Systematic Review of Immunotoxicity Associated With Exposure to PFOA or PFOS; Request for Information and Nominations of Scientific Experts for Proposed Peer Review Meeting, 48886-48887 [2015-20122]

Download as PDF 48886 Federal Register / Vol. 80, No. 157 / Friday, August 14, 2015 / Notices (Catalogue of Federal Domestic Assistance Program Nos. 93.866, Aging Research, National Institutes of Health, HHS) DEPARTMENT OF HEALTH AND HUMAN SERVICES Dated: August 11, 2015. Melanie J. Gray, Program Analyst, Office of Federal Advisory Committee Policy. [FR Doc. 2015–20099 Filed 8–13–15; 8:45 am] BILLING CODE 4140–01–P National Institutes of Health Systematic Review of Immunotoxicity Associated With Exposure to PFOA or PFOS; Request for Information and Nominations of Scientific Experts for Proposed Peer Review Meeting The Office of Health Assessment and Translation (OHAT), Division of the National Toxicology Program (DNTP), National Institute of Environmental Health Sciences is evaluating the scientific evidence regarding the association between exposures to perfluorooctanoic acid (PFOA) or perfluorooctane sulfonate (PFOS) and immunotoxicity. OHAT invites the submission of information about ongoing studies or upcoming publications on the immune-related health effects of PFOA or PFOS that might be considered for inclusion in the evaluation. OHAT also invites the nomination of scientific experts to potentially serve as members of an ad hoc expert panel to be convened to peer review the draft NTP monograph resulting from the systematic review of the evidence for an association between exposure to PFOA or PFOS and immunotoxicity. SUMMARY: DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health and Human Development; Notice of Closed Meeting asabaliauskas on DSK5VPTVN1PROD with NOTICES Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is hereby given of the following meeting. The meeting will be closed to the public in accordance with the provisions set forth in section 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Institute of Child Health and Human Development Initial Review Group; Health, Behavior, and Context Subcommittee. Date: October 26, 2015. Time: 8:00 a.m. to 5:00 p.m. Agenda: To review and evaluate grant applications. Place: Hyatt Regency Bethesda, One Bethesda Metro Center, 7400 Wisconsin Avenue, Bethesda, MD 20814. Contact Person: Priscah Mujuru, DRPH, MPH, Scientific Review Officer, Scientific Review Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6100 Executive Boulevard, Room 5B01, Bethesda, MD 20892–9304, (301) 435–6908, mujurup@mail.nih.gov. (Catalogue of Federal Domestic Assistance Program Nos. 93.864, Population Research; 93.865, Research for Mothers and Children; 93.929, Center for Medical Rehabilitation Research; 93.209, Contraception and Infertility Loan Repayment Program, National Institutes of Health, HHS) Dated: August 11, 2015. Michelle Trout, Program Analyst, Office of Federal Advisory Committee Policy. [FR Doc. 2015–20102 Filed 8–13–15; 8:45 am] BILLING CODE 4140–01–P VerDate Sep<11>2014 18:50 Aug 13, 2015 Jkt 235001 The deadline for receipt of information and nominations of scientific experts is September 30, 2015. ADDRESSES: Information can be submitted to xiey4@niehs.nih.gov. FOR FURTHER INFORMATION CONTACT: Dr. Yun Xie, NTP Designated Federal Official, Office of Liaison, Policy and Review, DNTP, NIEHS, P.O. Box 12233, MD K2–03, Research Triangle Park, NC 27709. Phone: (919) 541–3436, Fax: (301) 451–5455, Email: yun.xie@nih.gov. Hand Delivery/Courier: 530 Davis Drive, Room 2161, Morrisville, NC 27560. SUPPLEMENTARY INFORMATION: Background on PFOA and PFOS: PFOA and PFOS are persistent chemicals that are widely distributed in the environment in part because of high stability and little to no expected degradation in the environment. In terms of toxicity and exposure, PFOA and PFOS are the best studied perfluoroalkyl acids, a group of compounds used extensively over the last 50 years in commercial and industrial applications including food packaging, lubricants, water-resistant coatings, and fire-retarding foams. Through voluntary agreements, the primary manufacturer of PFOS phased out production in 2002, and PFOS is no longer manufactured in the United DATES: PO 00000 Frm 00083 Fmt 4703 Sfmt 4703 States. Similar arrangements have been made for PFOA, and eight companies that manufacture PFOA have committed to eliminate emissions and product content by 2015. Although emissions have been dramatically reduced, the persistence and bioaccumulation of both PFOA and PFOS result in detectable levels in the U.S. population and, therefore, these chemicals are of potential human health relevance. Several recent publications from 2012– 2014 have linked PFOA and PFOS exposure to functional immune changes in humans, which are consistent with evidence of PFOA- and PFOS-related immunotoxicity in animal studies. NTP is conducting a systematic review of the evidence for an association between exposure to PFOA or PFOS and immunotoxicity or immune-related health effects. The NTP evaluation concept for immunotoxicity associated with exposure to PFOA or PFOS was initially presented and discussed at the NTP Board of Scientific Counselors (BSC) meeting on December 10, 2014 (79 FR 62640). The NTP evaluation concept, related presentation, and BSC meeting minutes are available at https://ntp.niehs.nih.gov/ go/9741. The protocol for conducting this systematic review is available at https://ntp.niehs.nih.gov/go/749926. Request for Information: OHAT invites the public and other interested parties to submit information on PFOA and PFOS including immune-related effects from completed and ongoing epidemiology studies, non-human animal studies, and mechanistic or in vitro studies. This information will be considered in evaluating the potential immune-related health effects of exposure to PFOA and PFOS. Information should be submitted to Dr. Yun Xie (see ADDRESSES). Request for Nomination of Scientific Experts: OHAT invites nominations of qualified scientists to serve as members of an ad hoc expert panel to peer review the draft NTP monograph resulting from the systematic review of the evidence for an association between exposure to PFOA or PFOS and immunotoxicity. Scientists serving on the peer review panel will represent a wide range of expertise including, but not limited to, epidemiology, immunotoxicology, general toxicology, exposure assessment, and biostatistics. Each nomination should include (1) contact information for the nominee (name, affiliation, telephone number, and