National Institute of General Medical Sciences; Notice of Closed Meetings, 12515-12516 [2014-04774]
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Federal Register / Vol. 79, No. 43 / Wednesday, March 5, 2014 / Notices
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• HHS Reference No. E–055–2007/2—US
Provisional Patent Application No. 60/
957,140 filed 21 Aug 2007
• HHS Reference No. E–055–2007/3—PCT
Patent Application No. PCT/US2007/
086663 filed 06 Dec 2007, which published
as WO 2008/140602 on 20 Nov 2008, and
corresponding European Application No.
07874349.9; US Patent Application No. 12/
518,035 filed 05 Jun 2009
Licensing Contact: Cristina ThalhammerReyero, Ph.D., M.B.A.; 301–435–4507;
thalhamc@mail.nih.gov.
Collaborative Research Opportunity: The
National Institute of Allergy and Infectious
Diseases is seeking statements of capability
or interest from parties interested in
collaborative research to further develop,
evaluate or commercialize alpha-4 beta-7
integrin inhibitors. For collaboration
opportunities, please contact Bill
Ronnenberg, JD/MIP, MS at 301–451–3522 or
wr78k@nih.gov.
Beta-Amyloid and Tau Fibril Positron
Emissions Tomography (PET) Imaging
Agents
Description of Technology: The invention
relates to two novel classes of compounds
useful as radioligands for in vivo imaging of
beta-amyloid fibrils, peptides and plaques in
humans. Beta-amyloid peptide deposition in
the brain is a pathological feature of
Alzheimer’s disease (AD). Early detection of
beta-amyloid load in patients with suspected
AD is vital to initiating early treatment,
which can improve cognitive function and
quality of life for many patients. The
invention describes novel derivatives of
imidazopyridinylbenzeneamine (IMPY) and
benzothizolylbenzeneamine (BTA), which
demonstrate high in vitro binding affinity to
human beta-amyloid. The difference between
existing IMPY compounds and the novel
derivatives is the substitution of an aryl
halide with an aryl thioether group and
replacement of a sulfur group of the pyridine
ring with a nitrogen group. The new classes
of compounds have the potential of
providing improved amyloid imaging agents
for Positron Emission Tomography (PET)
with higher specificity for amyloid, low
background noise, better entry into the brain
and improved labeling efficiency.
Potential Commercial Applications:
• Alzheimer’s disease
• Alzheimer’s disease diagnostics
• Alzheimer’s disease early detection
Competitive Advantages: Specificity
Development Stage: In vitro data available
Inventors: Lisheng Cai, Victor W. Pike,
Robert B. Innis (all of NIMH)
Publications:
1. Nichols L, et al. Imaging and in vivo
quantitation of beta-amyloid: an exemplary
biomarker for Alzheimer’s disease? Biol
Psychiatry. 2006 May 15;59(10):940–7.
[PMID 16487944]
2. Toyama H, et al. PET imaging of brain with
the beta-amyloid probe, [11C]6–OH–BTA–
1, in a transgenic mouse model of
Alzheimer’s disease. Eur J Nucl Med Mol
Imaging. 2005 May;32(5):593–600. [PMID
15791432]
3. Cai L, et al. Synthesis and evaluation of
two 18F-labeled 6-iodo-2-(4’-N,N-
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dimethylamino)phenylimidazo[1,2a]pyridine derivatives as prospective
radioligands for beta-amyloid in
Alzheimer’s disease. J Med Chem. 2004
Apr 22;47(9):2208–18. [PMID 15084119]
Intellectual Property: HHS Reference No.
E–156–2006/0—
• US Patent Application 12/293,940 filed
September 17, 2008 (allowed)
• European Patent Application 07797254.5
filed April 19, 2007 (pending)
Related Technologies:
• HHS Reference No. E–136–2008/0—‘‘Beta
Amyloid PET Imaging Agents Based On 2(4-phenyl)benzo[d]thiazole Derivatives’’
• HHS Reference Nos. E–225–2011/0 and/
1—‘‘Beta-amyloid PET Imaging Agents
Based On Benzothiazoles (BTA)
Derivatives’’
Licensing Contact: Michael Shmilovich,
Esq., CLP; 301–435–5019; shmilovm@
mail.nih.gov.
