National Institute of Environmental Health Sciences; Notice of Meeting, 48695-48696 [2013-19283]
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Federal Register / Vol. 78, No. 154 / Friday, August 9, 2013 / Notices
pmangrum on DSK3VPTVN1PROD with NOTICES
Licensing Contact: Betty B. Tong,
Ph.D.; 301–594–6565;
tongb@mail.nih.gov.
Collaborative Research Opportunity:
The National Institute of Neurological
Disorders and Stroke (NINDS) is seeking
statements of capability or interest from
parties interested in collaborative
research to further develop, evaluate or
commercialize treatment of brain injury
or disease through transcranial drug
delivery. For collaboration
opportunities, please contact Melissa
Maderia, Ph.D., M.B.A. at
maderiam@mail.nih.gov or 240–276–
5533.
Tri-functional Imaging Agent for
Monoclonal Antibody Tumor-Targeted
Imaging
Description of Technology: This is a
novel lysine-based trifunctional chelate
which bears both a chelating moiety
(CHX-A″) for sequestering radiometals
(86Y or 111In) and a near-infrared dye,
e.g., Cy5.5, for dual modality PET (or
SPECT) and fluorescence imaging.
Successful conjugation of monoclonal
antibody trastuzumab (Herceptin) or
cetuximab (Erbitux), has also been
achieved by efficient thiol-maleimide
chemistry, thereby yielding an
immunoconjugate (Signaling agent
(Cy5.5-Lys(SMCC)-CHX-A″) conjugated
to trastuzumab) or (Signaling agent
(Cy7-Lys(SMCC)-CHX-A″) conjugated to
cetuximab). Both specifically target
antigen expressing cells and
internalization of the agent has been
imaged over time. Trastuzumab can be
radiolabeled with isothiocyanate
derivatives of the bifunctional chelating
agents 1B4M (2-(4-aminobenzy1)-6methyldiethylenetriaminepentaacetic
acid); and CHX-A″ (N-[(R)-2-amino-3-(paminophenyl)propyl]-trans-(S,S)cyclohexane-1,2-diamine-N,N,N′,N″,N″pentaacetic acid).
Potential Commercial Applications:
• Cancer imaging.
• Cancer diagnostics.
Competitive Advantages:
• Target specific.
• Multifunctional (imageable through
multiple platforms).
Development Stage:
• Early-stage.
• In vivo data available (animal).
Inventors: Martin W. Brechbiel, Heng
Wu, Kwamena E. Baidoo (all of NCI).
Publications:
1. Xu H, et al. Design, synthesis, and
characterization of a dual modality
positron emission tomography and
fluorescence imaging agent for
monoclonal antibody tumor-targeted
imaging. J Med Chem. 2007 Sep
20;50(19):4759–65. [PMID 17725340]
2. Nayak TK, et al. PET and MRI of
metastatic peritoneal and pulmonary
VerDate Mar<15>2010
17:53 Aug 08, 2013
Jkt 229001
colorectal cancer in mice with human
epidermal growth factor receptor 1targeted 89Zr-labeled panitumumab. J
Nucl Med. 2012 Jan;53(1):113–20.
[PMID 22213822]
3. Dadwal M, et al. Synthesis and
evaluation of a bifunctional chelate for
development of Bi(III)-labeled
radioimmunoconjugates. Bioorg Med
Chem Lett. 2011 Dec 15;21(24):7513–5.
[PMID 22047687]
4. Song HA, et al. Efficient
bifunctional decadentate ligand 3p-CDEPA for targeted alpharadioimmunotherapy applications.
Bioconjug Chem. 2011 Jun
15;22(6):1128–35. [PMID 21604692]
5. Bumb A, et al. Preparation and
characterization of a magnetic and
optical dual-modality molecular probe.
Nanotechnology. 2010 Apr
30;21(17):175704. [PMID 20368682]
Intellectual Property: HHS Reference
No. E–194–2007/0—US Patent
Application No. 12/667,790 filed 05 Jan
2010 (allowed).
Related Technology: HHS Reference
No. E–111–2013/0—US Provisional
Application No. 61/779,016 filed 13 Mar
2013.
Licensing Contact: Michael A.
Shmilovich, Esq., CLP; 301–435–5019;
shmilovm@mail.nih.gov.
