Prospective Grant of Exclusive Patent License: Development and Commercialization of Peptides Promoting Lipid Efflux for the Treatment of Hypertriglyceridemia, With or Without Concomitant Metabolic Syndrome, 16405-16406 [2017-06546]

Download as PDF Federal Register / Vol. 82, No. 63 / Tuesday, April 4, 2017 / Notices discussion, and evaluation of applications received in response to ‘‘Community Characteristics Associated with Geographic Disparities in Diabetes and Cardiometabolic Health’’, DP17– 001. Contact Person for More Information: Jaya Raman Ph.D., Scientific Review Officer, CDC, 4770 Buford Highway, Mailstop F80, Atlanta, Georgia 30341, Telephone: (770) 488–6511, kva5@ cdc.gov. The Director, Management Analysis and Services Office, has been delegated the authority to sign Federal Register notices pertaining to announcements of meetings and other committee management activities, for both the Centers for Disease Control and Prevention and the Agency for Toxic Substances and Disease Registry. Elaine L. Baker, Director, Management Analysis and Services Office, Centers for Disease Control and Prevention. [FR Doc. 2017–06536 Filed 4–3–17; 8:45 am] BILLING CODE 4163–18–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings asabaliauskas on DSK3SPTVN1PROD with NOTICES Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is hereby given of the following meetings. The meetings will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Institute on Aging Initial Review Group, Biological Aging Review Committee. Date: May 30–31, 2017. Time: 2:00 p.m. to 2:00 p.m. Agenda: To review and evaluate grant applications. Place: Torrance Marriott Redondo Beach, 3635 Fashion Way, Torrance, CA 90503. Contact Person: Bita Nakhai, Ph.D., Scientific Review Branch, National Institute on Aging, Gateway Bldg., 2C212, 7201 Wisconsin Avenue, Bethesda, MD 20814, 301–402–7701, nakhaib@nia.nih.gov. VerDate Sep<11>2014 16:21 Apr 03, 2017 Jkt 241001 Name of Committee: National Institute on Aging Initial Review Group, Neuroscience of Aging Review Committee, Date: June 1–2, 2017. Time: 2:00 p.m. to 2:00 p.m. Agenda: To review and evaluate grant applications. Place: Torrance Marriott Redondo Beach, 3635 Fashion Way, Torrance, CA 90503. Contact Person: Jeannette L. Johnson, Ph.D., Deputy Review Branch Chief, National Institutes of Health, National Institute on Aging, Gateway Building, Bethesda, MD 20892, 301–402–7705, johnsonj9@ nia.nih.gov. Name of Committee: National Institute on Aging Initial Review Group, Clinical Aging Review Committee. Date: June 1–2, 2017. Time: 2:00 p.m. to 2:00 p.m. Agenda: To review and evaluate grant applications. Place: Torrance Marriott Redondo Beach, 3635 Fashion Way, Torrance, CA 90503. Contact Person: Alicja L. Markowska, Ph.D., Dsc., National Institute on Aging, National Institutes of Health, Gateway Building 2C212, 7201 Wisconsin Avenue, Bethesda, MD 20892, 301–496–9666, markowsa@nia.nih.gov. (Catalogue of Federal Domestic Assistance Program Nos. 93.866, Aging Research, National Institutes of Health, HHS) 16405 Only written comments and/or applications for a license which are received by the NHLBI Office of Technology Transfer and Development on or before April 19, 2017 will be considered. ADDRESSES: Requests for copies of the patent application, inquiries, and comments relating to the contemplated exclusive license should be directed to: Cristina Thalhammer-Reyero, Ph.D., MBA, Senior Licensing and Patenting Manager, NHLBI Office of Technology Transfer and Development, 31 Center Drive Room 4A29, MSC2479, Bethesda, MD 20892–2479; Telephone: +1–301– 435–4507; Fax: +1–301–594–3080; Email: thalhamc@mail.nih.gov. SUPPLEMENTARY INFORMATION: The following represents the intellectual property to be licensed under the prospective agreement: U.S. Provisional Patent Application Serial No. 61/045,213, filed 04/15/2008; PCT Application No. PCT/US2009/ 040560, filed 04/14/2009; U.S. Patent Application Serial No.12/937,974, issued as 8,936,787 on 01/20/2015; Titled ‘‘Peptides Promoting Lipid Efflux’’ (NIH Reference No. E–138– Dated: March 29, 2017. 