Government-Owned Inventions; Availability for Licensing, 52452 [2016-18689]

Download as PDF 52452 Federal Register / Vol. 81, No. 152 / Monday, August 8, 2016 / Notices 2019, Bethesda, MD 20892, 301–443–2861, marmillotp@mail.nih.gov. Name of Committee: National Institute on Alcohol Abuse and Alcoholism Initial Review Group; Neuroscience Review Subcommittee. Date: October 27, 2016. Time: 8:30 a.m. to 5 p.m. Agenda: To review and evaluate grant applications. Place: National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Terrace Level Conference Room 508– 509, 5635 Fishers Lane, Rockville, MD 20852. Contact Person: Beata Buzas, Ph.D., Scientific Review Officer, National Institute On Alcohol Abuse and Alcoholism, National Institutes of Health, 5635 Fishers Lane, Rm. 2081, Rockville, MD 20852, 301–443–0800, bbuzas@mail.nih.gov. (Catalogue of Federal Domestic Assistance Program Nos. 93.271, Alcohol Research Career Development Awards for Scientists and Clinicians; 93.272, Alcohol National Research Service Awards for Research Training; 93.273, Alcohol Research Programs; 93.891, Alcohol Research Center Grants; 93.701, ARRA Related Biomedical Research and Research Support Awards, National Institutes of Health, HHS) Dated: August 2, 2016. Melanie J. Gray, Program Analyst, Office of Federal Advisory Committee Policy. [FR Doc. 2016–18688 Filed 8–5–16; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Government-Owned Inventions; Availability for Licensing National Institutes of Health, Department of Health and Human Services. ACTION: Notice. AGENCY: The invention listed below is owned by an agency of the U.S. Government and is available for licensing and/or co-development in the U.S. in accordance with 35 U.S.C. 209 and 37 CFR part 404 to achieve expeditious commercialization of results of federally-funded research and development. Foreign patent applications are filed on selected inventions to extend market coverage for companies and may also be available for licensing and/or co-development. ADDRESSES: Invention Development and Marketing Unit, Technology Transfer Center, National Cancer Institute, 9609 Medical Center Drive, Mail Stop 9702, Rockville, MD 20850–9702. FOR FURTHER INFORMATION CONTACT: Information on licensing and co- mstockstill on DSK3G9T082PROD with NOTICES SUMMARY: VerDate Sep<11>2014 22:23 Aug 05, 2016 Jkt 238001 development research collaborations, and copies of the U.S. patent applications listed below may be obtained by contacting: Attn. Invention Development and Marketing Unit, Technology Transfer Center, National Cancer Institute, 9609 Medical Center Drive, Mail Stop 9702, Rockville, MD, 20850–9702, Tel. 240–276–5515 or email ncitechtransfer@mail.nih.gov. A signed Confidential Disclosure Agreement may be required to receive copies of the patent applications. SUPPLEMENTARY INFORMATION: Technology description follows. Title of invention: Synthetic HumanDerived Peptides and Peptidomimetics for Cancer Therapeutics Keywords: Rpn13, selective proteasome inhibitor, proteasome ubiquitin receptors, (competition: carfilzomib and bortezomib too toxic, resistance developed), solid tumors, hematological cancer, HPV associated cancer, ovarian cancer, prostate cancer, gastric cancer, breast cancer, or colorectal cancer Description of Technology: FDA approved 26S proteasome inhibitors, such as carfilzomib and bortezomib (Velcade®) have proven to be effective at treating hematologic cancers. However, resistance to these agents as well as their toxicity have raised concerns and highlight the need for new 26S proteasome inhibitors. Investigators at the NCI’s Structural Biophysics Laboratory have developed a new class of proteasome inhibitors. They are hRpn2-derived peptides capable of specifically targeting the Pru domain of hRpn13. Disruption of the Rpn2/Rpn13 interaction inhibits proteolysis by a mechanism that differs from those of the approved proteasome inhibitors. Potential Commercial Applications: • New class of proteasome inhibitors, targeting hRpn13 of the regulatory particle. Value Proposition: • Synergistic with, and more specific than, known proteasome inhibitors. • Alternate mechanism of action compared to approved proteasome inhibitors. Development Stage: Discovery (Lead ID). Inventor(s): Kylie J. Walters (NCI), Fen Liu (NCI), and Xiuxiu Lu (NCI). Intellectual Property: HHS Reference No. E–278–2015/0– US–01. US Provisional Application 62/ 222,530 (HHS Reference No. E–278– 2015) filed September 23, 2015 entitled ‘‘Human RPN2 Derived Peptides Useful For Treating Cancer’’. PO 00000 Frm 00056 Fmt 4703 Sfmt 4703 Publications: 1. Lu X., et al., 2015 PLoS One 2015 Oct 14;10(10) PMID: 26466095. Contact Information: Requests for copies of the patent application or inquiries about licensing, research collaborations, and co-development opportunities should be sent to John D. Hewes, Ph.D., email: john.hewes@ nih.gov. Dated: July 26, 2016. John D. Hewes, Technology Transfer Specialist, Technology Transfer Center, National Cancer Institute. [FR Doc. 2016–18689 Filed 8–5–16; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Cancer Institute; Notice of Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App. 2), notice is hereby given of the meeting of the National Cancer Advisory Board (NCAB). The meeting will be open to the public as indicated below, with attendance limited to space available. Individuals who plan to attend and need special assistance, such as sign language interpretation or other reasonable accommodations, should notify the Contact Person listed below in advance of the meeting. The open session will be videocast and can be accessed from the NIH Videocasting and Podcasting Web site (https:// videocast.nih.gov). A portion of the National Cancer Advisory Board meeting will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Cancer Advisory Board. Open: September 7, 2016, 9:00 a.m. to 05:00 p.m. Agenda: Programs reports and presentations; business of the Board. Place: National Institutes of Health, Building 31, C-Wing, 6th Floor, Room 10, 9000 Rockville Pike, Bethesda, MD 20892. Closed: September 7, 2016, 04:00 p.m. to 05:00 p.m. E:\FR\FM\08AUN1.SGM 08AUN1

