National Institute of Environmental Health Sciences; Notice of Closed Meeting, 64809 [2014-25873]

Download as PDF asabaliauskas on DSK5VPTVN1PROD with NOTICES Federal Register / Vol. 79, No. 211 / Friday, October 31, 2014 / Notices protein and fat by-products resulting in seizures, strokes, and chronic kidney failure. A significant portion of MMA cases stem from a deficiency in a key mitochondrial enzyme, methylmalonylCoA mutase (MUT), required to break down amino acids and lipids. Currently, there are no treatments for MMA and the disease is managed primarily with dietary restriction of amino acid precursors and liver-kidney transplantation in severe cases. The present invention describes a synthetic codon-optimized MUT gene (co-MUT) that improves expression of human methylmalonyl-CoA mutase. A series of novel gene therapy vectors containing co-MUT rescued MMA mice from lethality and lowered levels of methylmalonic acid in the blood. Results of pre-clinical efficacy studies demonstrate a promising therapy for MMA and other renal-associated disorders. Potential Commercial Applications: • The co-MUT transgene could be used to treat MMA patients. • In addition, it could be used to produce MUT in vitro for MMA enzyme replacement therapy. Competitive Advantages: co-MUT transgene could be used through nonviral and viral gene delivery. Development Stage: • In vitro data available • In vivo data available (animal) Inventors: Charles P. Venditti and Randy J. Chandler (NHGRI) Intellectual Property: HHS Reference No. E–243–2012/0— • U.S. Provisional Application No. 61/792,081 filed 15 March 2013 • PCT Application No. PCT/US2014/ 028045 filed 14 March 2014 Licensing Contact: Vince Contreras, Ph.D.; 301–435–4711; vince.contreras@ nih.gov Collaborative Research Opportunity: The Organic Acid Research Section at the National Human Genome Research Institute is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize codon-optimized MUT constructs. For collaboration opportunities, please contact Claire T. Driscoll at cdriscoll@mail.nih.gov. Dated: October 28, 2014. Richard U. Rodriguez, Acting Director, Office of Technology Transfer, National Institutes of Health. [FR Doc. 2014–25874 Filed 10–30–14; 8:45 am] DEPARTMENT OF HEALTH AND HUMAN SERVICES DEPARTMENT OF HOMELAND SECURITY National Institutes of Health Office of the Secretary National Institute of Environmental Health Sciences; Notice of Closed Meeting [Docket No. DHS–2014–0053] Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is hereby given of the following meeting. The meeting will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Institute of Environmental Health Sciences Special Emphasis Panel; Review of NIEHS R13 Conference Grant Applications. Date: November 24, 2014. Time: 12:00 p.m. to 4:30 p.m. Agenda: To review and evaluate grant applications. Place: National Institute of Environmental Health Sciences, Keystone Building, Conference Room 3118, 530 Davis Drive, Research Triangle Park, NC 27709, (Telephone Conference Call). Contact Person: Janice B. Allen, Ph.D., Scientific Review Officer, Scientific Review Branch, Division of Extramural Research and Training, Nat. Institute of Environmental Health Science, P.O. Box 12233, MD EC–30/ Room 3170 B, Research Triangle Park, NC 27709, 919/541–7556. (Catalogue of Federal Domestic Assistance Program Nos. 93.115, Biometry and Risk Estimation—Health Risks from Environmental Exposures; 93.142, NIEHS Hazardous Waste Worker Health and Safety Training; 93.143, NIEHS Superfund Hazardous Substances—Basic Research and Education; 93.894, Resources and Manpower Development in the Environmental Health Sciences; 93.113, Biological Response to Environmental Health Hazards; 93.114, Applied Toxicological Research and Testing, National Institutes of Health, HHS) Dated: October 24, 2014. Carolyn Baum, Program Analyst, Office of Federal Advisory Committee Policy. [FR Doc. 2014–25873 Filed 10–30–14; 8:45 am] BILLING CODE 4140–01–P BILLING CODE 4140–01–P VerDate Sep<11>2014 18:51 Oct 30, 2014 Jkt 235001 64809 PO 00000 Frm 00069 Fmt 4703 Sfmt 4703 Privacy Act of 1974; Department of Homeland Security/United States Coast Guard—010 Physical Disability Evaluation System Files System of Records Privacy Office, Department of Homeland Security. ACTION: Notice of Privacy Act System of Records. AGENCY: In accordance with the Privacy Act of 1974, the Department of Homeland Security proposes to update and reissue a current Department of Homeland Security system of records titled, ‘‘Department of Homeland Security/United States Coast Guard Physical Disability Evaluation System Files System of Records.’’ This system of records allows the Department of Homeland Security/United States Coast Guard to collect and preserve the records regarding physical disability evaluation proceedings. As a result of the biennial review of this system, the system manager and address category has been updated. This updated system will be included in the Department of Homeland Security’s inventory of record systems. DATES: Submit comments on or before December 1, 2014. This updated system will be effective December 1, 2014. ADDRESSES: You may submit comments, identified by docket number DHS– 2014–0053 by one of the following methods: • Federal e-Rulemaking Portal: http:// www.regulations.gov. Follow the instructions for submitting comments. • Fax: 202–343–4010. • Mail: Karen L. Neuman, Chief Privacy Officer, Privacy Office, Department of Homeland Security, Washington, DC 20528. Instructions: All submissions received must include the agency name and docket number for this rulemaking. All comments received will be posted without change to http:// www.regulations.gov, including any personal information provided. Docket: For access to the docket to read background documents or comments received, please visit http:// www.regulations.gov. FOR FURTHER INFORMATION CONTACT: For general questions, please contact: Marilyn Scott-Perez (202–475–3515), Privacy Officer, Commandant (CG–61), United States Coast Guard, Mail Stop SUMMARY: E:\FR\FM\31OCN1.SGM 31OCN1

