Government-Owned Inventions; Availability for Licensing, 14257-14259 [2014-05472]

Download as PDF 14257 Federal Register / Vol. 79, No. 49 / Thursday, March 13, 2014 / Notices (NINDS), and the Office of AIDS Research (OAR). While these programs differ, their underlying concept is the same; they require U.S. scientists to collaborate with scientists from other countries in order to conduct scientifically meritorious investigations of mutual interest to both countries. The award, when possible. This information is needed to evaluate the effectiveness of these programs across NIH. OMB approval is requested for 3 years. There are no costs to respondents other than their time. The total estimated annualized burden hours are 128. proposed evaluation requests information about (1) accomplishments of the awards, (2) unique findings or opportunities due to the international collaborations, and (3) successes and challenges of these collaborations. The information will be collected one year into the award and at the end of the ESTIMATED ANNUALIZED BURDEN HOURS Number of respondents Type of respondents Principal Investigators Administrative Supplements ........................................ Principal Investigators Other Mechanisms ...................................................... Dated: March 7, 2014. Vivian Horovitch-Kelley, NCI Project Clearance Liaison, National Institutes of Health. [FR Doc. 2014–05514 Filed 3–12–14; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Government-Owned Inventions; Availability for Licensing AGENCY: National Institutes of Health, HHS. ACTION: Notice. The inventions listed below are owned by an agency of the U.S. Government and are available for licensing in the U.S. in accordance with 35 U.S.C. 209 and 37 CFR part 404 to achieve expeditious commercialization of results of federally-funded research and development. Foreign patent applications are filed on selected inventions to extend market coverage for companies and may also be available for licensing. SUMMARY: TKELLEY on DSK3SPTVN1PROD with NOTICES FOR FURTHER INFORMATION CONTACT: Licensing information and copies of the U.S. patent applications listed below may be obtained by writing to the indicated licensing contact at the Office of Technology Transfer, National Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville, Maryland 20852–3804; telephone: 301– 496–7057; fax: 301–402–0220. A signed Confidential Disclosure Agreement will be required to receive copies of the patent applications. VerDate Mar<15>2010 17:33 Mar 12, 2014 Jkt 232001 24 52 Rabies Vaccine for the Oral Immunization of Domesticated Animals, Wildlife and Feral Animals Description of Technology: This invention, developed by the CDC and collaborators, entails a live, attenuated recombinant rabies virus vaccine that can elicit an effective anti-rabies immune response in animal recipients. Inoculation with a live, attenuated, rabies virus allows for the optimized production of immunity in the absence of pathogenicity. Oral administration of rabies vaccines is often a preferred route of vaccine delivery because it is most effective in wildlife. Unfortunately, availability of an oral vaccine for canines has been a significant hurdle to date. This vaccine technology could be used for immunization of stray dogs by an oral route. In developing nations, more than 90% of human exposure events and 99% of human deaths due to rabies are caused by rabid dogs. Using this vaccine with a broadly implemented oral vaccination strategy provides a promising opportunity for reducing transmission of rabies between stray dogs and, thereby, increasing protection for people. Potential Commercial Applications: • Wildlife and humane shelter rabies prevention and control programs • Improved rabies vaccines for pets and livestock • Humane, targeted approach to elimination of rabies reservoirs in feral animal populations Competitive Advantages: • Safe and effective • Oral immunization is the most practical and efficient method of rabies vaccination of wildlife and feral animals • Vaccine has demonstrated protection in vivo • Recombinant, non-neuroinvasive virus expressing a neuroinvasive PO 00000 Frm 00046 Fmt 4703 Sfmt 4703 Number of responses per respondent 1 2 Average burden per response (in hours) Total annual burden hours 1 1 24 104 glycoprotein and/or pro-apoptotis gene safely induces a robust and desirable immunological response Development Stage: • In vitro data available • In vivo data available (animal) Inventors: Charles E. Rupprecht (CDC), et al. Intellectual Property: HHS Reference No. E–470–2013/0—U.S. Patent No. 7,074,413 issued 11 Jul 2006. Licensing Contact: Whitney