Agencies

[Federal Register Volume 81, Number 152 (Monday, August 8, 2016)]
[Notices]
[Page 52452]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2016-18689]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Government-Owned Inventions; Availability for Licensing

AGENCY: National Institutes of Health, Department of Health and Human 
Services.

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: The invention listed below is owned by an agency of the U.S. 
Government and is available for licensing and/or co-development in the 
U.S. in accordance with 35 U.S.C. 209 and 37 CFR part 404 to achieve 
expeditious commercialization of results of federally-funded research 
and development. Foreign patent applications are filed on selected 
inventions to extend market coverage for companies and may also be 
available for licensing and/or co-development.

ADDRESSES: Invention Development and Marketing Unit, Technology 
Transfer Center, National Cancer Institute, 9609 Medical Center Drive, 
Mail Stop 9702, Rockville, MD 20850-9702.

FOR FURTHER INFORMATION CONTACT: Information on licensing and co-
development research collaborations, and copies of the U.S. patent 
applications listed below may be obtained by contacting: Attn. 
Invention Development and Marketing Unit, Technology Transfer Center, 
National Cancer Institute, 9609 Medical Center Drive, Mail Stop 9702, 
Rockville, MD, 20850-9702, Tel. 240-276-5515 or email 
ncitechtransfer@mail.nih.gov. A signed Confidential Disclosure 
Agreement may be required to receive copies of the patent applications.

SUPPLEMENTARY INFORMATION: Technology description follows.
    Title of invention: Synthetic Human-Derived Peptides and 
Peptidomimetics for Cancer Therapeutics
    Keywords: Rpn13, selective proteasome inhibitor, proteasome 
ubiquitin receptors, (competition: carfilzomib and bortezomib too 
toxic, resistance developed), solid tumors, hematological cancer, HPV 
associated cancer, ovarian cancer, prostate cancer, gastric cancer, 
breast cancer, or colorectal cancer
    Description of Technology: FDA approved 26S proteasome inhibitors, 
such as carfilzomib and bortezomib (Velcade[supreg]) have proven to be 
effective at treating hematologic cancers. However, resistance to these 
agents as well as their toxicity have raised concerns and highlight the 
need for new 26S proteasome inhibitors.
    Investigators at the NCI's Structural Biophysics Laboratory have 
developed a new class of proteasome inhibitors. They are hRpn2-derived 
peptides capable of specifically targeting the Pru domain of hRpn13. 
Disruption of the Rpn2/Rpn13 interaction inhibits proteolysis by a 
mechanism that differs from those of the approved proteasome 
inhibitors.
    Potential Commercial Applications:
     New class of proteasome inhibitors, targeting hRpn13 of 
the regulatory particle.
    Value Proposition:
     Synergistic with, and more specific than, known proteasome 
inhibitors.
     Alternate mechanism of action compared to approved 
proteasome inhibitors.
    Development Stage: Discovery (Lead ID).
    Inventor(s): Kylie J. Walters (NCI), Fen Liu (NCI), and Xiuxiu Lu 
(NCI).
    Intellectual Property:
    HHS Reference No. E-278-2015/0-US-01.
    US Provisional Application 62/222,530 (HHS Reference No. E-278-
2015) filed September 23, 2015 entitled ``Human RPN2 Derived Peptides 
Useful For Treating Cancer''.
    Publications: 1. Lu X., et al., 2015 PLoS One 2015 Oct 14;10(10) 
PMID: 26466095.
    Contact Information: Requests for copies of the patent application 
or inquiries about licensing, research collaborations, and co-
development opportunities should be sent to John D. Hewes, Ph.D., 
email: john.hewes@nih.gov.

    Dated: July 26, 2016.
John D. Hewes,
Technology Transfer Specialist, Technology Transfer Center, National 
Cancer Institute.
[FR Doc. 2016-18689 Filed 8-5-16; 8:45 am]
 BILLING CODE 4140-01-P
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