Interagency Coordinating Committee on the Validation of Alternative Methods Communities of Practice Webinar on Machine Learning in Toxicology: Fundamentals of Application and Interpretation; Notice of Public Webinar; Registration Information, 823-824 [2018-00120]
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Federal Register / Vol. 83, No. 5 / Monday, January 8, 2018 / Notices
have proven to be both highly antigenic
and shown to be responsible in allowing
malaria parasites to evade the mosquito
immune system. Proof of concept in a
mouse model has demonstrated that
vaccination using specific P47 protein
fragments blocks Plasmodium
transmission by mosquitoes.
Immunization with the P47 protein
variants of this technology provides a
candidate for a potential, effective,
transmission blocking malaria vaccine
against Plasmodium species.
This technology is available for
licensing for commercial development
in accordance with 35 U.S.C. 209 and 37
CFR part 404, as well as for further
development and evaluation under a
research collaboration.
Potential Commercial Applications:
• Transmission blocking malaria
vaccine
Competitive Advantages:
• Transmission blocking of
Plasmodium
• Transmission blocking activity based
on recruiting the mosquito immune
system to kill Plasmodium parasites
by blocking Plasmodium immune
evasion
Development Stage:
sradovich on DSK3GMQ082PROD with NOTICES
• Early-stage
• In vitro data available
• In vivo data available (animal)
Inventors: Carolina Veronica BarillasMury, Alvaro Molina-Cruz, Gaspar
Exequiel Canepa, all of NIAID.
Publications:
Intellectual Property: HHS Reference
No. E–294–2016/0—U.S. Provisional
Application No. 62/463,011, filed
February 24, 2017.
Licensing Contact: Peter Tung, 240–
669–5483; peter.tung@nih.gov.
Collaborative Research Opportunity:
The National Institute of Allergy and
Infectious Diseases is seeking statements
of capability or interest from parties
interested in collaborative research to
further develop, evaluate or
commercialize P47 protein fragments as
a transmission blocking vaccine. For
collaboration opportunities, please
contact Peter Tung at 240–669–5483;
peter.tung@nih.gov.
Dated: December 13, 2017.
Suzanne Frisbie,
Deputy Director, Technology Transfer and
Intellectual Property Office, National Institute
of Allergy and Infectious Diseases.
[FR Doc. 2018–00121 Filed 1–5–18; 8:45 am]
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DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
Interagency Coordinating Committee
on the Validation of Alternative
Methods Communities of Practice
Webinar on Machine Learning in
Toxicology: Fundamentals of
Application and Interpretation; Notice
of Public Webinar; Registration
Information
AGENCY:
National Institutes of Health,
HHS.
ACTION:
Notice.
The Interagency Coordinating
Committee on the Validation of
Alternative Methods (ICCVAM)
announces a public webinar ‘‘Machine
Learning in Toxicology: Fundamentals
of Application and Interpretation.’’ The
webinar is organized on behalf of
ICCVAM by the National Toxicology
Program Interagency Center for the
Evaluation of Alternative Toxicological
Methods (NICEATM). Interested persons
may participate via WebEx. Time will
be allotted for questions from the
audience.
SUMMARY:
Webinar: January 23, 2018, 1:00
p.m. to approximately 2:30 p.m. Eastern
Standard Time (EST). Registration for
the Webinar: December 18, 2017, until
2:30 p.m. on January 23, 2018.
ADDRESSES: Webinar web page: https://
ntp.niehs.nih.gov/go/commprac-2018.
FOR FURTHER INFORMATION CONTACT: Dr.
Warren Casey, Director, NICEATM;
telephone: (984) 287–3118; email:
warren.casey@nih.gov.
SUPPLEMENTARY INFORMATION:
Background: ICCVAM promotes the
development and validation of toxicity
testing methods that protect human
health and the environment while
replacing, reducing, or refining animal
use. ICCVAM also provides guidance to
test method developers and facilitates
collaborations that promote the
development of new test methods. To
address these goals, ICCVAM will hold
a Communities of Practice webinar on
‘‘Machine Learning in Toxicology:
Fundamentals of Application and
Interpretation.’’
