National Institute of Allergy and Infectious Diseases; Notice of Closed Meetings, 512-513 [2014-30881]
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Federal Register / Vol. 80, No. 3 / Tuesday, January 6, 2015 / Notices
Request for Comments
NIH encourages the public to provide
comments on any aspect of the draft
policy outlined below. Comments
should be submitted electronically by
January 29, 2015, to the Office of
Clinical Research and Bioethics Policy,
Office of Science Policy, NIH, via email
at SingleIRBpolicy@mail.nih.gov; mail
to 6705 Rockledge Drive, Suite 750,
Bethesda, MD 20892; or fax at 301–496–
9839. Submitted comments are
considered public information; private
or confidential information should not
be submitted. Comments may be posted
along with the submitter’s name and
affiliation on the OCRBP Web site after
the public comment period closes.
Draft NIH Policy on the Use of a Single
Institutional Review Board for MultiSite Research
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Purpose. The purpose of this Policy is
to increase the use of single Institutional
Review Boards (IRB) for multi-site
studies funded by the National
Institutes of Health (NIH). Its goal is to
enhance and streamline the process of
IRB review and reduce inefficiencies so
that research can proceed efficiently
without compromising ethical
principles and protections.
Scope. NIH generally expects all
domestic sites of multi-site NIH-funded
studies to use a single IRB of record.
The Policy applies to all domestic sites
participating in NIH conducted or
supported multi-site studies, whether
supported through grants, contracts, or
the NIH intramural program. While
foreign sites in multi-site studies will
not be expected to follow this Policy,
they may elect to do so.
Responsibilities. All sites
participating in a multi-site study will
be expected to rely on a single IRB to
carry out the functions that are required
for institutional compliance with IRB
review set forth in the HHS regulations
for the Protection of Human Subjects.
The single IRB will be the IRB of record
for the other participating sites. The
single IRB will be accountable for
compliance with regulatory
requirements for IRBs specified under
the HHS regulations at 45 CFR part 46,
such as providing initial and continuing
review of the research.12 All
the use of a single IRB could lead to increased
liability and diminished accountability for
participating sites, and decreased consideration of
local context. See https://www.gpo.gov/fdsys/pkg/
FR–2011–07–26/html/2011–18792.htm
12 On March 5, 2009, OHRP published an ANPRM
requesting public comments on whether OHRP
should pursue rulemaking to hold institutional
review boards and institutions or organizations
operating them directly accountable for compliance
with the provisions of 45 CFR part 46 that relate
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participating sites will be responsible
for meeting other regulatory obligations,
such as obtaining informed consent,
overseeing the implementation of
approved protocols, and, reporting
unanticipated problems and adverse
events to the single IRB of record.
Agreements between the single IRB of
record and other participating sites will
be needed in accordance with 45 CFR
part 46. IRB Authorization Agreements
will document the delegation of
responsibilities of IRB review to the
designated IRB of record and that IRB
site’s acceptance of the responsibilities.
The agreement will set forth the specific
responsibilities of each participating
site. Participating sites will then rely on
the IRB of record to satisfy the
regulatory requirements relevant to the
IRB review. The awardee or lead site for
an NIH-funded, multi-site study will be
responsible for maintaining
authorization agreements and should be
prepared to provide copies of the
authorization agreements and other
necessary documentation to the NIH
funding Institute or Center upon
request. As necessary, mechanisms
should be established to enable the
single IRB of record to consider local
context issues during its deliberations.
A duplicate IRB review at a
participating site would be counter to
the intent and goal of the Policy, but the
Policy does not prohibit any
participating site from carrying out its
own IRB review. If this approach is
taken, the participating site should
expect to bear the cost of the additional
review.
Identification of the IRB that will
serve as the single IRB of record will be
the responsibility of the extramural
applicant or offerer, or the intramural
principal investigator. The funding NIH
Institute or Center has final decisional
authority for approving the selected
single IRB. Use of the designated single
IRB will be a term and condition of
award. If the agreed-upon single IRB is
a fee-based IRB, these costs will be
included in the Notice of Award as a
direct cost.
Compliance with this Policy will be a
term and condition in the Notice of
Award and a contract requirement in
the Contract Award.
Exceptions. Exceptions to the
expectation to use a single IRB may be
to IRB responsibilities. In the ANPRM, OHRP
identified: Responsibilities that may be unique to
IRBs and the institutions operating them;
responsibilities that may be unique to institutions
engaged in human subjects research; and,
responsibilities that may be fulfilled by either IRBs/
IORGs or institutions engaged in human subjects
research. See https://www.gpo.gov/fdsys/pkg/FR–
2009–03–05/pdf/E9–4628.pdf.
