Office of the Director, National Institutes of Health; Notice of Meeting, 63230-63231 [2013-24817]
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Federal Register / Vol. 78, No. 205 / Wednesday, October 23, 2013 / Notices
emcdonald on DSK67QTVN1PROD with NOTICES
Cannabinoid Receptor 1 (CB1) Inverse
Agonists for the Treatment of Diabetes,
Obesity and Their Complications
Description of Technology:
Endocannabinoids are lipid signaling
molecules that act on the same
cannabinoid receptors—CB1 and CB2—
that recognize and mediate the effects of
marijuana. Activation of CB1 receptors
increases appetite and the biosynthesis
and storage of lipids, inhibits the
actions of insulin and leptin, and
promotes tissue inflammation and
fibrosis. This has led to the
development of CB1 receptor blocking
drugs (inverse agonists) for the
treatment of obesity and its metabolic
complications, referred to as the
metabolic syndrome. However, many
CB1 inverse agonists can cross the
blood-brain barrier, causing psychiatric
side effects.
Researchers at NIH have now
developed a novel strategy to
structurally modify CB1 inverse agonists
with the goals of (1) limiting their brain
penetrance without losing their
metabolic efficacy due to CB1 inverse
agonism, and (2) generating compounds
whose primary metabolite directly
targets enzymes involved in
inflammatory and fibrotic processes
associated with metabolic disorders.
These modified CB1 inverse agonists
can be used to effectively treat
metabolic syndrome and its
complications without the risk of the
psychiatric side effects, and have
improved antiinflammatory and
antifibrotic efficacy due to acting on
more than one molecular target.
Potential Commercial Applications:
• Treatment for obesity
• Treatment for metabolic syndrome
• Treatment of diabetes
• Treatment of fibrosis
Competitive Advantages:
• Inhibits metabolic activity without
causing psychiatric side effects
• Offers improved antiinflammatory
and antifibrotic efficacy
Development Stage:
• In vitro data available
• In vivo data available (animal)
Inventors: George Kunos (NIAAA),
Milliga Iyer (NIAAA), Resat Cinar
(NIAAA), Kenner Rice (NIDA)
Intellectual Property: HHS Reference
No. E–282–2012/0—US Provisional
Application No. 61/725,949 filed 11
Nov 2012.
Licensing Contact: Jaime M. Greene;
301–435–5559; greenejaime@
mail.nih.gov.
Collaborative Research Opportunity:
The National Institute on Alcohol Abuse
and Alcoholism, Laboratory of
VerDate Mar<15>2010
18:13 Oct 22, 2013
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Physiologic Studies, is seeking
statements of capability or interest from
parties interested in collaborative
research to further develop, evaluate or
commercialize peripherally restricted
CB1 receptor blockers with improved
efficacy. For collaboration
opportunities, please contact George
Kunos, M.D., Ph.D. at George.Kunos@
nih.gov or 301–443–2069.
Software Method for 2–D NMR Tissue
Compartment Analysis
Description of Technology: The
invention pertains to a method for
improving the accuracy of compartment
characterization using NMR.
Conventional methods use Laplace
transformation analyzed one
dimensional transverse NMR
relaxometry to investigate spin-lattice
decay of water in diverse body
compartments using. This method,
although used extensively, is inaccurate
and limited by signal-to-noise
obscurities and when the materials and
compartments to be analyzed vary in
size or have disparate relaxation
characteristics.
The improved method of this
invention utilizes the detection of a 2dimensional (2–D) NMR signal, created
through use of a standard pulse
sequence and variations, analysis of the
signal using inverse Laplace transform,
followed by projection of the resultant
2–D data onto a single axis
corresponding to the parameter of
original interest. The method can be
extended to analyses for 3–D or higher
dimensional experiments and inverse
Laplace transforms.
Potential Commercial Applications:
• Compartment analysis
• Petroleum discovery
• Multiple sclerosis
Competitive Advantages:
Compartment resolution
Development Stage: Prototype
Inventors: Richard G. Spencer and
Hasan Celik (NIA)
Intellectual Property: HHS Reference
No. E–734–2013/0—Software. Patent
protection is not being pursued for this
technology.
