Change in Bank Control Notices; Acquisitions of Shares of a Bank or Bank Holding Company, 31113-31114 [2014-12578]
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Federal Register / Vol. 79, No. 104 / Friday, May 30, 2014 / Notices
II. Background
A. Purpose of FIFRA SAP
FIFRA SAP serves as the primary
scientific peer review mechanism of
EPA’s Office of Chemical Safety and
Pollution Prevention (OCSPP) and is
structured to provide scientific advice,
information and recommendations to
the EPA Administrator on pesticides
and pesticide-related issues as to the
impact of regulatory actions on health
and the environment. FIFRA SAP is a
Federal advisory committee established
in 1975 under FIFRA that operates in
accordance with requirements of the
Federal Advisory Committee Act. FIFRA
SAP is composed of a permanent panel
consisting of seven members who are
appointed by the EPA Administrator
from nominees provided by the National
Institutes of Health and the National
Science Foundation. FIFRA established
a Science Review Board consisting of at
least 60 scientists who are available to
the SAP on an ad hoc basis to assist in
reviews conducted by the SAP. As a
peer review mechanism, FIFRA SAP
provides comments, evaluations and
recommendations to improve the
effectiveness and quality of analyses
made by Agency scientists. Members of
FIFRA SAP are scientists who have
sufficient professional qualifications,
including training and experience, to
provide expert advice and
recommendation to the Agency.
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B. Public Meeting
EPA has made many recent advances
in high throughput bioactivity testing.
However, concurrent advances in rapid,
quantitative prediction of human and
ecological exposures have been lacking,
despite the clear importance of both
measures for a risk-based approach to
prioritizing and screening chemicals. A
recent report by the National Research
Council of the National Academies,
Exposure Science in the 21st Century: A
Vision and a Strategy (NRC 2012) laid
out a number of applications in
chemical evaluation of both toxicity and
risk in critical need of quantitative
exposure predictions, including
screening and prioritization of
chemicals for targeted toxicity testing,
focused exposure assessments or
monitoring studies, and quantification
of population vulnerability. Despite
these significant needs, for the majority
of chemicals (e.g. non-pesticide
environmental compounds) there are no
or limited estimates of exposure. For
example, exposure estimates exist for
only 7% of the ToxCast Phase II
chemical list. In addition, the data
required for generating exposure
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estimates for large numbers of chemicals
is severely lacking (Egeghy et al. 2012).
This SAP will review the use of EPA’s
ExpoCast model to rapidly estimate
potential chemical exposures for
prioritization and screening purposes.
The focus will be on bounded chemical
exposure values for people and the
environment for the Endocrine
Disruptor Screening Program (EDSP)
Universe of Chemicals. In addition to
exposure, the SAP will review methods
to extrapolate an in vivo dose from in
vitro dose data. This will involve
presenting pharmacokinetic (PK) data
for chemicals that have been run
through a battery of high throughput
endocrine screening assays and the
methodology to use that PK information
to estimate an in vivo dose. This
exposure and RTK information along
with high throughput in vitro bioactivity
data will allow the EPA to assign a risk
ranking to chemicals and prioritize
them accordingly.
ExpoCast is an EPA initiative to
develop the necessary approaches and
tools for rapidly prioritizing and
screening thousands of chemicals based
on the potential for human exposure.
This focus for ExpoCast is distinct from
many existing exposure tools that
support regulatory risk assessment.
Traditional exposure tools are lower
throughput, requiring considerable data
to make predictions of sufficient
precision for a full risk assessment.
ExpoCast efforts have focused on
empirically assessing the uncertainty in
forecasts made with limited available
data, finding that in some cases even
highly uncertain forecasts may be useful
for prioritization and screening.
In order to relate high throughput
bioactivity data and rapid exposure
predictions, an in vitro-in vivo
extrapolation (IVIVE) via PK is needed.
This IVIVE relates the in vitro
compound concentrations (mM) found to
be bioactive to the in vivo doses needed
to produce serum concentrations equal
to the in vitro concentrations. Without
the time and resources necessary to
generate in vivo PK data for the
thousands of chemicals in the EDSP
universe, high throughput
pharmacokinetics (HTPK) can serve as a
useful surrogate. HTPK methods were
developed for pharmaceuticals to
estimate therapeutic doses for clinical
studies. HTPK technologies have been
effective for pharmaceutical compounds
and predicted concentrations are
typically on the order of the measured
in vivo concentrations. For nontherapeutic compounds in humans, PK
data is not available and so it is
essential to carefully characterize the
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predictive ability of the HTPK models
and define the domain of applicability.
High throughput exposure prediction
and high throughput PK, when taken
together with in vitro bioactivity
profiling as a surrogate for hazard, will
allow for a risk-based, rapid
prioritization and screening of
chemicals in the EDSP universe and
beyond.