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[Federal Register Volume 79, Number 211 (Friday, October 31, 2014)]
[Notices]
[Page 64809]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 2014-25873]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


National Institute of Environmental Health Sciences; Notice of 
Closed Meeting

    Pursuant to section 10(d) of the Federal Advisory Committee Act, as 
amended (5 U.S.C. App.), notice is hereby given of the following 
meeting.
    The meeting will be closed to the public in accordance with the 
provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 
U.S.C., as amended. The grant applications and the discussions could 
disclose confidential trade secrets or commercial property such as 
patentable material, and personal information concerning individuals 
associated with the grant applications, the disclosure of which would 
constitute a clearly unwarranted invasion of personal privacy.

    Name of Committee: National Institute of Environmental Health 
Sciences Special Emphasis Panel; Review of NIEHS R13 Conference 
Grant Applications.
    Date: November 24, 2014.
    Time: 12:00 p.m. to 4:30 p.m.
    Agenda: To review and evaluate grant applications.
    Place: National Institute of Environmental Health Sciences, 
Keystone Building, Conference Room 3118, 530 Davis Drive, Research 
Triangle Park, NC 27709, (Telephone Conference Call).
    Contact Person: Janice B. Allen, Ph.D., Scientific Review 
Officer, Scientific Review Branch, Division of Extramural Research 
and Training, Nat. Institute of Environmental Health Science, P.O. 
Box 12233, MD EC-30/Room 3170 B, Research Triangle Park, NC 27709, 
919/541-7556.

(Catalogue of Federal Domestic Assistance Program Nos. 93.115, 
Biometry and Risk Estimation--Health Risks from Environmental 
Exposures; 93.142, NIEHS Hazardous Waste Worker Health and Safety 
Training; 93.143, NIEHS Superfund Hazardous Substances--Basic 
Research and Education; 93.894, Resources and Manpower Development 
in the Environmental Health Sciences; 93.113, Biological Response to 
Environmental Health Hazards; 93.114, Applied Toxicological Research 
and Testing, National Institutes of Health, HHS)

    Dated: October 24, 2014.
Carolyn Baum,
Program Analyst, Office of Federal Advisory Committee Policy.
[FR Doc. 2014-25873 Filed 10-30-14; 8:45 am]
BILLING CODE 4140-01-P