email), (2) curriculum vitae, and (3) a short description of the individual’s expertise such as formal academic training and experience in a relevant scientific field, publications in peer- E:\FR\FM\14AUN1.SGM 14AUN1 Federal Register / Vol. 80, No. 157 / Friday, August 14, 2015 / Notices reviewed journals, and membership in relevant professional societies. Nominations should be forwarded to Dr. Yun Xie (see ADDRESSES). Final selection of individuals to serve on the peer review panel will be made in accordance with the Federal Advisory Committee Act and Department of Health and Human Services implementing regulations. All panel members serve as individual experts and not as representatives of their employers or other organizations. Background Information on OHAT: OHAT was established to serve as an environmental health resource to the public and regulatory and health agencies (https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC3094430). This office conducts evaluations to assess the evidence that environmental chemicals, physical substances, or mixtures (collectively referred to as ‘‘substances’’) cause adverse health effects and provides opinions on whether these substances may be of concern given what is known about current human exposure levels. OHAT also organizes workshops or state-of-the-science evaluations to address issues of importance in environmental health sciences. Information about OHAT is found at https://ntp.niehs.nih.gov/go/ ohat. Dated: August 11, 2015. John R. Bucher, Associate Director, National Toxicology Program. [FR Doc. 2015–20122 Filed 8–13–15; 8:45 am] BILLING CODE 4140–01–P Dated: August 11, 2015. Michelle Trout, Program Analyst, Office of Federal Advisory Committee Policy. DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health [FR Doc. 2015–20119 Filed 8–13–15; 8:45 am] asabaliauskas on DSK5VPTVN1PROD with NOTICES National Heart, Lung, and Blood Institute; Notice of Meeting Jkt 235001 Name of Committee: National Institute of Child Health and Human Development Special, Emphasis Panel; Comparative and Developmental Perspectives on the Emergence of Cognitive Competence. Date: August 31, 2015. Time: 9:30 a.m. to 12:30 p.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health, 6100 Executive Boulevard, Rockville, MD 20852, (Telephone Conference Call). Contact Person: Marita R. Hopmann, Ph.D., Scientific Review Officer, Scientific Review Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6100 Executive Boulevard, Room 5B01, Bethesda, MD 20892–9304, (301) 435–6911, hopmannm@ mail.nih.gov. (Catalogue of Federal Domestic Assistance Program Nos. 93.864, Population Research; 93.865, Research for Mothers and Children; 93.929, Center for Medical Rehabilitation Research; 93.209, Contraception and Infertility Loan Repayment Program, National Institutes of Health, HHS) Dated: August 10, 2015. Michelle Trout, Program Analyst, Office of Federal Advisory Committee Policy. [FR Doc. 2015–19976 Filed 8–13–15; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HOMELAND SECURITY Coast Guard [Docket No. USCG–2015–0673] Commercial Fishing Safety Advisory Committee DEPARTMENT OF HEALTH AND HUMAN SERVICES AGENCY: National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health And Human Development; Notice of Closed Meeting Name of Committee: National Heart, Lung, and Blood Advisory Council. Date: September 2, 2015. Open: 1:30 p.m. to 5:00 p.m. 18:50 Aug 13, 2015 the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. BILLING CODE 4140–01–P Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is hereby given of a meeting of the National Heart, Lung, and Blood Advisory Council. The meeting will be open to the public as indicated below, with attendance limited to space available. Individuals who plan to attend and need special assistance, such as sign language interpretation or other reasonable accommodations, should notify the Contact Person listed below in advance of the meeting. VerDate Sep<11>2014 Agenda: To discuss program policies and issues. Place: National Institutes of Health, Building 35A, Porter Building, Room 640, 35A Convent Drive, Bethesda, MD 20892. Contact Person: Stephen C. Mockrin, Ph.D., Director, Division of Extramural Research Activities National Heart, Lung, and Blood Institute, National Institutes of Health, 6701 Rockledge Drive, Room 7100, Bethesda, MD 20892 (301) 435–0260 mockrins@ nhlbi.nih.gov. This notice is being published less than 15 days prior to the meeting due to internal discussions regarding agenda and scheduling details. Any interested person may file written comments with the committee by forwarding the statement to the Contact Person listed on this notice. The statement should include the name, address, telephone number and when applicable, the business or professional affiliation of the interested person. In the interest of security, NIH has instituted stringent procedures for entrance onto the NIH campus. All visitor vehicles, including taxicabs, hotel, and airport shuttles will be inspected before being allowed on campus. Visitors will be asked to show one form of identification (for example, a government-issued photo ID, driver’s license, or passport) and to state the purpose of their visit. Information is also available on the Institute’s/Center’s home page: www.nhlbi.nih.gov/meetings/nhlbac/ index.htm, where an agenda and any additional information for the meeting will be posted when available. (Catalogue of Federal Domestic Assistance Program Nos. 93.233, National Center for Sleep Disorders Research; 93.837, Heart and Vascular Diseases Research; 93.838, Lung Diseases Research; 93.839, Blood Diseases and Resources Research, National Institutes of Health, HHS) 48887 Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is hereby given of the following meeting. The meeting will be closed to the public in accordance with the provisions set forth in section 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and PO 00000 Frm 00084 Fmt 4703 Sfmt 4703 Coast Guard, Department of Homeland Security. ACTION: Notice of Federal Advisory Committee Meeting. The Commercial Fishing Safety Advisory Committee will meet in Seattle, Washington to discuss various issues relating to safety in the commercial fishing industry. This meeting will be open to the public. DATES: The Committee will meet on Tuesday, September 15 and Wednesday, September 16, 2015, from 8 a.m. to 5:30 p.m. The meeting may close early if all business is finished. ADDRESSES: The Committee will meet at the United States District Court House SUMMARY: E:\FR\FM\14AUN1.SGM 14AUN1

