National Institute of Environmental Health Sciences; Notice of Closed Meeting, 68456-68457 [2014-27059]
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Federal Register / Vol. 79, No. 221 / Monday, November 17, 2014 / Notices
asabaliauskas on DSK5VPTVN1PROD with NOTICES
Inventors: Jake Tsanyang Liang
(NIDDK), Zongyi Hu (NIDDK), Juan Jose
Marugan (NCATS), Noel Terrance
Southhall (NCATS), Xin Hu (NCATS),
Jingbo Xiao (NCATS), Shanshan He
(NIDDK), Marc Ferrer-Alegre (NCATS),
Wei Zhang (NCATS)
Intellectual Property: HHS Reference
No. E–161–2014/0—U.S. Provisional
Patent Application No. 62/011,462 filed
12 June2014
Licensing Contact: Kevin W. Chang,
Ph.D.; 301–435–5018; changke@
mail.nih.gov
Autodock Vina Software Process for
Efficient Large-Scale Cognate Ligand
Screening
Description of Technology: The
invention pertains to software
processes, additions, and docking
approaches to Autodock Vina that
speeds the rate and efficiency of
analyzing ligand interactions with a
receptor by cognate ligands and rewards
conformations in the scoring algorithm
for residue interactions that are based
on the biological data. The score is
multiplied by a weighting factor to
control the degree of ligand-residue
interactions that are considered. This
multiplier is then added to the docking
score for confirmation. This new scoring
mechanism is used to score each
compound in each generation of the
evolutionary genetic algorithm. This
docking approach can be used to score
and rank compounds in large-scale
virtual screening applications. The
software includes logic for converting
SDF formatted to an Autodock Vina
compatible format (containing approx.
25,000 compounds each) and submits
the job to the portable batch system on
the computing cluster to convert into
PDBC files (a concatenated filed type).
Modified Vina software stores the
analyzed binding pocket in RAM that
does not have to be recomputed upon
every docking process. This increases
the efficiency of the docking algorithm
by several orders of magnitude. The
software on the head node intelligently
monitors memory usage, CPU usage and
docking speed. Based on this
information, the head node elastically
controls the load on each node.
Potential Commercial Applications:
• Drug screening.
• Ligand identification.
Competitive Advantages:
• Speed.
• Batch processing.
• Efficient CPU processing.
Development Stage: In vitro data
available.
Inventors: Marvin Gershengorn,
Umesh Padia, Janak Padia, Elizabeth
Geras-Raaka (all of NIDDK).
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Intellectual Property: HHS Reference
No. E–289–2014/0—Software Tool.
Patent protection is not being pursued
for this technology.
Licensing Contact: Michael
Shmilovich, Esq.; 301–435–5019;
shmilovm@mail.nih.gov.
Collaborative Research Opportunity:
The National Institutes of Diabetes and
Digestive and Kidney Diseases is
seeking statements of capability or
interest from parties interested in
collaborative research to further
develop, evaluate or commercialize
Cognate Ligand Identification. For
collaboration opportunities, please
contact Anna Amar at 301–451–2305 or
aamar@mail.nih.gov.
Dated: November 10, 2014.
Richard U. Rodriguez,
Director, Division of Technology Development
and Transfer, Office of Technology Transfer,
National Institutes of Health.
[FR Doc. 2014–27083 Filed 11–14–14; 8:45 am]
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DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
National Institute of Mental Health:
Notice of Closed Meeting
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is
hereby given of the following meeting.
The meeting will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: National Institute of
Mental Health Special Emphasis Panel;
NIMH Career Transition Award for TenureTrack and Tenured Intramural Investigators
(K22).
Date: December 2, 2014.
Time: 12:30 p.m. to 1:30 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health
Neuroscience Center, 6001 Executive
Boulevard, Rockville, MD 20852 (Telephone
Conference Call).
Contact Person: Ingrid Y. Li, Ph.D., Health
Science Administrator Division of
Extramural Activities, National Institute of
Mental Health, NIH Neuroscience Center,
6001 Executive Blvd., Room 6154–C,
PO 00000
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Bethesda, MD 20892, 301–443–1421,
ili1@mail.nih.gov.
(Catalogue of Federal Domestic Assistance
Program No. 93.242, Mental Health Research
Grants, National Institutes of Health, HHS)
Dated: November 7, 2014.
Carolyn A. Baum,
Program Analyst, Office of Federal Advisory
Committee Policy.
[FR Doc. 2014–27060 Filed 11–14–14; 8:45 am]
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DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
National Institute of Environmental
Health Sciences; Notice of Closed
Meeting
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is
hereby given of the following meeting.
The meeting will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The contract proposals and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the contract
proposals, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: National Institute of
Environmental Health Sciences Special
Emphasis Panel; Alternative Toxicological
Methods Support Contract for the National
Toxicology Program (NTP).
