Seventy-Second Report of the TSCA Interagency Testing Committee to the Administrator of the Environmental Protection Agency; Receipt of Report and Request for Comments, 44857-44866 [2013-17545]
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Seventy-Second Report of the TSCA Interagency Testing Committee to the
Administrator of the Environmental Protection Agency; Receipt of Report
and Request for Comments; Notice
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Federal Register / Vol. 78, No. 142 / Wednesday, July 24, 2013 / Notices
ENVIRONMENTAL PROTECTION
AGENCY
[EPA–HQ–OPPT–2013–0248; FRL–9391–5]
Seventy-Second Report of the TSCA
Interagency Testing Committee to the
Administrator of the Environmental
Protection Agency; Receipt of Report
and Request for Comments
Environmental Protection
Agency (EPA).
ACTION: Notice.
AGENCY:
The Toxic Substances Control
Act (TSCA) Interagency Testing
Committee (ITC) transmitted its 72nd
ITC Report to the Acting EPA
Administrator on June 13, 2013. In the
72nd ITC Report, which is included
with this notice, the ITC is revising the
TSCA section 4(e) Priority Testing List
by removing 16 chemicals with
insufficient dermal absorption rate data,
98 High Production Volume (HPV)
Challenge Program orphan chemicals,
and 50 diisocyanates and related
compounds. The ITC is removing 16
chemicals with insufficient dermal
absorption rate data because
information from dermal studies can be
readily obtained through the
Organization for Economic Cooperation
and Development (OECD) and EPA
databases or other authoritative
scientific resources. The ITC is
removing the 98 HPV Challenge
Program orphan chemicals because they
no longer meet the ≥ 1 million lb
criterion for the HPV Challenge
Program. The ITC is removing the 50
diisocyanates and related compounds
because their production or importation
volumes were not reported to the 2006
Inventory Update Reporting (IUR) rule
or the 2012 Chemical Data Reporting
(CDR) rule.
DATES: Comments must be received on
or before August 23, 2013.
ADDRESSES: Submit your comments,
identified by docket identification (ID)
number EPA–HQ–OPPT–2013–0248, by
one of the following methods:
• Federal eRulemaking Portal: https://
www.regulations.gov. Follow the online
instructions for submitting comments.
• Mail: Document Control Office
(7407M), Office of Pollution Prevention
and Toxics (OPPT), Environmental
Protection Agency, 1200 Pennsylvania
Ave. NW., Washington, DC 20460–0001.
• Hand Delivery: OPPT Document
Control Office (DCO), EPA East Bldg.,
Rm. 6428, 1201 Constitution Ave. NW.,
Washington, DC. ATTN: Docket ID
Number EPA–HQ–OPPT–2013–0248.
The DCO is open from 8 a.m. to 4 p.m.,
Monday through Friday, excluding legal
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SUMMARY:
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holidays. The telephone number for the
DCO is (202) 564–8930. Such deliveries
are only accepted during the DCO’s
normal hours of operation, and special
arrangements should be made for
deliveries of boxed information.
Instructions: Direct your comments to
docket ID number EPA–HQ–OPPT–
2013–0248. EPA’s policy is that all
comments received will be included in
the docket without change and may be
made available online at https://
www.regulations.gov, including any
personal information provided, unless
the comment includes information
claimed to be Confidential Business
Information (CBI) or other information
whose disclosure is restricted by statute.
Do not submit information that you
consider to be CBI or otherwise
protected through regulations.gov or
email. The regulations.gov Web site is
an ‘‘anonymous access’’ system, which
means EPA will not know your identity
or contact information unless you
provide it in the body of your comment.
If you send an email comment directly
to EPA without going through
regulations.gov, your email address will
be automatically captured and included
as part of the comment that is placed in
the docket and made available on the
Internet. If you submit an electronic
comment, EPA recommends that you
include your name and other contact
information in the body of your
comment and with any disk or CD–ROM
you submit. If EPA cannot read your
comment due to technical difficulties
and cannot contact you for clarification,
EPA may not be able to consider your
comment. Electronic files should avoid
the use of special characters, any form
of encryption, and be free of any defects
or viruses.
Docket: All documents in the docket
are listed in the docket index available
at https://www.regulations.gov. Although
listed in the index, some information is
not publicly available, e.g., CBI or other
information whose disclosure is
restricted by statute. Certain other
material, such as copyrighted material,
will be publicly available only in hard
copy. Publicly available docket
materials are available electronically at
https://www.regulations.gov, or, if only
available in hard copy, at the OPPT
Docket. The OPPT Docket is located in
the EPA Docket Center (EPA/DC) at Rm.
3334, EPA West Bldg., 1301
Constitution Ave. NW., Washington,
DC. The EPA/DC Public Reading Room
hours of operation are 8:30 a.m. to 4:30
p.m., Monday through Friday, excluding
legal holidays. The telephone number of
the EPA/DC Public Reading Room is
(202) 566–1744, and the telephone
number for the OPPT Docket is (202)
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566–0280. Docket visitors are required
to show photographic identification,
pass through a metal detector, and sign
the EPA visitor log. All visitor bags are
processed through an X-ray machine
and subject to search. Visitors will be
provided an EPA/DC badge that must be
visible at all times in the building and
returned upon departure.
FOR FURTHER INFORMATION CONTACT: For
technical information contact: John D.
Walker, TSCA Interagency Testing
Committee (7405M), Chemical Control
Division, Office of Pollution Prevention
and Toxics, Environmental Protection
Agency, 1200 Pennsylvania Ave. NW.,
Washington, DC 20460–0001; telephone
number: (202) 564–7527; fax number:
(202) 564–7528; email address:
walker.johnd@epa.gov.
For general information contact: The
TSCA-Hotline, ABVI-Goodwill, 422
South Clinton Ave., Rochester, NY
14620; telephone number: (202) 554–
1404; email address: TSCAHotline@epa.gov.
SUPPLEMENTARY INFORMATION:
I. General Information
A. Does this action apply to me?
This notice is directed to the public
in general. It may, however, be of
particular interest to you if you
manufacture (defined by statute to
include import) and/or process TSCAcovered chemicals and you may be
identified by the North American
Industrial Classification System
(NAICS) codes 325 and 32411. Because
this notice is directed to the general
public and other entities may also be
interested, the Agency has not
attempted to describe all the specific
entities that may be interested in this
action.
B. What should I consider as I prepare
my comments for EPA?
1. Submitting CBI. Do not submit this
information to EPA through
regulations.gov or email. Clearly mark
the part or all of the information that
you claim to be CBI. For CBI
information in a disk or CD–ROM that
you mail to EPA, mark the outside of the
disk or CD–DOM as CBI and then
identify electronically within the disk or
CD–ROM the specific information that
is claimed as CBI. In addition to one
complete version of the comment that
includes information claimed as CBI, a
copy of the comment that does not
contain the information claimed as CBI
must be submitted for inclusion in the
public docket. Information so marked
will not be disclosed except in
accordance with procedures set forth in
40 CFR part 2.
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2. Tips for preparing your comments.
When submitting comments, remember
to:
i. Identify the document by docket ID
number and other identifying
information (subject heading, Federal
Register date and page number).
ii. Follow directions. The Agency may
ask you to respond to specific questions
or organize comments by referencing a
Code of Federal Regulations (CFR) part
or section number.
iii. Explain why you agree or disagree;
suggest alternatives and substitute
language for your requested changes.
iv. Describe any assumptions and
provide any technical information and/
or data that you used.
v. If you estimate potential costs or
burdens, explain how you arrived at
your estimate in sufficient detail to
allow for it to be reproduced.
vi. Provide specific examples to
illustrate your concerns and suggest
alternatives.
vii. Explain your views as clearly as
possible, avoiding the use of profanity
or personal threats.
viii. Make sure to submit your
comments by the comment period
deadline identified.
II. Background
The Toxic Substances Control Act
(TSCA) (15 U.S.C. 260l et seq.)
authorizes the Administrator of EPA to
promulgate regulations under TSCA
section 4(a) requiring testing of
chemicals and chemical groups in order
to develop data relevant to determining
the risks that such chemicals and
chemical groups may present to health
or the environment. Section 4(e) of
TSCA established the ITC to
recommend chemicals and chemical
groups to the Administrator of EPA for
priority testing consideration. Section
4(e) of TSCA directs the ITC to revise
the TSCA section 4(e) Priority Testing
List at least every 6 months.
You may access additional
information about the ITC at https://
www.epa.gov/oppt/itc.
A. The 72nd ITC Report
The ITC is revising the TSCA section
4(e) Priority Testing List by removing 16
chemicals with insufficient dermal
absorption rate data, 98 HPV Challenge
Program orphan chemicals, and 50
diisocyanates and related compounds.
B. Status of the TSCA Section 4(e)
Priority Testing List
The TSCA section 4(e) Priority Testing
List includes 2 alkylphenols, 50 HPV
Challenge Program orphan chemicals,
cadmium, a category of cadmium
compounds, 6 non-phthalate
plasticizers, 25 phosphate ester flame
retardants, 2 other flame retardants, 9
chemicals to which children living near
hazardous waste sites may be exposed,
and 19 diisocyanates and related
compounds.
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List of Subjects
Environmental protection, Chemicals,
Hazardous substances.
Dated: July 15, 2013.
Wendy C. Hamnett,
Director, Office of Pollution Prevention and
Toxics.
Seventy-Second Report of the TSCA
Interagency Testing Committee to the
Administrator of the Environmental
Protection Agency
Table of Contents
Summary
I. Background
II. ITC’s Activities During This Reporting
Period (December 2012 to May 2013)
III. Chemicals Removed From the TSCA
Section 4(e) Priority Testing List
A. Chemicals With Insufficient Dermal
Absorption Rate Data
B. HPV Challenge Program Orphan
Chemicals
C. Diisocyanates and Related Compounds
IV. References
V. The TSCA Interagency Testing Committee
Summary
The ITC is revising the Toxic
Substances Control Act (TSCA) section
4(e) Priority Testing List by removing 16
chemicals with insufficient dermal
absorption rate data, 98 High Production
Volume (HPV) Challenge Program
orphan chemicals, and 50 diisocyanates
and related compounds.