Blair, J.D., M.P.H.; 301–435–4937; whitney.blair@ nih.gov. Cable-Line Safety System: Electro/ Hydraulic Emergency Stop Device for a Winch, Drum or Capstan Description of Technology: This CDCdeveloped invention entails a system of electrical and hydraulic circuits used to stop a rotating winch in an emergency. Amongst other locations, one stop switch can be positioned on a capstan winch horn. This location makes it available to a victim entangled in rope being retrieved on a gypsy drum. As designed, the stop circuit could be used with an electrically, hydraulically or pneumatically operated winch. A variant of this safety system has been successfully tested on a purse seining fishing vessel in Alaskan waters. Potential Commercial Applications: • Retrofitting existing winches for additional safety and adherence to possible future regulations • Specifically designed and tested for the marine/fishing industries • Applications in mining, construction, forestry, and/or off-road automotive industries • Workers’ well-being concern groups • Insurers of fishing vessels; also mining, construction and forestry operations • Manufacturers of cable reel trailers and wire-drawing machinery Competitive Advantages: E:\FR\FM\13MRN1.SGM 13MRN1 14258 Federal Register / Vol. 79, No. 49 / Thursday, March 13, 2014 / Notices • Complies with numerous international safety regulations requiring winches, drums and capstans to have a master on/off switch in easy reach for worker safety • Can be packaged as a ‘retrofit kit’ for integration with current commercial winch/drum usage Development Stage: • In situ data available (on-site) • Prototype Inventors: Chelsea Woodward, Todd Ruff, Curtis Clark, Robert McKibbin, John Bevan, Greg Miller, Wayne Howie, Louis Martin, Jennifer Lincoln (all inventors from CDC–NIOSH). Intellectual Property: HHS Reference No. E–355–2013/0—Research Tool. Patent protection is not being pursued for this technology. Related Technologies: • HHS Reference No. E–504–2013/0 • HHS Reference No. E–567–2013/0 • HHS Reference No. E–568–2013/0 • HHS Reference No. E–643–2013/0 Licensing Contact: Whitney Blair, J.D., M.P.H.; 301–435–4937; whitney.blair@ nih.gov. TKELLEY on DSK3SPTVN1PROD with NOTICES Lead Detection Wipes for Potentially Contaminated Surfaces Description of Technology: This CDCdeveloped invention relates to a method for the detection of lead on surfaces (such as, for example, skin, floors, walls, windows sills) using a ‘handwipe’ system and a chemical test effecting a characteristic color change if contaminating lead is present. This invention is especially useful in detecting the presence of lead on skin and assessing the effectiveness of hand washing in removal of lead from the skin of exposed individuals. Further, this invention is useful in field evaluation for the presence of lead, exposure of individuals to lead, and the effectiveness of its subsequent removal in the workplace, home, school, and similar environments. Potential Commercial Applications: • Suitable for lead-testing surfaces such as floors, walls, windowsills and human skin • Evaluation of lead-removal effectiveness from surfaces in homes, hospitals, workplaces and schools • Confirming hand/skin/shoe/clothingwashing effectiveness of lead removal for military, target range personnel Competitive Advantages: • Simple color-change readout indicates the presence of lead on a surface • Rapid test; lead concentration can be inferred by degree of color shift • Safe for use on skin Development Stage: VerDate Mar<15>2010 17:33 Mar 12, 2014 Jkt 232001 • In vitro data available • In situ data available (on-site) Inventors: Eric J. Esswein, Mark F. Boeniger, Kevin E. Ashley (all of CDC). Publications: 1. Ashley K. Field-portable methods for monitoring occupational exposures to metals. J Chem Health Saf. 2010;17(3):22–8. [https://dx.doi.org/ 10.1016/j.jchas.2009.07.002] 2. NIOSH Manual of Analytical Methods (NMAM), Fourth Edition. Method 9105, Issue 1—Lead in Dust Wipes by Chemical Spot Test Method (Colorimetric Screening Method), 15 March 2003. U.S. National Institute for Occupational Safety and Health (NIOSH), Cincinnati, OH. [https:// www.cdc.gov/niosh/docs/2003–154/ pdfs/9105.pdf ] 3. Esswein EJ, et al. Handwipe Method for Removing Lead from Skin. Journal of ASTM International. 