Licensing Contact: Michael
Shmilovich; 301–435–5019;
shmilovm@mail.nih.gov
Dated: October 18, 2013.
Richard U. Rodriguez,
Director, Division of Technology Development
and Transfer, Office of Technology Transfer,
National Institutes of Health.
[FR Doc. 2013–24819 Filed 10–22–13; 8:45 am]
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DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
Office of the Director, National
Institutes of Health; Notice of Meeting
Pursuant to section 10(a) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is
hereby given of a stakeholder meeting
hosted by the NIH Scientific
Management Review Board (SMRB).
Presentations and discussions will
address the optimal approaches to
assessing the value of biomedical
research supported by the NIH and will
include input from stakeholders in
biomedical research.
The NIH Reform Act of 2006 (Pub. L.
109–482) provides organizational
authorities to HHS and NIH officials to:
(1) Establish or abolish national research
institutes; (2) reorganize the offices
within the Office of the Director, NIH
including adding, removing, or
transferring the functions of such offices
or establishing or terminating such
offices; and (3) reorganize, divisions,
centers, or other administrative units
within an NIH national research
institute or national center including
adding, removing, or transferring the
functions of such units, or establishing
or terminating such units. The purpose
of the SMRB is to advise appropriate
HHS and NIH officials on the use of
these organizational authorities and
identify the reasons underlying the
recommendations.
The meeting will be open to the
public, with attendance limited to space
available. Individuals who plan to
attend and need special assistance, such
as sign language interpretation or other
reasonable accommodations, should
notify the Contact Person listed below
in advance of the meeting.
Name of Committee: Scientific
Management Review Board (SMRB).
Date: October 24–25, 2013.
Time: 9 a.m. on October 24, 2013 to 12:30
p.m. on October 25, 2013.
Agenda: Presentations and discussions will
include: 1) an update from the SMRB’s
Working Group on Approaches to Assess the
Value of Biomedical Research Supported by
NIH, and 2) presentations that explore
approaches to assess the value of biomedical
research supported by NIH. Time will be
allotted on the agenda for public comment.
Sign up for public comments will begin
approximately at 7:30 a.m. on October 24,
2013, and will be restricted to one sign-in per
person. In the event that time does not allow
for all those interested to present oral
comments, any interested person may file
written comments with the committee by
forwarding the statement to the Contact
Person listed on this notice. The statement
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Federal Register / Vol. 78, No. 205 / Wednesday, October 23, 2013 / Notices
should include the name, address, telephone
number and when applicable, the business or
professional affiliation of the interested
person.
Place: National Institutes of Health,
Building 31, 6th Floor, Conference Room 6,
31 Center Drive, Bethesda, MD 20892.
Contact Person: Juanita Marner, Office of
Science Policy, Office of the Director, NIH,
National Institutes of Health, 6705 Rockledge
Drive, Suite 750, Bethesda, MD 20892, smrb@
mail.nih.gov, (301) 435–1770.
The meeting will also be webcast. The draft
meeting agenda and other information about
the SMRB, including information about
access to the webcast, will be available at
https://smrb.od.nih.gov.
In the interest of security, NIH has
instituted stringent procedures for entrance
onto the NIH campus. All visitor vehicles,
including taxis, hotel, and airport shuttles
will be inspected before being allowed on
campus. Visitors will be asked to show one
form of identification (for example, a
government-issued photo ID, driver’s license,
or passport) and to state the purpose of their
visit.
This notice is being published less than 15
days prior to the meeting due to the U.S.
government shutdown.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.14, Intramural Research
Training Award; 93.22, Clinical Research
Loan Repayment Program for Individuals
from Disadvantaged Backgrounds; 93.232,
Loan Repayment Program for Research
Generally; 93.39, Academic Research
Enhancement Award; 93.936, NIH Acquired
Immunodeficiency Syndrome Research Loan
Repayment Program; 93.187, Undergraduate
Scholarship Program for Individuals from
Disadvantaged Backgrounds, National
Institutes of Health, HHS)
Dated: October 18, 2013.
