Government-Owned Invention; Availability for Licensing, 22553 [2017-09791]

Download as PDF Federal Register / Vol. 82, No. 93 / Tuesday, May 16, 2017 / Notices Health, 6701 Rockledge Drive, Room 6194, MSC 7804, Bethesda, MD 20892, 301–594– 7945, smileyja@csr.nih.gov. Name of Committee: Musculoskeletal, Oral and Skin Sciences Integrated Review Group; Arthritis, Connective Tissue and Skin Study Section. Date: June 12–13, 2017. Time: 8:00 a.m. to 5:00 p.m. Agenda: To review and evaluate grant applications. Place: Hilton Long Beach and Executive Center, 701 West Ocean Boulevard, Long Beach, CA 90831. Contact Person: Alexey Belkin, Ph.D., Scientific Review Officer, Center for Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Room 4102, Bethesda, MD 20817, 301–435–1786, alexey.belkin@nih.gov. Name of Committee: Infectious Diseases and Microbiology Integrated Review Group; Clinical Research and Field Studies of Infectious Diseases Study Section. Date: June 12–13, 2017. Time: 8:30 a.m. to 5:00 p.m. Agenda: To review and evaluate grant applications. Place: Cambria Hotel and Suites, 1 Helen Heneghan Way, Rockville, MD 20850. Contact Person: Soheyla Saadi, Ph.D., Scientific Review Officer, Center for Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Room 3211, MSC 7808, Bethesda, MD 20892, 301–435– 0903, saadisoh@csr.nih.gov. (Catalogue of Federal Domestic Assistance Program Nos. 93.306, Comparative Medicine; 93.333, Clinical Research, 93.306, 93.333, 93.337, 93.393–93.396, 93.837–93.844, 93.846–93.878, 93.892, 93.893, National Institutes of Health, HHS) Dated: May 10, 2017. David Clary, Program Analyst, Office of Federal Advisory Committee Policy. [FR Doc. 2017–09780 Filed 5–15–17; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Government-Owned Invention; Availability for Licensing AGENCY: National Institutes of Health, HHS. ACTION: Notice. The inventions listed below are owned by an agency of the U.S. Government. sradovich on DSK3GMQ082PROD with NOTICES SUMMARY: FOR FURTHER INFORMATION CONTACT: Licensing information may be obtained by emailing the indicated licensing contact at the National Heart, Lung, and Blood, Office of Technology Transfer and Development Office of Technology Transfer, 31 Center Drive Room 4A29, VerDate Sep<11>2014 16:42 May 15, 2017 Jkt 241001 MSC 2479, Bethesda, MD 20892–2479; telephone: 301–402–5579. A signed Confidential Disclosure Agreement may be required to receive any unpublished information. SUPPLEMENTARY INFORMATION: The following inventions are available for licensing in accordance with 35 U.S.C. 209 and 37 CFR part 404 to achieve expeditious commercialization of results of federally-funded research and development. Technology description follows. Efficient mRNA-Based Genetic Engineering of Human NK Cells With High-Affinity CD16 and CCR7 Description of Technology: A highly efficient method to genetically modify natural killer (NK) cells to induce expression of high affinity CD16 (HA– CD16) through mRNA electroporation, to potentiate NK cell-mediated antibody-dependent cellular cytotoxicity (ADCC). ADCC is mediated by CD16+ NK cells following adoptive NK cell transfer, but most humans express CD16 which has a relatively low affinity for IgG1 antibodies. However, a single nucleotide polymorphism (SNP rs396991) in the CD16 gene, resulting in an amino acid substitution at position 158 (F158V), is associated with substantially higher affinity and superior NK cell-mediated ADCC than those with the 158F genotype. This HA– CD16–158V polymorphism has also been linked to enhanced ADCC capacity in vivo. The nearly 100% efficiency of our method resulted in: (a) Sustained surface expression of transgenes at high levels for up to 4 days without compromising NK cell cytotoxicity and viability; and (b) augmented ADCC against Daratumumab coated multiple myeloma cells by ex vivo expanded NK cells electroporated with mRNA coding for HA–CD16. This system is GMP compliant and has been used previously in FDA approved clinical trials. Potential Commercial Applications: Infusion of a large number of highly cytotoxic autologous ex vivo expanded NK cells expressing high-affinity CD16 into patients, to induce a more profound anti-malignancy response to specific monoclonal antibodies, including: multiple myeloma (Daratumumab); lymphoma (Rituximab); breast cancer (Trastuzumab); and colon cancer (Cetuximab). Development Stage: Early-stage; In vitro data available. Inventors: Richard W. Childs and Mattias Carlsten (NHLBI). Publications: (1) Carlsten M, Levy E, Karambelkar A, Li L, Reger R, Berg M, Peshwa MV and Childs RW (2016) Efficient mRNA- PO 00000 Frm 00077 Fmt 4703 Sfmt 4703 22553 Based Genetic Engineering of Human NK Cells with High-Affinity CD16 and CCR7 Augments Rituximab-Induced ADCC against Lymphoma and Targets NK Cell Migration toward the Lymph Node-Associated Chemokine CCL19. Front. Immunol. 7:105. doi: 10.3389/ fimmu.2016.00105. (2) Carlsten M and Childs RW (2015) Genetic manipulation of NK cells for cancer immunotherapy: techniques and clinical implications. Front. Immunol. 6:266. doi: 10.3389/fimmu.2015.00266. Intellectual Property: NIH Reference No. E–036–2015/0,1—US Application No. 62/079,975, filed 14 Nov 2014; and PCT Application No. PCT/US2015/ 060646, filed 13 Nov 2015. Licensing Contact: Cristina Thalhammer-Reyero, Ph.D., M.B.A.; 301–435–4507; thalhamc@mail.nih.gov. Dated: May 4, 2017. Cristina Thalhammer-Reyero, Senior Licensing and Patenting Manager, Office of Technology Transfer and Development, National Heart, Lung, and Blood Institute. [FR Doc. 2017–09791 Filed 5–15–17; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute on Minority Health and Health Disparities; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is hereby given of the following meeting. The meeting will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable materials, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Institute on Minority Health and Health Disparities, Special Emphasis Panel; NIH Support for Conferences and Scientific Meeting—DRI (01). Date: June 19, 2017. Time: 8:00 a.m. to 5:00 p.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health, Gateway Plaza, 533J, 7201 Wisconsin Avenue, Suite 533, Bethesda, MD 20814 (Teleconference). E:\FR\FM\16MYN1.SGM 16MYN1

