National Institute of Environmental Health Sciences; Notice of Closed Meeting, 64809 [2014-25873]
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Federal Register / Vol. 79, No. 211 / Friday, October 31, 2014 / Notices
protein and fat by-products resulting in
seizures, strokes, and chronic kidney
failure. A significant portion of MMA
cases stem from a deficiency in a key
mitochondrial enzyme, methylmalonylCoA mutase (MUT), required to break
down amino acids and lipids. Currently,
there are no treatments for MMA and
the disease is managed primarily with
dietary restriction of amino acid
precursors and liver-kidney
transplantation in severe cases.
The present invention describes a
synthetic codon-optimized MUT gene
(co-MUT) that improves expression of
human methylmalonyl-CoA mutase. A
series of novel gene therapy vectors
containing co-MUT rescued MMA mice
from lethality and lowered levels of
methylmalonic acid in the blood.
Results of pre-clinical efficacy studies
demonstrate a promising therapy for
MMA and other renal-associated
disorders.
Potential Commercial Applications:
• The co-MUT transgene could be
used to treat MMA patients.
• In addition, it could be used to
produce MUT in vitro for MMA enzyme
replacement therapy.
Competitive Advantages: co-MUT
transgene could be used through nonviral and viral gene delivery.
Development Stage:
• In vitro data available
• In vivo data available (animal)
Inventors: Charles P. Venditti and
Randy J. Chandler (NHGRI)
Intellectual Property: HHS Reference
No. E–243–2012/0—
• U.S. Provisional Application No.
61/792,081 filed 15 March 2013
• PCT Application No. PCT/US2014/
028045 filed 14 March 2014
Licensing Contact: Vince Contreras,
Ph.D.; 301–435–4711; vince.contreras@
nih.gov
Collaborative Research Opportunity:
The Organic Acid Research Section at
the National Human Genome Research
Institute is seeking statements of
capability or interest from parties
interested in collaborative research to
further develop, evaluate or
commercialize codon-optimized MUT
constructs. For collaboration
opportunities, please contact Claire T.
Driscoll at cdriscoll@mail.nih.gov.
Dated: October 28, 2014.
Richard U. Rodriguez,
Acting Director, Office of Technology
Transfer, National Institutes of Health.
[FR Doc. 2014–25874 Filed 10–30–14; 8:45 am]
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
DEPARTMENT OF HOMELAND
SECURITY
National Institutes of Health
Office of the Secretary
National Institute of Environmental
Health Sciences; Notice of Closed
Meeting
[Docket No. DHS–2014–0053]
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is
hereby given of the following meeting.
The meeting will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: National Institute of
Environmental Health Sciences Special
Emphasis Panel; Review of NIEHS R13
Conference Grant Applications.
Date: November 24, 2014.
Time: 12:00 p.m. to 4:30 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institute of Environmental
Health Sciences, Keystone Building,
Conference Room 3118, 530 Davis Drive,
Research Triangle Park, NC 27709,
(Telephone Conference Call).
Contact Person: Janice B. Allen, Ph.D.,
Scientific Review Officer, Scientific Review
Branch, Division of Extramural Research and
Training, Nat. Institute of Environmental
Health Science, P.O. Box 12233, MD EC–30/
Room 3170 B, Research Triangle Park, NC
27709, 919/541–7556.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.115, Biometry and Risk
Estimation—Health Risks from
Environmental Exposures; 93.142, NIEHS
Hazardous Waste Worker Health and Safety
Training; 93.143, NIEHS Superfund
Hazardous Substances—Basic Research and
Education; 93.894, Resources and Manpower
Development in the Environmental Health
Sciences; 93.113, Biological Response to
Environmental Health Hazards; 93.114,
Applied Toxicological Research and Testing,
National Institutes of Health, HHS)
Dated: October 24, 2014.
Carolyn Baum,
Program Analyst, Office of Federal Advisory
Committee Policy.