Collaborative Research Opportunity: The
National Institute of Mental Health is seeking
statements of capability or interest from
parties interested in collaborative research to
further develop, evaluate or commercialize
Alzheimer’s disease diagnostics. For
collaboration opportunities, please contact
Suzanne Winfield, Ph.D. at 301–402–4324.
Dated: February 27, 2014.
Richard U. Rodriguez,
Director, Division of Technology Development
and Transfer, Office of Technology Transfer,
National Institutes of Health.
[FR Doc. 2014–04771 Filed 3–4–14; 8:45 am]
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12515
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health
Neuroscience Center, 6001 Executive
Boulevard, Rockville, MD 20852 (Telephone
Conference Call).
Contact Person: Kausik Ray, Ph.D.,
Scientific Review Officer, National Institute
on Deafness and Other Communication
Disorders, National Institutes of Health
Rockville, MD 20850, 301–402–3587, rayk@
nidcd.nih.gov.
Name of Committee: National Institute on
Deafness and Other Communication
Disorders Special Emphasis Panel; VSL
Translational Applications Review.
Date: March 27, 2014.
Time: 3:30 p.m. to 5:30 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health,
Neuroscience Center, 6001 Executive
Boulevard, Rockville, MD 20852 (Telephone
Conference Call).
Contact Person: Christine A. Livingston,
Ph.D., Scientific Review Officer, Division of
Extramural Activities, National Institutes of
Health/NIDCD, 6001 Executive Blvd.—Room
8343, Bethesda, MD 20892, (301) 496–8683,
livingsc@mail.nih.gov.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.173, Biological Research
Related to Deafness and Communicative
Disorders, National Institutes of Health, HHS)
Dated: February 27, 2014.
Melanie J. Gray,
Program Analyst, Office of Federal Advisory
Committee Policy.
[FR Doc. 2014–04767 Filed 3–4–14; 8:45 am]
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
National Institute on Deafness and
Other Communication Disorders;
Notice of Closed Meetings
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is
hereby given of the following meetings.
The meetings will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: National Institute on
Deafness and Other Communication
Disorders Special Emphasis Panel; Neural/
Vestibular Prosthesis Review.
Date: March 21, 2014.
Time: 2:00 p.m. to 3:30 p.m.
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BILLING CODE 4140–01–P
National Institutes of Health
National Institute of General Medical
Sciences; Notice of Closed Meetings
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is
hereby given of the following meetings.
The meetings will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: National Institute of
General Medical Sciences Special Emphasis
Panel; Review of K99 Grant Applications.
Date: March 25, 2014.
Time: 8:00 a.m. to 5:00 p.m.
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Federal Register / Vol. 79, No. 43 / Wednesday, March 5, 2014 / Notices
Agenda: To review and evaluate grant
applications.
Place: Courtyard by Marriott Chevy Chase,
5520 Wisconsin Avenue, Chevy Chase, MD
20815.
Contact Person: Robert Horowits, Ph.D.,
Scientific Review Officer, Office of Scientific
Review, National Institute of General Medical
Sciences, National Institutes of Health, 45
Center Drive, Room 3An.18I, Bethesda, MD
20892, 301–594–6904, horowitr@
mail.nih.gov.
Name of Committee: National Institute of
General Medical Sciences Special Emphasis
Panel; Review of Research Grants.
Date: March 25, 2014.
Time: 9:00 a.m. to 12:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health,
Natcher Building, 45 Center Drive, Room
3An.12A, Bethesda, MD 20892, (Telephone
Conference Call).