Melanie J. Gray,
Program Analyst, Office of Federal Advisory
Committee Policy.
[FR Doc. 2013–24817 Filed 10–18–13; 4:15 pm]
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DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
emcdonald on DSK67QTVN1PROD with NOTICES
National Institute on Aging; Notice of
Closed Meeting
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is
hereby given of the following meeting.
The meeting will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
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applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: National Institute on
Aging Special Emphasis Panel; Osteoporosis
Omics.
Date: November 15, 2013.
Time: 12:00 p.m. to 4:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institute on Aging,
Gateway Building, Suite 2C212, 7201
Wisconsin Avenue, Bethesda, MD 20892,
(Telephone Conference Call).
Contact Person: Elaine Lewis, Ph.D.,
Scientific Review Officer, Scientific Review
Branch, National Institute on Aging, Gateway
Building, Suite 2C212, MSC–9205, 7201
Wisconsin Avenue, Bethesda, MD 20892,
301–402–7707, elainelewis@nia.nih.gov.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.866, Aging Research,
National Institutes of Health, HHS)
Dated: October 18, 2013.
Melanie J. Gray,
Program Analyst, Office of Federal Advisory
Committee Policy.
[FR Doc. 2013–24822 Filed 10–22–13; 8:45 am]
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DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
Office of the Director, National
Institutes of Health; Notice of Meeting
Pursuant to section 10(a) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is
hereby given of a meeting of the
Advisory Committee to the Deputy
Director for Intramural Research,
National Institutes of Health.
The meeting will be open to the
public, with attendance limited to space
available. Individuals who plan to
attend and need special assistance, such
as sign language interpretation or other
reasonable accommodations, should
notify the Contact Person listed below
in advance of the meeting.
Name of Committee: Advisory Committee
to the Deputy Director for Intramural
Research, National Institutes of Health.
Date: November 4, 2013.
Time: 1:30 p.m. to 3:00 p.m.
Agenda: To discuss site visit report.
Place: National Institutes of Health, Conf.
Line: 888–282–0367 Code: 13831, One Center
Drive, Rm. 160, Bethesda, MD 20892,
(Telephone Conference Call).
Contact Person: Michael M Gottesman,
Deputy Director for Intramural Research,
National Institutes of Health, One Center
Drive, Rm. 160, Bethesda, MD 20892, (301)
496–1921.
This meeting notice may be published less
than 15 days in advance of the meeting due
to the October 2013 Government shutdown.
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63231
(Catalogue of Federal Domestic Assistance
Program Nos. 93.14, Intramural Research
Training Award; 93.22, Clinical Research
Loan Repayment Program for Individuals
from Disadvantaged Backgrounds; 93.232,
Loan Repayment Program for Research
Generally; 93.39, Academic Research
Enhancement Award; 93.936, NIH Acquired
Immunodeficiency Syndrome Research Loan
Repayment Program; 93.187, Undergraduate
Scholarship Program for Individuals from
Disadvantaged Backgrounds, National
Institutes of Health, HHS)
Dated: October 17, 2013.
Anna Snouffer,
Deputy Director, Office of Federal Advisory
Committee Policy.
[FR Doc. 2013–24821 Filed 10–22–13; 8:45 am]
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DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
National Institute of General Medical
Sciences; Notice of Closed Meetings
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is
hereby given of the following meetings.
The meetings will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: National Institute of
General Medical Sciences Special Emphasis
Panel P20 INBRE Applications.
Date: October 29, 2013.
Time: 8:00 a.m. to 6:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: Double Tree by Hilton Hotel
Bethesda, 8120 Wisconsin Avenue, Bethesda,
MD 20814.
Contact Person: Nina Sidorova, Ph.D.,
Scientific Review Officer, Office of Scientific
Review, National Institute of General Medical
Sciences, National Institutes of Health, 45
Center Drive, Room 3An.22, Bethesda, MD
20892, 301–594–3663, sidorova@
nigms.nih.gov.
Name of Committee: National Institute of
General Medical Sciences Special Emphasis
Panel; Peer Review of SCORE (SB) Grant
Applications.
