Findings of Research Misconduct, 74091-74092 [2014-29295]

Download as PDF emcdonald on DSK67QTVN1PROD with NOTICES Federal Register / Vol. 79, No. 240 / Monday, December 15, 2014 / Notices expedited notification: 5 hours; and FR Y–4, post-consummation: 0.5 hours. Number of respondents: 279. General description of reports: The FR Y–3 application and FR Y–3N notification are mandatory (12 U.S.C. 1842(a), 1844(b), and 1843(j)(1)(b)). The FR Y–4 notification is mandatory (12 U.S.C. 1843(j)(1)(b)). These information collections are not given confidential treatment. Applicants may rely on any Freedom of Information Act (FOIA) exemption, but such requests for confidentiality must contain detailed justifications corresponding to the claimed FOIA exemption. Requests for confidentiality must be evaluated on a case-by-case basis. Abstract: The Federal Reserve requires the submission of these filings for regulatory and supervisory purposes and to allow the Federal Reserve to fulfill its statutory obligations under the Bank Holding Company Act of 1956 (the BHC Act). These filings collect information on proposals by BHCs involving formations, acquisitions, mergers, and nonbanking activities. The Federal Reserve must obtain this information to evaluate each individual transaction with respect to financial and managerial factors, permissibility, competitive effects, net public benefits, and the impact on the convenience and needs of affected communities. Current Actions: On September 24, 2014, the Federal Reserve published a notice in the Federal Register (79 FR 57101) requesting public comment for 60 days on the extension, without revision, for these information collections. The comment period for this notice expired on November 24, 2014. The Federal Reserve did not receive any comments. The information collection will be extended as proposed. 6. Report title: Application for a Foreign Organization to Acquire a Bank Holding Company. Agency form number: FR Y–3F. OMB control number: 7100–0119. Frequency: On occasion. Reporters: Any company organized under the laws of a foreign country seeking to acquire a U.S. subsidiary bank or bank holding company. Annual reporting hours: 440 hours. Estimated average hours per response: Initial application, 90 hours; subsequent application, 70 hours. Number of respondents: Initial application, 1; subsequent application, 5. General description of report: This information collection is required to obtain or retain a benefit under sections 3(a), 3(c), and 5(a) through 5(c) of the Bank Holding Company Act (12 U.S.C. 1842(a) and (c) and 1844(a) through (c)). VerDate Sep<11>2014 02:54 Dec 13, 2014 Jkt 235001 The information provided in the application is not confidential unless the applicant specifically requests confidentiality and the Federal Reserve approves the request. The instructions convey the confidentiality requirements to applicants. Abstract: Under the Bank Holding Company Act (BHCA), submission of this application is required for any company organized under the laws of a foreign country seeking to acquire a U.S. subsidiary bank or bank holding company. Applicants must provide financial and managerial information, discuss the competitive effects of the proposed transaction, and discuss how the proposed transaction would enhance the convenience and needs of the community to be served. The Federal Reserve uses the information, in part, to fulfill its supervisory responsibilities with respect to foreign banking organizations in the United States. Current Actions: On September 24, 2014, the Federal Reserve published a notice in the Federal Register (79 FR 57101) requesting public comment for 60 days on the extension, without revision, for this information collection. The comment period for this notice expired on November 24, 2014. The Federal Reserve did not receive any comments. The information collection will be extended as proposed. Board of Governors of the Federal Reserve System, December 9, 2014. Robert deV. Frierson, Secretary of the Board. 