Government-Owned Inventions; Availability for Licensing, 44139-44140 [2015-18101]

Download as PDF Federal Register / Vol. 80, No. 142 / Friday, July 24, 2015 / Notices DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health and Human Development; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is hereby given of the following meeting. The meeting will be closed to the public in accordance with the provisions set forth in section 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Institute of Child Health and Human Development Special Emphasis Panel Improving Health through Rehabilitation Robotic Technology. Date: August 19, 2015. Time: 1:00 p.m. to 3:00 p.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health, 6100 Executive Boulevard, Rockville, MD 20852 (Telephone Conference Call). Contact Person: Sathasiva B. Kandasamy, Ph.D., Scientific Review Officer, Scientific Review Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6100 Executive Boulevard, Room 5B01, Bethesda, MD 20892–9304, (301) 435–6680, skandasa@ mail.nih.gov. (Catalogue of Federal Domestic Assistance Program Nos. 93.864, Population Research; 93.865, Research for Mothers and Children; 93.929, Center for Medical Rehabilitation Research; 93.209, Contraception and Infertility Loan Repayment Program, National Institutes of Health, HHS) Dated: July 17, 2015. Michelle Trout, Program Analyst, Office of Federal Advisory Committee Policy. [FR Doc. 2015–18093 Filed 7–23–15; 8:45 am] asabaliauskas on DSK5VPTVN1PROD with NOTICES BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute on Aging; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the National Institute on VerDate Sep<11>2014 19:59 Jul 23, 2015 Jkt 235001 Aging Special Emphasis Panel, August 13, 2015, 12:00 p.m. to August 13, 2015, 4:00 p.m., National Institute on Aging, Gateway Building, 7201 Wisconsin Avenue, 2C212, Bethesda, MD 20892 which was published in the Federal Register on July 21, 2015, 80 FR 43101. The meeting notice is amended to change the date of the meeting from August 13, 2015 to August 12, 2015. The meeting is closed to the public. Dated: July 21, 2015. Melanie J. Gray, Program Analyst, Office of Federal Advisory Committee Policy. [FR Doc. 2015–18191 Filed 7–23–15; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Government-Owned Inventions; Availability for Licensing AGENCY: National Institutes of Health, HHS. ACTION: Notice. The inventions listed below are owned by an agency of the U.S. Government and are available for licensing in the U.S. in accordance with 35 U.S.C. 209 and 37 CFR part 404 to achieve expeditious commercialization of results of federally-funded research and development. Foreign patent applications are filed on selected inventions to extend market coverage for companies and may also be available for licensing. FOR FURTHER INFORMATION CONTACT: Licensing information and copies of the U.S. patent applications listed below may be obtained by writing to the indicated licensing contact at the Office of Technology Transfer, National Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville, Maryland 20852–3804; telephone: 301– 496–7057; fax: 301–402–0220. A signed Confidential Disclosure Agreement will be required to receive copies of the patent applications. SUPPLEMENTARY INFORMATION: Technology descriptions follow. SUMMARY: Bispecific Chimeric Antigen Receptors to CD22 and CD19 for Treating Hematological Cancers Description of Technology: Chimeric antigen receptors (CARs) are hybrid proteins that have antibody binding fragments fused to protein signaling domains that activate T cells. The antibody binding fragments allow the CAR to recognize specific cell types, PO 00000 Frm 00121 Fmt 4703 Sfmt 4703 44139 thereby activating the T cell through the protein signalling domain. Once activated, the T cells selectively eliminate the cells which they recognize. By engineering a T cell to express CARs with antibody binding fragments which are specific for cell surface proteins that are associated with diseased cells, it is possible to treat the disease. This is a promising new therapeutic approach known as adoptive cell therapy. CD22 and CD19 are cell surface proteins that are expressed on a large number of B cell lineage hematological cancers, such as leukemia and lymphoma. CD19 CAR T cells have demonstrated potent activity against leukemia in early clinical trials. However, some of these patients will relapse with leukemia that no longer expresses the CD19 protein. This technology concerns the use of two high affinity antibody binding fragments as the targeting moieties of a CAR: One to CD22 (m971), and one against CD19 (FMC63). The resulting CAR can be used in adoptive cell therapy treatment for cancers which express either CD22 or CD19. Potential Commercial Applications: • Treatment of diseases associated with increased or preferential expression of CD22 or CD19. • Specific diseases include hematological cancers such as chronic lymphocytic leukemia (CLL), hairy cell leukemia (HCL) acute lymphoblastic leukemia (ALL) and lymphoma. Competitive Advantages: • High affinity of the m971 and FMC63 antibody binding fragments increases the likelihood of successful targeting. • Targeted two antigens expressed on the same type of diseased cells may increase efficacy relative to targeting a single antigen. • Targeted therapy decreases nonspecific killing of healthy, essential cells, resulting in fewer non-specific side-effects and healthier patients. • Hematological cancers are susceptible to cytotoxic T cells because they are present in the bloodstream. Development Stage: • In vitro data available. • In vivo data available (animal). Inventors: Terry J. Fry, et al. (NCI). Publications: 1. Haso W, et al. Anti-CD22-chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia. Blood. 