Collaborative Research Opportunity:
The National Cancer Institute Radiation
Oncology Branch is seeking statements
of capability or interest from parties
interested in collaborative research to
further develop, evaluate or
commercialize Trifunctional Imaging
Agent for Monoclonal Antibody TumorTargeted Imaging. For collaboration
opportunities, please contact John D.
Hewes, Ph.D. at hewesj@mail.nih.gov.
Dated: August 6, 2013.
Richard U. Rodriguez,
Director, Division of Technology Development
and Transfer, Office of Technology Transfer,
National Institutes of Health.
[FR Doc. 2013–19285 Filed 8–8–13; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
National Institute of Environmental
Health Sciences; Notice of Meeting
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is
hereby given of a meeting of the
National Advisory Environmental
Health Sciences Council.
The meeting will be open to the
public as indicated below, with
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48695
attendance limited to space available.
Individuals who plan to attend and
need special assistance, such as sign
language interpretation or other
reasonable accommodations, should
notify the Contact Person listed below
in advance of the meeting.
The meeting will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: National Advisory
Environmental Health Sciences Council.
Date: September 10, 2013.
Open: 8:30 a.m. to 3:15 p.m.
Agenda: Discussion of program policies
and issues.
Place: Nat. Inst. of Environmental Health
Sciences, Building 101, Rodbell Auditorium,
111 T. W. Alexander Drive, Research
Triangle Park, NC 27709.
Closed: 3:30 p.m. to 5 p.m.
Agenda: To review and evaluate grant
applications.
Place: Nat. Inst. of Environmental Health
Sciences, Building 101, Rodbell Auditorium,
111 T. W. Alexander Drive, Research
Triangle Park, NC 27709.
Date: September 11, 2013.
Closed: 8:30 a.m. to 3:15 p.m.
Agenda: To review and evaluate grant
applications.
Place: Nat. Inst. of Environmental Health
Sciences, Building 101, Rodbell Auditorium,
111 T. W. Alexander Drive, Research
Triangle Park, NC 27709.
Contact Person: Gwen W. Collman, Ph.D.,
Interim Director, Division of Extramural
Research & Training, National Institutes of
Health, Nat. Inst. of Environmental Health
Sciences, 615 Davis Dr. KEY615/3112,
Research Triangle Park, NC 27709, (919) 541–
4980, collman@niehs.nih.gov.
Any interested person may file
written comments with the committee
by forwarding the statement to the
Contact Person listed on this notice. The
statement should include the name,
address, telephone number and when
applicable, the business or professional
affiliation of the interested person.
Information is also available on the
Institute’s/Center’s home page:
www.niehs.nih.gov/dert/c-agenda.htm,
where an agenda and any additional
information for the meeting will be
posted when available.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.115, Biometry and Risk
Estimation—Health Risks from
Environmental Exposures; 93.142, NIEHS
Hazardous Waste Worker Health and Safety
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48696
Federal Register / Vol. 78, No. 154 / Friday, August 9, 2013 / Notices
Training; 93.143, NIEHS Superfund
Hazardous Substances—Basic Research and
Education; 93.894, Resources and Manpower
Development in the Environmental Health
Sciences; 93.113, Biological Response to
Environmental Health Hazards; 93.114,
Applied Toxicological Research and Testing,
National Institutes of Health, HHS)
Dated: August 2, 2013.
Carolyn Baum,
Program Analyst, Office of Federal Advisory
Committee Policy.
[FR Doc. 2013–19283 Filed 8–8–13; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
this electronic service and who need
special assistance such as captioning or
other reasonable accommodations
should submit a request to the Contact
Person listed on this notice at least 5
days prior to the meeting.
This meeting notice is being
published less than 30 days in advance
of the meeting due to the urgent need of
the subcommittee to discuss the
subcommittees upcoming activities and
emerging issues in the autism
community.
Schedule subject to change.
Information about the IACC is
available on the Web site: https://
www.iacc.hhs.gov.
Dated: August 5, 2013.
Carolyn Baum,
Program Analyst, Office of Federal Advisory
Committee Policy.