2011 May;8(5):Paper ID JAI103527. [https://dx.doi.org/10.1520/ JAI103527] Intellectual Property: HHS Reference No. E–336–2013/0—U.S. Patent No. 6,248,593 issued 19 Jun 2001. Related Technology: • HHS Reference No. E–356–2013/0 • HHS Reference No. E–359–2013/0 Licensing Contact: Whitney Blair, J.D., M.P.H.; 301–435–4937; whitney.blair@ nih.gov. Mining Safety: Personal Dust Monitor Filters for Accurate, Quantifiable Spectrometric Analysis and Assessment of Worker Exposure Levels Description of Technology: This CDCdeveloped invention pertains to a novel dust monitor filter that is specially constructed of organic materials for spectrometric analysis, ultimately allowing for detection and accurate quantification of a particular chosen analyte (e.g., crystalline silica/quartz dust that may lead to silicosis). For miners, the risk of lung disease increases with the extent of dust exposure, and coal worker’s pneumoconiosis (aka, black lung disease) and silicosis are still dangers routinely faced by those in the industry. Expectedly, both the concentration and the composition of airborne particulate matter present in mining environments are points of regulatory concern. For some time, collecting airborne dust samples and subsequent determination of quartz content have been integral for assessing mine worker exposure and demonstrating compliance with US Federal regulations. Unfortunately, highly accurate spectrometric detection and quantification of particulate exposure has not always been possible. Generally, the filters used in existing oscillating PO 00000 Frm 00047 Fmt 4703 Sfmt 4703 microbalances (such as the TEOM® monitor) have been specially designed to for hydrophobicity, in order to retain as little moisture as possible on the filter. These specialized hydrophobic filters (and/or their mounting components) contain inorganic compounds that cannot be readily subjected to thermal or chemical destruction—a necessary first step of many instrumental analytical methods, such as spectroscopy. This CDC-developed filter consists of entirely ashable material, making it ideal for spectrometric analysis and rapid exposure assessment. As an example, this dust monitor filter can be made entirely of organic materials and designed for quick, easy ashing that will not produce interference with the spectroscopic characteristics of the chosen analyte(s). Further, filter ashing can be carried out by a variety of methods: thermal ashing, microwave ashing, low temperature ashing, or chemical destruction. Potential Commercial Applications: • Personal dust monitors worn wherever dust exposure levels and the presence of potentially injurious materials is evaluated • Occupationally-mandated pneumoconiosis, asbestosis and/or silicosis prevention and monitoring programs, for complying with safety regulations • Miners’ wellness concern groups and insurance companies Competitive Advantages: • Novel dust-monitoring instrument capable of providing near rapid particulate exposure information to miners/users • Improves upon older technology by allowing for accurate detection and quantification of chosen analyte(s) and, unlike other filters, does not produce overlap or interfere with spectroscopic analysis • Filter can be easily ashed for analysis by thermal ashing, microwave ashing, low temperature ashing, or chemical destruction Development Stage: • Early-stage • In vitro data available Publication: Tuchman DP. Implementing infrared determination of quartz particulates on novel filters for a prototype dust monitor. J Environ Monit. 2008 May;10(5):671–8. [PMID 18449405] Intellectual Property: HHS Reference No. E–312–2013/0—U.S. Patent No. 7,947,503 issued 24 May 2011. Licensing Contact: Whitney Blair, J.D., M.P.H.; 301–435–4937; whitney.blair@ nih.gov. E:\FR\FM\13MRN1.SGM 13MRN1 Federal Register / Vol. 79, No. 49 / Thursday, March 13, 2014 / Notices TKELLEY on DSK3SPTVN1PROD with NOTICES Computer Controlled Aerosol Generator With Multi-Walled Carbon Nanotube Inhalation Testing Capabilities Description of Technology: This invention pertains to a CDC–NIOSH developed sonic aerosol generator that provides a controllable, stable concentration of particulate aerosol over a long period of time for aerosol exposure studies. Specifically, in situ testing data indicate uniform aerosol stability can be maintainable for greater than 30 hours at concentrations of 15 mg/m3 or more. Additionally, the technology was specifically developed for, and validated in, animal studies assessing exposure to airborne multiwalled carbon nanotubes (MWCNT). It has been suggested that workers may be at risk for exposure to nanosized particles during the manufacture, handling, and cleanup of engineered nanomaterials. Compared to other technologies, this NIOSH aerosol generator is particularly helpful when used for generating high testing concentrations of MWCNT aerosols that more accurately represent particulate levels that may be seen in a workplace environment. Potential Commercial Applications: • Studying the size and shape of the aerosolized