C. FIFRA SAP Documents and Meeting
Minutes
EPA’s background paper, related
supporting materials, charge/questions
to FIFRA SAP, FIFRA SAP composition
(i.e., members and ad hoc members for
this meeting), and the meeting agenda
will be available by approximately July
9, 2014. In addition, the Agency may
provide additional background
documents as the materials become
available. You may obtain electronic
copies of these documents, and certain
other related documents that might be
available electronically, at https://
www.regulations.gov and the FIFRA
SAP homepage at https://www.epa.gov/
scipoly/sap.
FIFRA SAP will prepare meeting
minutes summarizing its
recommendations to the Agency
approximately 90 days after the
meeting. The meeting minutes will be
posted on the FIFRA SAP Web site or
may be obtained from the OPP Docket
or at https://www.regulations.gov.
List of Subjects
Environmental protection, Pesticides
and pests, Environmental justice.
Dated: May 20, 2014.
David J. Dix,
Director, Office of Science Coordination and
Policy.
[FR Doc. 2014–12593 Filed 5–29–14; 8:45 am]
BILLING CODE 6560–50–P
FEDERAL RESERVE SYSTEM
Change in Bank Control Notices;
Acquisitions of Shares of a Bank or
Bank Holding Company
The notificants listed below have
applied under the Change in Bank
Control Act (12 U.S.C. 1817(j)) and
§ 225.41 of the Board’s Regulation Y (12
CFR 225.41) to acquire shares of a bank
or bank holding company. The factors
that are considered in acting on the
notices are set forth in paragraph 7 of
the Act (12 U.S.C. 1817(j)(7)).
The notices are available for
immediate inspection at the Federal
Reserve Bank indicated. The notices
also will be available for inspection at
the offices of the Board of Governors.
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31114
Federal Register / Vol. 79, No. 104 / Friday, May 30, 2014 / Notices
Interested persons may express their
views in writing to the Reserve Bank
indicated for that notice or to the offices
of the Board of Governors. Comments
must be received not later than June 16,
2014.
A. Federal Reserve Bank of Kansas
City (Dennis Denney, Assistant Vice
President) 1 Memorial Drive, Kansas
City, Missouri 64198–0001:
1. Mary Lou Spanier, individually and
as trustee of the Jesse L. Thomas
Testamentary Trust, both of Sublette,
Kansas; to acquire voting shares of Santa
Fe Trail Banc Shares, Inc., and thereby
indirectly acquire voting shares of
Centera Bank, both in Sublette, Kansas.
Board of Governors of the Federal Reserve
System, May 27, 2014.
Margaret McCloskey Shanks,
Deputy Secretary of the Board.
Desk to maintain its policy of rolling
over maturing Treasury securities into
new issues and its policy of reinvesting
principal payments on all agency debt
and agency mortgage-backed securities
in agency mortgage-backed securities.
The System Open Market Account
Manager and the Secretary will keep the
Committee informed of ongoing
developments regarding the System’s
balance sheet that could affect the
attainment over time of the Committee’s
objectives of maximum employment
and price stability.
By order of the Federal Open Market
Committee, May 22, 2014.
William B. English,
Secretary, Federal Open Market Committee.
[FR Doc. 2014–12517 Filed 5–29–14; 8:45 am]
BILLING CODE 6210–01–P
[FR Doc. 2014–12578 Filed 5–29–14; 8:45 am]
BILLING CODE 6210–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
FEDERAL RESERVE SYSTEM
Agency for Toxic Substances and
Disease Registry
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Federal Open Market Committee;
Domestic Policy Directive of April 29–
30, 2014
In accordance with Section 271.25 of
its rules regarding availability of
information (12 CFR part 271), there is
set forth below the domestic policy
directive issued by the Federal Open
Market Committee at its meeting held
on April 29–30, 2014.1
Consistent with its statutory mandate,
the Federal Open Market Committee
seeks monetary and financial conditions
that will foster maximum employment
and price stability. In particular, the
Committee seeks conditions in reserve
markets consistent with federal funds
trading in a range from 0 to 1⁄4 percent.
The Committee directs the Desk to
undertake open market operations as
necessary to maintain such conditions.
Beginning in May, the Desk is directed
to purchase longer-term Treasury
securities at a pace of about $25 billion
per month and to purchase agency
mortgage-backed securities at a pace of
about $20 billion per month. The
Committee also directs the Desk to
engage in dollar roll and coupon swap
transactions as necessary to facilitate
settlement of the Federal Reserve’s
agency mortgage-backed securities
transactions. The Committee directs the
1 Copies of the Minutes of the Federal Open
Market Committee at its meeting held on April 29–
30, 2014, which includes the domestic policy
directive issued at the meeting, are available upon
request to the Board of Governors of the Federal
Reserve System, Washington, DC 20551. The
minutes are published in the Federal Reserve
Bulletin and in the Board’s Annual Report.