National Institutes of Health
National Institute of Mental Health;
Notice of Meeting
[FR Doc. 2013–19284 Filed 8–8–13; 8:45 am]
BILLING CODE 4140–01–P
Name of Committee: Interagency Autism
Coordinating Committee (IACC).
Type of meeting: Conference Call.
Date: August 27, 2013.
Time: 2 p.m.–4 p.m. *Eastern Time*—
Approximate end time.
Agenda: The committee will discuss future
subcommittee activities.
Place: Conference call only; No in-person
meeting.
Conference Call: Dial: 888–989–8135,
Access code: 3593305.
Cost: The conference call is free.
Contact Person: Ms. Lina Perez, Office of
Autism Research Coordination, National
Institute of Mental Health, NIH, 6001
Executive Boulevard, NSC, Room 6182A,
Rockville, MD 20852, Phone: (301) 443–6040,
Email: IACCPublicInquiries@mail.nih.gov.
pmangrum on DSK3VPTVN1PROD with NOTICES
Pursuant to section 10(a) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is
hereby given of a meeting of the
Interagency Autism Coordinating
Committee (IACC) Subcommittee for
Services Research and Policy
Subcommittee.
The IACC Subcommittee for Services
Research and Policy will be having a
conference call on Tuesday, August 27,
2013. The Subcommittee will discuss
future subcommittee activities. The
meeting will be accessible by conference
call.
SUMMARY:
Please Note: The meeting will be open
to the public and accessible via
conference call. Members of the public
who participate using the conference
call phone number will be able to listen
to the meeting but will not be heard. If
you experience any technical problems
with the conference call, please send an
email to helpdeskiacc@gmail.com or
call 415–652–8023 for technical
support.
Accommodations Statement:
Individuals who participate by using
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DEPARTMENT OF HOMELAND
SECURITY
Coast Guard
[Docket No. USCG–2013–0240]
Draft Revisions to the Marine Safety
Manual, Volume III, Chapters 20–26
Coast Guard, DHS.
ACTION: Notice of availability with
request for comments
AGENCY:
The Coast Guard announces
the availability of a draft update to the
Marine Safety Manual (MSM), Volume
III, Marine Industry Personnel, and the
corresponding Commandant Change
Notice that highlights the changes made
to that manual. MSM Volume III
provides information and
interpretations on international
conventions and U.S. statutory and
regulatory issues relating to marine
industry personnel. This Commandant
Change Notice discusses the substantive
changes to chapters 20 through 26 of
MSM Volume III. The Coast Guard seeks
and will consider comments on this
draft before issuing a final version of
this manual.
DATES: Comments must be received by
the Coast Guard on or before October 8,
2013.
ADDRESSES: To view the documents
mentioned in this notice, go to https://
www.regulations.gov and use ‘‘USCG–
2013–0240’’ as your search term. Locate
this notice in the search results, and use
the filters on the left side of the page to
locate specific documents by type. If
you do not have access to the Internet,
you may view the docket online by
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visiting the Docket Management Facility
in Room W12–140 on the ground floor
of the Department of Transportation
West Building, 1200 New Jersey Avenue
SE., Washington, DC 20590, between 9
a.m. and 5 p.m., Monday through
Friday, except Federal holidays. We
have an agreement with the Department
of Transportation to use the Docket
Management Facility.
If
you have questions on this notice, call
or email Lieutenant Corydon Heard,
Office of Commercial Vessel
Compliance, U.S. Coast Guard;
telephone 202–372–1208, email
Corydon.F.Heard@uscg.mil. If you have
questions on viewing material in the
docket, call Docket Operations at 202–
366–9826.
FOR FURTHER INFORMATION CONTACT:
SUPPLEMENTARY INFORMATION:
Viewing the Commandant Change
Notice and Draft of MSM Volume III,
Chapters 20–26: To view this
Commandant Change notice and Draft
MSM Volume III, chapters 20–26, go to
https://www.regulations.gov, use
‘‘USCG–2013–0240’’ as your search
term, and follow the instructions in the
ADDRESSES section above.
Background and Purpose
Volume III of the Marine Safety
Manual (MSM) provides information
and interpretations on international
conventions and U.S. statutory and
regulatory issues relating to marine
industry personnel. The last revisions to
Volume III of the MSM were released on
May 27, 1999. This notice updates
portions of chapters 20 through 26.