particles produced from simple vibrations of bulk material • Toxicological investigations and risk assessment of aerosol exposures, especially those related to nanoparticle manufacturing. • Any aerosolization application where the aggregating ‘‘bird’s nest’’ tendencies of airborne multi-walled carbon nanotubes must be overcome Competitive Advantages: • Fully automated system with integrated feedback control for optimized stability in testing • Maintains concentration of aerosols for >30 hours at concentrations of 15 mg/cubic meter or more • Capable of generating high concentrations of aerosols that more accurately represent the levels seen in a workplace environment • System insures that each run produces a constant particle concentration, air flow, pressure, temperature and humidity within a testing chamber Development Stage: • In vitro data available • In vivo data available (animal) • In situ data available (on-site) • Prototype Inventors: Walter G. McKinney, David G. Frazer, Bean Chen (all of CDC) Publications: VerDate Mar<15>2010 17:33 Mar 12, 2014 Jkt 232001 1. McKinney W, et al. Computer controlled multi-walled carbon nanotube inhalation exposure system. Inhal Toxicol. 2009 Oct;21(12):1053–61. [PMID 19555230] 2. Porter DW, et al. Acute pulmonary doseresponses to inhaled multi-walled carbon nanotubes. Nanotoxicology. 2013 Nov;7:1179–94. [PMID 22881873] 3. Porter DW, et al. Mouse pulmonary doseand time course-responses induced by exposure to multi-walled carbon nanotubes. Toxicology. 2010 Mar 10;269(2–3):136–47. [PMID 19857541] 4. Chen BT, et al. Multi-walled carbon nanotubes: sampling criteria and aerosol characterization. Inhal Toxicol. 2012 Oct;24(12):798–820. [PMID 23033994] Intellectual Property: HHS Reference No. E–156–2013/0—U.S. Patent Application No. 12/871,453 filed 30 Aug 2010. Licensing Contact: Whitney Blair, J.D., M.P.H.; 301–435–4937; whitney.blair@ nih.gov. Dated: March 10, 2014. Richard U. Rodriguez, Director, Division of Technology Development and Transfer, Office of Technology Transfer, National Institutes of Health. [FR Doc. 2014–05472 Filed 3–12–14; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is hereby given of the following meeting. The meeting will be open to the public, with attendance limited to space available. Individuals who plan to attend and need special assistance, such as sign language interpretation or other reasonable accommodations, should notify the Contact Person listed below in advance of the meeting. Name of Committee: National Institute of Child Health and Human Development Special Emphasis Panel; Collaborative Perinatal Project (CPP) Mortality Linkage Study Data Coordinating Center. Date: April 8, 2014. Time: 2:00 p.m. to 5:00 p.m. Agenda: To provide concept review of proposed concept review. Place: National Institutes of Health, 6100 Executive Boulevard, Rockville, MD 20852, (Telephone Conference Call). Contact Person: Sathasiva B. Kandasamy, Ph.D., Scientific Review Officer, Division of Scientific Review, National Institute of Child Health and Human Development, 6100 Executive Boulevard, Rockville, MD 20892– PO 00000 Frm 00048 Fmt 4703 Sfmt 4703 14259 9304, (301) 435–6680, skandasa@ mail.nih.gov. (Catalogue of Federal Domestic Assistance Program Nos. 93.864, Population Research; 93.865, Research for Mothers and Children; 93.929, Center for Medical Rehabilitation Research; 93.209, Contraception and Infertility Loan Repayment Program, National Institutes of Health, HHS). Dated: March 7, 2014. Michelle Trout, Program Analyst, Office of Federal Advisory Committee Policy. [FR Doc. 2014–05474 Filed 3–12–14; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is hereby given of the following meetings. The meetings will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Resource-Related Research Projects in Lung Diseases. Date: April 8, 2014. Time: 8:30 a.m. to 4:30 p.m. Agenda: To review and evaluate grant applications. Place: Embassy Suites Chevy Chase Pavilion, 4300 Military Road NW., Washington, MD 20015. Contact Person: Susan Wohler Sunnarborg, Ph.D. Scientific Review Officer, Office of Scientific Review/DERA, National, Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7182, Bethesda, MD 20892 sunnarborgsw@nhlbi.nih.gov. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Ancillary Studies in Clinical Trials. Date: April 11, 2014. Time: 8:00 a.m. to 3:00 p.m. Agenda: To review and evaluate grant applications. Place: Hilton Garden Inn Washington DC/ Bethesda, 7301 Waverly St., Bethesda, MD 20814. Contact Person: Kristen Page, Ph.D., Scientific Review Officer, Office of Scientific Review/DERA, National Heart, Lung, and E:\FR\FM\13MRN1.SGM 13MRN1