2013 Feb 14;121(7):1165–74. [PMID 23243285] 2. Lee DW, et al. T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial. Lancet. 2015 Feb7;385(9967):517– E:\FR\FM\24JYN1.SGM 24JYN1 44140 Federal Register / Vol. 80, No. 142 / Friday, July 24, 2015 / Notices 28. [PMID 25319501] Intellectual Property: HHS Reference No. E–106–2015/0–US–01—US Provisional Application No. 62/135,442 filed March 19, 2015. Related Technologies: • HHS Reference No. E–080–2008/0– US–03—US Patent Application No. 12/ 934,214 filed September 23, 2010. • HHS Reference No. E–291–2012/0– PCT–02—PCT Application No. PCT/ US2013/060332 filed September 18, 2013. Licensing Contact: David A. Lambertson, Ph.D.; 301–435–4632; lambertsond@mail.nih.gov. asabaliauskas on DSK5VPTVN1PROD with NOTICES Magnetic Resonance Magnification Imaging Description of Technology: With conventional MRI, it is inherently timeconsuming to generate high dimensional images with high spatial resolution. This invention, inspired by optical magnification, uses a fundamentally different approach to MRI image formation. It uses specially designed radiofrequency pulses to interact with the magnetic field gradient, wherein the region of interest is filled with more pixels resulting in increased spatial resolution and reduced overall scan times for patients at the region of interest. Currently, 3-fold magnification has been achieved in vivo. This invention allows the magnification of predefined regions of interest and improved diagnostic images for the same scan time. Potential Commercial Applications: • Diagnostic imaging. • Environmental Sampling/Testing. • Quality Control/Quality Assurance. Competitive Advantages: • Magnified image with increased image resolution. • A 3-fold increase in spatial resolution in vivo in comparison to traditional MRI scans. • Reduced scan time. • Patient friendly—with reduced scan time, there is less patient discomfort especially for those who experience claustrophobia. Development Stage: • Early-stage. • In vivo data available (animal). Inventor: Jun Shen (NIMH). Intellectual Property: HHS Reference No. E–252–2014/0—US Provisional Application No. 62/059,520 filed October 3, 2014. Licensing Contact: Jennifer Wong, M.S.; 301–435–4633; wongje@ mail.nih.gov. Collaborative Research Opportunity: The National Institute of Mental Health is seeking statements of capability or VerDate Sep<11>2014 19:59 Jul 23, 2015 Jkt 235001 interest from parties interested in collaborative research to further develop, evaluate or commercialize Magnetic Resonance Magnification Imaging. For collaboration opportunities, please contact Jun Shen at shenj@mail.nih.gov or 301–451–3408. Dated: July 20, 2015. Richard U. Rodriguez, Acting Director, Office of Technology Transfer, National Institutes of Health. [FR Doc. 2015–18101 Filed 7–23–15; 8:45 am] Dated: July 20, 2015. Melanie J. Gray, Program Analyst, Office of Federal Advisory Committee Policy. [FR Doc. 2015–18092 Filed 7–23–15; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health BILLING CODE 4140–01–P National Library of Medicine; Notice of Closed Meeting DEPARTMENT OF HEALTH AND HUMAN SERVICES Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App), notice is hereby given of the following meeting. The meeting will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable materials, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. National Institutes of Health Center for Scientific Review; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is hereby given of the following meeting. The meeting will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: Center for Scientific Review Special Emphasis Panel Clinical Trial Planning Grant for Interventions and Services to Improve Treatment and Prevention of HIV/ AIDS. Date: August 3, 2015. Time: 1:00 p.m. to 3:00 p.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892, (Telephone Conference Call). Contact Person: Jose H Guerrier, Ph.D., Scientific Review Officer, Center for Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Room 5218, MSC 7852, Bethesda, MD 20892, 301–435– 1137, guerriej@csr.nih.gov. This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. (Catalogue of Federal Domestic Assistance Program Nos. 93.306, Comparative Medicine; 93.333, Clinical Research, 93.306, 93.333, 93.337, 93.393–93.396, 93.837–93.844, 93.846–93.878, 93.892, 93.893, National Institutes of Health, HHS) PO 00000 Frm 00122 Fmt 4703 Sfmt 9990 Name of Committee: National Library of Medicine Special Emphasis Panel; UG4— Regional Medical Library Grants. Date: October 16, 2015. Time: 12:00 p.m. to 4:00 p.m. Agenda: To review and evaluate grant applications. Place: National Library of Medicine, 6705 Rockledge Drive, Suite 301, Bethesda, MD 20817 (Telephone Conference Call). Contact Person: Zoe E. Huang, MD, Scientific Review Officer, Extramural Programs, National Library of Medicine, NIH, 6705 Rockledge Drive, Suite 301, Bethesda, MD 20892–7968, 301–594–4937, huangz@ mail.nih.gov. (Catalogue of Federal Domestic Assistance Program No. 93.879, Medical Library Assistance, National Institutes of Health, HHS) Dated: July 21, 2015. Michelle Trout, Program Analyst, Office of the Federal Advisory Committee Policy. [FR Doc. 2015–18241 Filed 7–23–15; 8:45 am] BILLING CODE 4140–01–P E:\FR\FM\24JYN1.SGM 24JYN1

