Government-Owned Inventions; Availability for Licensing, 74731-74733 [2014-29319]

Download as PDF 74731 Federal Register / Vol. 79, No. 241 / Tuesday, December 16, 2014 / Notices listed below. This proposed information collection was previously published in the Federal Register on August 21, 2014, page 49523 and allowed 60 days for public comment. No public comments were received. The purpose of this notice is to request an additional 30 days for public comment and reinstatement without change. The Center for Scientific Review (CSR), National Institutes of Health, may not conduct or sponsor, and the respondent is not required to respond to, an information collection that has been extended, revised, or implemented on or after October 31, 2014, unless it displays a currently valid OMB control number. Direct Comments to OMB: Written comments and/or suggestions regarding the item(s) contained in this notice, especially regarding the estimated public burden and associated response time, should be directed to the: Office of Management and Budget, Office of Regulatory Affairs, OIRA_submission@ omb.eop.gov or by fax to 202–395–6974, Attention: NIH Desk Officer. DATES: Comment Due Date: Comments regarding this information collection are best assured of having their full effect if received within 30 days of the date of this publication. FOR FURTHER INFORMATION CONTACT: To obtain a copy of the data collection outside influence, timely; and (4) to develop new modes of operation based on customer need and customer feedback about the efficacy of implemented modifications. These surveys will almost certainly lead to quality improvement activities to enhance and/or streamline CSR’s operations. The major mechanism by which CSR will request input is through surveys. The major initiatives ongoing at the present time include: Evaluation of the peer review process, surveys of new and early stage investigators, satisfaction with study section meetings using alternative review platforms, quick feedback for peer review, satisfaction with new reviewer orientation sessions, teleworker space needs, improving study section alignment to ensure the best reviews, and others. Surveys will be collected via Internet or in focus groups. Information gathered from these surveys will be presented to, and used directly by, CSR management to enhance the operations, processes, organization of, and services provided by the Center. OMB approval is requested for 3 years. There are no costs to respondents other than their time. The total estimated annualized burden hours are 4323. plans and instruments, submit comments in writing, or request more information on the proposed project contact: Dr. Mary Ann Guadagno, Project Clearance Liaison, Center for Scientific Review, NIH, Room 3182, 6701 Rockledge Drive, Bethesda, MD 20892, or call non-toll-free number (301) 435–1251 or Email your request, including your address to: guadagma@ csr.nih.gov. Formal requests for additional plans and instruments must be requested in writing. Proposed Collection: Generic Clearance for Satisfaction Surveys of Customers (CSR), 0925–0474 expired October 31, 2014-reinstatement without change, Center for Scientific Review (CSR), National Institutes of Health (NIH). Need and Use of Information Collection: The information collected in these surveys will be used by the Center for Scientific Review management and personnel: (1) To assess the quality of the modified operations and processes now used by CSR to review grant applications; (2) to assess the quality of service provided by CSR to our customers; (3) to enable identification of the most promising biomedical research that will have the greatest impact on improving public health by using a peer review process that is fair unbiased from ESTIMATED ANNUALIZED BURDEN HOURS Number of respondents Form name Type of respondent A .................. B .................. Adult scientific professionals (via Mail/Telephone/Internet) .. Adult scientific professionals (via focus groups) ................... Dated: December 10, 2014. Mary Ann Guadagno, Project Clearance Liaison, Center for Scientific Review, National Institutes of Health. BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES FOR FURTHER INFORMATION CONTACT: mstockstill on DSK4VPTVN1PROD with NOTICES National Institutes of Health Government-Owned Inventions; Availability for Licensing AGENCY: National Institutes of Health, HHS. ACTION: Notice. The inventions listed below are owned by an agency of the U.S. Government and are available for SUMMARY: VerDate Sep<11>2014 19:38 Dec 15, 2014 Jkt 235001 7925 240 licensing in the U.S. in