Contact Person: Mona R. Trempe, Ph.D.,
Scientific Review Officer, Office of Scientific
Review, National Institute of General Medical
Sciences, National Institutes of Health, 45
Center Drive, Room 3An.12A, Bethesda, MD
20892, 301–594–3998, trempemo@
mail.nih.gov.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.375, Minority Biomedical
Research Support; 93.821, Cell Biology and
Biophysics Research; 93.859, Pharmacology,
Physiology, and Biological Chemistry
Research; 93.862, Genetics and
Developmental Biology Research; 93.88,
Minority Access to Research Careers; 93.96,
Special Minority Initiatives, National
Institutes of Health, HHS)
Dated: February 27, 2014.
Melanie J. Gray,
Program Analyst, Office of Federal Advisory
Committee Policy.
[FR Doc. 2014–04774 Filed 3–4–14; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
mstockstill on DSK4VPTVN1PROD with NOTICES
National Institute of General Medical
Sciences; Notice of Closed Meeting
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is
hereby given of the following meeting.
The meeting will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
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Name of Committee: National Institute of
General Medical Sciences Special Emphasis
Panel; Support of NIGMS Program Project
Grants (P01).
Date: March 26, 2014.
Time: 1:00 p.m. to 4:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health,
Natcher Building, 45 Center Drive, Room
3An.18A, Bethesda, MD 20892, (Telephone
Conference Call).
Contact Person: Lisa A. Newman, SCD,
Scientific Review Officer, Office of Scientific
Review, National Institute of General Medical
Sciences, National Institutes of Health, 45
Center Drive, Room 3An.18A, Bethesda, MD
20892, 301–594–2704, newmanla2@
mail.nih.gov.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.375, Minority Biomedical
Research Support; 93.821, Cell Biology and
Biophysics Research; 93.859, Pharmacology,
Physiology, and Biological Chemistry
Research; 93.862, Genetics and
Developmental Biology Research; 93.88,
Minority Access to Research Careers; 93.96,
Special Minority Initiatives, National
Institutes of Health, HHS)
Dated: February 27, 2014.
Melanie J. Gray,
Program Analyst, Office of Federal Advisory
Committee Policy.
[FR Doc. 2014–04773 Filed 3–4–14; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
Office of the Director, National
Institutes of Health; Notice of Meeting
Pursuant to section 10(a) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is
hereby given of a meeting of the
Advisory Committee on Research on
Women’s Health.
The meeting will be open to the
public, with attendance limited to space
available. Individuals who plan to
attend and need special assistance, such
as sign language interpretation or other
reasonable accommodations, should
notify the Contact Person listed below
in advance of the meeting.
Name of Committee: Advisory Committee
on Research on Women’s Health.
Date: April 8, 2014.
Time: 9:00 a.m. to 5:00 p.m.
Agenda: The Committee serves to advise
and make recommendations to the Director,
Office of Research on Women’s Health
(ORWH) on a broad range of topics including,
the current scope of research on women’s
health and the influence of sex and gender
on human health, efforts to understand the
issues related to women in biomedical
careers and their needs, and the current
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status of inclusion of women in clinical trials
research.
Place: National Institutes of Health,
Building 31, Room 6C, 31 Center Drive,
Bethesda, MD 20892.
Contact Person: Susan E Maier, Ph.D., NIH/
OD, 6707 Democracy Blvd., Room 400,
Bethesda, MD 20852, 301–435–1573,
maiers@mail.nih.gov.
Any interested person may file written
comments for the public record by registering
and submitting their comments at https://
palladianpartners.cvent.com/events/37thmeeting-of-the-nih-advisory-committee-onresearch-on-women-s-health/event-summary072e6bfa6a814aaca82491361dcd7afd.aspx.
Written comments for the public record must
not exceed two single-spaced, typed pages,
using a 12-point typeface and 1 inch margins;
it is preferred that the document be prepared
in the MS Word® format. Only testimony
submitted to this Web site and received in
advance of the meeting are part of the official
meeting record.
Supplementary Information: A draft
agenda for this meeting is posted at https://
orwh.od.nih.gov/about/acrwh/index.asp. The
meeting will be live-video streamed at https://
videocast.nih.gov/.