Agencies

[Federal Register Volume 80, Number 142 (Friday, July 24, 2015)]
[Notices]
[Pages 44139-44140]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2015-18101]


-----------------------------------------------------------------------

DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Government-Owned Inventions; Availability for Licensing

AGENCY: National Institutes of Health, HHS.

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: The inventions listed below are owned by an agency of the U.S. 
Government and are available for licensing in the U.S. in accordance 
with 35 U.S.C. 209 and 37 CFR part 404 to achieve expeditious 
commercialization of results of federally-funded research and 
development. Foreign patent applications are filed on selected 
inventions to extend market coverage for companies and may also be 
available for licensing.

FOR FURTHER INFORMATION CONTACT: Licensing information and copies of 
the U.S. patent applications listed below may be obtained by writing to 
the indicated licensing contact at the Office of Technology Transfer, 
National Institutes of Health, 6011 Executive Boulevard, Suite 325, 
Rockville, Maryland 20852-3804; telephone: 301-496-7057; fax: 301-402-
0220. A signed Confidential Disclosure Agreement will be required to 
receive copies of the patent applications.

SUPPLEMENTARY INFORMATION: Technology descriptions follow.

Bispecific Chimeric Antigen Receptors to CD22 and CD19 for Treating 
Hematological Cancers

    Description of Technology: Chimeric antigen receptors (CARs) are 
hybrid proteins that have antibody binding fragments fused to protein 
signaling domains that activate T cells. The antibody binding fragments 
allow the CAR to recognize specific cell types, thereby activating the 
T cell through the protein signalling domain. Once activated, the T 
cells selectively eliminate the cells which they recognize. By 
engineering a T cell to express CARs with antibody binding fragments 
which are specific for cell surface proteins that are associated with 
diseased cells, it is possible to treat the disease. This is a 
promising new therapeutic approach known as adoptive cell therapy.
    CD22 and CD19 are cell surface proteins that are expressed on a 
large number of B cell lineage hematological cancers, such as leukemia 
and lymphoma. CD19 CAR T cells have demonstrated potent activity 
against leukemia in early clinical trials. However, some of these 
patients will relapse with leukemia that no longer expresses the CD19 
protein. This technology concerns the use of two high affinity antibody 
binding fragments as the targeting moieties of a CAR: One to CD22 
(m971), and one against CD19 (FMC63). The resulting CAR can be used in 
adoptive cell therapy treatment for cancers which express either CD22 
or CD19.
    Potential Commercial Applications:
     Treatment of diseases associated with increased or 
preferential expression of CD22 or CD19.
     Specific diseases include hematological cancers such as 
chronic lymphocytic leukemia (CLL), hairy cell leukemia (HCL) acute 
lymphoblastic leukemia (ALL) and lymphoma.
    Competitive Advantages:
     High affinity of the m971 and FMC63 antibody binding 
fragments increases the likelihood of successful targeting.
     Targeted two antigens expressed on the same type of 
diseased cells may increase efficacy relative to targeting a single 
antigen.