accordance with 35 U.S.C. 209 and 37 CFR part 404 to achieve expeditious commercialization of results of federally-funded research and development. Foreign patent applications are filed on selected inventions to extend market coverage for companies and may also be available for licensing. [FR Doc. 2014–29460 Filed 12–15–14; 8:45 am] Licensing information and copies of the U.S. patent applications listed below may be obtained by writing to the indicated licensing contact at the Office of Technology Transfer, National Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville, Maryland 20852–3804; telephone: 301– 496–7057; fax: 301–402–0220. A signed Confidential Disclosure Agreement will be required to receive copies of the patent applications. PO 00000 Frm 00050 Fmt 4703 Sfmt 4703 Number of responses per respondent 1 1 Average burden per response (in hours) Total annual burden hours 30/60 90/60 3963 360 SUPPLEMENTARY INFORMATION: Technology descriptions follow. Microscopy System for Distinguishing Stimulated Emissions as a Means of Increasing Signal Description of Technology: The invention pertains to a system and method for distinguishing stimulated emissions as a means of enhancing signal strength of fluorescent markers in fluorescence microscopy applications. The system is arranged such that an excitation beam (e.g., laser beam) illuminates a sample along some axis exciting the fluorescent markers used in the sample. A second light beam, a stimulation beam, illuminates the sample along another axis, possibly the same as that of the excitation beam. It has been found that if the excited fluorescent molecules are illuminated with light of a stimulation beam at a E:\FR\FM\16DEN1.SGM 16DEN1 74732 Federal Register / Vol. 79, No. 241 / Tuesday, December 16, 2014 / Notices mstockstill on DSK4VPTVN1PROD with NOTICES particular wavelength after initial excitation, the fluorescent molecules will emit light at this wavelength that can be separately detected. An excited fluorescent molecule may be stimulated by light at a wavelength different from the initial excitation beam to boost the signal. The stimulated emission then generated by the fluorescent molecules travels along the same access as the stimulation beam and, as such, the system is configured by a stimulation beam block component associated with an objective lens that prevents or reduces stimulation beam detection but allows detection of the stimulated emission. Another way the invention achieves this is by refocusing both the excitation and stimulation beams through capture by an excitation objective. A filter is then used to filter out light focused by the excitation objective from the simulated emission sent back by the fluorescent molecule. Potential Commercial Applications: • Fluorescent microscopy • Sample detection Competitive Advantages: Enhanced signal strength in small or dilute samples. Development Stage: • Early-stage • Prototype Inventors: Andrew York (NIBIB), Sanjay Varma (Johns Hopkins University). Intellectual Property: HHS Reference No. E–247–2014/0—U.S. Provisional Patent Application 62/072,218 filed October 29, 2014. Licensing Contact: Michael Shmilovich; 301–435–5019; shmilovm@ mail.nih.gov. Collaborative Research Opportunity: The National Institute of Biological Imaging and Bioengineering is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize Fluorescent Microscopy resolution enhancement. For collaboration opportunities, please contact Cecilia Pazman at pazmance@ mail.nih.gov. A Novel Virus-Based Expression System Description of Technology: The present invention is related to a recombinant viral vector for vaccines. Currently available poxvirus vectors for humans and other animals exhibit suboptimal expression of recombinant gene(s) and high expression of vector proteins which causes weak immunogenicity and high anti-vector immune response. The present novel virus-based expression vectors are non-replicating VerDate Sep<11>2014 19:38 Dec 15, 2014 Jkt 235001 in human and animals, have high expression of exogenous genes to achieve strong immunogenicity, demonstrate low expression of vector proteins to minimize anti-vector immune responses and minimize competition with expression of recombinant proteins and are capable of stable propagation in a continuous cell line. The present virus based expression vectors may be suitable for manufacturing vaccines for inducing an immune response in vaccinated individuals. Potential Commercial Applications: • Vaccine • Tool for studying immune responses Competitive Advantages: • Non-replicating in human and animals • Achieve high expression of recombinant