National Institute on Aging; Notice of Closed Meeting, 81556 [2015-32773]

Download as PDF 81556 Federal Register / Vol. 80, No. 250 / Wednesday, December 30, 2015 / Notices obtained by contacting: Attn. Invention Development and Marketing Unit, Technology Transfer Center, National Cancer Institute, 9609 Medical Center Drive, Mail Stop 9702, Rockville, MD, 20850–9702, Tel. 240–276–5515 or email ncitechtransfer@mail.nih.gov. A signed Confidential Disclosure Agreement may be required to receive copies of the patent applications. SUPPLEMENTARY INFORMATION: Technology description follows. Title of invention: A Novel FullyHuman Anti-CD30 Chimeric Antigen Receptor for Treatment of CD30+ Lymphoma. Description of Technology: Chimeric antigen receptors (CARs) are hybrid proteins that consist of two major components: A targeting domain and a signaling domain. The targeting domain allows T cells which express the CAR to selectively recognize and bind to diseased cells that express a particular protein. Once the diseased cell is bound by the targeting domain of the CAR, the signaling domain of the CAR activates the T cell, thereby allowing it to kill the diseased cell. This is a promising new therapeutic approach known as adoptive cell therapy (ACT). Researchers at the National Cancer Institute’s Experimental Transplantation and Immunology Branch developed a CAR that recognizes human tumor necrosis factor receptor superfamily member 8 (TNFRSF8, also known as CD30). The expression of CD30 is deregulated in a variety of human cancers, including many lymphomas. By creating a CAR that recognizes CD30, it may be possible to treat these cancers using adoptive cell therapy. Potential Commercial Applications —Treatment of human cancers associated with expression of CD30 or variants thereof —Specific cancers include: NonHodgkins Lymphomas, Hodgkin’s Lymphomas, several solid malignancies mstockstill on DSK4VPTVN1PROD with NOTICES Value Proposition —Human components are less likely to cause adverse or neutralizing immune response in patients —Targeted therapies decrease nonspecific killing of healthy cells and tissues, resulting in fewer off-target sideeffects and healthier patients Development Stage In vivo/Lead Validation. Inventor(s) Jim N. Kochenderfer, M.D. (NCI). VerDate Sep<11>2014 17:59 Dec 29, 2015 Jkt 238001 Intellectual Property HHS Reference No. E–001–2016/0–US– 01 US Provisional Application 62/241,896 (HHS Reference No. E–001–2016/0– US–01) filed October 15, 2015 entitled ‘‘A Novel Fully-Human Anti-CD30 Chimeric Antigen Receptor for Treatment of CD30+ Lymphoma’’ Licensing Opportunity: Researchers at the NCI seek licensees for a chimeric antigen receptor (CAR) that recognizes human tumor necrosis factor receptor superfamily member 8 (TNFRSF8, also known as CD30) for use as a cancer therapeutic. Contact Information Requests for copies of the patent application or inquiries about licensing and/or research collaboration and codevelopment opportunities should be sent to John D. Hewes. Ph.D., email: john.hewes@nih.gov. Dated: December 22, 2015. Thomas M. Stackhouse, Associate Director, Technology Transfer Center, National Cancer Institute. [FR Doc. 2015–32879 Filed 12–29–15; 8:45 am] Institutes of Health, 7201 Wisconsin Avenue, Suite 2c212, Bethesda, MD 20892, 301–402– 7705, JOHNSONJ9@NIA.NIH.GOV. (Catalogue of Federal Domestic Assistance Program Nos. 93.866, Aging Research, National Institutes of Health, HHS) Dated: December 23, 2015. Melanie J. Gray, Program Analyst, Office of Federal Advisory Committee Policy. [FR Doc. 2015–32773 Filed 12–29–15; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HOMELAND SECURITY U.S. Citizenship and Immigration Services [OMB Control Number 1615–0014] Agency Information Collection Activities: Affidavit of Support, Form I–134; Extension, Without Change, of a Currently Approved Collection U.S. Citizenship and Immigration Services, Department of Homeland Security. ACTION: 60-day notice. AGENCY: BILLING CODE 4140–01–P The Department of Homeland Security (DHS), U.S. Citizenship and Immigration (USCIS) invites the general public and other Federal agencies to comment upon this proposed extension of a currently approved collection of information. In accordance with the Paperwork Reduction Act (PRA) of 1995, the information collection notice is published in the Federal Register to obtain comments regarding the nature of the information collection, the categories of respondents, the estimated burden (i.e. the time, effort, and resources used by the respondents to respond), the estimated cost to the respondent, and the actual information collection instruments. DATES: Comments are encouraged and will be accepted for 60 days until February 29, 2016. ADDRESSES: All submissions received must include the OMB Control Number 1615–0014 in the subject box, the agency name and Docket ID USCIS– 2006–0072. To avoid duplicate submissions, please use only one of the following methods to submit comments: (1) Online. Submit comments via the Federal eRulemaking Portal Web site at https://www.regulations.gov under e-Docket ID number USCIS–2006–0072; (2) Email. Submit comments to USCISFRComment@uscis.dhs.gov; (3) Mail. Submit written comments to DHS, USCIS, Office of Policy and Strategy, Chief, Regulatory Coordination SUMMARY: DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is hereby given of the following meeting. The meeting will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Institute on Aging Special Emphasis Panel; Alzheimer’s Center. Date: February 4, 2016. Time: 3:00 p.m. to 4:00 p.m. Agenda: To review and evaluate grant applications. Place: Bethesda North Marriott Hotel & Conference Center, 5701 Marinelli Road, North Bethesda, MD 20852. Contact Person: Jeannette L. Johnson, Ph.D., National Institutes on Aging, National PO 00000 Frm 00050 Fmt 4703 Sfmt 4703 E:\FR\FM\30DEN1.SGM 30DEN1

Agencies

[Federal Register Volume 80, Number 250 (Wednesday, December 30, 2015)]
[Notices]
[Page 81556]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2015-32773]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


National Institute on Aging; Notice of Closed Meeting

    Pursuant to section 10(d) of the Federal Advisory Committee Act, as 
amended (5 U.S.C. App.), notice is hereby given of the following 
meeting.
    The meeting will be closed to the public in accordance with the 
provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 
U.S.C., as amended. The grant applications and the discussions could 
disclose confidential trade secrets or commercial property such as 
patentable material, and personal information concerning individuals 
associated with the grant applications, the disclosure of which would 
constitute a clearly unwarranted invasion of personal privacy.

    Name of Committee: National Institute on Aging Special Emphasis 
Panel; Alzheimer's Center.
    Date: February 4, 2016.
    Time: 3:00 p.m. to 4:00 p.m.
    Agenda: To review and evaluate grant applications.
    Place: Bethesda North Marriott Hotel & Conference Center, 5701 
Marinelli Road, North Bethesda, MD 20852.
    Contact Person: Jeannette L. Johnson, Ph.D., National Institutes 
on Aging, National Institutes of Health, 7201 Wisconsin Avenue, 
Suite 2c212, Bethesda, MD 20892, 301-402-7705, 
JOHNSONJ9@NIA.NIH.GOV.

(Catalogue of Federal Domestic Assistance Program Nos. 93.866, Aging 
Research, National Institutes of Health, HHS)

    Dated: December 23, 2015.
Melanie J. Gray,
Program Analyst, Office of Federal Advisory Committee Policy.
[FR Doc. 2015-32773 Filed 12-29-15; 8:45 am]
BILLING CODE 4140-01-P

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