Short-Term Alternative Animal Models or In Vitro Tests Used To Identify Substances With the Potential To Cause Excessive Inflammation or Exaggerated Immune Responses; Request for Information, 74458 [2016-25924]

Download as PDF 74458 Federal Register / Vol. 81, No. 207 / Wednesday, October 26, 2016 / Notices appointed for the Committee leadership. The Committee structure has been expanded to include ex-officio representation from the Department of Veterans Affairs (VA). The VA has the largest conglomerate of hospitals in the United States. The agency has responsibility for the largest patient population that uses the largest quantity of blood and tissue products in the United States. Therefore, it was determined that involvement of the VA would be beneficial to the ACBTSA for ensuring that the Committee properly addresses current issues and concerns regarding blood and tissue safety and availability. On October 5, 2016, the new charter for the ACBTSA was approved by the Secretary of Health and Human Services, and it was filed with the appropriate Congressional committees and the Library of Congress on October 9, 2016. ACBTSA is authorized to operate until October 9, 2018. A copy of the charter can be obtained on the ACBTSA Web site at http:// www.hhs.gov/ash/bloodsafety. Copies of the charters for the designated committees also can be obtained by accessing the FACA database that is maintained by the Committee Management Secretariat under the General Services Administration. The Web site address for the FACA database is http:// facadatabase.gov/. Dated: October 20, 2016. Karen B. DeSalvo, Acting Assistant Secretary for Health. [FR Doc. 2016–25916 Filed 10–25–16; 8:45 am] BILLING CODE 4150–28–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Short-Term Alternative Animal Models or In Vitro Tests Used To Identify Substances With the Potential To Cause Excessive Inflammation or Exaggerated Immune Responses; Request for Information The National Toxicology Program (NTP) at the National Institute of Environmental Health Sciences (NIEHS) requests available data and information on approaches and/or technologies currently used to identify substances with the potential to cause excessive inflammation or exaggerated immune responses leading to tissue injury when swallowed, inhaled, or absorbed through the skin. Submitted information will be used to assess the state of the science and determine asabaliauskas on DSK3SPTVN1PROD with NOTICES SUMMARY: VerDate Sep<11>2014 18:25 Oct 25, 2016 Jkt 241001 technical needs for non-animal test methods that could be used to evaluate the potential of chemicals to induce inflammation and immune-related conditions. Receipt of information: Deadline is December 12, 2016. ADDRESSES: Data and information should be submitted electronically at http://ntp.niehs.nih.gov/go/input. FOR FURTHER INFORMATION CONTACT: Dr. Dori Germolec, Toxicology Branch, Division of NTP, NIEHS; email: germolec@niehs.nih.gov; telephone: (919) 541–3230. SUPPLEMENTARY INFORMATION: Background: NTP has an interest in developing more efficient and scalable test platforms to provide the scientific basis for predictive models of chemical effects on human disease. Short-term toxicity tests may be conducted to determine the potential for a single or short-term dose of a substance to cause inflammation-related responses or impact local and systemic immune function when inhaled (inhalation toxicity testing), swallowed (oral toxicity testing), or absorbed through the skin (dermal toxicity testing). A number of observations support a role for environmental influences on inflammatory and immune-related diseases such as diabetes. One specific use of information received in response to this request is to assist NTP in identifying in vitro or alternative animal model screens that might be used to assess the potential for chemicals to cause outcomes related to Type 1 diabetes. In addition, information received from this request will provide fundamental knowledge on the use of these in vitro platforms for identifying environmental triggers of excessive inflammation and exaggerated immune responses that could lead to tissue injury. Request for Information: NTP requests available data and information on approaches and/or technologies currently used to identify substances with the potential to cause excessive inflammation or exaggerated immune responses leading to tissue injury. Respondents should provide information on any activities relevant to the development or validation of alternatives to in vivo tests currently used in the assessment of immune toxicity and autoimmunity. Respondents to this request for information should include their name, affiliation (if applicable), mailing address, telephone, email, and sponsoring organization (if any) with their communications. The deadline for DATES: PO 00000 Frm 00068 Fmt 4703 Sfmt 4703 receipt of the requested information is December 12, 2016. Responses to this request are voluntary. No proprietary, classified, confidential, or sensitive information should be included in responses. This request for information is for planning purposes only and is not a solicitation for applications or an obligation on the part of the U.S. Government to provide support for any ideas identified in response to the request. Please note that the U.S. Government will not pay for the preparation of any information submitted or for its use of that information. Background Information on NTP: NTP is an interagency program established in 1978 (43 FR 53060) to strengthen the Department’s activities in toxicology research and testing and to develop and validate new and better testing methods. Other activities of the program focus on strengthening the science base in toxicology and providing information about potentially toxic chemicals to health-regulatory and research agencies, scientific and medical communities, and the public. NTP is located administratively at the NIEHS. Information about NIEHS and NTP is available at http://www.niehs.nih.gov and http://ntp.niehs.nih.gov, respectively. Dated: October 20, 2016. John R. Bucher, Associate Director, National Toxicology Program. [FR Doc. 2016–25924 Filed 10–25–16; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute of Allergy and Infectious Diseases; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is hereby given of the following meetings. The meetings will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. E:\FR\FM\26OCN1.SGM 26OCN1