genes • Low expression of vector genes • Stable propagation in a continuous cell line Development Stage: • Early-stage • In vitro data available • Prototype Intellectual Property: HHS Reference No. E–181–2014/0—U.S. Provisional Application No. 62/055,989 filed September 26, 2014. Related Technologies: • Moss B, et al. Recombinant poxviruses having foreign DNA expressed under the control of poxvirus regulatory sequences. U.S. Patent 6,998,252 issued February 14, 2006. • Moss B, et al. Prokaryotic expression in eukaryotic cells. U.S. Patent 5,550,035 issued August 27, 1996. Licensing Contact: John Stansberry, Ph.D.; 301–435–5236; stansbej@ mail.nih.gov. Collaborative Research Opportunity: The National Institute of Allergy and Infectious Diseases, Laboratory of Viral Diseases, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize A Novel Virus-Based Expression System. For collaboration opportunities, please contact Chris Kornak at chris.kornak@nih.gov. Ultra-Sensitive Diagnostic Detects fg/ mL-pg/mL Pathogen/Disease Protein by Visual Color Change Description of Technology: This technology is an ultra-sensitive colorimetric assay, based on an enzymecatalyzed gold nanoparticle growth process, for detection of diseaseassociated proteins (biomarkers) and disease diagnosis. Current detection PO 00000 Frm 00051 Fmt 4703 Sfmt 4703 methods, such as ELISA immunoassays, measure concentrations above 0.1 ng/ mL in a sample. PCR, although more sensitive than ELISA, requires expensive and specialized equipment and reagents, skilled labor, and complex analysis techniques. This assay detects fg/mL to pg/mL concentrations, allowing detection and diagnosis in the earliest stage of disease or infection. A simple to read colorless-to-red change of gold nanoparticle is read with the naked eye, without the need for advanced instruments. This assay can be performed in a standard ELISA plate. Prototype, proof of concept tests using this platform have been designed for enterovirus 71 (EV71) and prostate specific antigen (PSA). The limit of detection (LOD) for a PSA prototype exceeded the commercial ELISA by more than four orders of magnitude. This assay may be particularly well suited for field use/point-of-care detection of infections and early stage disease. Potential Commercial Applications: Infectious pathogen and disease diagnostics. Competitive Advantages: • Orders of magnitude more sensitive than most ELISA (detects fg/mL to pg/ mL) • Plain sight color-based confirmation does not require complex equipment • Field use/point-of-care detection Development Stage: • Early-stage • In vitro data available • Prototype Inventors: Dingbin Liu and Xiaoyuan Chen (NIBIB) Publication: Liu D, et al. Glucose oxidase-catalyzed growth of gold nanoparticles enables quantitative detection of attomolar cancer biomarkers. Anal Chem. 2014 Jun 17; 86(12):5800–6. [PMID 24896231] Intellectual Property: • HHS Reference No. E–167–2014/ 0—U.S. Provisional Application No. 61/ 994,622 filed May 16, 2014 • HHS Reference No. E–167–2014/ 1—U.S. Provisional Application No. 62/ 052,866 filed September 19, 2014 Licensing Contact: Edward (Tedd) Fenn; 424–297–0336; tedd.fenn@ nih.gov. Collaborative Research Opportunity: The National Institute of Biomedical Imaging and Bioengineering is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize this technology. For collaboration opportunities, please contact Cecilia Pazman, Ph.D. at pazmance@mail.nih.gov. E:\FR\FM\16DEN1.SGM 16DEN1 Federal Register / Vol. 79, No. 241 / Tuesday, December 16, 2014 / Notices Cannabinoid Receptor Meditating Compounds for Metabolic Disease Description of Technology: There is evidence that the metabolic effects of endocannabinoids are mediated by CB1 receptors in peripheral tissues. While prior attempts at generating CB1 receptor blockers have had serious neuropsychiatric side effects, inventors at NIH have discovered compounds that block CB1 receptors with reduced brain penetrance. In addition, some of these compounds also have a direct inhibitory effect on inducible nitric oxide synthase (iNOS), whereas another group of the compounds directly activates AMP kinas. These dual-target compounds may be useful for treating metabolic disease and related conditions such as obesity and diabetes and their complications, including liver or kidney fibrosis, without the dangerous the side effects. Potential Commercial Applications: Treatment of metabolic disease and related conditions such as diabetes, obesity and fibrotic disease. Competitive Advantages: Cannabinoid receptor blockers with reduced brain penetrance relative to older drugs of this class, also