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made with appropriate justification.
Exceptions will be allowed only if the
designated single IRB is unable to meet
the needs of specific populations or
where local IRB review is required by
federal, tribal, or state laws or
regulations.13
Effective Date. The Policy applies to
all new grant applications (Type 1 and
2) and contract proposals with receipt
dates after [date to be determined]. It
will also apply to intramural multi-site
studies submitted for initial review after
that date.14
Dated: December 24, 2014.
Lawrence Tabak,
Principal Deputy Director,
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DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
National Cancer Institute; Amended
Notice of Meeting
Notice is hereby given of a change in
the meeting of the National Cancer
Institute Special Emphasis Panel,
January 29, 2015 10:30 a.m. to January
30, 2015, 04:00 p.m., National Cancer
Institute Shady Grove, 9609 Medical
Center Drive, Rockville, MD 20850
which was published in the Federal
Register on November 26, 2014,
79FR70537.
The meeting notice is amended to
change the date and start time to be held
on January 29, 2015 at 10:00 a.m. The
meeting is closed to the public.
Dated: December 30, 2014.
David Clary,
Program Analyst, Office of Federal Advisory
Committee Policy.
[FR Doc. 2014–30883 Filed 1–5–15; 8:45 am]
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DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
National Institute of Allergy and
Infectious Diseases; Notice of Closed
Meetings
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
13 For example, FDA-regulated research involving
a device is required to have local IRB review under
21 U.S.C. 360j(g)(3)(A)).
14 When a final policy is issued, NIH will also
provide more specific procedural guidance to
facilitate implementation.
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Federal Register / Vol. 80, No. 3 / Tuesday, January 6, 2015 / Notices
amended (5 U.S.C. App.), notice is
hereby given of the following meetings.
The meetings will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: National Institute of
Allergy and Infectious Diseases Special
Emphasis Panel, NIAID Investigator Initiated
Program Project Applications (P01).
Date: January 27–28, 2015.
Time: 8:00 a.m. to 5:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, Room
3G50, 5601 Fisher Lane, Rockville, MD 20582
(Telephone Conference Call).
Contact Person: B. Duane Price, Ph.D.,
Scientific Review Officer, Scientific Review
Program, DHHS/NIH/NIAID, 5601 Fisher
Lane, Rockville, MD 20582, 240–669–5074,
pricebd@niaid.nih.gov.
Name of Committee: National Institute of
Allergy and Infectious Diseases Special
Emphasis Panel, Clinical Trial
Implementation Cooperative Agreement
(U01) and Clinical Trial Planning Grant
(R34).
Date: February 2, 2015.
Time: 8:00 a.m. to 5:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, Room
3G50, 5601 Fisher Lane, Rockville, MD
20892, (Telephone Conference Call).
Contact Person: B. Duane Price, Ph.D.,
Scientific Review Officer, Scientific Review
Program, DHHS/NIH/NIAID, 6700B
Rockledge Drive, MSC 7616, Room 3139,
Bethesda, MD 20892, (301) 451–2592,
pricebd@niaid.nih.gov.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.855, Allergy, Immunology,
and Transplantation Research; 93.856,
Microbiology and Infectious Diseases
Research, National Institutes of Health, HHS)
tkelley on DSK3SPTVN1PROD with NOTICES
Dated: December 30, 2014.
David Clary,
Program Analyst, Office of Federal Advisory
Committee Policy.
[FR Doc. 2014–30881 Filed 1–5–15; 8:45 am]
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National Institutes of Health
National Institute of Neurological
Disorders and Stroke; Notice of Closed
Meeting
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is
hereby given of the following meeting.
The meeting will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: National Institute of
Neurological Disorders and Stroke Initial
Review Group; Neurological Sciences and
Disorders C.
Date: February 26–27, 2015.
Time: 8:00 a.m. to 6:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: Embassy Suites Alexandria, 1900
Diagonal Road, Alexandria, Virginia 22314.
Contact Person: William C. Benzing, Ph.D.,
Scientific Review Officer, Scientific Review
Branch, Division of Extramural Research,
NINDS/NIH/DHHS/Neuroscience Center,
6001 Executive Boulevard, Suite 3208, MSC
9529, Bethesda, MD 20892–9529, 301–496–
0660, benzingw@mail.nih.gov.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.853, Clinical Research
Related to Neurological Disorders; 93.854,
Biological Basis Research in the
Neurosciences, National Institutes of Health,
HHS)
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provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: National Cancer
Institute Special Emphasis Panel;
Quantitative Imaging for Evaluation of
Response to Cancer Therapies-Renewal.