Date: December 11, 2014.
Time: 1:00 p.m. to 5:00 p.m.
Agenda: To review and evaluate contract
proposals.
Place: National Institute of Environmental
Health Sciences, Keystone Building,
Conference Room 2166, 530 Davis Drive,
Research Triangle Park, NC 27709,
(Telephone Conference Call).
Contact Person: RoseAnne M. McGee,
Scientific Review Officer, Scientific Review
Branch, Division of Extramural Research and
Training, Nat. Institute of Environmental
Health Sciences, P.O. Box 12233, MD EC–30,
Research Triangle Park, NC 27709 (919) 541–
0752, mcgee1@niehs.nih.gov.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.115, Biometry and Risk
Estimation—Health Risks from
Environmental Exposures; 93.142, NIEHS
Hazardous Waste Worker Health and Safety
Training; 93.143, NIEHS Superfund
Hazardous Substances—Basic Research and
Education; 93.894, Resources and Manpower
Development in the Environmental Health
Sciences; 93.113, Biological Response to
Environmental Health Hazards; 93.114,
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Federal Register / Vol. 79, No. 221 / Monday, November 17, 2014 / Notices
Applied Toxicological Research and Testing,
National Institutes of Health, HHS)
Dated: November 7, 2014.
Carolyn Baum,
Program Analyst, Office of Federal Advisory
Committee Policy.
and Transplantation Research; 93.856,
Microbiology and Infectious Diseases
Research, National Institutes of Health, HHS)
[FR Doc. 2014–27059 Filed 11–14–14; 8:45 am]
Dated: November 7, 2014.
David Clary,
Program Analyst, Office of Federal Advisory
Committee Policy.
BILLING CODE 4140–01–P
[FR Doc. 2014–27058 Filed 11–14–14; 8:45 am]
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DEPARTMENT OF HOMELAND
SECURITY
National Institutes of Health
National Institute of Allergy and
Infectious Diseases: Notice of Closed
Meetings
asabaliauskas on DSK5VPTVN1PROD with NOTICES
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is
hereby given of the following meetings.
The meetings will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: National Institute of
Allergy and Infectious Diseases Special
Emphasis Panel Modeling Immunity for
Biodefense (U19).
Date: December 8–10, 2014.
Time: 8:00 a.m. to 6:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: Sheraton—Silver Spring, Magnolia
Ballroom, 8777 Georgia Avenue Silver
Spring, MD 20910.
Contact Person: Quirijn Vos, Ph.D.,
Scientific Review Officer, Scientific Review
Program, Division of Extramural Activities,
DHHS/NIH/NIAID, 6700B Rockledge Drive,
MSC 7616, Bethesda, MD 20892, 301–451–
2666, qvos@niaid.nih.gov.
Name of Committee: National Institute of
Allergy and Infectious Diseases Special
Emphasis Panel Beyond HAART: Innovative
Approaches to Cure HIV–1 (U19).
Date: December 10–12, 2014.
Time: 8:00 a.m. to 5:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: Hyatt Regency Bethesda, Baccarat
Suite, One Bethesda Metro Center, Bethesda,
MD 20814.
Contact Person: Betty Poon, Ph.D.,
Scientific Review Officer, Scientific Review
Program Division of Extramural Activities,
NIAID/NIH/DHHS, 6700B Rockledge Drive,
MSC 7616, Bethesda, MD 20892–7616, 301–
402–6891, poonb@mail.nih.gov.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.855, Allergy, Immunology,
17:14 Nov 14, 2014
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www.regulations.gov. For more
information on submitting written
comments, see the SUPPLEMENTARY
INFORMATION section below.
FOR FURTHER INFORMATION CONTACT:
Kristin Wyckoff, DHS/S&T/RSD, 445
Murray Lane SW., Mail Stop 0208,
Washington, DC 20528–0208.
SUPPLEMENTARY INFORMATION:
I. Public Participation
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
VerDate Sep<11>2014
68457
[Docket No. DHS–2013–0074]
Request for Comments and Answers
to Specific Questions To Inform
Development of the National Critical
Infrastructure Security and Resilience
(NCISR) Research and Development
(R&D) Plan
Science and Technology
Directorate, DHS.
ACTION: Notice and Request for
Comments and Answers to Specific
Questions.
AGENCY:
This Notice requests general
comments and answers to specific
questions to inform development of the
National Critical Infrastructure Security
and Resilience Research and
Development Plan (NCISR R&D Plan)
called for in Presidential Policy
Directive (PPD) 21, Critical
Infrastructure Security and Resilience.
As part of a comprehensive national
review process, the Department of
Homeland Security (DHS) is soliciting
public comments to support the DHS
Science and Technology Directorate
(S&T) in writing the NCISR R&D Plan.