74091 the Board of Governors. Interested persons may express their views in writing on the standards enumerated in the BHC Act (12 U.S.C. 1842(c)). If the proposal also involves the acquisition of a nonbanking company, the review also includes whether the acquisition of the nonbanking company complies with the standards in section 4 of the BHC Act (12 U.S.C. 1843). Unless otherwise noted, nonbanking activities will be conducted throughout the United States. Unless otherwise noted, comments regarding each of these applications must be received at the Reserve Bank indicated or the offices of the Board of Governors not later than January 9, 2015. A. Federal Reserve Bank of New York (Ivan Hurwitz, Vice President) 33 Liberty Street, New York, New York 10045–0001: 1. Sterling Bancorp, Montebello, New York; to merge with Hudson Valley Holding Corporation, and thereby indirectly acquire Hudson Valley Bank, N.A., both of Yonkers, New York. Board of Governors of the Federal Reserve System, December 10, 2014. Michael J. Lewandowski, Associate Secretary of the Board. [FR Doc. 2014–29250 Filed 12–12–14; 8:45 am] BILLING CODE 6210–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES Office of the Secretary [FR Doc. 2014–29247 Filed 12–12–14; 8:45 am] Findings of Research Misconduct BILLING CODE 6210–01–P AGENCY: ACTION: FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR part 225), and all other applicable statutes and regulations to become a bank holding company and/or to acquire the assets or the ownership of, control of, or the power to vote shares of a bank or bank holding company and all of the banks and nonbanking companies owned by the bank holding company, including the companies listed below. The applications listed below, as well as other related filings required by the Board, are available for immediate inspection at the Federal Reserve Bank indicated. The applications will also be available for inspection at the offices of PO 00000 Frm 00029 Fmt 4703 Sfmt 4703 Office of the Secretary, HHS. Notice. Notice is hereby given that the Office of Research Integrity (ORI) has taken final action in the following case: H. Rosie Xing, Ph.D., University of Chicago: Based on the report of an investigation conducted by the University of Chicago (UC) and additional analysis by ORI in its oversight review, ORI found that Dr. H. Rosie Xing, former Assistant Professor, UC, engaged in research misconduct in research supported by National Cancer Institute (NCI), National Institutes of Health (NIH), grant R01 CA098022. ORI found that Respondent engaged in research misconduct (42 CFR 93.103– 104) by using images that had been among a set of manipulated images produced while at another institution, which had been found to be false by that institution. ORI found that Respondent falsely reported these images in Figures 1D, 2A, and Supplementary Figures 1B SUMMARY: E:\FR\FM\15DEN1.SGM 15DEN1 emcdonald on DSK67QTVN1PROD with NOTICES 74092 Federal Register / Vol. 79, No. 240 / Monday, December 15, 2014 / Notices and 1C in Molecular Cancer Therapeutics 9:2724–36, 2010. The Respondent does not agree with ORI’s finding of research misconduct and asserts that there are extenuating circumstances for her actions. Specifically, ORI found that Respondent: 1. included falsely labeled immunoblots in Figures 1D and 2A as follows: a. Figure 1D (lower panel), representing the total ERK levels in extracts from cells exposed to 15 Gy of gamma radiation for 0–120 minutes, by using results from an unrelated experiment for MAPK levels in extracts from cells exposed to 2, 12, or 20 Gy of gamma irradiation for 1, 5, 20, or 60 minutes b. Figure 2A (KSR1 panel), representing a control Flag-KSR1 immunoblot for extracts of cells transfected with control (TRE), wildtype KSR (KSR–S), or dominant negative inactive KSR (DN–KSR) exposed to no radiation or 5 minutes gamma irradiation, by using results form an unrelated experiment for KSRtransfected cells (KSR–S) irradiated with 0, 2, 5, 20, 15, 20 Gy irradiation c. Figure 2A (ERK panel), representing a control ERK immunoblot for extracts of cells transfected with control (TRE), wild-type KSR (KSR–S), or dominant negative inactive KSR (DN–KSR) exposed to no radiation or 5 minutes gamma irradiation, by using results from an unrelated experiment for KSRtransfected cells (KSR–S) irradiated with 0, 2, 5, 10, 15, 20 Gy irradiation 2. included falsified images in Figures 1D, 2A, and Supplementary Figures 1B and 1C by duplicating bands within the figures as follows: a. Figure 1D (top panel) for an immunoblot for p-ERK in A431 cells, by using the same bands to represent cells treated with ionizing radiation for 5 and 10 minutes with the bands for 60 and 90 minutes b. Figure 2A (top) for an in vitro kinase assay for p-GST-Elk-1, by duplicating lanes 2 and 5 to represent the control plasmid (TRE) at 5 minutes post radiation (lane 2) and the dominant negative inactive KSR (DN–KSR) NT lane (lane 5) c. Supplementary Figure 1B (middle panel) for an in vitro kinase assay for pGST–MEK, by using the same bands to represent cells exposed to 5 and 