Government-Owned Inventions; Availability for Licensing, 7821 [2016-02971]

Download as PDF Federal Register / Vol. 81, No. 30 / Tuesday, February 16, 2016 / Notices Licensing Opportunity: Researchers at the NICHD seek licensing and/or codevelopment research collaborations for the therapeutic management of Menkes Disease and related copper transport disorders. Contact Information Requests for copies of the patent application or inquiries about licensing, research collaborations, and codevelopment opportunities should be sent to John D. Hewes, Ph.D., email: john.hewes@nih.gov. Dated: February 8, 2016. John D. Hewes, Technology Transfer Specialist, Technology Transfer Center, National Cancer Institute. [FR Doc. 2016–02970 Filed 2–12–16; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Government-Owned Inventions; Availability for Licensing AGENCY: National Institutes of Health, HHS. ACTION: Notice. The invention listed below is owned by an agency of the U.S. Government and is available for licensing and/or co-development in the U.S. in accordance with 35 U.S.C. 209 and 37 CFR part 404 to achieve expeditious commercialization of results of federally-funded research and development. Foreign patent applications are filed on selected inventions to extend market coverage for companies and may also be available for licensing and/or co-development. ADDRESSES: Information on licensing, co-development research collaborations, and/or copies of the U.S. patent applications listed below may be obtained by contacting: Attn. Invention Development and Marketing Unit, Technology Transfer Center, National Cancer Institute, 9609 Medical Center Drive, Mail Stop 9702, Rockville, MD, 20850–9702, Tel. 240–276–5515 or email ncitechtransfer@mail.nih.gov. A signed Confidential Disclosure Agreement may be required to receive copies of the patent applications. FOR FURTHER INFORMATION CONTACT: Requests for copies of the patent application or inquiries about licensing and/or co-development should be sent to John D. Hewes, Ph.D., email: john.hewes@nih.gov. SUPPLEMENTARY INFORMATION: Technology description follows. mstockstill on DSK4VPTVN1PROD with NOTICES SUMMARY: VerDate Sep<11>2014 22:15 Feb 12, 2016 Jkt 238001 Title of invention: Modified griffithsin tandemers for enhanced activity and reduced viral aggregation. Description of Technology: Griffithsin (GRFT) is a lectin with potent antiviral properties that is capable of preventing and treating infections caused by a number of enveloped viruses (including HIV, SARS, HCV, HSV, and Japanese encephalitis) and is currently in clinical development as an anti-HIV microbicide. In addition to its broad antiviral activity, GRFT is stable at high temperature and at a broad pH range, displays low toxicity and immunogenicity, and is amenable to large-scale manufacturing. Native GRFT is a domain-swapped homodimer that binds to viral envelope glycoproteins and has displayed mid-picomolar activity in cell-based anti-HIV assays. This invention is directed to synthetic proteins that comprise two (or more) obligate monomers (‘‘mGRFT’’) joined by an amino acid linker to form tandemers (‘‘mGRFT tandemers’’). Each obligate monomer is generated by the addition of Gly-Ser residues in the hinge region of wild-type GRFT. Two or more obligate monomers are joined by an amino acid linker to form the mGRFT tandamers. The properties of the mGRFT tandemers can be modulated by the length of the amino acid linker and the number of obligate monomers cojoined. mGRFT tandemers exhibit gore potent anti-viral properties when compared against native GRFT and are equipotent against viruses that are both sensitive and resistant to naive GRFT. As such, potential uses of the invention tandemers include topical and intravenous therapy to treat HIV infection, particularly to treat HIV infections that are resistant to native GRFT. Potential Commercial Applications • Broad-spectrum antiviral agent similar to wild type GRFT • Potential activity against SARS CoV, MERS, Ebola, HCV and influenza Value Proposition • Broad antiviral activity • Stable at high temperature and at a broad pH range • Displays low toxicity and immunogenicity. Development Stage: In vivo/Lead Validation. Inventor(s): Barry R. O’Keefe (NCI), A. Wlodawer (NCI), T. Moulaei (NCI). Publication(s) —Moulaei T. et al., Griffithsin tandemers: flexible and potent lectin inhibitors of the human immunodeficiency virus. Retrovirology. 2015 Jan 23;12:6. PO 00000 Frm 00080 Fmt 4703 Sfmt 4703 7821 —A. Chatterjee et al.,Griffithsin and Carrageenan Combination To Target Herpes Simplex Virus 2 and Human Papillomavirus, Antimicrob Agents Chemother. 2015 Dec; 59(12): 7290–7298. Intellectual Property HHS Reference No. E–034–2013/0– US–01. PCT Application No. PCT/US2014/ 040992 (HHS Reference No. E–034– 2013/0- US–01) filed June 5, 2013 entitled ‘‘Modified griffithsin tandemers for enhanced activity and reduced viral aggregation’’. Licensing and Collaborative/CoDevelopment Research Opportunity: Researchers at the NCI seek licensees and/or co-development partners for the commercialization of Griffithsin and Griffithsin tandemers, specifically, additional studies on stability, toxicity, immunogenicity, and large-scale production. Dated: February 1, 2016. John D. Hewes, Technology Transfer Specialist, Technology Transfer Center, National Cancer Institute. [FR Doc. 2016–02971 Filed 2–12–16; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is hereby given of the following meeting. The meeting will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: Center for Scientific Review Special Emphasis Panel; Special Topic: Social Sciences and Population Studies. Date: February 23, 2016. Time: 12:00 p.m. to 12:30 p.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892 (Telephone Conference Call). Contact Person: Suzanne Ryan, Ph.D., Scientific Review Officer, Center for Scientific Review, National Institutes of E:\FR\FM\16FEN1.SGM 16FEN1

Agencies

[Federal Register Volume 81, Number 30 (Tuesday, February 16, 2016)]
[Notices]
[Page 7821]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2016-02971]


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 DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Government-Owned Inventions; Availability for Licensing

AGENCY: National Institutes of Health, HHS.