Date: October 30, 2013.
Time: 1:00 p.m. to 5:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health,
Natcher Building, 45 Center Drive, Room
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[Federal Register Volume 78, Number 205 (Wednesday, October 23, 2013)]
[Notices]
[Pages 63230-63231]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 2013-24817]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
Office of the Director, National Institutes of Health; Notice of
Meeting
Pursuant to section 10(a) of the Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is hereby given of a stakeholder
meeting hosted by the NIH Scientific Management Review Board (SMRB).
Presentations and discussions will address the optimal approaches to
assessing the value of biomedical research supported by the NIH and
will include input from stakeholders in biomedical research.
The NIH Reform Act of 2006 (Pub. L. 109-482) provides
organizational authorities to HHS and NIH officials to: (1) Establish
or abolish national research institutes; (2) reorganize the offices
within the Office of the Director, NIH including adding, removing, or
transferring the functions of such offices or establishing or
terminating such offices; and (3) reorganize, divisions, centers, or
other administrative units within an NIH national research institute or
national center including adding, removing, or transferring the
functions of such units, or establishing or terminating such units. The
purpose of the SMRB is to advise appropriate HHS and NIH officials on
the use of these organizational authorities and identify the reasons
underlying the recommendations.
The meeting will be open to the public, with attendance limited to
space available. Individuals who plan to attend and need special
assistance, such as sign language interpretation or other reasonable
accommodations, should notify the Contact Person listed below in
advance of the meeting.
Name of Committee: Scientific Management Review Board (SMRB).
Date: October 24-25, 2013.
Time: 9 a.m. on October 24, 2013 to 12:30 p.m. on October 25,
2013.
Agenda: Presentations and discussions will include: 1) an update
from the SMRB's Working Group on Approaches to Assess the Value of
Biomedical Research Supported by NIH, and 2) presentations that
explore approaches to assess the value of biomedical research
supported by NIH. Time will be allotted on the agenda for public
comment. Sign up for public comments will begin approximately at
7:30 a.m. on October 24, 2013, and will be restricted to one sign-in
per person. In the event that time does not allow for all those
interested to present oral comments, any interested person may file
written comments with the committee by forwarding the statement to
the Contact Person listed on this notice. The statement
[[Page 63231]]
should include the name, address, telephone number and when
applicable, the business or professional affiliation of the
interested person.
Place: National Institutes of Health, Building 31, 6th Floor,
Conference Room 6, 31 Center Drive, Bethesda, MD 20892.
Contact Person: Juanita Marner, Office of Science Policy, Office
of the Director, NIH, National Institutes of Health, 6705 Rockledge
Drive, Suite 750, Bethesda, MD 20892, smrb@mail.nih.gov, (301) 435-
1770.
The meeting will also be webcast. The draft meeting agenda and
other information about the SMRB, including information about access
to the webcast, will be available at https://smrb.od.nih.gov.
In the interest of security, NIH has instituted stringent
procedures for entrance onto the NIH campus. All visitor vehicles,
including taxis, hotel, and airport shuttles will be inspected
before being allowed on campus. Visitors will be asked to show one
form of identification (for example, a government-issued photo ID,
driver's license, or passport) and to state the purpose of their
visit.
This notice is being published less than 15 days prior to the
meeting due to the U.S. government shutdown.
(Catalogue of Federal Domestic Assistance Program Nos. 93.14,
Intramural Research Training Award; 93.22, Clinical Research Loan
Repayment Program for Individuals from Disadvantaged Backgrounds;
93.232, Loan Repayment Program for Research Generally; 93.39,
Academic Research Enhancement Award; 93.936, NIH Acquired
Immunodeficiency Syndrome Research Loan Repayment Program; 93.187,
Undergraduate Scholarship Program for Individuals from Disadvantaged
Backgrounds, National Institutes of Health, HHS)
Dated: October 18, 2013.
Melanie J. Gray,
Program Analyst, Office of Federal Advisory Committee Policy.
[FR Doc. 2013-24817 Filed 10-18-13; 4:15 pm]
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