The ICCVAM webinar will explore
the fundamentals of machine learning
approaches, including how they work,
how they are interpreted, and
precautions that should be taken when
evaluating their output. It will feature
presentations by two experts in use of
machine learning in toxicity texting
applications that will address issues
specific to use of machine learning
DATES:
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823
approaches in a regulatory context. Case
studies will be presented to highlight
where such techniques have been
successfully applied both nationally and
internationally. The preliminary agenda
and additional information about
presentations will be posted at https://
ntp.niehs.nih.gov/go/commprac-2018 as
available.
Webinar and Registration: This
webinar is open to the public with time
scheduled for questions by participants
following each presentation.
Registration for the webinar is required
and is open through 2:30 p.m. on
January 23, 2018. Registration is
available at https://ntp.niehs.nih.gov/go/
commprac-2018. Interested individuals
are encouraged to visit this web page to
stay abreast of the most current webinar
information. Registrants will receive
instructions on how to access and
participate in the webinar in an email
sent shortly before the webinar.
Individuals with disabilities who
need accommodation to participate in
this event should contact Elizabeth
Maull at phone: (984) 287–3157 or
email: maull@niehs.nih.gov. TTY users
should contact the Federal TTY Relay
Service at (800) 877–8339. Requests
should be made at least five business
days in advance of the event.
Background Information on ICCVAM
and NICEATM: ICCVAM is an
interagency committee composed of
representatives from 16 federal
regulatory and research agencies that
require, use, generate, or disseminate
toxicological and safety testing
information. ICCVAM conducts
technical evaluations of new, revised,
and alternative safety testing methods
and integrated testing strategies with
regulatory applicability and promotes
the scientific validation and regulatory
acceptance of testing methods that more
accurately assess the safety and hazards
of chemicals and products and replace,
reduce, or refine (enhance animal wellbeing and lessen or avoid pain and
distress) animal use.
The ICCVAM Authorization Act of
2000 (42 U.S.C. 285l–3) establishes
ICCVAM as a permanent interagency
committee of the National Institute of
Environmental Health Sciences and
provides the authority for ICCVAM
involvement in activities relevant to the
development of alternative test
methods. ICCVAM acts to ensure that
new and revised test methods are
validated to meet the needs of federal
agencies, increase the efficiency and
effectiveness of federal agency test
method review, and optimize utilization
of scientific expertise outside the federal
government. Additional information
E:\FR\FM\08JAN1.SGM
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824
Federal Register / Vol. 83, No. 5 / Monday, January 8, 2018 / Notices
about ICCVAM can be found at https://
ntp.niehs.nih.gov/go/iccvam.
NICEATM administers ICCVAM,
provides scientific and operational
support for ICCVAM-related activities,
and conducts and publishes analyses
and evaluations of data from new,
revised, and alternative testing
approaches. NICEATM and ICCVAM
work collaboratively to evaluate new
and improved testing approaches
applicable to the needs of U.S. federal
agencies. NICEATM and ICCVAM
welcome the public nomination of new,
revised, and alternative test methods
and strategies for validation studies and
technical evaluations. Additional
information about NICEATM can be
found at https://ntp.niehs.nih.gov/go/
niceatm.
Dated: December 20, 2017.
John R. Bucher,
Associate Director, National Toxicology
Program.
[FR Doc. 2018–00120 Filed 1–5–18; 8:45 am]
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Agency Information Collection
Activities: Application for Allowance in
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U.S. Customs and Border
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Homeland Security.
ACTION: 60-Day notice and request for
comments; extension of an existing
collection of information.
AGENCY:
The Department of Homeland
Security, U.S. Customs and Border
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following information collection request
to the Office of Management and Budget
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accordance with the Paperwork
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information collection is published in
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from the public and affected agencies.
Comments are encouraged and will be
accepted (no later than March 9, 2018)
to be assured of consideration.
ADDRESSES: Written comments and/or
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contained in this notice must include
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To avoid duplicate submissions, please
use only one of the following methods
to submit comments:
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FOR FURTHER INFORMATION CONTACT:
Requests for additional PRA information
should be directed to Seth Renkema,
Chief, Economic Impact Analysis
Branch, U.S. Customs and Border
Protection, Office of Trade, Regulations
and Rulings, 90 K Street NE, 10th Floor,
Washington, DC 20229–1177,
Telephone number (202) 325–0056 or
via email CBP_PRA@cbp.dhs.gov. Please
note that the contact information
provided here is solely for questions
regarding this notice. Individuals
seeking information about other CBP
programs should contact the CBP
National Customer Service Center at
877–227–5511, (TTY) 1–800–877–8339,
or CBP website at https://
www.cbp.gov/.