     Targeted therapy decreases non-specific killing of 
healthy, essential cells, resulting in fewer non-specific side-effects 
and healthier patients.
     Hematological cancers are susceptible to cytotoxic T cells 
because they are present in the bloodstream.
    Development Stage:
     In vitro data available.
     In vivo data available (animal).
    Inventors: Terry J. Fry, et al. (NCI).
    Publications:

1. Haso W, et al. Anti-CD22-chimeric antigen receptors targeting B-
cell precursor acute lymphoblastic leukemia. Blood. 2013 Feb 
14;121(7):1165-74. [PMID 23243285]
2. Lee DW, et al. T cells expressing CD19 chimeric antigen receptors 
for acute lymphoblastic leukaemia in children and young adults: a 
phase 1 dose-escalation trial. Lancet. 2015 Feb7;385(9967):517-

[[Page 44140]]

28. [PMID 25319501]

    Intellectual Property: HHS Reference No. E-106-2015/0-US-01--US 
Provisional Application No. 62/135,442 filed March 19, 2015.
    Related Technologies:
     HHS Reference No. E-080-2008/0-US-03--US Patent 
Application No. 12/934,214 filed September 23, 2010.
     HHS Reference No. E-291-2012/0-PCT-02--PCT Application No. 
PCT/US2013/060332 filed September 18, 2013.
    Licensing Contact: David A. Lambertson, Ph.D.; 301-435-4632; 
lambertsond@mail.nih.gov.

Magnetic Resonance Magnification Imaging

    Description of Technology: With conventional MRI, it is inherently 
time-consuming to generate high dimensional images with high spatial 
resolution. This invention, inspired by optical magnification, uses a 
fundamentally different approach to MRI image formation. It uses 
specially designed radiofrequency pulses to interact with the magnetic 
field gradient, wherein the region of interest is filled with more 
pixels resulting in increased spatial resolution and reduced overall 
scan times for patients at the region of interest. Currently, 3-fold 
magnification has been achieved in vivo. This invention allows the 
magnification of predefined regions of interest and improved diagnostic 
images for the same scan time.
    Potential Commercial Applications:
     Diagnostic imaging.
     Environmental Sampling/Testing.
     Quality Control/Quality Assurance.
    Competitive Advantages:
     Magnified image with increased image resolution.
     A 3-fold increase in spatial resolution in vivo in 
comparison to traditional MRI scans.
     Reduced scan time.
     Patient friendly--with reduced scan time, there is less 
patient discomfort especially for those who experience claustrophobia.
    Development Stage:
     Early-stage.
     In vivo data available (animal).
    Inventor: Jun Shen (NIMH).
    Intellectual Property: HHS Reference No. E-252-2014/0--US 
Provisional Application No. 62/059,520 filed October 3, 2014.
    Licensing Contact: Jennifer Wong, M.S.; 301-435-4633; 
wongje@mail.nih.gov.
    Collaborative Research Opportunity: The National Institute of 
Mental Health is seeking statements of capability or interest from 
parties interested in collaborative research to further develop, 
evaluate or commercialize Magnetic Resonance Magnification Imaging. For 
collaboration opportunities, please contact Jun Shen at 
shenj@mail.nih.gov or 301-451-3408.

    Dated: July 20, 2015.
Richard U. Rodriguez,
Acting Director, Office of Technology Transfer, National Institutes of 
Health.
[FR Doc. 2015-18101 Filed 7-23-15; 8:45 am]
 BILLING CODE 4140-01-P
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