The TSCA section 4(e) Priority Testing
List is Table 1 of this unit.
TABLE 1—TSCA SECTION 4(e) PRIORITY TESTING LIST
[May 2013]
ITC report
Date
Chemical name/group
Action
Branched 4-nonylphenol (mixed isomers) ..............................................................
Phenol, 4-(1,1,3,3-tetramethylbutyl)- ......................................................................
49 High Production Volume (HPV) Challenge Program orphan chemicals ...........
1 HPV Challenge Program orphan chemical, naphtha (petroleum), clay-treated
light straight-run.
Cadmium .................................................................................................................
Cadmium compounds .............................................................................................
6 Non-phthalate plasticizers ...................................................................................
25 Phosphate ester flame retardants .....................................................................
2 Other flame retardants ........................................................................................
9 Chemicals to which children living near hazardous waste sites may be exposed.
19 Diisocyanates and related compounds .............................................................
Recommended.
Recommended.
Recommended.
Recommended.
.................
.................
.................
.................
November 1995 ................
November 1997 ................
December 2004 ................
August 2005 .....................
68
69
69
69
69
69
.................
.................
.................
.................
.................
.................
May 2011 ..........................
November 2011 ................
November 2011 ................
November 2011 ................
November 2011 ................
November 2011 ................
69 .................
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41
55
56
November 2011 ................
I. Background
The ITC was established by TSCA
section 4(e) ‘‘to make recommendations
to the Administrator respecting the
chemical substances and mixtures to
which the Administrator should give
priority consideration for the
promulgation of rules for testing under
section 4(a) * * * At least every six
months * * *, the Committee shall
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make such revisions to the Priority
Testing List as it determines to be
necessary and transmit them to the
Administrator together with the
Committee’s reasons for the revisions’’
(Public Law 94–469, 90 Stat. 2003 et
seq., 15 U.S.C. 2601 et seq.). ITC reports
are available from the ITC’s Web site
(https://www.epa.gov/oppt/itc) and from
regulations.gov (https://
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Recommended.
Recommended.
Recommended.
Recommended.
Recommended.
Recommended.
Recommended.
www.regulations.gov) after publication
in the Federal Register. The ITC
produces its revisions to the TSCA
section 4(e) Priority Testing List with
administrative and technical support
from the ITC staff and ITC members. ITC
members and staff are listed at the end
of this report.
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II. ITC’s Activities During This
Reporting Period (December 2012 to
May 2013)
The ITC welcomed a new member
and new alternate member from the
Department of Commerce’s National
Institute of Standards and Technology
and a new member from the National
Science Foundation.
During this reporting period, the ITC
discussed the 16 chemicals with
insufficient dermal absorption rate data,
branched 4-nonylphenol (mixed
isomers), phenol, 4-(1,1,3,3tetramethylbutyl)-, 148 HPV Challenge
Program orphan chemicals, cadmium
and cadmium compounds, 6 nonphthalate plasticizers, 25 phosphate
ester and 2 other flame retardants, 9
chemicals to which children living near
hazardous waste sites may be exposed,
and 69 diisocyanates and related
compounds remaining on the TSCA
section 4(e) Priority Testing List. As a
result of these discussions, the ITC
removed 16 chemicals with insufficient
dermal absorption rate data, 98 HPV
Challenge Program orphan chemicals,
and 50 diisocyanates and related
compounds from the TSCA section 4(e)
Priority Testing List. Orphan chemicals
are those HPV chemicals for which no
sponsors have volunteered to develop
and submit robust summaries of basic
hazard and fate testing data to the EPA.
The hazard and fate testing data
requested by the EPA for HPV Challenge
Program orphan chemicals are necessary
to establish a screening level
understanding of their potential human
health and environmental impacts. The
chemicals with insufficient dermal
absorption rate data, HPV Challenge
Program orphan chemicals and
diisocyanates and related compounds
are discussed further in Unit III. of this
72nd ITC Report.
As noted in this unit, the ITC also
discussed the following chemicals that
remain on the TSCA section 4(e) Priority
Testing List: Branched 4-nonylphenol
(mixed isomers), phenol, 4-(1,1,3,3tetramethylbutyl)-, cadmium and
cadmium compounds, 6 non-phthalate
plasticizers, 25 phosphate ester flame
retardants, 2 other flame retardants, and
9 chemicals to which children living
near hazardous waste sites may be
exposed.
Branched 4-nonylphenol (mixed
isomers) (CAS No. 84852–15–3) and
phenol, 4-(1,1,3,3-tetramethylbutyl)(CAS No. 140–66–9) were added to the
TSCA section 4(e) Priority Testing List
in the ITC’s 37th and 41st Reports along
with numerous other alkylphenols,
alkylphenol ethoxylates, and poly
alkylphenols (Refs. 1 and 2). The
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remaining data needed for branched 4nonylphenol (mixed isomers) and
phenol, 4-(1,1,3,3-tetramethylbutyl)- can
be obtained from avian reproduction
testing and fish multi-generation testing,
respectively. Branched 4-nonylphenol
(mixed isomers) and phenol, 4-(1,1,3,3tetramethylbutyl)- will remain on the
TSCA section 4(e) Priority Testing List
until the avian reproduction testing and
fish multi-generation testing is
completed or other information becomes
available to justify removing them from
the TSCA section 4(e) Priority Testing
List.
Cadmium and cadmium compounds
were added to the TSCA section 4(e)
Priority Testing List in the ITC’s 68th
and 69th Reports (Refs. 3 and 4).
Cadmium and cadmium compounds
were included in a TSCA section 8(d)
Health and Safety Data Reporting
(HaSDR) rule that was published in the
Federal Register of December 3, 2012
(77 FR 71561) (FRL–9355–9). After
receiving adverse comments to the
HaSDR rule, EPA published a document
withdrawing the HaSDR rule in the
Federal Register of December 28, 2012
(77 FR 76419) (FRL–9375–3) due to
questions and concerns raised about the
scope and extent of the HaSDR rule.
EPA is considering the questions and
concerns raised in response to the
HaSDR rule and next steps with regard
to that rule.
Six non-phthalate plasticizers, 25
phosphate ester flame retardants, and 2
other flame retardants were added to the
TSCA section 4(e) Priority Testing List
in the ITC’s 69th Report (Ref. 4). They
were added to obtain existing biomonitoring data on urinary metabolites
that will be used to assess the risks of
these chemicals. The 2 other flame
retardants, 1,2-benzenedicarboxylic
acid, 3,4,5,6-tetrabromo-, 1,2-bis(2ethylhexyl) ester, a.k.a. bis(2-ethyl-1hexyl) tetrabromophthalate (CAS No.
26040–51–7) and benzoic acid, 2,3,4,5tetrabromo-, 2-ethylhexyl ester, a.k.a. 2ethylhexyl-2,3,4,5-tetrabromobenzoate
(CAS No. 183658–27–7) are included in
the assessment strategy that EPA
developed for brominated phthalates
(https://www.epa.gov/oppt/
existingchemicals/pubs/
2013wpractivities.html).
The U.S. Department of the Interior
(DOI) and Environment Canada are
collaborating on a study involving
exposure of American Kestrels (Falco
sparverius) to 4 of the phosphate ester
flame retardants discussed in the ITC’s
69th Report (Ref. 4). The 4 phosphate
ester flame retardants include: Ethanol,
2-butoxy-, 1,1’,1’’-phosphate, a.k.a. tri(2butoxyethyl) phosphate (CAS No. 78–
51–3); ethanol, 2-chloro-, phosphate
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(3:1), a.k.a. tris(2-chloroethyl) phosphate
(CAS No. 115–96–8); 2-propanol, 1chloro-, 2,2’,2’’-phosphate, a.k.a. tris(1chloro-2-propyl)phosphate (CAS No.
13674–84–5) and 2-propanol, 1,3dichloro-, phosphate (3:1), a.k.a. tris(1,3dichloro-2-propyl) phosphate (CAS#:
13674–87–8). The study will provide
novel information on uptake kinetics
and potential toxicity of priority
phosphate ester flame retardants that are
currently found in wild bird eggs in
North America. One of these phosphate
ester flame retardants, ethanol,
2-chloro-, phosphate (3:1), a.k.a. tris(2chloroethyl) phosphate (CAS No. 115–
96–8) is included in the risk assessment
strategy that EPA is developing for
chlorinated phosphate esters (https://
www.epa.gov/oppt/existingchemicals/
pubs/2013wpractivities.html).
Nine chemicals to which children
living near hazardous waste sites may
be exposed were added to the TSCA
section 4(e) Priority Testing List in the
ITC’s 69th Report (Ref. 4). They were
added to obtain existing biomonitoring
data on blood levels that will be used to
fill priority data needs that were
identified during the development of
ATSDR’s Toxicological Profiles. Priority
data needs are published in the Federal
Register and represent a wide variety of
needs, including biomonitoring studies
to help establish reference values for
exposed populations as well as
background levels for the general
population (https://www.atsdr.cdc.gov/
pdns/index.asp). The 9 chemicals to
which children living near hazardous
waste sites may be exposed are from the
current unfilled priority data needs and
any biomonitoring data will be used to
conduct public health assessments. The
EPA is deliberating options for
satisfying the data needs for these 9
chemicals.
III. Chemicals Removed From the TSCA
Section (4)(e) Priority Testing List
A. Chemicals With Insufficient Dermal
Absorption Rate Data
In its 31st, 32nd, and 35th ITC
Reports, the Occupational Safety and
Health Administration (OSHA)
requested that the ITC add 24, 34, and
25 chemicals, respectively, to the TSCA
section 4(e) Priority Testing List and
designate them for testing to develop
dermal absorption rate data (Refs. 5, 6,
and 7). The ITC removed methyl
methacrylate and diethyl phthalate from
the TSCA section 4(e) Priority Testing
List in its 34th ITC Report (Ref. 8) and
cyclohexanone from the TSCA section
4(e) Priority Testing List in its 36th ITC
Report (Ref. 9). Methyl methacrylate,
diethyl phthalate, and cyclohexanone
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were removed from the TSCA section
4(e) Priority Testing List because dermal
absorption rate data were identified
after these chemicals were added to the
TSCA section 4(e) Priority Testing List.