having secondary target for improved therapeutic efficacy. Development Stage: Early-stage. Inventors: George Kunos (NIAAA), Malliga R. Iyer (NIAAA), Resat Cinar (NIAAA), Kenner C. Rice (NIDA). Intellectual Property: HHS Reference No. E–140–2014/0—U.S. Provisional Application No. 61/991,333 filed May 9, 2014. Related Technologies: • HHS Reference No. E–211–2006/ 0—U.S. Patent No. 8,293,724 issued October 23, 2012 • HHS Reference No. E–282–2012/ 0—PCT Application No. PCT/ US2013069686 filed December 11, 2013 • HHS Reference No. E–103–2013/ 0—PCT Application No. PCT/US2014/ 043924 filed June 24, 2014 Licensing Contact: Jaime M. Greene; 301–435–5559; greenejaime@ mail.nih.gov. mstockstill on DSK4VPTVN1PROD with NOTICES Octopod (8-Pointed Star-Shape) Iron Oxide Nanoparticles Enhance MRI T2 Contrast Description of Technology: The octopod-shaped iron oxide nanoparticles of this technology significantly enhance contrast in MRI imaging compared to spherical superparamagnetic iron oxide nanoparticle T2 contrast agents. These octopod iron oxide nanoparticles show a transverse relaxivity that is over five times greater than comparable spherical agents. Because the unique octopod VerDate Sep<11>2014 19:38 Dec 15, 2014 Jkt 235001 shape creates a greater effective radius than spherical agents, but maintains similar magnetization properties, the relaxation rate is improved. The improved relaxation rate greatly enhances the contrast of images. These octopod agents appear to be biocompatible and may be suitable for intravenous delivery. The synthesis of these agents is also easily reproducible and scaled. The superior contrast greatly improves diagnostic sensitivities, compared to current FDA approved spherical contrast agents. These octopod-shaped iron oxide nanoparticle T2 contrast agents may have a number of medical imaging uses, such as tumor detection, atherosclerosis imaging and delivery of therapeutic treatments. Potential Commercial Applications: Medical imaging, such as tumor detection, atherosclerosis imaging and delivery of therapeutic treatments. Competitive Advantages: • Enhanced T2 contrast • Reproducible and scalable synthesis • Improved imaging and diagnostic capability Development Stage: In vivo data available (animal). Inventors: Xiaoyuan Chen (NIBIB), Jinhao Gao (Xiamen University, China), Zhenghuan Zhao (Xiamen University, China). Publication: Zhao Z, et al. Octapod iron oxide nanoparticles as highperformance T2 contrast agents for magnetic resonance imaging. Nat Commun. 2013; 4:2266. [PMID 23903002]. Intellectual Property: HHS Reference No. E–314–2013/0—PCT Application No. PCT/CN2013/076645 filed June 3, 2013. Licensing Contact: Edward (Tedd) Fenn; 424–297–0336; tedd.fenn@ nih.gov. Collaborative Research Opportunity: The National Institute of Biomedical Imaging and Bioengineering is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize this technology. For collaboration opportunities, please contact Cecilia Pazman, Ph.D. at pazmance@mail.nih.gov. Dated: December 9, 2014. Richard U. Rodriguez, Acting Director, Office of Technology Transfer, National Institutes of Health. [FR Doc. 2014–29319 Filed 12–15–14; 8:45 am] BILLING CODE 4140–01–P PO 00000 Frm 00052 Fmt 4703 Sfmt 4703 74733 DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute of Neurological Disorders and Stroke; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is hereby given of the following meeting. The meeting will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Institute of Neurological Disorders and Stroke Special Emphasis Panel; Translational. Date: January 23, 2015. Time: 8:00 a.m. to 6:00 p.m. Agenda: To review and evaluate grant applications. Place: Hotel Monaco, 700 F Street NW., Washington, DC 20004. Contact Person: Joel A. Saydoff, Ph.D., Scientific Review Officer, Scientific Review Branch, Division of Extramural Research, NINDS/NIH/DHHS/Neuroscience Center, 6001 Executive Boulevard, Suite 3205, MSC 9529, Bethesda, MD 20892–9529, 301–496– 9223, joel.saydoff@nih.gov. (Catalogue of Federal Domestic Assistance Program Nos. 93.853, Clinical Research Related to Neurological Disorders; 93.854, Biological Basis Research in the Neurosciences, National Institutes of Health, HHS) Dated: December 9, 2014. Carolyn Baum, Program Analyst, Office of Federal Advisory Committee Policy. [FR Doc. 2014–29322 Filed 12–15–14; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute of Allergy and Infectious Diseases; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is hereby given of the following meeting. The meeting will be closed to the public in accordance with the E:\FR\FM\16DEN1.SGM 16DEN1