Agencies

[Federal Register Volume 79, Number 49 (Thursday, March 13, 2014)]
[Notices]
[Pages 14257-14259]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 2014-05472]


-----------------------------------------------------------------------

DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Government-Owned Inventions; Availability for Licensing

AGENCY: National Institutes of Health, HHS.

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: The inventions listed below are owned by an agency of the U.S. 
Government and are available for licensing in the U.S. in accordance 
with 35 U.S.C. 209 and 37 CFR part 404 to achieve expeditious 
commercialization of results of federally-funded research and 
development. Foreign patent applications are filed on selected 
inventions to extend market coverage for companies and may also be 
available for licensing.

FOR FURTHER INFORMATION CONTACT: Licensing information and copies of 
the U.S. patent applications listed below may be obtained by writing to 
the indicated licensing contact at the Office of Technology Transfer, 
National Institutes of Health, 6011 Executive Boulevard, Suite 325, 
Rockville, Maryland 20852-3804; telephone: 301-496-7057; fax: 301-402-
0220. A signed Confidential Disclosure Agreement will be required to 
receive copies of the patent applications.

Rabies Vaccine for the Oral Immunization of Domesticated Animals, 
Wildlife and Feral Animals

    Description of Technology: This invention, developed by the CDC and 
collaborators, entails a live, attenuated recombinant rabies virus 
vaccine that can elicit an effective anti-rabies immune response in 
animal recipients. Inoculation with a live, attenuated, rabies virus 
allows for the optimized production of immunity in the absence of 
pathogenicity. Oral administration of rabies vaccines is often a 
preferred route of vaccine delivery because it is most effective in 
wildlife. Unfortunately, availability of an oral vaccine for canines 
has been a significant hurdle to date.
    This vaccine technology could be used for immunization of stray 
dogs by an oral route. In developing nations, more than 90% of human 
exposure events and 99% of human deaths due to rabies are caused by 
rabid dogs. Using this vaccine with a broadly implemented oral 
vaccination strategy provides a promising opportunity for reducing 
transmission of rabies between stray dogs and, thereby, increasing 
protection for people.