In its 45th ITC Report (Ref. 10), the ITC
removed 47 chemicals designated for
dermal absorption rate testing from the
TSCA section 4(e) Priority Testing List,
because the EPA published a rule
proposing dermal absorption rate testing
for these chemicals (Ref. 11). In 2004,
the EPA reviewed more recent
production volume, exposure, and
dermal absorption rate data and
promulgated a rule requiring dermal
absorption rate testing for 34 of these
chemicals (Ref. 12). The rationales for
EPA’s decision not to finalize testing
requirements for the other 13 chemicals
in the proposed rule are described in
Ref. 11. In its 59th ITC Report, the ITC
removed 16 more chemicals with
insufficient dermal absorption rate data
from the TSCA section 4(e) Priority
Testing List (Ref. 13). The ITC removed
these 16 chemicals because their
production volumes indicated low
potential for occupational exposures. In
this 72nd ITC Report, the ITC is
removing the 16 remaining chemicals
with insufficient dermal absorption rate
data from the TSCA section 4(e) Priority
Testing List (Table 2 of this unit). OSHA
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determined that for these 16 chemicals,
information from dermal studies can be
readily obtained through the OECD
existing chemical database
(eChemPortal), the EPA HPV database
(High Production Volume Information
System (HPVIS) or other authoritative
scientific resources (Ref. 14). The ITC is
removing these chemicals as a result of
OSHA’s determination that sufficient
information is currently available on the
dermal absorption characteristics of
these chemicals to warrant their
removal from the TSCA section 4(e)
Priority Testing List.
TABLE 2—CHEMICALS WITH INSUFFICIENT DERMAL ABSORPTION RATE DATA BEING REMOVED FROM THE PRIORITY
TESTING LIST
CAS No.
Chemical name
75–12–7 .............
88–72–2 .............
89–72–5 .............
90–04–0 .............
95–13–6 .............
96–18–4 .............
99–08–1 .............
100–63–0 ...........
106–49–0 ...........
108–44–1 ...........
108–87–2 ...........
121–14–2 ...........
287–92–3 ...........
540–59–0 ...........
542–92–7 ...........
626–17–5 ...........
Formamide.
Benzene, 1-methyl-2-nitro-; o-nitrotoluene.
Phenol, 2-(1-methylpropyl)-; o-sec-butylphenol.
Benzenamine, 2-methoxy-; o-anisidine.
1H-Indene; indene.
Propane, 1,2,3-trichloro-; 1,2,3-trichloropropane.
Benzene, 1-methyl-3-nitro-; m-nitrotoluene.
Hydrazine, phenyl-; phenylhydrazine.
Benzenamine, 4-methyl-; p-toluidine.
Benzenamine, 3-methyl-; m-toluidine.
Cyclohexane, methyl-; methylcyclohexane.
Benzene, 1-methyl-2,4-dinitro-; 2,4-dinitrotoluene.
Cyclopentane.
Ethene, 1,2-dichloro-; 1,2-dichloroethylene.
1,3-Cyclopentadiene.
1,3-Benzenedicarbonitrile; 1,3-dicyanobenzene.
B. HPV Challenge Program Orphan
Chemicals
In 2004, at the EPA’s request, the ITC
added 281 HPV Challenge Program
orphan (unsponsored) chemicals to the
TSCA section 4(e) Priority Testing List
in the ITC’s 55th and 56th Reports (Refs.
15 and 16). As of December 2012, 133
HPV Challenge Program orphan
chemicals had been removed from the
TSCA section 4(e) Priority Testing List
because they were included in EPA’s
test rules, the testing was voluntarily
sponsored or because they no longer
met the > 1 million lb criterion for the
HPV Challenge Program. Based on data
received from the 2006 IUR rule, and
the 2012 CDR rule, EPA identified 98
HPV Challenge Program orphan
chemicals with production volumes
consistently below 1 million lb. Since
these 98 chemicals no longer exceed the
1 million lb criterion for the HPV
Challenge Program, EPA is requesting
their removal from the TSCA section
4(e) Priority Testing List in this 72nd
ITC Report (Ref. 17). The 98 HPV
Challenge Program orphan chemicals
being removed from the TSCA section
4(e) Priority Testing List are listed in
Table 3 of this unit. The 50 HPV
Challenge Program orphan chemicals
remaining on the TSCA section 4(e)
Priority Testing List are listed in Table
4 of this unit.
TABLE 3—HIGH PRODUCTION VOLUME CHALLENGE PROGRAM ORPHAN CHEMICALS BEING REMOVED FROM THE TSCA
SECTION 4(e) PRIORITY TESTING LIST
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CAS No.
Chemical name
77–76–9 .............
81–07–2 .............
81–84–5 .............
85–40–5 .............
97–00–7 .............
101–34–8 ...........
104–93–8 ...........
110–33–8 ...........
111–91–1 ...........
118–90–1 ...........
138–25–0 ...........
139–40–2 ...........
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Propane, 2,2-dimethoxy-.
1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide.
1H,3H-Naphtho[1,8-cd]pyran-1,3-dione.
1H-Isoindole-1,3(2H)-dione, 3a,4,7,7a-tetrahydro-.
Benzene, 1-chloro-2,4-dinitro-.
9-Octadecenoic acid, 12-(acetyloxy)-, 1,1′,1″-(1,2,3-propanetriyl) ester, (9Z,9′Z,9″Z,12R,12′R,12″R)-.
Benzene, 1-methoxy-4-methyl-.
Hexanedioic acid, 1,6-dihexyl ester.
Ethane, 1,1′-[methylenebis(oxy)]bis[2-chloro-.
Benzoic acid, 2-methyl-.
1,3-Benzenedicarboxylic acid, 5-sulfo-, 1,3-dimethyl ester.
1,3,5-Triazine-2,4-diamine, 6-chloro-N2,N4-bis(1-methylethyl)-.
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TABLE 3—HIGH PRODUCTION VOLUME CHALLENGE PROGRAM ORPHAN CHEMICALS BEING REMOVED FROM THE TSCA
SECTION 4(e) PRIORITY TESTING LIST—Continued
CAS No.
Chemical name
140–93–2 ...........
142–73–4 ...........
330–54–1 ...........
513–74–6 ...........
529–33–9 ...........
557–61–9 ...........
563–72–4 ...........
592–45–0 ...........
617–94–7 ...........
628–13–7 ...........
628–96–6 ...........
645–62–5 ...........
693–95–8 ...........
756–80–9 ...........
939–97–9 ...........
1000–82–4 .........
1002–69–3 .........
1111–78–0 .........
1445–45–0 .........
1498–51–7 .........
1912–24–9 .........
2152–64–9 .........
2524–03–0 .........
2814–20–2 .........
2905–62–6 .........
2915–53–9 .........
3132–99–8 .........
3779–63–3 .........
3965–55–7 .........
4035–89–6 .........
4316–73–8 .........
5216–25–1 .........
5460–09–3 .........
5915–41–3 .........
7795–95–1 .........
10265–69–7 .......
13749–94–5 .......
13826–35–2 .......
17321–47–0 .......
19438–61–0 .......
19525–59–8 .......
20068–02–4 .......
20227–53–6 .......
Carbonodithioic acid, O-(1-methylethyl) ester, sodium salt (1:1).
Glycine, N-(carboxymethyl)-.
Urea, N ′ -(3,4-dichlorophenyl)-N,N-dimethyl-.
Carbamodithioic acid, ammonium salt (1:1).
1-Naphthalenol, 1,2,3,4-tetrahydro-.
1-Octacosanol.
Ethanedioic acid, calcium salt (1:1).
1,4-Hexadiene.
Benzenemethanol, .alpha.,.alpha.-dimethyl-.
Pyridine, hydrochloride (1:1).
1,2-Ethanediol, 1,2-dinitrate.
2-Hexenal, 2-ethyl-.
Thiazole, 4-methyl-.
Phosphorodithioic acid, O,O-dimethyl ester.
Benzaldehyde, 4-(1,1-dimethylethyl)-.
Urea, N-(hydroxymethyl)-.
Decane, 1-chloro-.
Carbamic acid, ammonium salt (1:1).
Ethane, 1,1,1-trimethoxy-.
Phosphorodichloridic acid, ethyl ester.
1,3,5-Triazine-2,4-diamine, 6-chloro-N2-ethyl-N4-(1-methylethyl)-.
Benzenamine, 4,4′-[[4-(phenylimino)-2,5-cyclohexadien-1-ylidene]methylene]bis[N-phenyl-, hydrochloride (1:1).
Phosphorochloridothioic acid, O,O-dimethyl ester.
4(3H)-Pyrimidinone, 6-methyl-2-(1-methylethyl)-.
Benzoyl chloride, 3,5-dichloro-.
2-Butenedioic acid (2Z)-, 1,4-dioctyl ester.
Benzaldehyde, 3-bromo-.
1,3,5-Triazine-2,4,6(1H,3H,5H)-trione, 1,3,5-tris(6-isocyanatohexyl)-.
1,3-Benzenedicarboxylic acid, 5-sulfo-, 1,3-dimethyl ester, sodium salt (1:1).
Imidodicarbonic diamide, N,N ′,2-tris(6-isocyanatohexyl)-.
Glycine, N-methyl-, sodium salt (1:1).
Benzene, 1-chloro-4-(trichloromethyl)-.
2,7-Naphthalenedisulfonic acid, 4-amino-5-hydroxy-, sodium salt (1:1).
1,3,5-Triazine-2,4-diamine, 6-chloro-N2-(1,1-dimethylethyl)-N4-ethyl-.
1-Octanesulfonyl chloride.
Glycine, N-phenyl-, sodium salt (1:1).
Ethanimidothioic acid, N-hydroxy-, methyl ester.
Benzenemethanol, 3-phenoxy-.
Phosphoramidothioic acid, O,O-dimethyl ester.
1,3-Isobenzofurandione, 5-methyl-.
Glycine, N-phenyl-, potassium salt (1:1).
2-Butenenitrile, 2-methyl-, (2Z)-.