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: The invention listed below is owned by an agency of the U.S. 
Government and is available for licensing and/or co-development in the 
U.S. in accordance with 35 U.S.C. 209 and 37 CFR part 404 to achieve 
expeditious commercialization of results of federally-funded research 
and development. Foreign patent applications are filed on selected 
inventions to extend market coverage for companies and may also be 
available for licensing and/or co-development.

ADDRESSES: Information on licensing, co-development research 
collaborations, and/or copies of the U.S. patent applications listed 
below may be obtained by contacting: Attn. Invention Development and 
Marketing Unit, Technology Transfer Center, National Cancer Institute, 
9609 Medical Center Drive, Mail Stop 9702, Rockville, MD, 20850-9702, 
Tel. 240-276-5515 or email ncitechtransfer@mail.nih.gov. A signed 
Confidential Disclosure Agreement may be required to receive copies of 
the patent applications.

FOR FURTHER INFORMATION CONTACT: Requests for copies of the patent 
application or inquiries about licensing and/or co-development should 
be sent to John D. Hewes, Ph.D., email: john.hewes@nih.gov.

SUPPLEMENTARY INFORMATION: Technology description follows.
    Title of invention: Modified griffithsin tandemers for enhanced 
activity and reduced viral aggregation.
    Description of Technology: Griffithsin (GRFT) is a lectin with 
potent antiviral properties that is capable of preventing and treating 
infections caused by a number of enveloped viruses (including HIV, 
SARS, HCV, HSV, and Japanese encephalitis) and is currently in clinical 
development as an anti-HIV microbicide. In addition to its broad 
antiviral activity, GRFT is stable at high temperature and at a broad 
pH range, displays low toxicity and immunogenicity, and is amenable to 
large-scale manufacturing. Native GRFT is a domain-swapped homodimer 
that binds to viral envelope glycoproteins and has displayed mid-
picomolar activity in cell-based anti-HIV assays. This invention is 
directed to synthetic proteins that comprise two (or more) obligate 
monomers (``mGRFT'') joined by an amino acid linker to form tandemers 
(``mGRFT tandemers''). Each obligate monomer is generated by the 
addition of Gly-Ser residues in the hinge region of wild-type GRFT. Two 
or more obligate monomers are joined by an amino acid linker to form 
the mGRFT tandamers. The properties of the mGRFT tandemers can be 
modulated by the length of the amino acid linker and the number of 
obligate monomers co-joined. mGRFT tandemers exhibit gore potent anti-
viral properties when compared against native GRFT and are equipotent 
against viruses that are both sensitive and resistant to naive GRFT. As 
such, potential uses of the invention tandemers include topical and 
intravenous therapy to treat HIV infection, particularly to treat HIV 
infections that are resistant to native GRFT.

Potential Commercial Applications

 Broad-spectrum antiviral agent similar to wild type GRFT
 Potential activity against SARS CoV, MERS, Ebola, HCV and 
influenza

Value Proposition

 Broad antiviral activity
 Stable at high temperature and at a broad pH range
 Displays low toxicity and immunogenicity.

    Development Stage: In vivo/Lead Validation.
    Inventor(s): Barry R. O'Keefe (NCI), A. Wlodawer (NCI), T. Moulaei 
(NCI).

Publication(s)

--Moulaei T. et al., Griffithsin tandemers: flexible and potent 
lectin inhibitors of the human immunodeficiency virus. 
Retrovirology. 2015 Jan 23;12:6.
--A. Chatterjee et al.,Griffithsin and Carrageenan Combination To 
Target Herpes Simplex Virus 2 and Human Papillomavirus, Antimicrob 
Agents Chemother. 2015 Dec; 59(12): 7290-7298.

Intellectual Property

    HHS Reference No. E-034-2013/0-US-01.
    PCT Application No. PCT/US2014/040992 (HHS Reference No. E-034-
2013/0- US-01) filed June 5, 2013 entitled ``Modified griffithsin 
tandemers for enhanced activity and reduced viral aggregation''.
    Licensing and Collaborative/Co-Development Research Opportunity: 
Researchers at the NCI seek licensees and/or co-development partners 
for the commercialization of Griffithsin and Griffithsin tandemers, 
specifically, additional studies on stability, toxicity, 
immunogenicity, and large-scale production.

    Dated: February 1, 2016.
John D. Hewes,
Technology Transfer Specialist, Technology Transfer Center, National 
Cancer Institute.
[FR Doc. 2016-02971 Filed 2-12-16; 8:45 am]
 BILLING CODE 4140-01-P
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