Draft Current Intelligence Bulletin: The Occupational Exposure Banding Process: Guidance for the Evaluation of Chemical Hazards; Notice of Public Meeting; Request for Comments, 15709 [C1-2017-05115]
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utility: (1) Adjusted risk estimates (e.g.,
odds ratio, relative risk, hazards ratio);
(2) discrimination (e.g., area under the
receiver operating characteristic curve
[AUROC]); and (3) measures of
diagnostic accuracy (e.g., sensitivity,
specificity, positive predictive values,
and negative predictive values).
The predictive utility is defined in
terms of the physiologic measure’s
ability to identify patients who have
severe injury. Defining and
operationalizing what ‘‘severe injury’’
means is challenging for several reasons.
Whether a patient had a serious injury
at the time of field triage cannot be
determined conclusively and we expect
that clinical outcomes (e.g., death or
disability) are affected by out-of-hospital
and in-hospital treatment (i.e., a person
can have a serious injury and recover).
For this reason, we accept several
indicators that a patient was seriously
injured. These include outcomes, such
as death, whether the patient required
treatments and interventions used for
serious injury, or whether the injury is
rated as severe using accepted rating
scales. It is possible the review will
identify additional indicators that a
patient had a severe injury; however the
following list includes those that have
been used in prior research.
Indicators of Serious Injury
I. In-hospital mortality.
II. Resource use/intervention
standards or lists.
a. Published Consensus-Based
Criterion Standard—This list defines
need for trauma center care as any one
of the following 10 specific indicators:
Major surgery, advanced airway, blood
products, admission for spinal cord
injury, thoracotomy, pericardiocentesis,
cesarean delivery, intracranial pressure
monitoring, interventional radiology,
and in-hospital death.
b. Need For Life-Saving
Interventions—Lists used by the U.S.
military that include angioembolization,
blood transfusion, cardiopulmonary
resuscitation, chest tube, intubation,
needle decompression, surgical
cricothyrotomy or thoracotomy,
pericardiocentesis, angiography with
embolization, angiography without and
surgical intervention.
c. Major Surgery—Not including
orthopedic surgery.
d. Ratings of Injury Severity—Injury
Severity Score (ISS) >15, as this is a
commonly used threshold for high risk
patients, but other cut-offs will be
considered if used in included studies.
The ISS score is based on an assessment
that divides the body into nine regions,
classifies the level of injury in each of
the three most severely injured regions
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15709
on a scale of 1 to 6, squares these values,
and adds them together.
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
Timing
Centers for Disease Control and
Prevention
Physiological measures upon the
arrival of EMS personnel to the scene of
injury, during treatment in the field, and
during transport (referred to as out-ofhospital or in the field). Studies with
measures taken upon arrival at an
emergency department will be
considered. Details about timing of
measurement will be recorded in data
abstraction if they are reported.
Settings
Include:
I. Studies measuring physiologic
compromise in the field/out of
hospital
II. Studies of initial ED measurement as
indirect evidence only if out of
hospital evidence is not available
and the measure is deemed
clinically relevant
III. Studies conducted in civilian or
military settings
Exclude:
Study Designs
Include:
I. Any study that assesses the predictive
utility of included measures either
individually or that compares two
or more measures. Designs may
include trials and prospective and
retrospective observational studies
a. Systematic reviews
Exclude:
I. Nonsystematic reviews,
commentaries, and letters
II. Descriptions of the properties or
performance of measures that do
not include predictive utility
Sharon B. Arnold,
Acting Director.
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Draft Current Intelligence Bulletin: The
Occupational Exposure Banding
Process: Guidance for the Evaluation
of Chemical Hazards; Notice of Public
Meeting; Request for Comments
Correction
In notice document 2017–5115,
beginning on page 13809, in the issue of
Wednesday, March 15, 2017, make the
following correction:
On page 13809, in the third column,
in the second line of the DATES
paragraph, ‘‘Tuesday, May 23, 2016’’
should read, ‘‘Tuesday, May 23, 2017.’’
[FR Doc. C1–2017–05115 Filed 3–29–17; 8:45 am]
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DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
I. Inpatient, clinic, or emergency
department (ED)
II. Studies conducted in developing
countries with out-of-hospital care
systems that differ from those in the
United States
PO 00000
[CDC–2017–0028, Docket Number NIOSH–
290]
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Eunice Kennedy Shriver National
Institute of Child Health & Human
Development; Notice of Closed
Meetings
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is
hereby given of the following meetings.
The meetings will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: National Institute of
Child Health and Human Development
Special Emphasis Panel.
Date: April 24, 2017.
Time: 10:00 a.m. to 12:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, 6710 B
Rockledge Drive, Bethesda, MD 20892
(Telephone Conference Call).
Contact Person: Kimberly Lynette Houston,
Scientific Review Officer, Division of
Scientific Review, OD, Eunice Kennedy
Shriver National Institute of Child Health
and Human Development, NIH, DHHS,
6710B Rockledge Drive, Bethesda, Maryland
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Agencies
[Federal Register Volume 82, Number 60 (Thursday, March 30, 2017)]
[Notices]
[Page 15709]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: C1-2017-05115]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
Centers for Disease Control and Prevention
[CDC-2017-0028, Docket Number NIOSH-290]
Draft Current Intelligence Bulletin: The Occupational Exposure
Banding Process: Guidance for the Evaluation of Chemical Hazards;
Notice of Public Meeting; Request for Comments
Correction
In notice document 2017-5115, beginning on page 13809, in the issue
of Wednesday, March 15, 2017, make the following correction:
On page 13809, in the third column, in the second line of the DATES
paragraph, ``Tuesday, May 23, 2016'' should read, ``Tuesday, May 23,
2017.''
[FR Doc. C1-2017-05115 Filed 3-29-17; 8:45 am]
BILLING CODE 1301-00-P