CBP
invites the general public and other
Federal agencies to comment on the
proposed and/or continuing information
collections pursuant to the Paperwork
Reduction Act of 1995 (44 U.S.C. 3501
et seq.). This process is conducted in
accordance with 5 CFR 1320.8. Written
comments and suggestions from the
public and affected agencies should
address one or more of the following
four points: (1) Whether the proposed
collection of information is necessary
for the proper performance of the
functions of the agency, including
whether the information will have
practical utility; (2) the accuracy of the
agency’s estimate of the burden of the
proposed collection of information,
including the validity of the
methodology and assumptions used; (3)
suggestions to enhance the quality,
utility, and clarity of the information to
be collected; and (4) suggestions to
minimize the burden of the collection of
information on those who are to
respond, including through the use of
appropriate automated, electronic,
mechanical, or other technological
collection techniques or other forms of
information technology, e.g., permitting
electronic submission of responses. The
comments that are submitted will be
summarized and included in the request
for approval. All comments will become
a matter of public record.
SUPPLEMENTARY INFORMATION:
U.S. Customs and Border Protection
SUMMARY:
(1) Email. Submit comments to: CBP_
PRA@cbp.dhs.gov.
(2) Mail. Submit written comments to
CBP Paperwork Reduction Act Officer,
U.S. Customs and Border Protection,
Office of Trade, Regulations and
Rulings, Economic Impact Analysis
Branch, 90 K Street NE, 10th Floor,
Washington, DC 20229–1177.
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Overview of This Information
Collection
Title: Application for Allowance in
Duties.
OMB Number: 1651–0007.
Form Number: CBP Form 4315.
Action: CBP proposes to extend the
expiration date of this information
collection with no change to the burden
hours or to Form 4315.
Type of Review: Extension (without
change).
Abstract: CBP Form 4315,
‘‘Application for Allowance in Duties,’’
is submitted to CBP in instances of
claims of damaged or defective
imported merchandise on which an
allowance in duty is made in the
liquidation of the entry. The
information on this form is used to
substantiate an importer’s claim for
such duty allowances. CBP Form 4315
is authorized by 19 U.S.C. 1506 and
provided for by 19 CFR 158.11, 158.13
and 158.23. This form is accessible at:
https://www.cbp.gov/sites/default/files/
documents/CBP%20Form%204315_
0.pdf.
Affected Public: Businesses.
Estimated Number of Respondents:
12,000.
Estimated Number of Total Annual
Responses: 12,000.
Estimated Time per Response: 8
minutes.
Estimated Annual Burden Hours:
1,600.
Dated: January 2, 2018.
Seth Renkema,
Branch Chief, Economic Impact Analysis
Branch, U.S. Customs and Border Protection.
[FR Doc. 2018–00071 Filed 1–5–18; 8:45 am]
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DEPARTMENT OF HOMELAND
SECURITY
U.S. Customs and Border Protection
[1651–0127]
Agency Information Collection
Activities: Guarantee of Payment
U.S. Customs and Border
Protection (CBP), Department of
Homeland Security.
ACTION: 60-Day notice and request for
comments; extension of an existing
collection of information.
AGENCY:
The Department of Homeland
Security, U.S. Customs and Border
Protection will be submitting the
following information collection request
to the Office of Management and Budget
(OMB) for review and approval in
accordance with the Paperwork
SUMMARY:
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]]>Agencies
[Federal Register Volume 83, Number 5 (Monday, January 8, 2018)]
[Notices]
[Pages 823-824]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2018-00120]
-----------------------------------------------------------------------
DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
Interagency Coordinating Committee on the Validation of
Alternative Methods Communities of Practice Webinar on Machine Learning
in Toxicology: Fundamentals of Application and Interpretation; Notice
of Public Webinar; Registration Information
AGENCY: National Institutes of Health, HHS.
ACTION: Notice.