Agencies

[Federal Register Volume 79, Number 241 (Tuesday, December 16, 2014)]
[Notices]
[Pages 74731-74733]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 2014-29319]


-----------------------------------------------------------------------

DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Government-Owned Inventions; Availability for Licensing

AGENCY: National Institutes of Health, HHS.

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: The inventions listed below are owned by an agency of the U.S. 
Government and are available for licensing in the U.S. in accordance 
with 35 U.S.C. 209 and 37 CFR part 404 to achieve expeditious 
commercialization of results of federally-funded research and 
development. Foreign patent applications are filed on selected 
inventions to extend market coverage for companies and may also be 
available for licensing.

FOR FURTHER INFORMATION CONTACT: Licensing information and copies of 
the U.S. patent applications listed below may be obtained by writing to 
the indicated licensing contact at the Office of Technology Transfer, 
National Institutes of Health, 6011 Executive Boulevard, Suite 325, 
Rockville, Maryland 20852-3804; telephone: 301-496-7057; fax: 301-402-
0220. A signed Confidential Disclosure Agreement will be required to 
receive copies of the patent applications.

SUPPLEMENTARY INFORMATION: Technology descriptions follow.

Microscopy System for Distinguishing Stimulated Emissions as a Means of 
Increasing Signal

    Description of Technology: The invention pertains to a system and 
method for distinguishing stimulated emissions as a means of enhancing 
signal strength of fluorescent markers in fluorescence microscopy 
applications. The system is arranged such that an excitation beam 
(e.g., laser beam) illuminates a sample along some axis exciting the 
fluorescent markers used in the sample. A second light beam, a 
stimulation beam, illuminates the sample along another axis, possibly 
the same as that of the excitation beam. It has been found that if the 
excited fluorescent molecules are illuminated with light of a 
stimulation beam at a

[[Page 74732]]

particular wavelength after initial excitation, the fluorescent 
molecules will emit light at this wavelength that can be separately 
detected. An excited fluorescent molecule may be stimulated by light at 
a wavelength different from the initial excitation beam to boost the 
signal. The stimulated emission then generated by the fluorescent 
molecules travels along the same access as the stimulation beam and, as 
such, the system is configured by a stimulation beam block component 
associated with an objective lens that prevents or reduces stimulation 
beam detection but allows detection of the stimulated emission. Another 
way the invention achieves this is by refocusing both the excitation 
and stimulation beams through capture by an excitation objective. A 
filter is then used to filter out light focused by the excitation 
objective from the simulated emission sent back by the fluorescent 
molecule.
    Potential Commercial Applications:
     Fluorescent microscopy
     Sample detection
    Competitive Advantages: Enhanced signal strength in small or dilute 
samples.
    Development Stage:
     Early-stage
     Prototype
    Inventors: Andrew York (NIBIB), Sanjay Varma (Johns Hopkins 
University).
    Intellectual Property: HHS Reference No. E-247-2014/0--U.S. 
Provisional Patent Application 62/072,218 filed October 29, 2014.
    Licensing Contact: Michael Shmilovich; 301-435-5019; 
shmilovm@mail.nih.gov.
    Collaborative Research Opportunity: The National Institute of 
Biological Imaging and Bioengineering is seeking statements of 
capability or interest from parties interested in collaborative 
research to further develop, evaluate or commercialize Fluorescent 
Microscopy resolution enhancement. For collaboration opportunities, 
please contact Cecilia Pazman at pazmance@mail.nih.gov.

