innovation Access, National Institute of Dental and Craniofacial Research, National Institutes of Health. [FR Doc. 2018–13443 Filed 6–21–18; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Government-Owned Inventions; Availability for Licensing AGENCY: National Institutes of Health, HHS. ACTION: Notice. The invention listed below is owned by an agency of the U.S. Government and is available for licensing to achieve expeditious commercialization of results of federally-funded research and development. Foreign patent applications are filed on selected inventions to extend market coverage for companies and may also be available for licensing. FOR FURTHER INFORMATION CONTACT: Dr. Barry Buchbinder, 240–627–3678; barry.buchbinder@nih.gov. Licensing information and copies of the U.S. patent application listed below may be obtained by communicating with the indicated licensing contact at the Technology Transfer and Intellectual Property Office, National Institute of Allergy and Infectious Diseases, 5601 Fishers Lane, Rockville, MD 20852; tel. 301–496–2644. A signed Confidential SUMMARY: E:\FR\FM\22JNN1.SGM 22JNN1 29128 Federal Register / Vol. 83, No. 121 / Friday, June 22, 2018 / Notices Disclosure Agreement will be required to receive copies of unpublished patent applications. SUPPLEMENTARY INFORMATION: Technology description follows. Recombinant HIV-1 Envelope Protein for Vaccine Use Description of Technology In pursuit of an effective vaccine to end the global HIV-1/AIDS pandemic, researchers at the Vaccine Research Center (‘‘VRC’’) continue to study the structure of HIV-1. Recently, these researchers have determined the threedimensional structure of the HIV-1 Envelope trimeric ectodomain (‘‘Env’’), comprised of three gp120 and three gp41 subunits, in its prefusion, mature, closed conformation. The researchers hypothesize that immunization with the prefusion, closed HIV-1 Env protein will elicit a neutralizing immune response. The VRC researchers engineered a portion of the HIV-1 Env trimer to stabilize it in this closed conformation for use as an immunogen. This technology is available for licensing for commercial development in accordance with 35 U.S.C. 209 and 37 CFR part 404, as well as for further development and evaluation under a research collaboration. trimeric pre-fusion HIV-1 Env. Nature. 2014 Oct 23; 514(7523):455–61. [PMID: 25296255]. Intellectual Property: HHS Reference Number E–178–2014 includes U.S. Provisional Patent Application No. 62/ 046,059 filed September 4, 2014; U.S. Provisional Patent Application No. 62/ 136,480 filed March 21, 2015; PCT Application No. PCT/US2015/048729 filed September 4, 2015; U.S. Patent Application No. 15/508,885 filed March 3, 2017; and EPO Patent Application No. 15766697.5 filed March 29, 2017. Licensing Contact: Dr. Barry Buchbinder, 240–627–3674; barry.buchbinder@nih.gov. Collaborative Research Opportunity: The National Institute of Allergy and Infectious Diseases is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize HIV-1 immunogens for treating or preventing HIV-1 infection. For collaboration opportunities, please contact Dr. Barry Buchbinder, 240–627– 3674; barry.buchbinder@nih.gov. Dated: June 14, 2018. Suzanne M. Frisbie, Deputy Director, Technology Transfer and Intellectual Property Office, National Institute of Allergy and Infectious Diseases. [FR Doc. 2018–13416 Filed 6–21–18; 8:45 am] BILLING CODE 4140–01–P Potential Commercial