2008/0). Melanie J. Pantoja, With respect to persons who have an obligation to assign their right, title and Program Analyst, Office of Federal Advisory Committee Policy. interest to the Government of the United States of America, the patent rights in [FR Doc. 2017–06553 Filed 4–3–17; 8:45 am] these inventions have been assigned to BILLING CODE 4140–01–P the Government of the United States of America. The prospective exclusive license DEPARTMENT OF HEALTH AND territory may be worldwide and the HUMAN SERVICES field of use may be limited to: National Institutes of Health ‘‘Treatment of Hypertriglyceridemia, with or without concomitant metabolic Prospective Grant of Exclusive Patent syndrome’’. License: Development and The invention pertains to Commercialization of Peptides compositions and methods of use of Promoting Lipid Efflux for the ApoC–II mimetic peptides with Treatment of Hypertriglyceridemia, multiple amphipathic alpha helical With or Without Concomitant domains that have the dual ability to Metabolic Syndrome promote lipid efflux from cells and stimulate lipoprotein lipase activity, AGENCY: National Institutes of Health, without inducing toxicity. This notice is HHS. made in accordance with 35 U.S.C. 209 ACTION: Notice. and 37 CFR part 404. The prospective SUMMARY: The National Heart, Lung, and Exclusive Patent License will be royalty Blood Institute (NHLBI), an institute of bearing and may be granted unless the National Institutes of Health; an within fifteen (15) days from the date of agency within the Department of Health this published notice, the NHLBI Office and Human Services, is contemplating of Technology Transfer and the grant of an exclusive patent license Development receives written evidence to commercialize the invention(s) and argument that establishes that the embodied in the intellectual property grant of the license would not be estate stated in the Summary consistent with the requirements of 35 Information section of this notice to U.S.C. 209 and 37 CFR part 404. Complete applications for a license in Corvidia Therapeutics Inc. (Corvidia) the prospective field of use that are located in Waltham, MA and timely filed in response to this notice incorporated under the laws of will be treated as objections to the grant Delaware. PO 00000 Frm 00072 Fmt 4703 Sfmt 4703 DATES: E:\FR\FM\04APN1.SGM 04APN1 16406 Federal Register / Vol. 82, No. 63 / Tuesday, April 4, 2017 / Notices of the contemplated Exclusive Patent License. Comments and objections to this notice submitted will not be made available for public inspection and, to the extent permitted by law, will not be released under the Freedom of Information Act, 5 U.S.C. 552. Dated: March 21, 2017. Cristina Thalhammer-Reyero, Senior Licensing and Patenting Manager, Office of Technology Transfer and Development, National Heart, Lung, and Blood Institute. [FR Doc. 2017–06546 Filed 4–3–17; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Prospective Grant of Start-up Exclusive Evaluation Option Patent License: ‘‘The Development and Use of Diazeniumdiolated and Hybrid Diazeniumdiolated Compounds for the Treatment of Ovarian Cancer in Humans’’ AGENCY: National Institutes of Health, HHS. ACTION: Notice. The National Cancer Institute, an institute of the National Institutes of Health, Department of Health and Human Services, is contemplating the grant of a Start-up Exclusive Evaluation Option License to practice the inventions embodied in the Patents and Patent Applications listed in the Supplementary Information section of this notice to Tar Meta Biosciences, Inc. (‘‘TarMeta’’) located in King of Prussia, PA, USA. DATES: Only written comments and/or applications for a license which are received by the National Cancer Institute’s Technology Transfer Center on or before April 19, 2017 will be considered. ADDRESSES: Requests for copies of the patent application, inquiries, and comments relating to the contemplated Start-up Exclusive Evaluation Option License should be directed to: Kathleen Higinbotham, Senior Technology Transfer Manager, NCI Technology Transfer Center, Riverside 5, Suite 400, 8490 Progress Dr., Frederick, MD 21701, Telephone: (301)-624–8775; Facsimile: (301)-631–3027 Email: higinbok@ mail.nih.gov. SUPPLEMENTARY INFORMATION: asabaliauskas on DSK3SPTVN1PROD with NOTICES SUMMARY: Intellectual Property (1) E–025–2010/0 entitled ‘‘Nitric Oxidebased Cancer Therapeutic Agents For Lung VerDate Sep<11>2014 16:21 Apr 03, 2017 Jkt 241001 Cancers With Elevated Levels Of Reactive Oxygen Species (ROS) And/or Low Levels Of Antioxidant Defense/DNA Repair Mechanisms.’’ (a) United States Provisional Patent Application No. 61/261,175 filed November 13, 2009; (b) PCT Application No. PCT/US2010/ 056446 filed November 12, 2010; (c) United States Patent Application No. 13/509,431 filed June 01, 2012, US Patent 9,205,091 issued December 08, 2015; (d) Australian Patent Application No. 2010319398 filed May 09, 2012; (e) Canadian Patent Application No. 2,780,633 filed May 10, 2012; (f) European Patent Application No. 10778814.3 filed May 14, 2012; (2) E–220–2011/0 entitled ‘‘Hybrid Diazeniumdiolated Compounds, Pharmaceutical Compositions, And Method Of Treating Cancer.’’ (a) United States Provisional Patent Application No. 61/549,862, filed October 21, 2011; (b) PCT Application No. PCT/US2012/ 060785 filed October 18, 2012; (c) United States Patent Application No. 14/352,096 filed April 16, 2014, US Patent 9,168,266 issued October 27, 2015; (d) Australian Patent Application No. 2012326105 filed April 14, 2014; (e) Canadian Patent Application No. 2,852,682 filed April 14, 2014; (f) European Patent Application No. 12841601.3 filed April 14, 2014, European Patent 2768824 issued December 07, 2016; (i) German Patent 602012026435.7 issued December 07, 2016; (ii) French Patent 2768824 issued December 07, 2016; and (iii) UK Patent 2768824 issued December 07, 2016. The patent rights in these inventions have been assigned to the government of the United States of America. The prospective exclusive license territory may be worldwide and the field of use may be limited to ‘‘The development and use of diazeniumdiolated and hybrid diazeniumdiolated compounds for the treatment of ovarian cancer in humans.’’ The present inventions describe the use of diazeniumdiolate-based nitric oxide (NO)-releasing compounds wherein the cancer cell has an elevated level of reactive oxygen species (ROS), as well as the use of hybrid prodrug molecules that combine a diazeniumdiolated compound and a poly(ADP-ribose) polymerase (PARP) inhibitor in cancer cells to produce synergistic effects, whether alone or as an adjuvant for other therapies. The hybrid prodrug is expected to enhance cytotoxicity by creating DNA damage with NO and preventing its repair with the PARP inhibitor. The prodrug and the hybrid are activated by glutathione S-transferase and are predicted to be effective in cancers with reactive oxygen species (ROS), both of which are PO 00000 Frm 00073 Fmt 4703 Sfmt 4703 elevated in many cancers. In addition, the prodrug and hybrid may have synergy with therapeutics (such as proteasome inhibitor bortezomib and doxorubicin) which act through generation of ROS. Taken together, these features suggest that the prodrug and hybrid may have therapeutic applications in cancer patients whose tumors include high levels of ROS. This notice is made in accordance with 35 U.S.C. 209 and 37 CFR part 404. The prospective Start-up Exclusive Evaluation Option License will be royalty bearing, and the prospective exclusive license may be granted unless within fifteen (15) days from the date of this published notice, the National Cancer Institute receives written evidence and argument that establishes that the grant of the license would not be consistent with the requirements of 35 U.S.C. 209 and 37 CFR part 404. Complete applications for a license in the prospective field of use that are filed in response to this notice will be treated as objections to the grant of the contemplated Start-up Exclusive Evaluation Option License Agreement. Comments and objections submitted to this notice will not be made available for public inspection and, to the extent permitted by law, will not be released under the Freedom of Information Act, 5 U.S.C. 552. Dated: March 21, 2017. Richard U. Rodriguez, Associate Director, Technology Transfer Center, National Cancer Institute. [FR Doc. 2017–06545 Filed 4–3–17; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is hereby given of the following meeting. The meeting will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. E:\FR\FM\04APN1.SGM 04APN1