A Novel Virus-Based Expression System

    Description of Technology: The present invention is related to a 
recombinant viral vector for vaccines.
    Currently available poxvirus vectors for humans and other animals 
exhibit suboptimal expression of recombinant gene(s) and high 
expression of vector proteins which causes weak immunogenicity and high 
anti-vector immune response.
    The present novel virus-based expression vectors are non-
replicating in human and animals, have high expression of exogenous 
genes to achieve strong immunogenicity, demonstrate low expression of 
vector proteins to minimize anti-vector immune responses and minimize 
competition with expression of recombinant proteins and are capable of 
stable propagation in a continuous cell line. The present virus based 
expression vectors may be suitable for manufacturing vaccines for 
inducing an immune response in vaccinated individuals.
    Potential Commercial Applications:
     Vaccine
     Tool for studying immune responses
    Competitive Advantages:
     Non-replicating in human and animals
     Achieve high expression of recombinant genes
     Low expression of vector genes
     Stable propagation in a continuous cell line
    Development Stage:
     Early-stage
     In vitro data available
     Prototype
    Intellectual Property: HHS Reference No. E-181-2014/0--U.S. 
Provisional Application No. 62/055,989 filed September 26, 2014.
    Related Technologies:
     Moss B, et al. Recombinant poxviruses having foreign DNA 
expressed under the control of poxvirus regulatory sequences. U.S. 
Patent 6,998,252 issued February 14, 2006.
     Moss B, et al. Prokaryotic expression in eukaryotic cells. 
U.S. Patent 5,550,035 issued August 27, 1996.
    Licensing Contact: John Stansberry, Ph.D.; 301-435-5236; 
stansbej@mail.nih.gov.
    Collaborative Research Opportunity: The National Institute of 
Allergy and Infectious Diseases, Laboratory of Viral Diseases, is 
seeking statements of capability or interest from parties interested in 
collaborative research to further develop, evaluate or commercialize A 
Novel Virus-Based Expression System. For collaboration opportunities, 
please contact Chris Kornak at chris.kornak@nih.gov.

Ultra-Sensitive Diagnostic Detects fg/mL-pg/mL Pathogen/Disease Protein 
by Visual Color Change

    Description of Technology: This technology is an ultra-sensitive 
colorimetric assay, based on an enzyme-catalyzed gold nanoparticle 
growth process, for detection of disease-associated proteins 
(biomarkers) and disease diagnosis. Current detection methods, such as 
ELISA immunoassays, measure concentrations above 0.1 ng/mL in a sample. 
PCR, although more sensitive than ELISA, requires expensive and 
specialized equipment and reagents, skilled labor, and complex analysis 
techniques. This assay detects fg/mL to pg/mL concentrations, allowing 
detection and diagnosis in the earliest stage of disease or infection. 
A simple to read colorless-to-red change of gold nanoparticle is read 
with the naked eye, without the need for advanced instruments. This 
assay can be performed in a standard ELISA plate. Prototype, proof of 
concept tests using this platform have been designed for enterovirus 71 
(EV71) and prostate specific antigen (PSA). The limit of detection 
(LOD) for a PSA prototype exceeded the commercial ELISA by more than 
four orders of magnitude. This assay may be particularly well suited 
for field use/point-of-care detection of infections and early stage 
disease.
    Potential Commercial Applications: Infectious pathogen and disease 
diagnostics.
    Competitive Advantages:
     Orders of magnitude more sensitive than most ELISA 
(detects fg/mL to pg/mL)
     Plain sight color-based confirmation does not require 
complex equipment
     Field use/point-of-care detection
    Development Stage:
     Early-stage
     In vitro data available
     Prototype
    Inventors: Dingbin Liu and Xiaoyuan Chen (NIBIB)
    Publication: Liu D, et al. Glucose oxidase-catalyzed growth of gold 
nanoparticles enables quantitative detection of attomolar cancer 
biomarkers. Anal Chem. 2014 Jun 17; 86(12):5800-6. [PMID 24896231]
    Intellectual Property:
     HHS Reference No. E-167-2014/0--U.S. Provisional 
Application No. 61/994,622 filed May 16, 2014
     HHS Reference No. E-167-2014/1--U.S. Provisional 
Application No. 62/052,866 filed September 19, 2014
    Licensing Contact: Edward (Tedd) Fenn; 424-297-0336; 
tedd.fenn@nih.gov.
    Collaborative Research Opportunity: The National Institute of 
Biomedical Imaging and Bioengineering is seeking statements of 
capability or interest from parties interested in collaborative 
research to further develop, evaluate or commercialize this technology. 
For collaboration opportunities, please contact Cecilia Pazman, Ph.D. 
at pazmance@mail.nih.gov.

