National Institute of Environmental Health Sciences; Notice of Closed Meeting, 40122 [2014-16260]
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Federal Register / Vol. 79, No. 133 / Friday, July 11, 2014 / Notices
• Clinical research
• Basic research
Competitive Advantages:
• More sensitivity
• Higher efficiency
• Low cytotoxicity
• Multiple functionality
• Multiple targets
• Visualization
• Controlled activation
Development Stage:
• In vitro data available
• In vivo data available
Inventors: Bruce A. Shapiro, Kirill A.
Afonin, Angelica N. Martins, Mathias D.
Viard (all of NCI)
Intellectual Property: HHS Reference
No. E–765–2013/0—US Provisional
Application No. 61/878,758 filed 17 Sep
2013.
Related Technologies:
• HHS Reference No. E–039–2012
• HHS Reference No. E–156–2014
Licensing Contact: John Stansberry,
Ph.D.; 301–435–5236; stansbej@
mail.nih.gov
Collaborative Research Opportunity:
The National Cancer Institute is seeking
statements of capability or interest from
parties interested in collaborative
research to further develop, evaluate or
commercialize scaling up, animal
models, multiple targets, delivery. For
collaboration opportunities, please
contact John D. Hewes, Ph.D. at hewesj@
mail.nih.gov.
tkelley on DSK3SPTVN1PROD with NOTICES
Nucleic Acid Nanoparticles for
Triggering RNA Interference
Description of Technology: RNA
interference (RNAi) is a naturally
occurring cellular post-transcriptional
gene regulation process that utilizes
small double-stranded RNAs to trigger
and guide gene silencing. By
introducing synthetic RNA duplexes
called small-interfering RNAs (siRNAs),
we can harness the RNAi machinery for
therapeutic gene control and the
treatment of various diseases.
The present invention discloses RNA,
RNA–DNA, DNA–RNA, hybrid
nanocubes consisting of a DNA or RNA
core (composed of six strands) with
attached RNA or DNA hybrid duplexes.
The nanocubes can induce the
reassociation of the RNA duplexes,
which can then be processed by the
human recombinant Dicer enzyme, thus
activating RNAi. This technology opens
a new route for the development of
‘‘smart’’ nucleic acid based
nanoparticles for a wide range of
biomedical applications. Immune
responses can be controlled by altering
the composition of the particles.
Potential Commercial Applications:
• Treatment for various diseases
• Clinical research
VerDate Mar<15>2010
20:23 Jul 10, 2014
Jkt 232001
• Basic research
Competitive Advantages:
• Low cytotoxicity
• Chemical stability
• More specificity
• Controlled activation
• Multiple targets
• Visualization
Development Stage: In vitro data
available
Inventors: Bruce A. Shapiro, Kirill A.
Afonin, Mathias D. Viard (all of NCI)
Publications:
1. Afonin KA, et al. Computational and
experimental characterization of RNA cubic
nanoscaffolds. Methods. 2014 May
15;67(2):256–65. [PMID 24189588]
2. Afonin KA, et al. In vitro assembly of
cubic RNA-based scaffolds designed in silico.
Nat Nanotechnol. 2010 Sep;5(9):676–82.
[PMID 20802494]
Intellectual Property: HHS Reference
No. E–156–2014/0—US Provisional
Application 61/989,520 filed 06 May
2014
Related Technologies:
• HHS Reference No. E–765–2013
• HHS Reference No. E–039–2012
Licensing Contact: John Stansberry,
Ph.D.; 301–435–5236; stansbej@
mail.nih.gov
Collaborative Research Opportunity:
The National Cancer Institute is seeking
statements of capability or interest from
parties interested in collaborative
research to further develop, evaluate or
commercialize scaling up, animal
models, multiple targets, delivery. For
collaboration opportunities, please
contact John D. Hewes, Ph.D. at hewesj@
mail.nih.gov.
Dated: July 10, 2014.
Richard U. Rodriguez,
Director, Division of Technology Development
and Transfer, Office of Technology Transfer,
National Institutes of Health.
