Center for Scientific Review; Amended Notice of Meeting, 61879 [2014-24380]
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Federal Register / Vol. 79, No. 199 / Wednesday, October 15, 2014 / Notices
tkelley on DSK3SPTVN1PROD with NOTICES
treatment of various human cancers
expressing 5T4.
Competitive Advantages:
• The fully human antibodies may
have better drugability, especially less
immunogenicity and better safety.
• This antibodies could be used as
naked mAbs, CARs and/or as ADCs.
• The confined expression of 5T4
makes it an attractive target for cancer
immunotherapy.
• 5T4 mAbs could be used to treat
several solid tumor cancers.
Development Stage: In vitro data
available
Inventors: Dimiter Dimitrov, Tianlei
Ying, Yang Feng (all of NCI)
Intellectual Property: HHS Reference
No. E–158–2014/0—U.S. Provisional
Application No. 62/034,995 filed 08
August 2014
Licensing Contact: Whitney Hastings;
301–451–7337; hastingw@mail.nih.gov
Quantitative Multiplex Methods for
Rapid Detection and Identification of
Viral Nucleic Acids
Description of Technology: The
subject technologies are quantitative
multiplex loop mediated isothermal
amplification assays that can detect and
distinguish different viral pathogens,
including HIV, Hepatitis B Virus (HBV),
Hepatitis C Virus (HCV), Hepatitis E
Virus (HEV), Dengue Virus (DENV),
Chikungunya virus (CHIKV) and West
Nile Virus (WNV). The assay has the
advantage of distinguishing between
different genotypes of HCV. It has the
potential to detect other pathogens. A
quantitative multiplex variation of the
assay can detect and identify all seven
viruses using one reaction mixture. The
detection-reaction is performed on a
simple heat-source and viral
quantitation can be measured using a
simple fluorospectrophotometer. The
entire detection process using these
assays can be accomplished within 30 to
60 minutes in a doctor’s office,
laboratory setting, or in the field.
Detection limits of as little as 1–10
International Units (viral copies) are
possible with the use of fluorogenic
oligonucleotides. The assays
demonstrate very high specificity when
tested with human clinical samples.
Potential Commercial Applications:
Detection assays for viral pathogens
such as HIV, HBV, HCV, HEV, Dengue
Virus, Chikungunya, and West Nile
Virus.
Competitive Advantages:
• Assays can be completed within 30
to 60 minutes and in a doctor’s office,
laboratory setting, or in the field.
• Assays can be performed without
expensive instrumentation or
specialized technical operators.
VerDate Sep<11>2014
18:00 Oct 14, 2014
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• Assays are highly specific and can
distinguish between different viruses
and between different genotypes of
viruses.
Development Stage:
• Early-stage
• In vitro data available
• In vivo data available (human)
Inventors: Dougbeh-Chris Nyan
(FDA), Deborah R. Taylor (FDA), Maria
Rios (FDA), Kevin L. Swinson (Morgan
State University), Laura E. Ulitzky
(FDA)
Publication: Nyan DC, et al. Rapid
Detection of Hepatitis B Virus in Blood
Plasma by a Specific and Sensitive
Loop-Mediated Isothermal
Amplification Assay. Clin Infect Dis.
2014 July 1;59(1):16–23. [PMID
24704724]
Intellectual Property: HHS Reference
No. E–135–2014/0—US Provisional
Patent Application No. 61/979,446 filed
14 April 2014
Licensing Contact: Kevin W. Chang,
Ph.D.; 301–435–5018; changke@
mail.nih.gov
Collaborative Research Opportunity:
The Food and Drug Administration,
Center for Biologics Evaluation and
Research, is seeking statements of
capability or interest from parties
interested in collaborative research to
further develop, evaluate or
commercialize blood screening test and/
or diagnostic test for infectious diseases.
For collaboration opportunities, please
contact Nisha Narayan at
Nisha.Narayan@fda.hhs.gov or 240–
402–9770.
Dated: October 8, 2014.
Richard U. Rodriguez,
Director, Division of Technology Development
and Transfer, Office of Technology Transfer,
National Institutes of Health.
[FR Doc. 2014–24403 Filed 10–14–14; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
Center for Scientific Review; Amended
Notice of Meeting
Notice is hereby given of a change in
the meeting of the Center for Scientific
Review Special Emphasis Panel,
October 27, 2014, 07:30 a.m. to October
28, 2014, 06:00 p.m., Doubletree Guest
Suites Santa Monica, 1707 Fourth
Street, Santa Monica, CA, 90401 which
was published in the Federal Register
on October 06, 2014, 79 FR 60175.
The meeting will start on October 27,
2014. The meeting time and location
remains the same.
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61879
The meeting is closed to the public.
Dated: October 7, 2014.
Michelle Trout,
Program Analyst, Office of Federal Advisory
Committee Policy.
[FR Doc. 2014–24380 Filed 10–14–14; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
National Library of Medicine; Notice of
Meeting
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. App), notice is
hereby given of meetings of the Board of
Regents of the National Library of
Medicine.
The meeting will be open to the
public as indicated below, with
attendance limited to space available.
Individuals who plan to attend and
need special assistance, such as sign
language interpretation or other
reasonable accommodations, should
notify the Contact Person listed below
in advance of the meeting.
The meeting will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable materials,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: Board of Regents of
the National Library of Medicine; Extramural
Programs Subcommittee.
Date: February 10, 2015.
Closed: 7:45 a.m. to 8:45 a.m.
Agenda: To review and evaluate grant
applications.
Place: National Library of Medicine,
Building 38, Billings Conference Room, 8600
Rockville Pike, Bethesda, MD 20892.
Contact Person: Donald A.B. Lindberg, MD,
Director, National Library of Medicine, 8600
Rockville Pike, Bethesda, MD 20892, 301–
496–6221, lindberg@mail.nih.gov.
Name of Committee: Board of Regents of
the National Library of Medicine;
Subcommittee on Outreach and Public
Information.
Date: February 10, 2015.
Open: 7:45 a.m. to 8:45 a.m.
Agenda: To review and discuss outreach
activities.
Place: National Library of Medicine,
Building 38, 2nd Floor, Conference Room B,
8600 Rockville Pike, Bethesda, MD 20892.
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[Federal Register Volume 79, Number 199 (Wednesday, October 15, 2014)]
[Notices]
[Page 61879]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 2014-24380]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
Center for Scientific Review; Amended Notice of Meeting
Notice is hereby given of a change in the meeting of the Center for
Scientific Review Special Emphasis Panel, October 27, 2014, 07:30 a.m.
to October 28, 2014, 06:00 p.m., Doubletree Guest Suites Santa Monica,
1707 Fourth Street, Santa Monica, CA, 90401 which was published in the
Federal Register on October 06, 2014, 79 FR 60175.
The meeting will start on October 27, 2014. The meeting time and
location remains the same.
The meeting is closed to the public.
Dated: October 7, 2014.
Michelle Trout,
Program Analyst, Office of Federal Advisory Committee Policy.
[FR Doc. 2014-24380 Filed 10-14-14; 8:45 am]
BILLING CODE 4140-01-P