-----------------------------------------------------------------------
SUMMARY: The Interagency Coordinating Committee on the Validation of
Alternative Methods (ICCVAM) announces a public webinar ``Machine
Learning in Toxicology: Fundamentals of Application and
Interpretation.'' The webinar is organized on behalf of ICCVAM by the
National Toxicology Program Interagency Center for the Evaluation of
Alternative Toxicological Methods (NICEATM). Interested persons may
participate via WebEx. Time will be allotted for questions from the
audience.
DATES: Webinar: January 23, 2018, 1:00 p.m. to approximately 2:30 p.m.
Eastern Standard Time (EST). Registration for the Webinar: December 18,
2017, until 2:30 p.m. on January 23, 2018.
ADDRESSES: Webinar web page: https://ntp.niehs.nih.gov/go/commprac-2018.
FOR FURTHER INFORMATION CONTACT: Dr. Warren Casey, Director, NICEATM;
telephone: (984) 287-3118; email: [email protected].
SUPPLEMENTARY INFORMATION: Background: ICCVAM promotes the development
and validation of toxicity testing methods that protect human health
and the environment while replacing, reducing, or refining animal use.
ICCVAM also provides guidance to test method developers and facilitates
collaborations that promote the development of new test methods. To
address these goals, ICCVAM will hold a Communities of Practice webinar
on ``Machine Learning in Toxicology: Fundamentals of Application and
Interpretation.''
The ICCVAM webinar will explore the fundamentals of machine
learning approaches, including how they work, how they are interpreted,
and precautions that should be taken when evaluating their output. It
will feature presentations by two experts in use of machine learning in
toxicity texting applications that will address issues specific to use
of machine learning approaches in a regulatory context. Case studies
will be presented to highlight where such techniques have been
successfully applied both nationally and internationally. The
preliminary agenda and additional information about presentations will
be posted at https://ntp.niehs.nih.gov/go/commprac-2018 as available.
Webinar and Registration: This webinar is open to the public with
time scheduled for questions by participants following each
presentation. Registration for the webinar is required and is open
through 2:30 p.m. on January 23, 2018. Registration is available at
https://ntp.niehs.nih.gov/go/commprac-2018. Interested individuals are
encouraged to visit this web page to stay abreast of the most current
webinar information. Registrants will receive instructions on how to
access and participate in the webinar in an email sent shortly before
the webinar.
Individuals with disabilities who need accommodation to participate
in this event should contact Elizabeth Maull at phone: (984) 287-3157
or email: [email protected]. TTY users should contact the Federal TTY
Relay Service at (800) 877-8339. Requests should be made at least five
business days in advance of the event.
Background Information on ICCVAM and NICEATM: ICCVAM is an
interagency committee composed of representatives from 16 federal
regulatory and research agencies that require, use, generate, or
disseminate toxicological and safety testing information. ICCVAM
conducts technical evaluations of new, revised, and alternative safety
testing methods and integrated testing strategies with regulatory
applicability and promotes the scientific validation and regulatory
acceptance of testing methods that more accurately assess the safety
and hazards of chemicals and products and replace, reduce, or refine
(enhance animal well-being and lessen or avoid pain and distress)
animal use.
The ICCVAM Authorization Act of 2000 (42 U.S.C. 285l-3) establishes
ICCVAM as a permanent interagency committee of the National Institute
of Environmental Health Sciences and provides the authority for ICCVAM
involvement in activities relevant to the development of alternative
test methods. ICCVAM acts to ensure that new and revised test methods
are validated to meet the needs of federal agencies, increase the
efficiency and effectiveness of federal agency test method review, and
optimize utilization of scientific expertise outside the federal
government. Additional information
[[Page 824]]
about ICCVAM can be found at https://ntp.niehs.nih.gov/go/iccvam.
NICEATM administers ICCVAM, provides scientific and operational
support for ICCVAM-related activities, and conducts and publishes
analyses and evaluations of data from new, revised, and alternative
testing approaches. NICEATM and ICCVAM work collaboratively to evaluate
new and improved testing approaches applicable to the needs of U.S.
federal agencies. NICEATM and ICCVAM welcome the public nomination of
new, revised, and alternative test methods and strategies for
validation studies and technical evaluations. Additional information
about NICEATM can be found at https://ntp.niehs.nih.gov/go/niceatm.
Dated: December 20, 2017.
John R. Bucher,
Associate Director, National Toxicology Program.
[FR Doc. 2018-00120 Filed 1-5-18; 8:45 am]
BILLING CODE 4140-01-P