Phosphorous acid, 2-(1,1-dimethylethyl)-4-[1-[3-(1,1-dimethylethyl)-4-hydroxyphenyl]-1-methylethyl]phenyl bis(4-nonylphenyl)
ester.
Piperazineethanol.
Benzene, chloromethyl-.
Phenol, (1-methylethyl)-.
Octadecanoic acid, 2-(1-carboxyethoxy)-1-methyl-2-oxoethyl ester, sodium salt (1:1).
Phosphorodithioic acid, O,O-dimethyl ester, sodium salt (1:1).
Phosphorous acid, isooctyl diphenyl ester.
Phenol, (1,1,3,3-tetramethylbutyl)-.
2-Butenenitrile, 2-methyl-, (2E)-.
Phenol, methyl-, sodium salt (1:1).
Benzenesulfonic acid, 4-chloro-3,5-dinitro-, potassium salt (1:1).
Benzaldehyde, 3-phenoxy-.
1-Octanesulfonyl fluoride.
Butanedioic acid, 2-oxo-, 1,4-diethyl ester, ion(1-), sodium (1:1).
Benzene, 1-(bromomethyl)-3-phenoxy-.
Ethanol, 2-butoxy-, sodium salt (1:1).
Chromate(3-),
bis[3-(hydroxy-.kappa.O)-4-[2-[2-(hydroxy-.kappa.O)-1-naphthalenyl]
diazenyl-.kappa.N1]-7-nitro-1naphthalenesulfonato(3-)]-, sodium (1:3).
Sulfonic acids, petroleum.
Phosphorochloridous acid, bis(4-nonylphenyl) ester.
Alkenes, C>10 .alpha.-.
Phenols (petroleum).
Extracts, coal tar oil alk.
Extract oils (coal), tar base.
Extract residues (coal), tar oil alk.
Phenol, nonyl derivs.
Paraffin oils, chlorosulfonated, saponified.
Fatty acids, tall-oil, 2-(2-hydroxyethoxy)ethyl esters.
emcdonald on DSK67QTVN1PROD with NOTICES2
25154–38–5
25168–05–2
25168–06–3
25383–99–7
26377–29–7
26401–27–4
27193–28–8
30574–97–1
34689–46–8
38185–06–7
39515–51–0
40630–63–5
40876–98–0
51632–16–7
52663–57–7
57693–14–8
.......
.......
.......
.......
.......
.......
.......
.......
.......
.......
.......
.......
.......
.......
.......
.......
61789–85–3
63302–49–8
64743–02–8
64743–03–9
65996–83–0
65996–86–3
65996–87–4
68081–86–7
68188–18–1
68309–16–0
.......
.......
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TABLE 3—HIGH PRODUCTION VOLUME CHALLENGE PROGRAM ORPHAN CHEMICALS BEING REMOVED FROM THE TSCA
SECTION 4(e) PRIORITY TESTING LIST—Continued
CAS No.
Chemical name
68608–59–3 .......
68609–05–2 .......
68815–50–9 .......
68915–05–9 .......
68918–16–1 .......
68937–29–1 .......
68937–69–9 .......
68955–37–3 .......
68987–41–7 .......
68987–66–6 .......
68990–65–8 .......
70851–08–0 .......
72854–27–4 .......
83864–02–2 .......
84501–86–0 .......
90640–86–1 .......
125997–20–8 .....
Ethane, 1,2-dichloro-, manuf. of, by-products from, distn. lights.
Cyclohexane, oxidized, non-acidic by-products, distn. lights.
Octadecanoic acid, reaction products with 2-[(2-aminoethyl)amino]ethanol.
Fatty acids, tall-oil, low-boiling, reaction products with ammonia-ethanolamine reaction by-products.
Tar, coal, dried and oxidized.
1,6-Hexanediol, distn. residues.
Carboxylic acids, C6–18 and C5–15-di-.
Acid chlorides, tallow, hydrogenated.
Benzene, ethylenated.
Ethene, hydrated, by-products from.
Fats and Glyceridic oils, vegetable, reclaimed.
Amides, coco, N-[3-(dimethylamino)propyl], alkylation products with sodium 3-chloro-2-hydroxypropanesulfonate.
Tannins, reaction products with sodium bisulfite, sodium polysulfide and sodium sulfite.
Nickel, bis[(cyano-.kappa.C)triphenylborato(1-)-kappa.N]bis(hexanedinitrile-.kappa.N,.kappa.N ′)-.
Hexanedioic acid, esters with high-boiling C6–10-alkene hydroformylation products.
Distillates (coal tar), heavy oils.
Phosphoric acid, mixed 3-bromo-2,2-dimethylpropyl and 2-bromoethyl and 2-chloroethyl esters.
TABLE 4—HIGH PRODUCTION VOLUME PROGRAM ORPHAN CHEMICALS REMAINING ON THE TSCA SECTION 4(e) PRIORITY
TESTING LIST
emcdonald on DSK67QTVN1PROD with NOTICES2
CAS No.
Chemical name
94–96–2 .............
104–66–5 ...........
107–39–1 ...........
107–40–4 ...........
111–85–3 ...........
121–82–4 ...........
137–20–2 ...........
529–34–0 ...........
590–19–2 ...........
598–72–1 ...........
1401–55–4 .........
1738–25–6 .........
2210–79–9 .........
2372–45–4 .........
2409–55–4 .........
2425–54–9 .........
2691–41–0 .........
3039–83–6 .........
3386–33–2 .........
4170–30–3 .........
4860–03–1 .........
8001–58–9 .........
17103–31–0 .......
17976–43–1 .......
21351–39–3 .......
24794–58–9 .......
26680–54–6 .......
28908–00–1 .......
38321–18–5 .......
52184–19–7 .......
56803–37–3 .......
68187–41–7 .......
68187–59–7 .......
68308–74–7 .......
68309–27–3 .......
68441–66–7 .......
68515–89–9 .......
68527–22–0 .......
68584–25–8 .......
68602–81–3 .......
68649–42–3 .......
68650–36–2 .......
68782–97–8 .......
68919–17–5 .......
68953–80–0 .......
68955–76–0 .......
68990–61–4 .......
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1,3-Hexanediol, 2-ethyl-.
Benzene, 1,1′-[1,2-ethanediylbis(oxy)]bis-.
1-Pentene, 2,4,4-trimethyl-.
2-Pentene, 2,4,4-trimethyl-.
Octane, 1-chloro-.
1,3,5-Triazine, hexahydro-1,3,5-trinitro-.
Ethanesulfonic acid, 2-[methyl[(9Z)-1-oxo-9-octadecen-1-yl]amino]-, sodium salt (1:1).
1(2H)-Naphthalenone, 3,4-dihydro-.
1,2-Butadiene.
Propanoic acid, 2-bromo-.
Tannins.
Propanenitrile, 3-(dimethylamino)-.
Oxirane, 2-[(2-methylphenoxy)methyl]-.
1-Butanol, sodium salt (1:1).
Phenol, 2-(1,1-dimethylethyl)-4-methyl-.
Tetradecane, 1-chloro-.
1,3,5,7-Tetrazocine, octahydro-1,3,5,7-tetranitro-.
Ethenesulfonic acid, sodium salt (1:1).
Octadecane, 1-chloro-.
2-Butenal.
Hexadecane, 1-chloro-.
Creosote.
Urea, sulfate (2:1).
2,4,6,8,3,5,7-Benzotetraoxatriplumbacycloundecin-3,5,7-triylidene, 1,9-dihydro-1,9-dioxo-.
Urea, sulfate (1:1).
Formic acid, compd. with 2,2′,2″-nitrilotris[ethanol] (1:1).
2,5-Furandione, dihydro-3-(octen-1-yl)-.
Benzothiazole, 2-[(chloromethyl)thio]-.
Ethanol, 2-(2-butoxyethoxy)-, sodium salt (1:1).
Phenol, 2,4-bis(1,1-dimethylpropyl)-6-[2-(2-nitrophenyl)diazenyl]-.
Phosphoric acid, (1,1-dimethylethyl)phenyl diphenyl ester.
Phosphorodithioic acid, O,O-di-C1–14-alkyl esters.
Coal, anthracite, calcined.
Amides, tall-oil fatty, N,N-di-Me.
Fatty acids, tall-oil, sulfonated, sodium salts.
Decanoic acid, mixed esters with dipentaerythritol, octanoic acid and valeric acid.
Barium, carbonate nonylphenol complexes.
Naphtha (petroleum), clay-treated light straight-run.
Benzenesulfonic acid, C10–16-alkyl derivs., compds. with triethanolamine.
Distillates, hydrocarbon resin prodn. higher boiling.
Phosphorodithioic acid, O,O-di-C1–14-alkyl esters, zinc salts.
Aromatic hydrocarbons, C8, o-xylene-lean.
Distillates (petroleum), hydrofined lubricating-oil.
Hydrocarbons, C12–20, catalytic alkylation by-products.
Benzene, mixed with toluene, dealkylation product.
Aromatic hydrocarbons, C9–16, biphenyl deriv.-rich.
Tar, coal, high-temp., high-solids.
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TABLE 4—HIGH PRODUCTION VOLUME PROGRAM ORPHAN CHEMICALS REMAINING ON THE TSCA SECTION 4(e) PRIORITY
TESTING LIST—Continued
CAS No.
Chemical name
70084–98–9 .......
71077–05–9 .......
119345–02–7 .....
Terpenes and Terpenoids, C10–30, distn. residues.
Ethanol, 2,2′-oxybis-, reaction products with ammonia, morpholine product tower residues.
Benzene, 1,1′-oxybis-, tetrapropylene derivs.
C. Diisocyanates and Related
Compounds
At the request of the current EPA
member to the ITC, 69 diisocyanates
and related compounds were added to
the TSCA section 4(e) Priority Testing
List in the ITC’s 69th Report. They were
added to obtain numerous data on
diisocyanates and related compounds
used to formulate a broad class of
polyurethane products (e.g., sealants,
adhesives, etc.) that are intended to
further react upon end-use (Ref. 4). The
EPA determined that 50 of these
diisocyanates and related compounds
were not reported to the EPA’s 2006 IUR
and 2012 CDR rules. Since these 50
diisocyanates and related compounds
were not reported to the EPA’s 2006 IUR
and 2012 CDR rules, EPA is requesting
their removal from the TSCA section
4(e) Priority Testing List in this 72nd
ITC Report (Ref. 17). The 50
diisocyanates and related compounds
being removed from the TSCA section
4(e) Priority Testing List are listed in
Table 5 of this unit. The 19
diisocyanates and related compounds
remaining on the TSCA section 4(e)
Priority Testing List are listed in Table
6 of this unit.