Individuals who plan to attend the meeting
in person should register at the following
link https://palladianpartners.cvent.com/
ACRWHSpring2014. Members of the media
will also need to register. In the interest of
security, NIH has instituted stringent
procedures for entrance onto the NIH
campus. All visitor vehicles, including
taxicabs, hotel, and airport shuttles will be
inspected before being allowed on campus.
Visitors will be asked to show one form of
identification (for example, a governmentissued photo ID, driver’s license, or passport)
and to state the purpose of their visit.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.14, Intramural Research
Training Award; 93.22, Clinical Research
Loan Repayment Program for Individuals
from Disadvantaged Backgrounds; 93.232,
Loan Repayment Program for Research
Generally; 93.39, Academic Research
Enhancement Award; 93.936, NIH Acquired
Immunodeficiency Syndrome Research Loan
Repayment Program; 93.187, Undergraduate
Scholarship Program for Individuals from
Disadvantaged Backgrounds, National
Institutes of Health, HHS)
Dated: February 27, 2014.
Carolyn Baum,
Program Analyst, Office of Federal Advisory
Committee Policy.
[FR Doc. 2014–04766 Filed 3–4–14; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
Center for Scientific Review; Notice of
Closed Meetings
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
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[Federal Register Volume 79, Number 43 (Wednesday, March 5, 2014)]
[Notices]
[Pages 12515-12516]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 2014-04774]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
National Institute of General Medical Sciences; Notice of Closed
Meetings
Pursuant to section 10(d) of the Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is hereby given of the following
meetings.
The meetings will be closed to the public in accordance with the
provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5
U.S.C., as amended. The grant applications and the discussions could
disclose confidential trade secrets or commercial property such as
patentable material, and personal information concerning individuals
associated with the grant applications, the disclosure of which would
constitute a clearly unwarranted invasion of personal privacy.
Name of Committee: National Institute of General Medical
Sciences Special Emphasis Panel; Review of K99 Grant Applications.
Date: March 25, 2014.
Time: 8:00 a.m. to 5:00 p.m.
[[Page 12516]]
Agenda: To review and evaluate grant applications.
Place: Courtyard by Marriott Chevy Chase, 5520 Wisconsin Avenue,
Chevy Chase, MD 20815.
Contact Person: Robert Horowits, Ph.D., Scientific Review
Officer, Office of Scientific Review, National Institute of General
Medical Sciences, National Institutes of Health, 45 Center Drive,
Room 3An.18I, Bethesda, MD 20892, 301-594-6904,
horowitr@mail.nih.gov.
Name of Committee: National Institute of General Medical
Sciences Special Emphasis Panel; Review of Research Grants.
Date: March 25, 2014.
Time: 9:00 a.m. to 12:00 p.m.
Agenda: To review and evaluate grant applications.
Place: National Institutes of Health, Natcher Building, 45
Center Drive, Room 3An.12A, Bethesda, MD 20892, (Telephone
Conference Call).
Contact Person: Mona R. Trempe, Ph.D., Scientific Review
Officer, Office of Scientific Review, National Institute of General
Medical Sciences, National Institutes of Health, 45 Center Drive,
Room 3An.12A, Bethesda, MD 20892, 301-594-3998,
trempemo@mail.nih.gov.
(Catalogue of Federal Domestic Assistance Program Nos. 93.375,
Minority Biomedical Research Support; 93.821, Cell Biology and
Biophysics Research; 93.859, Pharmacology, Physiology, and
Biological Chemistry Research; 93.862, Genetics and Developmental
Biology Research; 93.88, Minority Access to Research Careers; 93.96,
Special Minority Initiatives, National Institutes of Health, HHS)
Dated: February 27, 2014.
Melanie J. Gray,
Program Analyst, Office of Federal Advisory Committee Policy.
[FR Doc. 2014-04774 Filed 3-4-14; 8:45 am]
BILLING CODE 4140-01-P