Applications • Vaccine for prevention of HIV-1 infection. • Therapeutic vaccine for treatment of HIV-1 infection. Competitive Advantages daltland on DSKBBV9HB2PROD with NOTICES Development Stage • In vitro studies characterizing the immunogen and its interaction with HIV antibodies. • In vivo results including immunogenicity in rabbits and guinea pigs, neutralizing activity of resulting serum. Inventors: Peter D. Kwong (NIAID), Ivelin S. Georgiev (NIAID), Michael Gordon Joyce (NIAID), Marie L. Pancera (NIAID), Tongqing Zhou (NIAID), Priyamvada Acharya (NIAID), Jason J. Gorman (NIAID), Yongping Yang (NIAID), Aliaksandr A. Druz (NIAID), Guillaume Stewart-Jones (NIAID), Rita Chen (NIAID), Gwo-Yu Chuang (NIAID), Ulrich Baxa (NIAID), John R. Mascola (NIAID), Rebecca M. Lynch (NIAID), Baoshan Zhang (NIAID), Cheng Cheng (NIAID). Publications: Pancera M., et al. Structure and immune recognition of 17:16 Jun 21, 2018 Jkt 244001 National Institutes of Health National Eye Institute; Notice of Closed Meetings • Currently, no licensed HIV-1 vaccine exists. VerDate Sep<11>2014 DEPARTMENT OF HEALTH AND HUMAN SERVICES Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended, notice is hereby given of the following meetings. The meetings will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Eye Institute Special Emphasis Panel; NEI Cooperative Agreement (UG1) and Clinical Trial Planning Grant (R34) Applications. Date: July 13, 2018. Time: 1:00 p.m. to 4:00 p.m. Agenda: To review and evaluate cooperative agreement applications. PO 00000 Frm 00041 Fmt 4703 Sfmt 4703 Place: National Institutes of Health, 5635 Fishers Lane, Bethesda, MD 20892 (Virtual Meeting). Contact Person: Anne E. Schaffner, Ph.D., Chief, Scientific Review Branch, Division of Extramural Research, National Eye Institute, 5635 Fishers Lane, Suite 1300, MSC 9300, Bethesda, MD 20892–9300, (301) 451–2020, aes@nei.nih.gov. Name of Committee: National Eye Institute Special Emphasis Panel; NEI Research Project Grant Applications (R01). Date: July 25, 2018. Time: 12:00 p.m. to 2:00 p.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health 5635 Fishers Lane, Bethesda, MD 20892 (Telephone Conference Call). Contact Person: Brian Hoshaw, Ph.D., Scientific Review Officer National Eye Institute National Institutes of Health, Division of Extramural Research 5635 Fishers Lane, Suite 1300, Rockville, MD 20892, 301– 451–2020, hoshawb@mail.nih.gov. (Catalogue of Federal Domestic Assistance Program Nos. 93.867, Vision Research, National Institutes of Health, HHS) Dated: June 19, 2018. Natasha M. Copeland, Program Analyst, Office of Federal Advisory Committee Policy. [FR Doc. 2018–13413 Filed 6–21–18; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute on Drug Abuse; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended, notice is hereby given of the following meetings. The meetings will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The contract proposals and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the contract proposals, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Institute on Drug Abuse Special Emphasis Panel; Receptor Profiling and Predictive Toxicology (8937). Date: July 19, 2018. Time: 10:00 a.m. to 12:30 p.m. Agenda: To review and evaluate contract proposals. Place: National Institutes of Health, Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852 (Telephone Conference Call). E:\FR\FM\22JNN1.SGM 22JNN1