Critical infrastructure includes cyber
and physical assets, systems, and
networks comprising the 16 critical
infrastructure sectors identified in PPD–
21.
DATES: Written comments are
encouraged and will be accepted until
December 17, 2014.
ADDRESSES: You may submit comments,
identified by docket number DHS–
2013–0074, by any of the following
methods:
• Federal eRulemaking Portal: https://
www.regulations.gov. Follow the
instructions for submitting comments.
• Email: R&DWG@hq.dhs.gov.
Include the docket number DHS–2013–
0074 in the subject line of the message.
• Mail: Kristin Wyckoff, DHS/S&T/
RSD, 445 Murray Lane SW., Mail Stop
0208, Washington, DC 20528–0208.
Docket: For access to the docket to
read background documents or
comments received, go to https://
SUMMARY:
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DHS invites interested persons to
provide input and answers to specific
questions to inform the identification of
national R&D priorities for the NCISR
R&D Plan. Input is welcome from
stakeholder groups, private and public
entities, and individuals on content to
be included to best fulfill the intended
purpose of the plan. Comments that will
provide the most assistance to DHS will
include a rationale for the stated answer
or recommendation, along with
supplemental data, information, or
authority that supports the response.
II. Additional Instructions for Written
Submissions
All written submissions must include
the words ‘‘Department of Homeland
Security’’ and the docket number for
this action. All comments received (via
any of the identified methods) will be
posted without change to https://
www.regulations.gov, including any
personal information provided. Please
submit your comments and material by
only one means to avoid the posting of
duplicate submissions.
If you submit comments by mail, your
submission should be an unbound
document and no larger than 8.5 by 11
inches to enable copying and electronic
document management. Please limit
submissions to a maximum of ten pages
of text if possible. If you want DHS to
acknowledge receipt of comments by
mail, include with your comments a
self-addressed, stamped postcard that
includes the docket number for this
action. DHS will date your postcard and
return it to you via regular mail.
III. Background
On February 12, 2013, President
Obama signed PPD–21,1 Critical
Infrastructure Security and Resilience,
which builds on the extensive work
done to date to protect and enhance the
resilience of the Nation’s critical
infrastructure. This directive aims to
clarify roles and responsibilities across
the Federal Government and establish a
more effective partnership with owners
1 PPD–21 can be found at: https://
www.whitehouse.gov/the-press-office/2013/02/12/
presidential-policy-directive-critical-infrastructuresecurity-and-resil.
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Agencies
[Federal Register Volume 79, Number 221 (Monday, November 17, 2014)]
[Notices]
[Pages 68456-68457]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 2014-27059]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
National Institute of Environmental Health Sciences; Notice of
Closed Meeting
Pursuant to section 10(d) of the Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is hereby given of the following
meeting.
The meeting will be closed to the public in accordance with the
provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5
U.S.C., as amended. The contract proposals and the discussions could
disclose confidential trade secrets or commercial property such as
patentable material, and personal information concerning individuals
associated with the contract proposals, the disclosure of which would
constitute a clearly unwarranted invasion of personal privacy.
Name of Committee: National Institute of Environmental Health
Sciences Special Emphasis Panel; Alternative Toxicological Methods
Support Contract for the National Toxicology Program (NTP).
Date: December 11, 2014.
Time: 1:00 p.m. to 5:00 p.m.
Agenda: To review and evaluate contract proposals.
Place: National Institute of Environmental Health Sciences,
Keystone Building, Conference Room 2166, 530 Davis Drive, Research
Triangle Park, NC 27709, (Telephone Conference Call).
Contact Person: RoseAnne M. McGee, Scientific Review Officer,
Scientific Review Branch, Division of Extramural Research and
Training, Nat. Institute of Environmental Health Sciences, P.O. Box
12233, MD EC-30, Research Triangle Park, NC 27709 (919) 541-0752,
mcgee1@niehs.nih.gov.
(Catalogue of Federal Domestic Assistance Program Nos. 93.115,
Biometry and Risk Estimation--Health Risks from Environmental
Exposures; 93.142, NIEHS Hazardous Waste Worker Health and Safety
Training; 93.143, NIEHS Superfund Hazardous Substances--Basic
Research and Education; 93.894, Resources and Manpower Development
in the Environmental Health Sciences; 93.113, Biological Response to
Environmental Health Hazards; 93.114,
[[Page 68457]]
Applied Toxicological Research and Testing, National Institutes of
Health, HHS)
Dated: November 7, 2014.
Carolyn Baum,
Program Analyst, Office of Federal Advisory Committee Policy.
[FR Doc. 2014-27059 Filed 11-14-14; 8:45 am]
BILLING CODE 4140-01-P