TABLE 5—FIFTY DIISOCYANATES AND RELATED COMPOUNDS BEING REMOVED FROM THE TSCA SECTION 4(e) PRIORITY
TESTING LIST
emcdonald on DSK67QTVN1PROD with NOTICES2
CAS No.
Chemical name
104–49–4 ...........
123–61–5 ...........
139–25–3 ...........
2422–91–5 .........
2536–05–2 .........
3634–83–1 .........
4035–89–6 .........
4128–73–8 .........
7517–76–2 .........
9017–01–0 .........
9019–85–6 .........
10347–54–3 .......
13622–90–7 .......
16325–38–5 .......
17589–24–1 .......
23370–68–5 .......
25686–28–6 .......
25854–16–4 .......
26603–40–7 .......
31107–36–5 .......
38661–72–2 .......
42170–25–2 .......
50639–37–7 .......
50830–59–6 .......
51508–06–6 .......
53880–05–0 .......
55525–54–7 .......
60732–52–7 .......
65087–21–0 .......
65104–99–6 .......
65105–00–2 .......
65105–02–4 .......
67873–91–0 .......
68083–39–6 .......
68092–73–9 .......
68092–74–0 .......
68133–14–2 .......
68310–46–3 .......
Benzene, 1,4-diisocyanato-.
Benzene, 1,3-diisocyanato-.
Benzene, 1,1′-methylenebis[4-isocyanato-3-methyl-.
Benzene, 1,1′,1″-methylidynetris[4-isocyanato-.
Benzene, 1,1′-methylenebis[2-isocyanato-.
Benzene, 1,3-bis(isocyanatomethyl)-.
Imidodicarbonic diamide, N,N ′2-tris(6-isocyanatohexyl)-.
Benzene, 1,1′-oxybis[4-isocyanato-.
Cyclohexane, 1,4-diisocyanato-, trans-.
Benzene, 1,3-diisocyanatomethyl-, homopolymer; TDI homopolymer.
Benzene, 1,3-diisocyanatomethyl-, trimer.
Cyclohexane, 1,4-bis(isocyanatomethyl)-.
Cyclohexane, 1,1′-methylenebis[4-isocyanato-, (trans,trans)-.
Benzene, 1,2,4,5-tetrachloro-3,6-bis(isocyanatomethyl)-.
1,3-Diazetidine-2,4-dione, 1,3-bis[4-[(4-isocyanatophenyl)methyl]phenyl]-.
1,3-Diazetidine-2,4-dione, 1,3-bis[(5-isocyanato-1,3,3-trimethylcyclohexyl)methyl]-.
Benzene, 1,1′-methylenebis[4-isocyanato-, homopolymer; MDI homopolymer.
Benzene, bis(isocyanatomethyl)-.
1,3,5-Triazine-2,4,6(1H,3H,5H)-trione, 1,3,5-tris(3-isocyanatomethylphenyl)-.
1,3-Diazetidine-2-one, 1,3-bis[4-[(4-isocyanatophenyl)methyl]phenyl]-4-[[4-[(4-isocyanatophenyl)methyl]phenyl]imino]-.
Cyclohexane, 1,3-bis(isocyanatomethyl)-.
Cyclohexane, bis(isocyanatomethyl)-.
2H-1,3,5-Oxadiazine-2,4,6(3H,5H)-trione, 3,5-bis(6-isocyanatohexyl)-.
1,3,4-Thiadiazole, 2-isocyanato-5-(trifluoromethyl)-, dimer.
1,3,4-Thiadiazole, 2-(1,1-dimethylethyl)-5-isocyanato-, dimer.
Cyclohexane, 5-isocyanato-1-(isocyanatomethyl)-1,3,3-trimethyl-, homopolymer; isophorone diisocyanate homopolymer.
Urea, N,N ′-bis[(5-isocyanato-1,3,3-trimethylcyclohexyl)methyl]-.
Carbamic acid, N,N’-(3-isocyanatomethylphenyl)-, C,C ′-(oxydi-2,1-ethanediyl) ester.
Carbamic acid, N-[4-[(4-isocyanatocyclohexyl)methyl]cyclohexyl]-, C,C ′-(oxydi-2,1-ethanediyl) ester.
Imidodicarbonic diamide, 2,2′-[methylenebis(2-chloro-4,1-phenylene)]bis[N,N ′-bis(3-isocyanatomethylphenyl)-.
Carbamic acid, N-(3-isocyanatomethylphenyl)-, C,C ′-(1-methyl-1,3-propanediyl) ester.
Carbamic acid, N-(3-isocyanatomethylphenyl)-, C,C ′-(1,4-butanediyl) ester.
1,3,5-Triazine-2,4,6(1H,3H,5H)-trione, 1,3,5-tris[(5-isocyanato-1,3,3-trimethylcyclohexyl)methyl]-.
Benzenamine, N,N ′-methanetetraylbis[3-isocyanato-2,4,6-tris(1-methylethyl)-.
Carbamic acid, N-(3-isocyanatomethylphenyl)-, C,C ′-(1,2-ethanediyl) ester.
Carbamic acid, N-(3-isocyanatomethylphenyl)-, C,C ′-[oxybis(1-methyl-2,1-ethanediyl)] ester.
Carbamic acid, N-(3-isocyanatomethylphenyl)-, C,C ′-[[[(diethoxyphosphinyl)methyl]imino]di-2,1-ethanediyl] ester.
Hexanoic
acid,
[[2-ethyl-2-[[[[[5-isocyanato-1(or
5)-(methoxycarbonyl)pentyl]amino]carbonyl]oxy]methyl]-1,3propanediyl]bis(oxycarbonylimino)]bis[isocyanato-, 1,1′-dimethyl ester.
Carbamic acid, N-[5-isocyanato-2(or 4)-methylphenyl]-, C,C ′-(1-methyl-1,3-propanediyl) ester.
1,3-Diazetidine-2,4-dione, 1,3-bis(4-isocyanato-3-methylphenyl)-.
Carbamic acid, N-[(5-isocyanato-1,3,3-trimethylcyclohexyl)methyl]-, C,C ′-(oxydi-2,1-ethanediyl) ester.
Hexanoic acid, 2,6-diisocyanato-, 2-isocyanatoethyl ester.
Hexatriacontane, diisocyanato-, branched.
Undecane, 1,6,11-triisocyanato-.
Urea, N-(3-isocyanatomethylphenyl)-N ′-[[[4-[[[(3-isocyanatomethylphenyl)amino]carbonyl]amino]phenyl]methyl]phenyl]-.
Carbamic acid, N-[4-[(4-isocyanatophenyl)methyl]phenyl]-, C,C ′-(oxydi-2,1-ethanediyl) ester.
68366–14–3
68555–56–6
68975–84–8
69878–18–8
70024–76–9
70198–24–2
71130–76–2
71832–70–7
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TABLE 5—FIFTY DIISOCYANATES AND RELATED COMPOUNDS BEING REMOVED FROM THE TSCA SECTION 4(e) PRIORITY
TESTING LIST—Continued
CAS No.
Chemical name
75790–84–0 .......
75790–87–3 .......
85702–90–5 .......
Benzene, 2-isocyanato-4-[(4-isocyanatophenyl)methyl]-1-methyl-.
Benzene, 1-isocyanato-2-[(4-isocyanatophenyl)thio]-.
2,9,11,13-Tetraazanonadecanethioic acid, 19-isocyanato-11-(6-isocyanatohexyl)-10,12-dioxo-, S-[3-(trimethoxysilyl)propyl]
ester.
Benzenamine, 4-isocyanato-N,N-bis(4-isocyanatophenyl)-2,5-dimethoxy-.
106790–31–2 .....
TABLE 6—NINETEEN DIISOCYANATES AND RELATED COMPOUNDS REMAINING ON THE TSCA SECTION 4(e) PRIORITY
TESTING LIST
CAS No.
Chemical name
91–08–7 .............
91–97–4 .............
101–68–8 ...........
584–84–9 ...........
822–06–0 ...........
2778–42–9 .........
3173–72–6 .........
3779–63–3 .........
4098–71–9 .........
5124–30–1 .........
5873–54–1 .........
9016–87–9 .........
15646–96–5 .......
16938–22–0 .......
26447–40–5 .......
26471–62–5 .......
26747–90–0 .......
28182–81–2 .......
68239–06–5 .......
Benzene, 1,3-diisocyanato-2-methyl-.
1,1′-Biphenyl, 4,4′-diisocyanato-3,3′-dimethyl-.
Benzene, 1,1′-methylenebis[4-isocyanato-.
Benzene, 2,4-diisocyanato-1-methyl-.
Hexane, 1,6-diisocyanato-.
Benzene, 1,3-bis(1-isocyanato-1-methylethyl)-.
Naphthalene, 1,5-diisocyanato-.
1,3,5-Triazine-2,4,6(1H,3H,5H)-trione, 1,3,5-tris(6-isocyanatohexyl)-.
Cyclohexane, 5-isocyanato-1-(isocyanatomethyl)-1,3,3-trimethyl-.
Cyclohexane, 1,1′-methylenebis[4-isocyanato-.
Benzene, 1-isocyanato-2-[(4-isocyanatophenyl)methyl]-.
Isocyanic acid, polymethylenepolyphenylene ester.
Hexane, 1,6-diisocyanato-2,4,4-trimethyl-.
Hexane, 1,6-diisocyanato-2,2,4-trimethyl-.
Benzene, 1,1′-methylenebis[isocyanato-.
Benzene, 1,3-diisocyanatomethyl-.
1,3-Diazetidine-2,4-dione, 1,3-bis(3-isocyanatomethylphenyl)-.
