Government-Owned Inventions; Availability for Licensing, 11475 [2017-03452]
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Federal Register / Vol. 82, No. 35 / Thursday, February 23, 2017 / Notices
Place: National Institutes of Health, 6701
Rockledge Drive, Bethesda, MD 20892,
(Telephone Conference Call).
Contact Person: Syed M Quadri, Ph.D.,
Scientific Review Officer, Center for
Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 6210,
MSC 7804, Bethesda, MD 20892, 301–435–
1211, quadris@csr.nih.gov.
Name of Committee: Center for Scientific
Review Special Emphasis Panel; Member
Conflict: Emerging Technologies in
Neuroscience.
Date: March 24, 2017.
Time: 10:00 a.m. to 4:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, 6701
Rockledge Drive, Bethesda, MD 20892,
(Virtual Meeting).
Contact Person: Sharon S Low, Ph.D.,
Scientific Review Officer, Center for
Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 5104,
MSC 5104, Bethesda, MD 20892–5104, 301–
237–1487, lowss@csr.nih.gov.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.306, Comparative Medicine;
93.333, Clinical Research, 93.306, 93.333,
93.337, 93.393–93.396, 93.837–93.844,
93.846–93.878, 93.892, 93.893, National
Institutes of Health, HHS)
Dated: February 17, 2017.
Anna Snouffer,
Deputy Director, Office of Federal Advisory
Committee Policy.
[FR Doc. 2017–03528 Filed 2–22–17; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
Government-Owned Inventions;
Availability for Licensing
AGENCY:
National Institutes of Health,
HHS.
ACTION:
Notice.
The invention listed below is
owned by an agency of the U.S.
Government and is available for
licensing to achieve expeditious
commercialization of results of
federally-funded research and
development. Foreign patent
applications are filed on selected
inventions to extend market coverage
for companies and may also be available
for licensing.
FOR FURTHER INFORMATION CONTACT:
Licensing information and copies of the
patent applications listed below may be
obtained by communicating with the
indicated licensing contact at the
Technology Transfer and Intellectual
Property Office, National Institute of
Allergy and Infectious Diseases, 5601
Fishers Lane, Rockville, MD, 20852; tel.
rmajette on DSK2TPTVN1PROD with NOTICES
SUMMARY:
VerDate Sep<11>2014
14:10 Feb 22, 2017
Jkt 241001
301–496–2644. A signed Confidential
Disclosure Agreement will be required
to receive copies of unpublished patent
applications.
SUPPLEMENTARY INFORMATION:
Technology description follows.
CD300b Expression Exacerbates
Endotoxemia and Septic Peritonitis
Description of Technology: The innate
immune system is the first line of host
defense against invading pathogens.
Lipopolysaccharides (LPS), present in
gram-negative bacteria membranes,
cause strong immune responses
following detection by the Toll-like
receptor 4 (TLR4) on immune cells. This
detection results in the release of proinflammatory cytokines, such as tumor
necrosis factor alpha, interleukin-6, and
interferon gamma, to assist with
clearance of the infectious insult. In
parallel, interleukin-10 (IL–10), an antiinflammatory cytokine, is induced to
limit the immune response. This is
because unchecked immune activation
leads to a more severe
immunopathology, such as septic shock
and subsequently death. Current
therapies to treat sepsis are ineffective,
and clinical trials based on
neutralization of specific inflammatory
cytokines have failed.
The inventors, listed below, have
discovered that CD300b is a LPS
binding receptor. This interaction
results in a reduced IL–10 production,
leading to an amplification of lethal
inflammation. In vitro, anti-CD300b
antibodies block LPS binding to
CD300b, stopping association with
TLR4 and CD14 and increases IL–10
levels. In vivo, administration of antiCD300b antibodies protects animals
from septic shock, due to a reduce level
of pro-inflammatory cytokines but
subsequent increase in the antiinflammatory cytokine, IL–10.
This technology is available for
licensing for commercial development
in accordance with 35 U.S.C. 209 and 37
CFR part 404, as well as for further
development and evaluation under a
research collaboration.
Potential Commercial Applications:
As a means of treating endotoxemia and
septic peritonitis.
Competitive Advantages: No current
therapeutics are available to treat septic
shock.
Development Stage: Pre-clinical.
Inventors:
John E. Coligan, NIAID, NIH
Oliver H. Voss, NIAID, NIH
Konrad Krzewski, NIAID, NIH
Publications: Voss, Oliver H., et al.
‘‘Lipopolysaccharide-induced CD300b
receptor binding to toll-like receptor 4
PO 00000
Frm 00050
Fmt 4703
Sfmt 4703
11475
alters signaling to drive cytokine
responses that enhance septic shock.’’
Immunity 44.6 (2016): 1365–1378.
Intellectual Property: HHS Reference
No. E–112–2016/0—U.S. Patent
Application No. 62/308,144 filed 03/14/
2016.
Licensing Contact: Chris Kornak, 240–
627–3705, chris.kornak@nih.gov.
Collaborative Research Opportunity:
The National Institute of Allergy and
Infectious Diseases is seeking statements
of capability or interest from parties
interested in collaborative research to
further co-develop CD300b antagonists.