    Potential Commercial Applications:

 Wildlife and humane shelter rabies prevention and control 
programs
 Improved rabies vaccines for pets and livestock
 Humane, targeted approach to elimination of rabies reservoirs 
in feral animal populations

    Competitive Advantages:

 Safe and effective
 Oral immunization is the most practical and efficient method 
of rabies vaccination of wildlife and feral animals
 Vaccine has demonstrated protection in vivo
 Recombinant, non-neuroinvasive virus expressing a 
neuroinvasive glycoprotein and/or pro-apoptotis gene safely induces a 
robust and desirable immunological response
    Development Stage:

 In vitro data available
 In vivo data available (animal)

    Inventors: Charles E. Rupprecht (CDC), et al.
    Intellectual Property: HHS Reference No. E-470-2013/0--U.S. Patent 
No. 7,074,413 issued 11 Jul 2006.
    Licensing Contact: Whitney Blair, J.D., M.P.H.; 301-435-4937; 
whitney.blair@nih.gov.

Cable-Line Safety System: Electro/Hydraulic Emergency Stop Device for a 
Winch, Drum or Capstan

    Description of Technology: This CDC-developed invention entails a 
system of electrical and hydraulic circuits used to stop a rotating 
winch in an emergency. Amongst other locations, one stop switch can be 
positioned on a capstan winch horn. This location makes it available to 
a victim entangled in rope being retrieved on a gypsy drum. As 
designed, the stop circuit could be used with an electrically, 
hydraulically or pneumatically operated winch. A variant of this safety 
system has been successfully tested on a purse seining fishing vessel 
in Alaskan waters.

    Potential Commercial Applications:

 Retrofitting existing winches for additional safety and 
adherence to possible future regulations
 Specifically designed and tested for the marine/fishing 
industries
 Applications in mining, construction, forestry, and/or off-
road automotive industries
 Workers' well-being concern groups
 Insurers of fishing vessels; also mining, construction and 
forestry operations
 Manufacturers of cable reel trailers and wire-drawing 
machinery

    Competitive Advantages:


[[Page 14258]]


 Complies with numerous international safety regulations 
requiring winches, drums and capstans to have a master on/off switch in 
easy reach for worker safety
 Can be packaged as a `retrofit kit' for integration with 
current commercial winch/drum usage

    Development Stage:

 In situ data available (on-site)
 Prototype

    Inventors: Chelsea Woodward, Todd Ruff, Curtis Clark, Robert 
McKibbin, John Bevan, Greg Miller, Wayne Howie, Louis Martin, Jennifer 
Lincoln (all inventors from CDC-NIOSH).
    Intellectual Property: HHS Reference No. E-355-2013/0--Research 
Tool. Patent protection is not being pursued for this technology.
    Related Technologies:

 HHS Reference No. E-504-2013/0
 HHS Reference No. E-567-2013/0
 HHS Reference No. E-568-2013/0
 HHS Reference No. E-643-2013/0

    Licensing Contact: Whitney Blair, J.D., M.P.H.; 301-435-4937; 
whitney.blair@nih.gov.

Lead Detection Wipes for Potentially Contaminated Surfaces

    Description of Technology: This CDC-developed invention relates to 
a method for the detection of lead on surfaces (such as, for example, 
skin, floors, walls, windows sills) using a `handwipe' system and a 
chemical test effecting a characteristic color change if contaminating 
lead is present. This invention is especially useful in detecting the 
presence of lead on skin and assessing the effectiveness of hand 
washing in removal of lead from the skin of exposed individuals. 
Further, this invention is useful in field evaluation for the presence 
of lead, exposure of individuals to lead, and the effectiveness of its 
subsequent removal in the workplace, home, school, and similar 
environments.
    Potential Commercial Applications:

 Suitable for lead-testing surfaces such as floors, walls, 
windowsills and human skin
 Evaluation of lead-removal effectiveness from surfaces in 
homes, hospitals, workplaces and schools
 Confirming hand/skin/shoe/clothing-washing effectiveness of 
lead removal for military, target range personnel

    Competitive Advantages:

 Simple color-change readout indicates the presence of lead on 
a surface
 Rapid test; lead concentration can be inferred by degree of 
color shift
 Safe for use on skin