Hexane, 1,6-diisocyanato-, homopolymer; HDI homopolymer.
Cyclohexane, 2-heptyl-3,4-bis(9-isocyanatononyl)-1-pentyl-.
emcdonald on DSK67QTVN1PROD with NOTICES2
IV. References
1. ITC. Thirty-Seventh Report of the ITC;
Notice. Federal Register (61 FR 4188,
February 2, 1996) (FRL–4991–6).
Available at www.regulations.gov.
Docket ID number EPA–HQ–OPPT–
2013–0248.
2. ITC. Forty-First Report of the ITC; Notice.
Federal Register (63 FR 17658, April 9,
1998) (FRL–5773–5). Available at
www.regulations.gov. Docket ID number
EPA–HQ–OPPT–2013–0248.
3. ITC. Sixty-Eighth Report of the ITC;
Notice. Federal Register (76 FR 46174,
August 1, 2011) (FRL–8879–3). Available
at www.regulations.gov. Docket ID
number EPA–HQ–OPPT–2013–0248.
4. ITC. Sixty-Ninth Report of the ITC; Notice.
Federal Register (77 FR 30856, May 23,
2012) (FRL–9346–3). Available at
www.regulations.gov. Docket ID number
EPA–HQ–OPPT–2013–0248.
5. ITC. Thirty-First Report of the ITC; Notice.
Federal Register (58 FR 26898, May 5,
1993) (FRL–4583–4). Available at
www.regulations.gov. Docket ID number
EPA–HQ–OPPT–2013–0248.
6. ITC. Thirty-Second Report of the ITC;
Notice. Federal Register (58 FR 38490,
July 16, 1993) (FRL–4630–2). Available
at www.regulations.gov. Docket ID
number EPA–HQ–OPPT–2013–0248.
7. ITC. Thirty-Fifth Report of the ITC; Notice.
Federal Register (59 FR 67596,
December 29, 1994) (FRL–4923–2).
Available at www.regulations.gov.
VerDate Mar<15>2010
18:42 Jul 23, 2013
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Docket ID number EPA–HQ–OPPT–
2013–0248.
8. ITC. Thirty-Fourth Report of the ITC;
Notice. Federal Register (59 FR 35720,
July 13, 1994) (FRL–4870–4). Available
at www.regulations.gov. Docket ID
number EPA–HQ–OPPT–2013–0248.
9. ITC. Thirty-Sixth Report of the ITC; Notice.
Federal Register (60 FR 42982, August
17, 1995) (FRL–4965–6). Available at
www.regulations.gov. Docket ID number
EPA–HQ–OPPT–2013–0248.
10. ITC. Forty-Fifth Report of the ITC; Notice.
Federal Register (65 FR 75544,
December 1, 2000) (FRL–6399–5).
Available at www.regulations.gov.
Docket ID number EPA–HQ–OPPT–
2013–0248.
11. EPA. Proposed Test Rule for In Vitro
Dermal Absorption Rate Testing of
Certain Chemicals of Interest to
Occupational Safety and Health
Administration; Proposed Rule. Federal
Register (64 FR 31074, June 9, 1999)
(FRL–5760–3). Available at
www.regulations.gov. Docket ID number
EPA–HQ–OPPT–2013–0248.
12. EPA. In Vitro Dermal Absorption Rate
Testing of Certain Chemicals of Interest
to the Occupational Safety and Health
Administration; Final Rule. Federal
Register (69 FR 22402, April 26, 2004)
(FRL–7312–2). Available at
www.regulations.gov. Docket ID number
EPA–HQ–OPPT–2013–0248.
13. ITC. Fifty-Ninth Report of the ITC;
Notice. Federal Register (72 FR 2756,
PO 00000
Frm 00009
Fmt 4701
Sfmt 4703
January 22, 2007) (FRL 8110–2).
Available at www.regulations.gov.
Docket ID number EPA–HQ–OPPT–
2013–0248.
14. OSHA. Letter to Dr. John D. Walker, re:
OSHA’s comments for removal of 16
chemicals on the TSCA Section 4(e)
Priority Testing List. April 10, 2013.
Available at www.regulations.gov.
Docket ID number EPA–HQ–OPPT–
2013–0248.
15. ITC. Fifty-Fifth Report of the ITC; Notice.
Federal Register (70 FR 7364, February
11, 2005) (FRL–7692–1). Available at
www.regulations.gov. Docket ID number
EPA–HQ–OPPT–2013–0248.
16. ITC. Fifty-Sixth Report of the ITC; Notice.
Federal Register (70 FR 61520, October
24, 2005) (FRL–7739–9). Available at
www.regulations.gov. Docket ID number
EPA–HQ–OPPT–2013–0248.
17. EPA. Memo to Dr. John D. Walker, re:
EPA’s comments on removal of 98 High
Production Volume (HPV) Challenge
Program orphan chemicals and 50
diisocyants and related compounds from
the TSCA Section 4(e) Priority Testing
List. May 8, 2013. Available at
www.regulations.gov. Docket ID number
EPA–HQ–OPPT–2013–0248.
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V. The TSCA Interagency Testing
Committee
Statutory Organizations With
Representatives
emcdonald on DSK67QTVN1PROD with NOTICES2
Department of Commerce
National Institute of Standards and
Technology
Michele Schantz, Member
Jessica Reliner, Alternate
Environmental Protection Agency
Robert W. Jones, Member
John E. Schaeffer, Alternate
National Institute of Environmental
Health Sciences
Nigel Walker, Member
Scott Masten, Alternate
National Institute for Occupational
Safety and Health
Dennis W. Lynch, Alternate
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National Science Foundation
Tyrone D. Mitchell, Member
Occupational Safety and Health
Administration
Janet Carter, Member and Chairperson
Thomas Nerad, Alternate
Barnett A. Rattner, Member
Food and Drug Administration
Kirk Arvidson, Member
Ronald F. Chanderbhan, Alternate
Liaison Organizations With
Representatives
John D. Walker, Director
Carol Savage, Administrative Assistant
(NOWCC Employee)
Agency for Toxic Substances and
Disease Registry
Glenn D. Todd, Member
Consumer Product Safety Commission
Dominique Johnson, Member
Department of Agriculture
Clifford P. Rice, Member
Cathleen J. Hapeman, Alternate
Department of Defense
Laurie E. Roszell, Member
Department of the Interior
PO 00000
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ITC Staff
TSCA Interagency Testing Committee
(7405M), Office of Pollution Prevention
and Toxics, Environmental Protection
Agency, 1200 Pennsylvania Ave. NW.,
Washington, DC 20460–0001; email
address: savage.carol@epa.gov; URL:
https://www.epa.gov/oppt/itc.
[FR Doc. 2013–17545 Filed 7–23–13; 8:45 am]
BILLING CODE 6560–50–P
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[Federal Register Volume 78, Number 142 (Wednesday, July 24, 2013)]
[Notices]
[Pages 44857-44866]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 2013-17545]
[[Page 44857]]
Vol. 78
Wednesday,
No. 142
July 24, 2013
Part V
Environmental Protection Agency
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Seventy-Second Report of the TSCA Interagency Testing Committee to the
Administrator of the Environmental Protection Agency; Receipt of Report
and Request for Comments; Notice
Federal Register / Vol. 78, No. 142 / Wednesday, July 24, 2013 /
Notices
[[Page 44858]]
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ENVIRONMENTAL PROTECTION AGENCY
[EPA-HQ-OPPT-2013-0248; FRL-9391-5]
Seventy-Second Report of the TSCA Interagency Testing Committee
to the Administrator of the Environmental Protection Agency; Receipt of
Report and Request for Comments
AGENCY: Environmental Protection Agency (EPA).
ACTION: Notice.
-----------------------------------------------------------------------
SUMMARY: The Toxic Substances Control Act (TSCA) Interagency Testing
Committee (ITC) transmitted its 72nd ITC Report to the Acting EPA
Administrator on June 13, 2013. In the 72nd ITC Report, which is
included with this notice, the ITC is revising the TSCA section 4(e)
Priority Testing List by removing 16 chemicals with insufficient dermal
absorption rate data, 98 High Production Volume (HPV) Challenge Program
orphan chemicals, and 50 diisocyanates and related compounds. The ITC
is removing 16 chemicals with insufficient dermal absorption rate data
because information from dermal studies can be readily obtained through
the Organization for Economic Cooperation and Development (OECD) and
EPA databases or other authoritative scientific resources. The ITC is
removing the 98 HPV Challenge Program orphan chemicals because they no
longer meet the = 1 million lb criterion for the HPV
Challenge Program. The ITC is removing the 50 diisocyanates and related
compounds because their production or importation volumes were not
reported to the 2006 Inventory Update Reporting (IUR) rule or the 2012
Chemical Data Reporting (CDR) rule.
DATES: Comments must be received on or before August 23, 2013.
ADDRESSES: Submit your comments, identified by docket identification
(ID) number EPA-HQ-OPPT-2013-0248, by one of the following methods:
Federal eRulemaking Portal: https://www.regulations.gov.
Follow the online instructions for submitting comments.
Mail: Document Control Office (7407M), Office of Pollution
Prevention and Toxics (OPPT), Environmental Protection Agency, 1200
Pennsylvania Ave. NW., Washington, DC 20460-0001.
Hand Delivery: OPPT Document Control Office (DCO), EPA
East Bldg., Rm. 6428, 1201 Constitution Ave. NW., Washington, DC. ATTN:
Docket ID Number EPA-HQ-OPPT-2013-0248. The DCO is open from 8 a.m. to
4 p.m., Monday through Friday, excluding legal holidays. The telephone
number for the DCO is (202) 564-8930. Such deliveries are only accepted
during the DCO's normal hours of operation, and special arrangements
should be made for deliveries of boxed information.