For collaboration opportunities, please
contact Chris Kornak, 240–627–3705,
chris.kornak@nih.gov.
Dated: February 16, 2017.
Suzanne Frisbie,
Deputy Director, Technology Transfer and
Intellectual Property Office, National Institute
of Allergy and Infectious Diseases.
[FR Doc. 2017–03452 Filed 2–22–17; 8:45 am]
BILLING CODE 4140–01–P
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HUMAN SERVICES
National Institutes of Health
National Institute of Allergy and
Infectious Diseases; Notice of Closed
Meeting
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is
hereby given of the following meeting.
The meeting will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: National Institute of
Allergy and Infectious Diseases Special
Emphasis Panel, Elucidation of Mechanisms
of Radiation-Induced Endovascular Injury
and Development of Treatments/Mitigators
for Radiation-Induced Endothelial Cell and
Vascular Dysfunction (U01).
Date: March 16–17, 2017.
Time: 10:00 a.m. to 5:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, 5601
Fishers Lane, Rockville, MD 20892,
(Telephone Conference Call).
Contact Person: Zhuqing (Charlie) Li,
Ph.D., Scientific Review Officer, Scientific
Review Program, Division of Extramural
E:\FR\FM\23FEN1.SGM
23FEN1
Agencies
[Federal Register Volume 82, Number 35 (Thursday, February 23, 2017)]
[Notices]
[Page 11475]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2017-03452]
-----------------------------------------------------------------------
DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
Government-Owned Inventions; Availability for Licensing
AGENCY: National Institutes of Health, HHS.
ACTION: Notice.
-----------------------------------------------------------------------
SUMMARY: The invention listed below is owned by an agency of the U.S.
Government and is available for licensing to achieve expeditious
commercialization of results of federally-funded research and
development. Foreign patent applications are filed on selected
inventions to extend market coverage for companies and may also be
available for licensing.
FOR FURTHER INFORMATION CONTACT: Licensing information and copies of
the patent applications listed below may be obtained by communicating
with the indicated licensing contact at the Technology Transfer and
Intellectual Property Office, National Institute of Allergy and
Infectious Diseases, 5601 Fishers Lane, Rockville, MD, 20852; tel. 301-
496-2644. A signed Confidential Disclosure Agreement will be required
to receive copies of unpublished patent applications.
SUPPLEMENTARY INFORMATION: Technology description follows.
CD300b Expression Exacerbates Endotoxemia and Septic Peritonitis
Description of Technology: The innate immune system is the first
line of host defense against invading pathogens. Lipopolysaccharides
(LPS), present in gram-negative bacteria membranes, cause strong immune
responses following detection by the Toll-like receptor 4 (TLR4) on
immune cells. This detection results in the release of pro-inflammatory
cytokines, such as tumor necrosis factor alpha, interleukin-6, and
interferon gamma, to assist with clearance of the infectious insult. In
parallel, interleukin-10 (IL-10), an anti-inflammatory cytokine, is
induced to limit the immune response. This is because unchecked immune
activation leads to a more severe immunopathology, such as septic shock
and subsequently death. Current therapies to treat sepsis are
ineffective, and clinical trials based on neutralization of specific
inflammatory cytokines have failed.
The inventors, listed below, have discovered that CD300b is a LPS
binding receptor. This interaction results in a reduced IL-10
production, leading to an amplification of lethal inflammation. In
vitro, anti-CD300b antibodies block LPS binding to CD300b, stopping
association with TLR4 and CD14 and increases IL-10 levels. In vivo,
administration of anti-CD300b antibodies protects animals from septic
shock, due to a reduce level of pro-inflammatory cytokines but
subsequent increase in the anti-inflammatory cytokine, IL-10.
This technology is available for licensing for commercial
development in accordance with 35 U.S.C. 209 and 37 CFR part 404, as
well as for further development and evaluation under a research
collaboration.
Potential Commercial Applications: As a means of treating
endotoxemia and septic peritonitis.
Competitive Advantages: No current therapeutics are available to
treat septic shock.
Development Stage: Pre-clinical.
Inventors:
John E. Coligan, NIAID, NIH
Oliver H. Voss, NIAID, NIH
Konrad Krzewski, NIAID, NIH
Publications: Voss, Oliver H., et al. ``Lipopolysaccharide-induced
CD300b receptor binding to toll-like receptor 4 alters signaling to
drive cytokine responses that enhance septic shock.'' Immunity 44.6
(2016): 1365-1378.
Intellectual Property: HHS Reference No. E-112-2016/0--U.S. Patent
Application No. 62/308,144 filed 03/14/2016.
Licensing Contact: Chris Kornak, 240-627-3705,
chris.kornak@nih.gov.
Collaborative Research Opportunity: The National Institute of
Allergy and Infectious Diseases is seeking statements of capability or
interest from parties interested in collaborative research to further
co-develop CD300b antagonists. For collaboration opportunities, please
contact Chris Kornak, 240-627-3705, chris.kornak@nih.gov.
Dated: February 16, 2017.
Suzanne Frisbie,
Deputy Director, Technology Transfer and Intellectual Property Office,
National Institute of Allergy and Infectious Diseases.
[FR Doc. 2017-03452 Filed 2-22-17; 8:45 am]
BILLING CODE 4140-01-P