Agencies

[Federal Register Volume 83, Number 121 (Friday, June 22, 2018)]
[Notices]
[Pages 29127-29128]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2018-13416]


-----------------------------------------------------------------------

DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Government-Owned Inventions; Availability for Licensing

AGENCY: National Institutes of Health, HHS.

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: The invention listed below is owned by an agency of the U.S. 
Government and is available for licensing to achieve expeditious 
commercialization of results of federally-funded research and 
development. Foreign patent applications are filed on selected 
inventions to extend market coverage for companies and may also be 
available for licensing.

FOR FURTHER INFORMATION CONTACT: Dr. Barry Buchbinder, 240-627-3678; 
[email protected]. Licensing information and copies of the U.S. 
patent application listed below may be obtained by communicating with 
the indicated licensing contact at the Technology Transfer and 
Intellectual Property Office, National Institute of Allergy and 
Infectious Diseases, 5601 Fishers Lane, Rockville, MD 20852; tel. 301-
496-2644. A signed Confidential

[[Page 29128]]

Disclosure Agreement will be required to receive copies of unpublished 
patent applications.

SUPPLEMENTARY INFORMATION: Technology description follows.

Recombinant HIV-1 Envelope Protein for Vaccine Use

Description of Technology

    In pursuit of an effective vaccine to end the global HIV-1/AIDS 
pandemic, researchers at the Vaccine Research Center (``VRC'') continue 
to study the structure of HIV-1. Recently, these researchers have 
determined the three-dimensional structure of the HIV-1 Envelope 
trimeric ectodomain (``Env''), comprised of three gp120 and three gp41 
subunits, in its prefusion, mature, closed conformation.
    The researchers hypothesize that immunization with the prefusion, 
closed HIV-1 Env protein will elicit a neutralizing immune response. 
The VRC researchers engineered a portion of the HIV-1 Env trimer to 
stabilize it in this closed conformation for use as an immunogen.
    This technology is available for licensing for commercial 
development in accordance with 35 U.S.C. 209 and 37 CFR part 404, as 
well as for further development and evaluation under a research 
collaboration.

Potential Commercial Applications

     Vaccine for prevention of HIV-1 infection.
     Therapeutic vaccine for treatment of HIV-1 infection.

Competitive Advantages

     Currently, no licensed HIV-1 vaccine exists.

Development Stage

     In vitro studies characterizing the immunogen and its 
interaction with HIV antibodies.
     In vivo results including immunogenicity in rabbits and 
guinea pigs, neutralizing activity of resulting serum.
    Inventors: Peter D. Kwong (NIAID), Ivelin S. Georgiev (NIAID), 
Michael Gordon Joyce (NIAID), Marie L. Pancera (NIAID), Tongqing Zhou 
(NIAID), Priyamvada Acharya (NIAID), Jason J. Gorman (NIAID), Yongping 
Yang (NIAID), Aliaksandr A. Druz (NIAID), Guillaume Stewart-Jones 
(NIAID), Rita Chen (NIAID), Gwo-Yu Chuang (NIAID), Ulrich Baxa (NIAID), 
John R. Mascola (NIAID), Rebecca M. Lynch (NIAID), Baoshan Zhang 
(NIAID), Cheng Cheng (NIAID).
    Publications: Pancera M., et al. Structure and immune recognition 
of trimeric pre-fusion HIV-1 Env. Nature. 2014 Oct 23; 514(7523):455-
61. [PMID: 25296255].
    Intellectual Property: HHS Reference Number E-178-2014 includes 
U.S. Provisional Patent Application No. 62/046,059 filed September 4, 
2014; U.S. Provisional Patent Application No. 62/136,480 filed March 
21, 2015; PCT Application No. PCT/US2015/048729 filed September 4, 
2015; U.S. Patent Application No. 15/508,885 filed March 3, 2017; and 
EPO Patent Application No. 15766697.5 filed March 29, 2017.
    Licensing Contact: Dr. Barry Buchbinder, 240-627-3674; 
[email protected].
    Collaborative Research Opportunity: The National Institute of 
Allergy and Infectious Diseases is seeking statements of capability or 
interest from parties interested in collaborative research to further 
develop, evaluate, or commercialize HIV-1 immunogens for treating or 
preventing HIV-1 infection. For collaboration opportunities, please 
contact Dr. Barry Buchbinder, 240-627-3674; [email protected].

    Dated: June 14, 2018.
Suzanne M. Frisbie,
Deputy Director, Technology Transfer and Intellectual Property Office, 
National Institute of Allergy and Infectious Diseases.
[FR Doc. 2018-13416 Filed 6-21-18; 8:45 am]
 BILLING CODE 4140-01-P

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