Instructions: Direct your comments to docket ID number EPA-HQ-OPPT-
2013-0248. EPA's policy is that all comments received will be included
in the docket without change and may be made available online at https://www.regulations.gov, including any personal information provided,
unless the comment includes information claimed to be Confidential
Business Information (CBI) or other information whose disclosure is
restricted by statute. Do not submit information that you consider to
be CBI or otherwise protected through regulations.gov or email. The
regulations.gov Web site is an ``anonymous access'' system, which means
EPA will not know your identity or contact information unless you
provide it in the body of your comment. If you send an email comment
directly to EPA without going through regulations.gov, your email
address will be automatically captured and included as part of the
comment that is placed in the docket and made available on the
Internet. If you submit an electronic comment, EPA recommends that you
include your name and other contact information in the body of your
comment and with any disk or CD-ROM you submit. If EPA cannot read your
comment due to technical difficulties and cannot contact you for
clarification, EPA may not be able to consider your comment. Electronic
files should avoid the use of special characters, any form of
encryption, and be free of any defects or viruses.
Docket: All documents in the docket are listed in the docket index
available at https://www.regulations.gov. Although listed in the index,
some information is not publicly available, e.g., CBI or other
information whose disclosure is restricted by statute. Certain other
material, such as copyrighted material, will be publicly available only
in hard copy. Publicly available docket materials are available
electronically at https://www.regulations.gov, or, if only available in
hard copy, at the OPPT Docket. The OPPT Docket is located in the EPA
Docket Center (EPA/DC) at Rm. 3334, EPA West Bldg., 1301 Constitution
Ave. NW., Washington, DC. The EPA/DC Public Reading Room hours of
operation are 8:30 a.m. to 4:30 p.m., Monday through Friday, excluding
legal holidays. The telephone number of the EPA/DC Public Reading Room
is (202) 566-1744, and the telephone number for the OPPT Docket is
(202) 566-0280. Docket visitors are required to show photographic
identification, pass through a metal detector, and sign the EPA visitor
log. All visitor bags are processed through an X-ray machine and
subject to search. Visitors will be provided an EPA/DC badge that must
be visible at all times in the building and returned upon departure.
FOR FURTHER INFORMATION CONTACT: For technical information contact:
John D. Walker, TSCA Interagency Testing Committee (7405M), Chemical
Control Division, Office of Pollution Prevention and Toxics,
Environmental Protection Agency, 1200 Pennsylvania Ave. NW.,
Washington, DC 20460-0001; telephone number: (202) 564-7527; fax
number: (202) 564-7528; email address: walker.johnd@epa.gov.
For general information contact: The TSCA-Hotline, ABVI-Goodwill,
422 South Clinton Ave., Rochester, NY 14620; telephone number: (202)
554-1404; email address: TSCA-Hotline@epa.gov.
SUPPLEMENTARY INFORMATION:
I. General Information
A. Does this action apply to me?
This notice is directed to the public in general. It may, however,
be of particular interest to you if you manufacture (defined by statute
to include import) and/or process TSCA-covered chemicals and you may be
identified by the North American Industrial Classification System
(NAICS) codes 325 and 32411. Because this notice is directed to the
general public and other entities may also be interested, the Agency
has not attempted to describe all the specific entities that may be
interested in this action.
B. What should I consider as I prepare my comments for EPA?
1. Submitting CBI. Do not submit this information to EPA through
regulations.gov or email. Clearly mark the part or all of the
information that you claim to be CBI. For CBI information in a disk or
CD-ROM that you mail to EPA, mark the outside of the disk or CD-DOM as
CBI and then identify electronically within the disk or CD-ROM the
specific information that is claimed as CBI. In addition to one
complete version of the comment that includes information claimed as
CBI, a copy of the comment that does not contain the information
claimed as CBI must be submitted for inclusion in the public docket.
Information so marked will not be disclosed except in accordance with
procedures set forth in 40 CFR part 2.
[[Page 44859]]
2. Tips for preparing your comments. When submitting comments,
remember to:
i. Identify the document by docket ID number and other identifying
information (subject heading, Federal Register date and page number).
ii. Follow directions. The Agency may ask you to respond to
specific questions or organize comments by referencing a Code of
Federal Regulations (CFR) part or section number.
iii. Explain why you agree or disagree; suggest alternatives and
substitute language for your requested changes.
iv. Describe any assumptions and provide any technical information
and/or data that you used.
v. If you estimate potential costs or burdens, explain how you
arrived at your estimate in sufficient detail to allow for it to be
reproduced.
vi. Provide specific examples to illustrate your concerns and
suggest alternatives.
vii. Explain your views as clearly as possible, avoiding the use of
profanity or personal threats.
viii. Make sure to submit your comments by the comment period
deadline identified.
II. Background
The Toxic Substances Control Act (TSCA) (15 U.S.C. 260l et seq.)
authorizes the Administrator of EPA to promulgate regulations under
TSCA section 4(a) requiring testing of chemicals and chemical groups in
order to develop data relevant to determining the risks that such
chemicals and chemical groups may present to health or the environment.
Section 4(e) of TSCA established the ITC to recommend chemicals and
chemical groups to the Administrator of EPA for priority testing
consideration. Section 4(e) of TSCA directs the ITC to revise the TSCA
section 4(e) Priority Testing List at least every 6 months.
You may access additional information about the ITC at https://www.epa.gov/oppt/itc.
A. The 72nd ITC Report
The ITC is revising the TSCA section 4(e) Priority Testing List by
removing 16 chemicals with insufficient dermal absorption rate data, 98
HPV Challenge Program orphan chemicals, and 50 diisocyanates and
related compounds.
B. Status of the TSCA Section 4(e) Priority Testing List
The TSCA section 4(e) Priority Testing List includes 2
alkylphenols, 50 HPV Challenge Program orphan chemicals, cadmium, a
category of cadmium compounds, 6 non-phthalate plasticizers, 25
phosphate ester flame retardants, 2 other flame retardants, 9 chemicals
to which children living near hazardous waste sites may be exposed, and
19 diisocyanates and related compounds.
List of Subjects
Environmental protection, Chemicals, Hazardous substances.
Dated: July 15, 2013.
Wendy C. Hamnett,
Director, Office of Pollution Prevention and Toxics.
Seventy-Second Report of the TSCA Interagency Testing Committee to the
Administrator of the Environmental Protection Agency
Table of Contents
Summary
I. Background
II. ITC's Activities During This Reporting Period (December 2012 to
May 2013)
III. Chemicals Removed From the TSCA Section 4(e) Priority Testing
List
A. Chemicals With Insufficient Dermal Absorption Rate Data
B. HPV Challenge Program Orphan Chemicals
C. Diisocyanates and Related Compounds
IV. References
V. The TSCA Interagency Testing Committee
Summary
The ITC is revising the Toxic Substances Control Act (TSCA) section
4(e) Priority Testing List by removing 16 chemicals with insufficient
dermal absorption rate data, 98 High Production Volume (HPV) Challenge
Program orphan chemicals, and 50 diisocyanates and related compounds.
The TSCA section 4(e) Priority Testing List is Table 1 of this
unit.
Table 1--TSCA Section 4(e) Priority Testing List
[May 2013]
----------------------------------------------------------------------------------------------------------------
ITC report Date Chemical name/group Action
----------------------------------------------------------------------------------------------------------------
37..................... November 1995........ Branched 4-nonylphenol (mixed Recommended.
isomers).
41..................... November 1997........ Phenol, 4-(1,1,3,3-tetramethylbutyl)- Recommended.
.
55..................... December 2004........ 49 High Production Volume (HPV) Recommended.
Challenge Program orphan chemicals.
56..................... August 2005.......... 1 HPV Challenge Program orphan Recommended.
chemical, naphtha (petroleum), clay-
treated light straight-run.
68..................... May 2011............. Cadmium............................. Recommended.
69..................... November 2011........ Cadmium compounds................... Recommended.
69..................... November 2011........ 6 Non-phthalate plasticizers........ Recommended.
69..................... November 2011........ 25 Phosphate ester flame retardants. Recommended.
69..................... November 2011........ 2 Other flame retardants............ Recommended.
69..................... November 2011........ 9 Chemicals to which children living Recommended.
near hazardous waste sites may be
exposed.
69..................... November 2011........ 19 Diisocyanates and related Recommended.
compounds.
----------------------------------------------------------------------------------------------------------------
I. Background
The ITC was established by TSCA section 4(e) ``to make
recommendations to the Administrator respecting the chemical substances
and mixtures to which the Administrator should give priority
consideration for the promulgation of rules for testing under section
4(a) * * * At least every six months * * *, the Committee shall make
such revisions to the Priority Testing List as it determines to be
necessary and transmit them to the Administrator together with the
Committee's reasons for the revisions'' (Public Law 94-469, 90 Stat.
2003 et seq., 15 U.S.C. 2601 et seq.). ITC reports are available from
the ITC's Web site (https://www.epa.gov/oppt/itc) and from
regulations.gov (https://www.regulations.gov) after publication in the
Federal Register. The ITC produces its revisions to the TSCA section
4(e) Priority Testing List with administrative and technical support
from the ITC staff and ITC members. ITC members and staff are listed at
the end of this report.
[[Page 44860]]
II. ITC's Activities During This Reporting Period (December 2012 to May
2013)
The ITC welcomed a new member and new alternate member from the
Department of Commerce's National Institute of Standards and Technology
and a new member from the National Science Foundation.
During this reporting period, the ITC discussed the 16 chemicals
with insufficient dermal absorption rate data, branched 4-nonylphenol
(mixed isomers), phenol, 4-(1,1,3,3-tetramethylbutyl)-, 148 HPV
Challenge Program orphan chemicals, cadmium and cadmium compounds, 6
non-phthalate plasticizers, 25 phosphate ester and 2 other flame
retardants, 9 chemicals to which children living near hazardous waste
sites may be exposed, and 69 diisocyanates and related compounds
remaining on the TSCA section 4(e) Priority Testing List. As a result
of these discussions, the ITC removed 16 chemicals with insufficient
dermal absorption rate data, 98 HPV Challenge Program orphan chemicals,
and 50 diisocyanates and related compounds from the TSCA section 4(e)
Priority Testing List. Orphan chemicals are those HPV chemicals for
which no sponsors have volunteered to develop and submit robust
summaries of basic hazard and fate testing data to the EPA. The hazard
and fate testing data requested by the EPA for HPV Challenge Program
orphan chemicals are necessary to establish a screening level
understanding of their potential human health and environmental
impacts. The chemicals with insufficient dermal absorption rate data,
HPV Challenge Program orphan chemicals and diisocyanates and related
compounds are discussed further in Unit III. of this 72nd ITC Report.