Agencies

[Federal Register Volume 82, Number 93 (Tuesday, May 16, 2017)]
[Notices]
[Page 22553]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2017-09791]


-----------------------------------------------------------------------

DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Government-Owned Invention; Availability for Licensing

AGENCY: National Institutes of Health, HHS.

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: The inventions listed below are owned by an agency of the U.S. 
Government.

FOR FURTHER INFORMATION CONTACT: Licensing information may be obtained 
by emailing the indicated licensing contact at the National Heart, 
Lung, and Blood, Office of Technology Transfer and Development Office 
of Technology Transfer, 31 Center Drive Room 4A29, MSC 2479, Bethesda, 
MD 20892-2479; telephone: 301-402-5579. A signed Confidential 
Disclosure Agreement may be required to receive any unpublished 
information.

SUPPLEMENTARY INFORMATION: The following inventions are available for 
licensing in accordance with 35 U.S.C. 209 and 37 CFR part 404 to 
achieve expeditious commercialization of results of federally-funded 
research and development. Technology description follows.

Efficient mRNA-Based Genetic Engineering of Human NK Cells With High-
Affinity CD16 and CCR7

    Description of Technology: A highly efficient method to genetically 
modify natural killer (NK) cells to induce expression of high affinity 
CD16 (HA-CD16) through mRNA electroporation, to potentiate NK cell-
mediated antibody-dependent cellular cytotoxicity (ADCC). ADCC is 
mediated by CD16\+\ NK cells following adoptive NK cell transfer, but 
most humans express CD16 which has a relatively low affinity for IgG1 
antibodies. However, a single nucleotide polymorphism (SNP rs396991) in 
the CD16 gene, resulting in an amino acid substitution at position 158 
(F158V), is associated with substantially higher affinity and superior 
NK cell-mediated ADCC than those with the 158F genotype. This HA-CD16-
158V polymorphism has also been linked to enhanced ADCC capacity in 
vivo. The nearly 100% efficiency of our method resulted in: (a) 
Sustained surface expression of transgenes at high levels for up to 4 
days without compromising NK cell cytotoxicity and viability; and (b) 
augmented ADCC against Daratumumab coated multiple myeloma cells by ex 
vivo expanded NK cells electroporated with mRNA coding for HA-CD16. 
This system is GMP compliant and has been used previously in FDA 
approved clinical trials.
    Potential Commercial Applications: Infusion of a large number of 
highly cytotoxic autologous ex vivo expanded NK cells expressing high-
affinity CD16 into patients, to induce a more profound anti-malignancy 
response to specific monoclonal antibodies, including: multiple myeloma 
(Daratumumab); lymphoma (Rituximab); breast cancer (Trastuzumab); and 
colon cancer (Cetuximab).
    Development Stage: Early-stage; In vitro data available.
    Inventors: Richard W. Childs and Mattias Carlsten (NHLBI).
    Publications:
    (1) Carlsten M, Levy E, Karambelkar A, Li L, Reger R, Berg M, 
Peshwa MV and Childs RW (2016) Efficient mRNA-Based Genetic Engineering 
of Human NK Cells with High-Affinity CD16 and CCR7 Augments Rituximab-
Induced ADCC against Lymphoma and Targets NK Cell Migration toward the 
Lymph Node-Associated Chemokine CCL19. Front. Immunol. 7:105. doi: 
10.3389/fimmu.2016.00105.
    (2) Carlsten M and Childs RW (2015) Genetic manipulation of NK 
cells for cancer immunotherapy: techniques and clinical implications. 
Front. Immunol. 6:266. doi: 10.3389/fimmu.2015.00266.
    Intellectual Property: NIH Reference No. E-036-2015/0,1--US 
Application No. 62/079,975, filed 14 Nov 2014; and PCT Application No. 
PCT/US2015/060646, filed 13 Nov 2015.
    Licensing Contact: Cristina Thalhammer-Reyero, Ph.D., M.B.A.; 301-
435-4507; thalhamc@mail.nih.gov.

    Dated: May 4, 2017.
Cristina Thalhammer-Reyero,
Senior Licensing and Patenting Manager, Office of Technology Transfer 
and Development, National Heart, Lung, and Blood Institute.
[FR Doc. 2017-09791 Filed 5-15-17; 8:45 am]
BILLING CODE 4140-01-P
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