Agencies

[Federal Register Volume 82, Number 63 (Tuesday, April 4, 2017)]
[Notices]
[Pages 16405-16406]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2017-06546]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Prospective Grant of Exclusive Patent License: Development and 
Commercialization of Peptides Promoting Lipid Efflux for the Treatment 
of Hypertriglyceridemia, With or Without Concomitant Metabolic Syndrome

AGENCY: National Institutes of Health, HHS.

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: The National Heart, Lung, and Blood Institute (NHLBI), an 
institute of the National Institutes of Health; an agency within the 
Department of Health and Human Services, is contemplating the grant of 
an exclusive patent license to commercialize the invention(s) embodied 
in the intellectual property estate stated in the Summary Information 
section of this notice to Corvidia Therapeutics Inc. (Corvidia) located 
in Waltham, MA and incorporated under the laws of Delaware.

DATES: Only written comments and/or applications for a license which 
are received by the NHLBI Office of Technology Transfer and Development 
on or before April 19, 2017 will be considered.

ADDRESSES: Requests for copies of the patent application, inquiries, 
and comments relating to the contemplated exclusive license should be 
directed to: Cristina Thalhammer-Reyero, Ph.D., MBA, Senior Licensing 
and Patenting Manager, NHLBI Office of Technology Transfer and 
Development, 31 Center Drive Room 4A29, MSC2479, Bethesda, MD 20892-
2479; Telephone: +1-301-435-4507; Fax: +1-301-594-3080; Email: 
thalhamc@mail.nih.gov.

SUPPLEMENTARY INFORMATION: The following represents the intellectual 
property to be licensed under the prospective agreement:
    U.S. Provisional Patent Application Serial No. 61/045,213, filed 
04/15/2008; PCT Application No. PCT/US2009/040560, filed 04/14/2009; 
U.S. Patent Application Serial No.12/937,974, issued as 8,936,787 on 
01/20/2015; Titled ``Peptides Promoting Lipid Efflux'' (NIH Reference 
No. E-138-2008/0).
    With respect to persons who have an obligation to assign their 
right, title and interest to the Government of the United States of 
America, the patent rights in these inventions have been assigned to 
the Government of the United States of America.
    The prospective exclusive license territory may be worldwide and 
the field of use may be limited to: ``Treatment of 
Hypertriglyceridemia, with or without concomitant metabolic syndrome''.
    The invention pertains to compositions and methods of use of ApoC-
II mimetic peptides with multiple amphipathic alpha helical domains 
that have the dual ability to promote lipid efflux from cells and 
stimulate lipoprotein lipase activity, without inducing toxicity. This 
notice is made in accordance with 35 U.S.C. 209 and 37 CFR part 404. 
The prospective Exclusive Patent License will be royalty bearing and 
may be granted unless within fifteen (15) days from the date of this 
published notice, the NHLBI Office of Technology Transfer and 
Development receives written evidence and argument that establishes 
that the grant of the license would not be consistent with the 
requirements of 35 U.S.C. 209 and 37 CFR part 404.
    Complete applications for a license in the prospective field of use 
that are timely filed in response to this notice will be treated as 
objections to the grant

[[Page 16406]]

of the contemplated Exclusive Patent License. Comments and objections 
to this notice submitted will not be made available for public 
inspection and, to the extent permitted by law, will not be released 
under the Freedom of Information Act, 5 U.S.C. 552.

    Dated: March 21, 2017.
Cristina Thalhammer-Reyero,
Senior Licensing and Patenting Manager, Office of Technology Transfer 
and Development, National Heart, Lung, and Blood Institute.
[FR Doc. 2017-06546 Filed 4-3-17; 8:45 am]
 BILLING CODE 4140-01-P

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