[FR Doc. 2014–25873 Filed 10–30–14; 8:45 am]
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Privacy Act of 1974; Department of
Homeland Security/United States
Coast Guard—010 Physical Disability
Evaluation System Files System of
Records
Privacy Office, Department of
Homeland Security.
ACTION: Notice of Privacy Act System of
Records.
AGENCY:
In accordance with the
Privacy Act of 1974, the Department of
Homeland Security proposes to update
and reissue a current Department of
Homeland Security system of records
titled, ‘‘Department of Homeland
Security/United States Coast Guard
Physical Disability Evaluation System
Files System of Records.’’ This system
of records allows the Department of
Homeland Security/United States Coast
Guard to collect and preserve the
records regarding physical disability
evaluation proceedings. As a result of
the biennial review of this system, the
system manager and address category
has been updated. This updated system
will be included in the Department of
Homeland Security’s inventory of
record systems.
DATES: Submit comments on or before
December 1, 2014. This updated system
will be effective December 1, 2014.
ADDRESSES: You may submit comments,
identified by docket number DHS–
2014–0053 by one of the following
methods:
• Federal e-Rulemaking Portal: https://
www.regulations.gov. Follow the
instructions for submitting comments.
• Fax: 202–343–4010.
• Mail: Karen L. Neuman, Chief
Privacy Officer, Privacy Office,
Department of Homeland Security,
Washington, DC 20528.
Instructions: All submissions received
must include the agency name and
docket number for this rulemaking. All
comments received will be posted
without change to https://
www.regulations.gov, including any
personal information provided.
Docket: For access to the docket to
read background documents or
comments received, please visit https://
www.regulations.gov.
FOR FURTHER INFORMATION CONTACT: For
general questions, please contact:
Marilyn Scott-Perez (202–475–3515),
Privacy Officer, Commandant (CG–61),
United States Coast Guard, Mail Stop
SUMMARY:
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]]>Agencies
[Federal Register Volume 79, Number 211 (Friday, October 31, 2014)]
[Notices]
[Page 64809]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 2014-25873]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
National Institute of Environmental Health Sciences; Notice of
Closed Meeting
Pursuant to section 10(d) of the Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is hereby given of the following
meeting.
The meeting will be closed to the public in accordance with the
provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5
U.S.C., as amended. The grant applications and the discussions could
disclose confidential trade secrets or commercial property such as
patentable material, and personal information concerning individuals
associated with the grant applications, the disclosure of which would
constitute a clearly unwarranted invasion of personal privacy.
Name of Committee: National Institute of Environmental Health
Sciences Special Emphasis Panel; Review of NIEHS R13 Conference
Grant Applications.
Date: November 24, 2014.
Time: 12:00 p.m. to 4:30 p.m.
Agenda: To review and evaluate grant applications.
Place: National Institute of Environmental Health Sciences,
Keystone Building, Conference Room 3118, 530 Davis Drive, Research
Triangle Park, NC 27709, (Telephone Conference Call).
Contact Person: Janice B. Allen, Ph.D., Scientific Review
Officer, Scientific Review Branch, Division of Extramural Research
and Training, Nat. Institute of Environmental Health Science, P.O.
Box 12233, MD EC-30/Room 3170 B, Research Triangle Park, NC 27709,
919/541-7556.
(Catalogue of Federal Domestic Assistance Program Nos. 93.115,
Biometry and Risk Estimation--Health Risks from Environmental
Exposures; 93.142, NIEHS Hazardous Waste Worker Health and Safety
Training; 93.143, NIEHS Superfund Hazardous Substances--Basic
Research and Education; 93.894, Resources and Manpower Development
in the Environmental Health Sciences; 93.113, Biological Response to
Environmental Health Hazards; 93.114, Applied Toxicological Research
and Testing, National Institutes of Health, HHS)
Dated: October 24, 2014.
Carolyn Baum,
Program Analyst, Office of Federal Advisory Committee Policy.
[FR Doc. 2014-25873 Filed 10-30-14; 8:45 am]
BILLING CODE 4140-01-P