    Development Stage:

 In vitro data available
 In situ data available (on-site)

    Inventors: Eric J. Esswein, Mark F. Boeniger, Kevin E. Ashley (all 
of CDC).
    Publications:

1. Ashley K. Field-portable methods for monitoring occupational 
exposures to metals. J Chem Health Saf. 2010;17(3):22-8. [https://dx.doi.org/10.1016/j.jchas.2009.07.002]
2. NIOSH Manual of Analytical Methods (NMAM), Fourth Edition. Method 
9105, Issue 1--Lead in Dust Wipes by Chemical Spot Test Method 
(Colorimetric Screening Method), 15 March 2003. U.S. National 
Institute for Occupational Safety and Health (NIOSH), Cincinnati, 
OH. [https://www.cdc.gov/niosh/docs/2003-154/pdfs/9105.pdf ]
    3. Esswein EJ, et al. Handwipe Method for Removing Lead from 
Skin. Journal of ASTM International. 2011 May;8(5):Paper ID 
JAI103527. [https://dx.doi.org/10.1520/JAI103527]

    Intellectual Property: HHS Reference No. E-336-2013/0--U.S. Patent 
No. 6,248,593 issued 19 Jun 2001.
    Related Technology:

 HHS Reference No. E-356-2013/0
 HHS Reference No. E-359-2013/0

    Licensing Contact: Whitney Blair, J.D., M.P.H.; 301-435-4937; 
whitney.blair@nih.gov.

Mining Safety: Personal Dust Monitor Filters for Accurate, Quantifiable 
Spectrometric Analysis and Assessment of Worker Exposure Levels

    Description of Technology: This CDC-developed invention pertains to 
a novel dust monitor filter that is specially constructed of organic 
materials for spectrometric analysis, ultimately allowing for detection 
and accurate quantification of a particular chosen analyte (e.g., 
crystalline silica/quartz dust that may lead to silicosis).
    For miners, the risk of lung disease increases with the extent of 
dust exposure, and coal worker's pneumoconiosis (aka, black lung 
disease) and silicosis are still dangers routinely faced by those in 
the industry. Expectedly, both the concentration and the composition of 
airborne particulate matter present in mining environments are points 
of regulatory concern. For some time, collecting airborne dust samples 
and subsequent determination of quartz content have been integral for 
assessing mine worker exposure and demonstrating compliance with US 
Federal regulations.
    Unfortunately, highly accurate spectrometric detection and 
quantification of particulate exposure has not always been possible. 
Generally, the filters used in existing oscillating microbalances (such 
as the TEOM[supreg] monitor) have been specially designed to for 
hydrophobicity, in order to retain as little moisture as possible on 
the filter. These specialized hydrophobic filters (and/or their 
mounting components) contain inorganic compounds that cannot be readily 
subjected to thermal or chemical destruction--a necessary first step of 
many instrumental analytical methods, such as spectroscopy.
    This CDC-developed filter consists of entirely ashable material, 
making it ideal for spectrometric analysis and rapid exposure 
assessment. As an example, this dust monitor filter can be made 
entirely of organic materials and designed for quick, easy ashing that 
will not produce interference with the spectroscopic characteristics of 
the chosen analyte(s). Further, filter ashing can be carried out by a 
variety of methods: thermal ashing, microwave ashing, low temperature 
ashing, or chemical destruction.
    Potential Commercial Applications:

 Personal dust monitors worn wherever dust exposure levels and 
the presence of potentially injurious materials is evaluated
 Occupationally-mandated pneumoconiosis, asbestosis and/or 
silicosis prevention and monitoring programs, for complying with safety 
regulations
 Miners' wellness concern groups and insurance companies

    Competitive Advantages:

 Novel dust-monitoring instrument capable of providing near 
rapid particulate exposure information to miners/users
 Improves upon older technology by allowing for accurate 
detection and quantification of chosen analyte(s) and, unlike other 
filters, does not produce overlap or interfere with spectroscopic 
analysis
 Filter can be easily ashed for analysis by thermal ashing, 
microwave ashing, low temperature ashing, or chemical destruction