Date: January 30, 2015.
Time: 10:00 a.m. to 1:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Cancer Institute Shady
Grove, 9609 Medical Center Drive, Room
1E030, Rockville, MD 20850, (Telephone
Conference Call).
Contact Person: Gerald G. Lovinger, Ph.D.,
Scientific Review Officer, Research
Technology and Contract Review Branch,
Division of Extramural Activities, National
Cancer Institute, 9609 Medical Center Drive,
Room 7W266, Bethesda, MD 20892–9750,
240–276–6385, lovingeg@mail.nih.gov.
Information is also available on the
Institute’s/Center’s home page: https://
deainfo.nci.nih.gov/advisory/sep/sep.htm,
where an agenda and any additional
information for the meeting will be posted
when available.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.392, Cancer Construction;
93.393, Cancer Cause and Prevention
Research; 93.394, Cancer Detection and
Diagnosis Research; 93.395, Cancer
Treatment Research; 93.396, Cancer Biology
Research; 93.397, Cancer Centers Support;
93.398, Cancer Research Manpower; 93.399,
Cancer Control, National Institutes of Health,
HHS)
Dated: December 30, 2014.
David Clary,
Program Analyst, Office of Federal Advisory
Committee Policy.
Dated: December 30, 2014.
Carolyn Baum,
Program Analyst, Office of Federal Advisory
Committee Policy.
[FR Doc. 2014–30880 Filed 1–5–15; 8:45 am]
[FR Doc. 2014–30876 Filed 1–5–15; 8:45 am]
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
BILLING CODE 4140–01–P
BILLING CODE 4140–01–P
National Institutes of Health
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
National Cancer Institute; Notice of
Closed Meeting
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is
hereby given of the following meeting.
The meeting will be closed to the
public in accordance with the
BILLING CODE 4140–01–P
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DEPARTMENT OF HEALTH AND
HUMAN SERVICES
513
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National Cancer Institute; Notice of
Closed Meetings
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is
hereby given of the following meetings.
The meetings will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
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Agencies
[Federal Register Volume 80, Number 3 (Tuesday, January 6, 2015)]
[Notices]
[Pages 512-513]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 2014-30881]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
National Institute of Allergy and Infectious Diseases; Notice of
Closed Meetings
Pursuant to section 10(d) of the Federal Advisory Committee Act, as
[[Page 513]]
amended (5 U.S.C. App.), notice is hereby given of the following
meetings.
The meetings will be closed to the public in accordance with the
provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5
U.S.C., as amended. The grant applications and the discussions could
disclose confidential trade secrets or commercial property such as
patentable material, and personal information concerning individuals
associated with the grant applications, the disclosure of which would
constitute a clearly unwarranted invasion of personal privacy.
Name of Committee: National Institute of Allergy and Infectious
Diseases Special Emphasis Panel, NIAID Investigator Initiated
Program Project Applications (P01).
Date: January 27-28, 2015.
Time: 8:00 a.m. to 5:00 p.m.
Agenda: To review and evaluate grant applications.
Place: National Institutes of Health, Room 3G50, 5601 Fisher
Lane, Rockville, MD 20582 (Telephone Conference Call).
Contact Person: B. Duane Price, Ph.D., Scientific Review
Officer, Scientific Review Program, DHHS/NIH/NIAID, 5601 Fisher
Lane, Rockville, MD 20582, 240-669-5074, pricebd@niaid.nih.gov.
Name of Committee: National Institute of Allergy and Infectious
Diseases Special Emphasis Panel, Clinical Trial Implementation
Cooperative Agreement (U01) and Clinical Trial Planning Grant (R34).
Date: February 2, 2015.
Time: 8:00 a.m. to 5:00 p.m.
Agenda: To review and evaluate grant applications.
Place: National Institutes of Health, Room 3G50, 5601 Fisher
Lane, Rockville, MD 20892, (Telephone Conference Call).
Contact Person: B. Duane Price, Ph.D., Scientific Review
Officer, Scientific Review Program, DHHS/NIH/NIAID, 6700B Rockledge
Drive, MSC 7616, Room 3139, Bethesda, MD 20892, (301) 451-2592,
pricebd@niaid.nih.gov.
(Catalogue of Federal Domestic Assistance Program Nos. 93.855,
Allergy, Immunology, and Transplantation Research; 93.856,
Microbiology and Infectious Diseases Research, National Institutes
of Health, HHS)
Dated: December 30, 2014.
David Clary,
Program Analyst, Office of Federal Advisory Committee Policy.
[FR Doc. 2014-30881 Filed 1-5-15; 8:45 am]
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