20 Gy ionizing radiation d. Supplementary Figure 1C (top panel) for an immunoblot for p-MEK1/ 2, by using the same bands to represent cells exposed to 2 and 20 Gy ionizing radiation VerDate Sep<11>2014 04:14 Dec 13, 2014 Jkt 235001 Dr. Xing has entered into a Voluntary Settlement Agreement (Agreement) and has voluntarily agreed: (1) that if within three (3) years from the effective date of the Agreement, Respondent receives or applies for U.S. Public Health Service (PHS) support, Respondent agrees to have her PHSsupported research supervised for a period of three (3) years beginning on the date of her employment in which she receives or applies for PHS support, and to notify her employer(s)/ institution(s) of the terms of this supervision; Respondent agrees that prior to the submission of an application for PHS support for a research project on which the Respondent’s participation is proposed and prior to Respondent’s participation in any capacity on PHS-supported research, Respondent shall ensure that a plan for supervision of her duties is submitted to ORI for approval; the supervision plan must be designed to ensure the scientific integrity of Respondent’s research; Respondent agrees that she shall not participate in any PHS-supported research until such a supervision plan is submitted to and approved by ORI; Respondent agrees to maintain responsibility for compliance with the agreed upon supervision plan; (2) that if within three (3) years from the effective date of this Agreement, Respondent receives or applies for PHS support, for a period of three (3) years beginning on the date of her employment in which she receives or applies for PHS support, any institution employing her to work on PHSsupported projects shall submit, in conjunction with each application for PHS funds, or report, manuscript, or abstract involving PHS-supported research in which Respondent is involved, a certification to ORI that the data provided by Respondent are based on actual experiments or are otherwise legitimately derived and that the data, procedures, and methodology are accurately reported in the application, report, manuscript, or abstract; and (3) to exclude herself voluntarily from serving in any advisory capacity to PHS including, but not limited to, service on any PHS advisory committee, board, and/or peer review committee, or as a consultant for a period of three (3) years beginning on November 13, 2014. FOR FURTHER INFORMATION CONTACT: Acting Director, Office of Research Integrity, 1101 Wootton Parkway, Suite PO 00000 Frm 00030 Fmt 4703 Sfmt 4703 750, Rockville, MD 20852, (240) 453– 8200. Donald Wright, Acting Director, Office of Research Integrity. [FR Doc. 2014–29295 Filed 12–12–14; 8:45 am] BILLING CODE 4150–31–P DEPARTMENT OF HEALTH AND HUMAN SERVICES Office of the Secretary Findings of Research Misconduct Office of the Secretary, HHS. Notice. AGENCY: ACTION: Notice is hereby given that the Office of Research Integrity (ORI) has taken final action in the following case: James P. Warne, Ph.D., University of California San Francisco: Based on an assessment conducted by the University of California San Francisco (UCSF), the Respondent’s admission, and additional analysis conducted by ORI in its oversight review, ORI found that Dr. James P. Warne, former Senior Scientist, Diabetes Center, UCSF School of Medicine, engaged in research misconduct in research supported by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), grants DK080427, DK007161, and DK063720. ORI found that Respondent engaged in research misconduct by falsifying data that were included in the following two (2) publications and two (2) grant applications: • Cell Metabolism 14:791–803, 2011 (hereafter referred to as the ‘‘Cell Metabolism paper’’) • Journal of Neuroscience 33(29):11972–85, 2013 (hereafter referred to as the ‘‘Journal of Neuroscience paper’’) • R01 DK080427–06A1 submitted to NIDDK, NIH • R01 AA022665–01A1 submitted to the National Institute on Alcohol Abuse and Alcoholism (NIAAA), NIH ORI found that Respondent falsified data and related text by altering the experimental data to support the experimental hypothesis. Specifically: 1. Respondent fabricated graphs purported to represent the results of ten (10) different ELISA experiments measuring norephinephrin (NE) or leptin levels in wild-type mice, in AGRP knockout mice, or in AGRP RNAi mice and controls that had received brain infusions of alpha-MPT, a tyrosine hydroxylase inhibitor or vehicle and leptin or AGRP in the following figures: SUMMARY: E:\FR\FM\15DEN1.SGM 15DEN1