Agencies

[Federal Register Volume 80, Number 157 (Friday, August 14, 2015)]
[Notices]
[Pages 48886-48887]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2015-20122]


-----------------------------------------------------------------------

DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Systematic Review of Immunotoxicity Associated With Exposure to 
PFOA or PFOS; Request for Information and Nominations of Scientific 
Experts for Proposed Peer Review Meeting

SUMMARY: The Office of Health Assessment and Translation (OHAT), 
Division of the National Toxicology Program (DNTP), National Institute 
of Environmental Health Sciences is evaluating the scientific evidence 
regarding the association between exposures to perfluorooctanoic acid 
(PFOA) or perfluorooctane sulfonate (PFOS) and immunotoxicity. OHAT 
invites the submission of information about ongoing studies or upcoming 
publications on the immune-related health effects of PFOA or PFOS that 
might be considered for inclusion in the evaluation. OHAT also invites 
the nomination of scientific experts to potentially serve as members of 
an ad hoc expert panel to be convened to peer review the draft NTP 
monograph resulting from the systematic review of the evidence for an 
association between exposure to PFOA or PFOS and immunotoxicity.

DATES: The deadline for receipt of information and nominations of 
scientific experts is September 30, 2015.

ADDRESSES: Information can be submitted to xiey4@niehs.nih.gov.