[[Page 74733]]

Cannabinoid Receptor Meditating Compounds for Metabolic Disease

    Description of Technology: There is evidence that the metabolic 
effects of endocannabinoids are mediated by CB1 receptors in peripheral 
tissues. While prior attempts at generating CB1 receptor blockers have 
had serious neuropsychiatric side effects, inventors at NIH have 
discovered compounds that block CB1 receptors with reduced brain 
penetrance. In addition, some of these compounds also have a direct 
inhibitory effect on inducible nitric oxide synthase (iNOS), whereas 
another group of the compounds directly activates AMP kinas. These 
dual-target compounds may be useful for treating metabolic disease and 
related conditions such as obesity and diabetes and their 
complications, including liver or kidney fibrosis, without the 
dangerous the side effects.
    Potential Commercial Applications: Treatment of metabolic disease 
and related conditions such as diabetes, obesity and fibrotic disease.
    Competitive Advantages: Cannabinoid receptor blockers with reduced 
brain penetrance relative to older drugs of this class, also having 
secondary target for improved therapeutic efficacy.
    Development Stage: Early-stage.
    Inventors: George Kunos (NIAAA), Malliga R. Iyer (NIAAA), Resat 
Cinar (NIAAA), Kenner C. Rice (NIDA).
    Intellectual Property: HHS Reference No. E-140-2014/0--U.S. 
Provisional Application No. 61/991,333 filed May 9, 2014.
    Related Technologies:
     HHS Reference No. E-211-2006/0--U.S. Patent No. 8,293,724 
issued October 23, 2012
     HHS Reference No. E-282-2012/0--PCT Application No. PCT/
US2013069686 filed December 11, 2013
     HHS Reference No. E-103-2013/0--PCT Application No. PCT/
US2014/043924 filed June 24, 2014
    Licensing Contact: Jaime M. Greene; 301-435-5559; 
greenejaime@mail.nih.gov.

Octopod (8-Pointed Star-Shape) Iron Oxide Nanoparticles Enhance MRI 
T[bdi2] Contrast

    Description of Technology: The octopod-shaped iron oxide 
nanoparticles of this technology significantly enhance contrast in MRI 
imaging compared to spherical superparamagnetic iron oxide nanoparticle 
T2 contrast agents. These octopod iron oxide nanoparticles 
show a transverse relaxivity that is over five times greater than 
comparable spherical agents. Because the unique octopod shape creates a 
greater effective radius than spherical agents, but maintains similar 
magnetization properties, the relaxation rate is improved. The improved 
relaxation rate greatly enhances the contrast of images. These octopod 
agents appear to be bio-compatible and may be suitable for intravenous 
delivery. The synthesis of these agents is also easily reproducible and 
scaled. The superior contrast greatly improves diagnostic 
sensitivities, compared to current FDA approved spherical contrast 
agents. These octopod-shaped iron oxide nanoparticle T2 
contrast agents may have a number of medical imaging uses, such as 
tumor detection, atherosclerosis imaging and delivery of therapeutic 
treatments.
    Potential Commercial Applications: Medical imaging, such as tumor 
detection, atherosclerosis imaging and delivery of therapeutic 
treatments.
    Competitive Advantages:
     Enhanced T2 contrast
     Reproducible and scalable synthesis
     Improved imaging and diagnostic capability
    Development Stage: In vivo data available (animal).
    Inventors: Xiaoyuan Chen (NIBIB), Jinhao Gao (Xiamen University, 
China), Zhenghuan Zhao (Xiamen University, China).
    Publication: Zhao Z, et al. Octapod iron oxide nanoparticles as 
high-performance T2 contrast agents for magnetic resonance 
imaging. Nat Commun. 2013; 4:2266. [PMID 23903002].
    Intellectual Property: HHS Reference No. E-314-2013/0--PCT 
Application No. PCT/CN2013/076645 filed June 3, 2013.
    Licensing Contact: Edward (Tedd) Fenn; 424-297-0336; 
tedd.fenn@nih.gov.
    Collaborative Research Opportunity: The National Institute of 
Biomedical Imaging and Bioengineering is seeking statements of 
capability or interest from parties interested in collaborative 
research to further develop, evaluate or commercialize this technology. 
For collaboration opportunities, please contact Cecilia Pazman, Ph.D. 
at pazmance@mail.nih.gov.

    Dated: December 9, 2014.
Richard U. Rodriguez,
Acting Director, Office of Technology Transfer, National Institutes of 
Health.
[FR Doc. 2014-29319 Filed 12-15-14; 8:45 am]
BILLING CODE 4140-01-P
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.