Specifically, substantive changes
include: (1) Updated provisions for
vessel manning, including guidance for
the issuing of safe manning documents;
(2) clarifying roles, responsibilities, and
facilitation of communications with the
appropriate offices at Coast Guard
Headquarters in alignment with Deputy
Commandant for Operations
Organization 3.0; and (3) revised
discussion on the impact of multiple
international standards, including the
Officer’s Competency Certificates
Convention (OCCC) 1936, the
International Convention for Safety of
Life at Sea (SOLAS), the Global
Maritime Distress and Safety System
(GMDSS), and the Principles of
Minimum Safe Manning (IMO
Resolution A.1047(27)). Additionally,
this draft clarifies the applicability of
tonnage measurement systems to U.S.
flag vessels, and it also includes changes
resulting from the consolidation of
merchant mariner qualification
credentials, including the removal of
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]]>Agencies
[Federal Register Volume 78, Number 154 (Friday, August 9, 2013)]
[Notices]
[Pages 48695-48696]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 2013-19283]
-----------------------------------------------------------------------
DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
National Institute of Environmental Health Sciences; Notice of
Meeting
Pursuant to section 10(d) of the Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is hereby given of a meeting of the
National Advisory Environmental Health Sciences Council.
The meeting will be open to the public as indicated below, with
attendance limited to space available. Individuals who plan to attend
and need special assistance, such as sign language interpretation or
other reasonable accommodations, should notify the Contact Person
listed below in advance of the meeting.
The meeting will be closed to the public in accordance with the
provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5
U.S.C., as amended. The grant applications and the discussions could
disclose confidential trade secrets or commercial property such as
patentable material, and personal information concerning individuals
associated with the grant applications, the disclosure of which would
constitute a clearly unwarranted invasion of personal privacy.
Name of Committee: National Advisory Environmental Health
Sciences Council.
Date: September 10, 2013.
Open: 8:30 a.m. to 3:15 p.m.
Agenda: Discussion of program policies and issues.
Place: Nat. Inst. of Environmental Health Sciences, Building
101, Rodbell Auditorium, 111 T. W. Alexander Drive, Research
Triangle Park, NC 27709.
Closed: 3:30 p.m. to 5 p.m.
Agenda: To review and evaluate grant applications.
Place: Nat. Inst. of Environmental Health Sciences, Building
101, Rodbell Auditorium, 111 T. W. Alexander Drive, Research
Triangle Park, NC 27709.
Date: September 11, 2013.
Closed: 8:30 a.m. to 3:15 p.m.
Agenda: To review and evaluate grant applications.
Place: Nat. Inst. of Environmental Health Sciences, Building
101, Rodbell Auditorium, 111 T. W. Alexander Drive, Research
Triangle Park, NC 27709.
Contact Person: Gwen W. Collman, Ph.D., Interim Director,
Division of Extramural Research & Training, National Institutes of
Health, Nat. Inst. of Environmental Health Sciences, 615 Davis Dr.
KEY615/3112, Research Triangle Park, NC 27709, (919) 541-4980,
collman@niehs.nih.gov.
Any interested person may file written comments with the committee
by forwarding the statement to the Contact Person listed on this
notice. The statement should include the name, address, telephone
number and when applicable, the business or professional affiliation of
the interested person.
Information is also available on the Institute's/Center's home
page: www.niehs.nih.gov/dert/c-agenda.htm, where an agenda and any
additional information for the meeting will be posted when available.
(Catalogue of Federal Domestic Assistance Program Nos. 93.115,
Biometry and Risk Estimation--Health Risks from Environmental
Exposures; 93.142, NIEHS Hazardous Waste Worker Health and Safety
[[Page 48696]]
Training; 93.143, NIEHS Superfund Hazardous Substances--Basic
Research and Education; 93.894, Resources and Manpower Development
in the Environmental Health Sciences; 93.113, Biological Response to
Environmental Health Hazards; 93.114, Applied Toxicological Research
and Testing, National Institutes of Health, HHS)
Dated: August 2, 2013.
Carolyn Baum,
Program Analyst, Office of Federal Advisory Committee Policy.
[FR Doc. 2013-19283 Filed 8-8-13; 8:45 am]
BILLING CODE 4140-01-P