FOR FURTHER INFORMATION CONTACT: Dr. Yun Xie, NTP Designated Federal 
Official, Office of Liaison, Policy and Review, DNTP, NIEHS, P.O. Box 
12233, MD K2-03, Research Triangle Park, NC 27709. Phone: (919) 541-
3436, Fax: (301) 451-5455, Email: yun.xie@nih.gov. Hand Delivery/
Courier: 530 Davis Drive, Room 2161, Morrisville, NC 27560.

SUPPLEMENTARY INFORMATION: 
    Background on PFOA and PFOS: PFOA and PFOS are persistent chemicals 
that are widely distributed in the environment in part because of high 
stability and little to no expected degradation in the environment. In 
terms of toxicity and exposure, PFOA and PFOS are the best studied 
perfluoroalkyl acids, a group of compounds used extensively over the 
last 50 years in commercial and industrial applications including food 
packaging, lubricants, water-resistant coatings, and fire-retarding 
foams. Through voluntary agreements, the primary manufacturer of PFOS 
phased out production in 2002, and PFOS is no longer manufactured in 
the United States. Similar arrangements have been made for PFOA, and 
eight companies that manufacture PFOA have committed to eliminate 
emissions and product content by 2015. Although emissions have been 
dramatically reduced, the persistence and bioaccumulation of both PFOA 
and PFOS result in detectable levels in the U.S. population and, 
therefore, these chemicals are of potential human health relevance. 
Several recent publications from 2012-2014 have linked PFOA and PFOS 
exposure to functional immune changes in humans, which are consistent 
with evidence of PFOA- and PFOS-related immunotoxicity in animal 
studies.
    NTP is conducting a systematic review of the evidence for an 
association between exposure to PFOA or PFOS and immunotoxicity or 
immune-related health effects. The NTP evaluation concept for 
immunotoxicity associated with exposure to PFOA or PFOS was initially 
presented and discussed at the NTP Board of Scientific Counselors (BSC) 
meeting on December 10, 2014 (79 FR 62640). The NTP evaluation concept, 
related presentation, and BSC meeting minutes are available at https://ntp.niehs.nih.gov/go/9741. The protocol for conducting this systematic 
review is available at https://ntp.niehs.nih.gov/go/749926.
    Request for Information: OHAT invites the public and other 
interested parties to submit information on PFOA and PFOS including 
immune-related effects from completed and ongoing epidemiology studies, 
non-human animal studies, and mechanistic or in vitro studies. This 
information will be considered in evaluating the potential immune-
related health effects of exposure to PFOA and PFOS. Information should 
be submitted to Dr. Yun Xie (see ADDRESSES).
    Request for Nomination of Scientific Experts: OHAT invites 
nominations of qualified scientists to serve as members of an ad hoc 
expert panel to peer review the draft NTP monograph resulting from the 
systematic review of the evidence for an association between exposure 
to PFOA or PFOS and immunotoxicity. Scientists serving on the peer 
review panel will represent a wide range of expertise including, but 
not limited to, epidemiology, immunotoxicology, general toxicology, 
exposure assessment, and biostatistics. Each nomination should include 
(1) contact information for the nominee (name, affiliation, telephone 
number, and email), (2) curriculum vitae, and (3) a short description 
of the individual's expertise such as formal academic training and 
experience in a relevant scientific field, publications in peer-

[[Page 48887]]

reviewed journals, and membership in relevant professional societies. 
Nominations should be forwarded to Dr. Yun Xie (see ADDRESSES). Final 
selection of individuals to serve on the peer review panel will be made 
in accordance with the Federal Advisory Committee Act and Department of 
Health and Human Services implementing regulations. All panel members 
serve as individual experts and not as representatives of their 
employers or other organizations.
    Background Information on OHAT: OHAT was established to serve as an 
environmental health resource to the public and regulatory and health 
agencies (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094430). This 
office conducts evaluations to assess the evidence that environmental 
chemicals, physical substances, or mixtures (collectively referred to 
as ``substances'') cause adverse health effects and provides opinions 
on whether these substances may be of concern given what is known about 
current human exposure levels. OHAT also organizes workshops or state-
of-the-science evaluations to address issues of importance in 
environmental health sciences. Information about OHAT is found at 
https://ntp.niehs.nih.gov/go/ohat.

    Dated: August 11, 2015.
John R. Bucher,
Associate Director, National Toxicology Program.
[FR Doc. 2015-20122 Filed 8-13-15; 8:45 am]
 BILLING CODE 4140-01-P
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