[FR Doc. 2014–16265 Filed 7–10–14; 8:45 am]
BILLING CODE 4140–01–P
National Institutes of Health
National Institute of Environmental
Health Sciences; Notice of Closed
Meeting
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is
hereby given of the following meeting.
The meeting will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
Frm 00065
Fmt 4703
Name of Committee: National Institute of
Environmental Health Sciences Special
Emphasis Panel,Pathway to Independence
Awards.
Date: August 6, 2014.
Time: 1:00 p.m. to 5:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institute of Environmental
Health Sciences, Keystone Building,
Conference Room 1002, 530 Davis Drive,
Research Triangle Park, NC 27709,
(Telephone Conference Call).
Contact Person: Leroy Worth, Ph.D.,
Scientific Review Officer, Scientific Review
Branch, Division of Extramural Research and
Training, Nat. Institute of Environmental
Health Sciences, P. O. Box 12233, MD EC–
30/Room 3171, Research Triangle Park, NC
27709, (919) 541–0670, worth@niehs.nih.gov.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.115, Biometry and Risk
Estimation—Health Risks from
Environmental Exposures; 93.142, NIEHS
Hazardous Waste Worker Health and Safety
Training; 93.143, NIEHS Superfund
Hazardous Substances—Basic Research and
Education; 93.894, Resources and Manpower
Development in the Environmental Health
Sciences; 93.113, Biological Response to
Environmental Health Hazards; 93.114,
Applied Toxicological Research and Testing,
National Institutes of Health, HHS).
Dated: July 8, 2014.
Carolyn Baum,
Program Analyst, Office of Federal Advisory
Committee Policy.
[FR Doc. 2014–16260 Filed 7–10–14; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
PO 00000
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Sfmt 4703
National Institute of General Medical
Sciences; Notice of Closed Meetings
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is
hereby given of the following meetings.
The meetings will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
E:\FR\FM\11JYN1.SGM
11JYN1
]]>Agencies
[Federal Register Volume 79, Number 133 (Friday, July 11, 2014)]
[Notices]
[Page 40122]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 2014-16260]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
National Institute of Environmental Health Sciences; Notice of
Closed Meeting
Pursuant to section 10(d) of the Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is hereby given of the following
meeting.
The meeting will be closed to the public in accordance with the
provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5
U.S.C., as amended. The grant applications and the discussions could
disclose confidential trade secrets or commercial property such as
patentable material, and personal information concerning individuals
associated with the grant applications, the disclosure of which would
constitute a clearly unwarranted invasion of personal privacy.
Name of Committee: National Institute of Environmental Health
Sciences Special Emphasis Panel,Pathway to Independence Awards.
Date: August 6, 2014.
Time: 1:00 p.m. to 5:00 p.m.
Agenda: To review and evaluate grant applications.
Place: National Institute of Environmental Health Sciences,
Keystone Building, Conference Room 1002, 530 Davis Drive, Research
Triangle Park, NC 27709, (Telephone Conference Call).
Contact Person: Leroy Worth, Ph.D., Scientific Review Officer,
Scientific Review Branch, Division of Extramural Research and
Training, Nat. Institute of Environmental Health Sciences, P. O. Box
12233, MD EC-30/Room 3171, Research Triangle Park, NC 27709, (919)
541-0670, worth@niehs.nih.gov.
(Catalogue of Federal Domestic Assistance Program Nos. 93.115,
Biometry and Risk Estimation--Health Risks from Environmental
Exposures; 93.142, NIEHS Hazardous Waste Worker Health and Safety
Training; 93.143, NIEHS Superfund Hazardous Substances--Basic
Research and Education; 93.894, Resources and Manpower Development
in the Environmental Health Sciences; 93.113, Biological Response to
Environmental Health Hazards; 93.114, Applied Toxicological Research
and Testing, National Institutes of Health, HHS).
Dated: July 8, 2014.
Carolyn Baum,
Program Analyst, Office of Federal Advisory Committee Policy.
[FR Doc. 2014-16260 Filed 7-10-14; 8:45 am]
BILLING CODE 4140-01-P