Agencies

[Federal Register Volume 79, Number 240 (Monday, December 15, 2014)]
[Notices]
[Pages 74091-74092]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 2014-29295]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

Office of the Secretary


Findings of Research Misconduct

AGENCY: Office of the Secretary, HHS.

ACTION: Notice.

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SUMMARY: Notice is hereby given that the Office of Research Integrity 
(ORI) has taken final action in the following case:
    H. Rosie Xing, Ph.D., University of Chicago: Based on the report of 
an investigation conducted by the University of Chicago (UC) and 
additional analysis by ORI in its oversight review, ORI found that Dr. 
H. Rosie Xing, former Assistant Professor, UC, engaged in research 
misconduct in research supported by National Cancer Institute (NCI), 
National Institutes of Health (NIH), grant R01 CA098022.
    ORI found that Respondent engaged in research misconduct (42 CFR 
93.103-104) by using images that had been among a set of manipulated 
images produced while at another institution, which had been found to 
be false by that institution. ORI found that Respondent falsely 
reported these images in Figures 1D, 2A, and Supplementary Figures 1B

[[Page 74092]]

and 1C in Molecular Cancer Therapeutics 9:2724-36, 2010. The Respondent 
does not agree with ORI's finding of research misconduct and asserts 
that there are extenuating circumstances for her actions.
    Specifically, ORI found that Respondent:
    1. included falsely labeled immunoblots in Figures 1D and 2A as 
follows:
    a. Figure 1D (lower panel), representing the total ERK levels in 
extracts from cells exposed to 15 Gy of gamma radiation for 0-120 
minutes, by using results from an unrelated experiment for MAPK levels 
in extracts from cells exposed to 2, 12, or 20 Gy of gamma irradiation 
for 1, 5, 20, or 60 minutes
    b. Figure 2A (KSR1 panel), representing a control Flag-KSR1 
immunoblot for extracts of cells transfected with control (TRE), wild-
type KSR (KSR-S), or dominant negative inactive KSR (DN-KSR) exposed to 
no radiation or 5 minutes gamma irradiation, by using results form an 
unrelated experiment for KSR-transfected cells (KSR-S) irradiated with 
0, 2, 5, 20, 15, 20 Gy irradiation
    c. Figure 2A (ERK panel), representing a control ERK immunoblot for 
extracts of cells transfected with control (TRE), wild-type KSR (KSR-
S), or dominant negative inactive KSR (DN-KSR) exposed to no radiation 
or 5 minutes gamma irradiation, by using results from an unrelated 
experiment for KSR-transfected cells (KSR-S) irradiated with 0, 2, 5, 
10, 15, 20 Gy irradiation
    2. included falsified images in Figures 1D, 2A, and Supplementary 
Figures 1B and 1C by duplicating bands within the figures as follows:
    a. Figure 1D (top panel) for an immunoblot for p-ERK in A431 cells, 
by using the same bands to represent cells treated with ionizing 
radiation for 5 and 10 minutes with the bands for 60 and 90 minutes
    b. Figure 2A (top) for an in vitro kinase assay for p-GST-Elk-1, by 
duplicating lanes 2 and 5 to represent the control plasmid (TRE) at 5 
minutes post radiation (lane 2) and the dominant negative inactive KSR 
(DN-KSR) NT lane (lane 5)
    c. Supplementary Figure 1B (middle panel) for an in vitro kinase 
assay for p-GST-MEK, by using the same bands to represent cells exposed 
to 5 and 20 Gy ionizing radiation
    d. Supplementary Figure 1C (top panel) for an immunoblot for p-
MEK1/2, by using the same bands to represent cells exposed to 2 and 20 
Gy ionizing radiation
    Dr. Xing has entered into a Voluntary Settlement Agreement 
(Agreement) and has voluntarily agreed:
    (1) that if within three (3) years from the effective date of the 
Agreement, Respondent receives or applies for U.S. Public Health 
Service (PHS) support, Respondent agrees to have her PHS-supported 
research supervised for a period of three (3) years beginning on the 
date of her employment in which she receives or applies for PHS 
support, and to notify her employer(s)/institution(s) of the terms of 
this supervision; Respondent agrees that prior to the submission of an 
application for PHS support for a research project on which the 
Respondent's participation is proposed and prior to Respondent's 
participation in any capacity on PHS-supported research, Respondent 
shall ensure that a plan for supervision of her duties is submitted to 
ORI for approval; the supervision plan must be designed to ensure the 
scientific integrity of Respondent's research; Respondent agrees that 
she shall not participate in any PHS-supported research until such a 
supervision plan is submitted to and approved by ORI; Respondent agrees 
to maintain responsibility for compliance with the agreed upon 
supervision plan;
    (2) that if within three (3) years from the effective date of this 
Agreement, Respondent receives or applies for PHS support, for a period 
of three (3) years beginning on the date of her employment in which she 
receives or applies for PHS support, any institution employing her to 
work on PHS-supported projects shall submit, in conjunction with each 
application for PHS funds, or report, manuscript, or abstract involving 
PHS-supported research in which Respondent is involved, a certification 
to ORI that the data provided by Respondent are based on actual 
experiments or are otherwise legitimately derived and that the data, 
procedures, and methodology are accurately reported in the application, 
report, manuscript, or abstract; and
    (3) to exclude herself voluntarily from serving in any advisory 
capacity to PHS including, but not limited to, service on any PHS 
advisory committee, board, and/or peer review committee, or as a 
consultant for a period of three (3) years beginning on November 13, 
2014.

FOR FURTHER INFORMATION CONTACT: Acting Director, Office of Research 
Integrity, 1101 Wootton Parkway, Suite 750, Rockville, MD 20852, (240) 
453-8200.

Donald Wright,
Acting Director, Office of Research Integrity.
[FR Doc. 2014-29295 Filed 12-12-14; 8:45 am]
BILLING CODE 4150-31-P
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