Agencies

[Federal Register Volume 81, Number 207 (Wednesday, October 26, 2016)]
[Notices]
[Page 74458]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2016-25924]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Short-Term Alternative Animal Models or In Vitro Tests Used To 
Identify Substances With the Potential To Cause Excessive Inflammation 
or Exaggerated Immune Responses; Request for Information

SUMMARY: The National Toxicology Program (NTP) at the National 
Institute of Environmental Health Sciences (NIEHS) requests available 
data and information on approaches and/or technologies currently used 
to identify substances with the potential to cause excessive 
inflammation or exaggerated immune responses leading to tissue injury 
when swallowed, inhaled, or absorbed through the skin. Submitted 
information will be used to assess the state of the science and 
determine technical needs for non-animal test methods that could be 
used to evaluate the potential of chemicals to induce inflammation and 
immune-related conditions.

DATES: Receipt of information: Deadline is December 12, 2016.

ADDRESSES: Data and information should be submitted electronically at 
http://ntp.niehs.nih.gov/go/input.

FOR FURTHER INFORMATION CONTACT: Dr. Dori Germolec, Toxicology Branch, 
Division of NTP, NIEHS; email: germolec@niehs.nih.gov; telephone: (919) 
541-3230.

SUPPLEMENTARY INFORMATION: 
    Background: NTP has an interest in developing more efficient and 
scalable test platforms to provide the scientific basis for predictive 
models of chemical effects on human disease. Short-term toxicity tests 
may be conducted to determine the potential for a single or short-term 
dose of a substance to cause inflammation-related responses or impact 
local and systemic immune function when inhaled (inhalation toxicity 
testing), swallowed (oral toxicity testing), or absorbed through the 
skin (dermal toxicity testing). A number of observations support a role 
for environmental influences on inflammatory and immune-related 
diseases such as diabetes. One specific use of information received in 
response to this request is to assist NTP in identifying in vitro or 
alternative animal model screens that might be used to assess the 
potential for chemicals to cause outcomes related to Type 1 diabetes. 
In addition, information received from this request will provide 
fundamental knowledge on the use of these in vitro platforms for 
identifying environmental triggers of excessive inflammation and 
exaggerated immune responses that could lead to tissue injury.
    Request for Information: NTP requests available data and 
information on approaches and/or technologies currently used to 
identify substances with the potential to cause excessive inflammation 
or exaggerated immune responses leading to tissue injury. Respondents 
should provide information on any activities relevant to the 
development or validation of alternatives to in vivo tests currently 
used in the assessment of immune toxicity and autoimmunity.
    Respondents to this request for information should include their 
name, affiliation (if applicable), mailing address, telephone, email, 
and sponsoring organization (if any) with their communications. The 
deadline for receipt of the requested information is December 12, 2016.
    Responses to this request are voluntary. No proprietary, 
classified, confidential, or sensitive information should be included 
in responses. This request for information is for planning purposes 
only and is not a solicitation for applications or an obligation on the 
part of the U.S. Government to provide support for any ideas identified 
in response to the request. Please note that the U.S. Government will 
not pay for the preparation of any information submitted or for its use 
of that information.
    Background Information on NTP: NTP is an interagency program 
established in 1978 (43 FR 53060) to strengthen the Department's 
activities in toxicology research and testing and to develop and 
validate new and better testing methods. Other activities of the 
program focus on strengthening the science base in toxicology and 
providing information about potentially toxic chemicals to health-
regulatory and research agencies, scientific and medical communities, 
and the public. NTP is located administratively at the NIEHS. 
Information about NIEHS and NTP is available at http://www.niehs.nih.gov and http://ntp.niehs.nih.gov, respectively.

    Dated: October 20, 2016.
John R. Bucher,
Associate Director, National Toxicology Program.
[FR Doc. 2016-25924 Filed 10-25-16; 8:45 am]
 BILLING CODE 4140-01-P