    Development Stage:

 Early-stage
 In vitro data available

    Publication:

Tuchman DP. Implementing infrared determination of quartz 
particulates on novel filters for a prototype dust monitor. J 
Environ Monit. 2008 May;10(5):671-8. [PMID 18449405]

    Intellectual Property: HHS Reference No. E-312-2013/0--U.S. Patent 
No. 7,947,503 issued 24 May 2011.
    Licensing Contact: Whitney Blair, J.D., M.P.H.; 301-435-4937; 
whitney.blair@nih.gov.

[[Page 14259]]

Computer Controlled Aerosol Generator With Multi-Walled Carbon Nanotube 
Inhalation Testing Capabilities

    Description of Technology: This invention pertains to a CDC-NIOSH 
developed sonic aerosol generator that provides a controllable, stable 
concentration of particulate aerosol over a long period of time for 
aerosol exposure studies. Specifically, in situ testing data indicate 
uniform aerosol stability can be maintainable for greater than 30 hours 
at concentrations of 15 mg/m3 or more. Additionally, the technology was 
specifically developed for, and validated in, animal studies assessing 
exposure to airborne multi-walled carbon nanotubes (MWCNT). It has been 
suggested that workers may be at risk for exposure to nanosized 
particles during the manufacture, handling, and cleanup of engineered 
nanomaterials. Compared to other technologies, this NIOSH aerosol 
generator is particularly helpful when used for generating high testing 
concentrations of MWCNT aerosols that more accurately represent 
particulate levels that may be seen in a workplace environment.
    Potential Commercial Applications:

 Studying the size and shape of the aerosolized particles 
produced from simple vibrations of bulk material
 Toxicological investigations and risk assessment of aerosol 
exposures, especially those related to nanoparticle manufacturing.
 Any aerosolization application where the aggregating ``bird's 
nest'' tendencies of airborne multi-walled carbon nanotubes must be 
overcome

    Competitive Advantages:

 Fully automated system with integrated feedback control for 
optimized stability in testing
 Maintains concentration of aerosols for >30 hours at 
concentrations of 15 mg/cubic meter or more
 Capable of generating high concentrations of aerosols that 
more accurately represent the levels seen in a workplace environment
 System insures that each run produces a constant particle 
concentration, air flow, pressure, temperature and humidity within a 
testing chamber

    Development Stage:
 In vitro data available
 In vivo data available (animal)
 In situ data available (on-site)
 Prototype
    Inventors: Walter G. McKinney, David G. Frazer, Bean Chen (all of 
CDC)

    Publications:

1. McKinney W, et al. Computer controlled multi-walled carbon 
nanotube inhalation exposure system. Inhal Toxicol. 2009 
Oct;21(12):1053-61. [PMID 19555230]
2. Porter DW, et al. Acute pulmonary dose-responses to inhaled 
multi-walled carbon nanotubes. Nanotoxicology. 2013 Nov;7:1179-94. 
[PMID 22881873]
3. Porter DW, et al. Mouse pulmonary dose- and time course-responses 
induced by exposure to multi-walled carbon nanotubes. Toxicology. 
2010 Mar 10;269(2-3):136-47. [PMID 19857541]
4. Chen BT, et al. Multi-walled carbon nanotubes: sampling criteria 
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    Intellectual Property: HHS Reference No. E-156-2013/0--U.S. Patent 
Application No. 12/871,453 filed 30 Aug 2010.
    Licensing Contact: Whitney Blair, J.D., M.P.H.; 301-435-4937; 
whitney.blair@nih.gov.

    Dated: March 10, 2014.
Richard U. Rodriguez,
Director, Division of Technology Development and Transfer, Office of 
Technology Transfer, National Institutes of Health.
[FR Doc. 2014-05472 Filed 3-12-14; 8:45 am]
BILLING CODE 4140-01-P
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