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technology; and (e) estimates of capital
or start-up costs and costs of operation,
maintenance, and purchase of services
to provide information. Burden means
the total time, effort, or financial
resources expended by persons to
generate, maintain, retain, disclose or
provide information to or for a Federal
agency. This includes the time needed
to review instructions; to develop,
acquire, install and utilize technology
and systems for the purpose of
collecting, validating and verifying
information, processing and
maintaining information, and disclosing
and providing information; to train
personnel and to be able to respond to
a collection of information, to search
data sources, to complete and review
the collection of information; and to
transmit or otherwise disclose the
information. Written comments should
be received within 60 days of this
notice.
Proposed Project
[60Day–14–14AEH]
Proposed Data Collections Submitted
for Public Comment and
Recommendations
Assessment of Chemical Exposures
(ACE) Investigations—New—Agency for
Toxic Substances and Disease Registry
(ATSDR)
Background and Brief Description
The Agency for Toxic Substances and
Disease Registry (ATSDR), as part of its
continuing effort to reduce public
burden, invites the general public and
other Federal agencies to take this
opportunity to comment on proposed
and/or continuing information
collections, as required by the
Paperwork Reduction Act of 1995. To
request more information on the below
proposed project or to obtain a copy of
the information collection plan and
instruments, call 404–639–7570 or send
comments to LeRoy Richardson, 1600
Clifton Road, MS–D74, Atlanta, GA
30333 or send an email to omb@cdc.gov.
Comments submitted in response to
this notice will be summarized and/or
included in the request for Office of
Management and Budget (OMB)
approval. Comments are invited on: (a)
Whether the proposed collection of
information is necessary for the proper
performance of the functions of the
agency, including whether the
information shall have practical utility;
(b) the accuracy of the agency’s estimate
of the burden of the proposed collection
of information; (c) ways to enhance the
quality, utility, and clarity of the
information to be collected; (d) ways to
minimize the burden of the collection of
information on respondents, including
through the use of automated collection
techniques or other forms of information
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The Agency for Toxic Substances and
Disease Registry (ATSDR) is requesting
a three-year generic clearance for the
Assessment of Chemical Exposures
(ACE) Investigations to assist state and
local health departments after toxic
substance spills or chemical incidents.
ACE investigations are a component of
the National Toxic Substance Incidents
Program (NTSIP). NTSIP was
introduced in 2010 as a comprehensive
agency approach to toxic substance
incident surveillance, prevention, and
response. This three-part program
includes a proposal for state-based
surveillance for toxic substance releases,
a national database of toxic substance
incidents combining data from many
sources, and the ACE investigations.
The ACE Investigations focus on
performing rapid epidemiological
assessments to assist state, regional,
local, or tribal health departments (the
requesting agencies) to respond to or
prepare for acute chemical releases. The
main objectives for performing these
rapid assessments are to:
1. Characterize exposure and acute
health effects of respondents exposed to
toxic substances from discrete, chemical
releases and determine their health
statuses;
2. identify needs (i.e. medical and
basic) of those exposed during the
releases to aid in planning interventions
in the community;
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[Federal Register Volume 79, Number 104 (Friday, May 30, 2014)]
[Notices]
[Pages 31113-31114]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 2014-12578]
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FEDERAL RESERVE SYSTEM
Change in Bank Control Notices; Acquisitions of Shares of a Bank
or Bank Holding Company
The notificants listed below have applied under the Change in Bank
Control Act (12 U.S.C. 1817(j)) and Sec. 225.41 of the Board's
Regulation Y (12 CFR 225.41) to acquire shares of a bank or bank
holding company. The factors that are considered in acting on the
notices are set forth in paragraph 7 of the Act (12 U.S.C. 1817(j)(7)).
The notices are available for immediate inspection at the Federal
Reserve Bank indicated. The notices also will be available for
inspection at the offices of the Board of Governors.
[[Page 31114]]
Interested persons may express their views in writing to the Reserve
Bank indicated for that notice or to the offices of the Board of
Governors. Comments must be received not later than June 16, 2014.
A. Federal Reserve Bank of Kansas City (Dennis Denney, Assistant
Vice President) 1 Memorial Drive, Kansas City, Missouri 64198-0001:
1. Mary Lou Spanier, individually and as trustee of the Jesse L.
Thomas Testamentary Trust, both of Sublette, Kansas; to acquire voting
shares of Santa Fe Trail Banc Shares, Inc., and thereby indirectly
acquire voting shares of Centera Bank, both in Sublette, Kansas.
Board of Governors of the Federal Reserve System, May 27, 2014.
Margaret McCloskey Shanks,
Deputy Secretary of the Board.
[FR Doc. 2014-12578 Filed 5-29-14; 8:45 am]
BILLING CODE 6210-01-P