As noted in this unit, the ITC also discussed the following
chemicals that remain on the TSCA section 4(e) Priority Testing List:
Branched 4-nonylphenol (mixed isomers), phenol, 4-(1,1,3,3-
tetramethylbutyl)-, cadmium and cadmium compounds, 6 non-phthalate
plasticizers, 25 phosphate ester flame retardants, 2 other flame
retardants, and 9 chemicals to which children living near hazardous
waste sites may be exposed.
Branched 4-nonylphenol (mixed isomers) (CAS No. 84852-15-3) and
phenol, 4-(1,1,3,3-tetramethylbutyl)- (CAS No. 140-66-9) were added to
the TSCA section 4(e) Priority Testing List in the ITC's 37th and 41st
Reports along with numerous other alkylphenols, alkylphenol
ethoxylates, and poly alkylphenols (Refs. 1 and 2). The remaining data
needed for branched 4-nonylphenol (mixed isomers) and phenol, 4-
(1,1,3,3-tetramethylbutyl)- can be obtained from avian reproduction
testing and fish multi-generation testing, respectively. Branched 4-
nonylphenol (mixed isomers) and phenol, 4-(1,1,3,3-tetramethylbutyl)-
will remain on the TSCA section 4(e) Priority Testing List until the
avian reproduction testing and fish multi-generation testing is
completed or other information becomes available to justify removing
them from the TSCA section 4(e) Priority Testing List.
Cadmium and cadmium compounds were added to the TSCA section 4(e)
Priority Testing List in the ITC's 68th and 69th Reports (Refs. 3 and
4). Cadmium and cadmium compounds were included in a TSCA section 8(d)
Health and Safety Data Reporting (HaSDR) rule that was published in the
Federal Register of December 3, 2012 (77 FR 71561) (FRL-9355-9). After
receiving adverse comments to the HaSDR rule, EPA published a document
withdrawing the HaSDR rule in the Federal Register of December 28, 2012
(77 FR 76419) (FRL-9375-3) due to questions and concerns raised about
the scope and extent of the HaSDR rule. EPA is considering the
questions and concerns raised in response to the HaSDR rule and next
steps with regard to that rule.
Six non-phthalate plasticizers, 25 phosphate ester flame
retardants, and 2 other flame retardants were added to the TSCA section
4(e) Priority Testing List in the ITC's 69th Report (Ref. 4). They were
added to obtain existing bio-monitoring data on urinary metabolites
that will be used to assess the risks of these chemicals. The 2 other
flame retardants, 1,2-benzenedicarboxylic acid, 3,4,5,6-tetrabromo-,
1,2-bis(2-ethylhexyl) ester, a.k.a. bis(2-ethyl-1-hexyl)
tetrabromophthalate (CAS No. 26040-51-7) and benzoic acid, 2,3,4,5-
tetrabromo-, 2-ethylhexyl ester, a.k.a. 2-ethylhexyl-2,3,4,5-
tetrabromobenzoate (CAS No. 183658-27-7) are included in the assessment
strategy that EPA developed for brominated phthalates (https://www.epa.gov/oppt/existingchemicals/pubs/2013wpractivities.html).
The U.S. Department of the Interior (DOI) and Environment Canada
are collaborating on a study involving exposure of American Kestrels
(Falco sparverius) to 4 of the phosphate ester flame retardants
discussed in the ITC's 69th Report (Ref. 4). The 4 phosphate ester
flame retardants include: Ethanol, 2-butoxy-, 1,1',1''-phosphate,
a.k.a. tri(2-butoxyethyl) phosphate (CAS No. 78-51-3); ethanol, 2-
chloro-, phosphate (3:1), a.k.a. tris(2-chloroethyl) phosphate (CAS No.
115-96-8); 2-propanol, 1-chloro-, 2,2',2''-phosphate, a.k.a. tris(1-
chloro-2-propyl)phosphate (CAS No. 13674-84-5) and 2-propanol, 1,3-
dichloro-, phosphate (3:1), a.k.a. tris(1,3-dichloro-2-propyl)
phosphate (CAS: 13674-87-8). The study will provide novel
information on uptake kinetics and potential toxicity of priority
phosphate ester flame retardants that are currently found in wild bird
eggs in North America. One of these phosphate ester flame retardants,
ethanol, 2-chloro-, phosphate (3:1), a.k.a. tris(2-chloroethyl)
phosphate (CAS No. 115-96-8) is included in the risk assessment
strategy that EPA is developing for chlorinated phosphate esters
(https://www.epa.gov/oppt/existingchemicals/pubs/2013wpractivities.html).
Nine chemicals to which children living near hazardous waste sites
may be exposed were added to the TSCA section 4(e) Priority Testing
List in the ITC's 69th Report (Ref. 4). They were added to obtain
existing biomonitoring data on blood levels that will be used to fill
priority data needs that were identified during the development of
ATSDR's Toxicological Profiles. Priority data needs are published in
the Federal Register and represent a wide variety of needs, including
biomonitoring studies to help establish reference values for exposed
populations as well as background levels for the general population
(https://www.atsdr.cdc.gov/pdns/index.asp). The 9 chemicals to which
children living near hazardous waste sites may be exposed are from the
current unfilled priority data needs and any biomonitoring data will be
used to conduct public health assessments. The EPA is deliberating
options for satisfying the data needs for these 9 chemicals.
III. Chemicals Removed From the TSCA Section (4)(e) Priority Testing
List
A. Chemicals With Insufficient Dermal Absorption Rate Data
In its 31st, 32nd, and 35th ITC Reports, the Occupational Safety
and Health Administration (OSHA) requested that the ITC add 24, 34, and
25 chemicals, respectively, to the TSCA section 4(e) Priority Testing
List and designate them for testing to develop dermal absorption rate
data (Refs. 5, 6, and 7). The ITC removed methyl methacrylate and
diethyl phthalate from the TSCA section 4(e) Priority Testing List in
its 34th ITC Report (Ref. 8) and cyclohexanone from the TSCA section
4(e) Priority Testing List in its 36th ITC Report (Ref. 9). Methyl
methacrylate, diethyl phthalate, and cyclohexanone
[[Page 44861]]
were removed from the TSCA section 4(e) Priority Testing List because
dermal absorption rate data were identified after these chemicals were
added to the TSCA section 4(e) Priority Testing List. In its 45th ITC
Report (Ref. 10), the ITC removed 47 chemicals designated for dermal
absorption rate testing from the TSCA section 4(e) Priority Testing
List, because the EPA published a rule proposing dermal absorption rate
testing for these chemicals (Ref. 11). In 2004, the EPA reviewed more
recent production volume, exposure, and dermal absorption rate data and
promulgated a rule requiring dermal absorption rate testing for 34 of
these chemicals (Ref. 12). The rationales for EPA's decision not to
finalize testing requirements for the other 13 chemicals in the
proposed rule are described in Ref. 11. In its 59th ITC Report, the ITC
removed 16 more chemicals with insufficient dermal absorption rate data
from the TSCA section 4(e) Priority Testing List (Ref. 13). The ITC
removed these 16 chemicals because their production volumes indicated
low potential for occupational exposures. In this 72nd ITC Report, the
ITC is removing the 16 remaining chemicals with insufficient dermal
absorption rate data from the TSCA section 4(e) Priority Testing List
(Table 2 of this unit). OSHA determined that for these 16 chemicals,
information from dermal studies can be readily obtained through the
OECD existing chemical database (eChemPortal), the EPA HPV database
(High Production Volume Information System (HPVIS) or other
authoritative scientific resources (Ref. 14). The ITC is removing these
chemicals as a result of OSHA's determination that sufficient
information is currently available on the dermal absorption
characteristics of these chemicals to warrant their removal from the
TSCA section 4(e) Priority Testing List.
Table 2--Chemicals With Insufficient Dermal Absorption Rate Data Being
Removed From the Priority Testing List
------------------------------------------------------------------------
CAS No. Chemical name
------------------------------------------------------------------------
75-12-7............. Formamide.
88-72-2............. Benzene, 1-methyl-2-nitro-; o-nitrotoluene.
89-72-5............. Phenol, 2-(1-methylpropyl)-; o-sec-butylphenol.
90-04-0............. Benzenamine, 2-methoxy-; o-anisidine.
95-13-6............. 1H-Indene; indene.
96-18-4............. Propane, 1,2,3-trichloro-; 1,2,3-trichloropropane.
99-08-1............. Benzene, 1-methyl-3-nitro-; m-nitrotoluene.
100-63-0............ Hydrazine, phenyl-; phenylhydrazine.
106-49-0............ Benzenamine, 4-methyl-; p-toluidine.
108-44-1............ Benzenamine, 3-methyl-; m-toluidine.
108-87-2............ Cyclohexane, methyl-; methylcyclohexane.
121-14-2............ Benzene, 1-methyl-2,4-dinitro-; 2,4-
dinitrotoluene.
287-92-3............ Cyclopentane.
540-59-0............ Ethene, 1,2-dichloro-; 1,2-dichloroethylene.
542-92-7............ 1,3-Cyclopentadiene.
626-17-5............ 1,3-Benzenedicarbonitrile; 1,3-dicyanobenzene.
------------------------------------------------------------------------
B. HPV Challenge Program Orphan Chemicals
In 2004, at the EPA's request, the ITC added 281 HPV Challenge
Program orphan (unsponsored) chemicals to the TSCA section 4(e)
Priority Testing List in the ITC's 55th and 56th Reports (Refs. 15 and
16). As of December 2012, 133 HPV Challenge Program orphan chemicals
had been removed from the TSCA section 4(e) Priority Testing List
because they were included in EPA's test rules, the testing was
voluntarily sponsored or because they no longer met the 1
million lb criterion for the HPV Challenge Program. Based on data
received from the 2006 IUR rule, and the 2012 CDR rule, EPA identified
98 HPV Challenge Program orphan chemicals with production volumes
consistently below 1 million lb. Since these 98 chemicals no longer
exceed the 1 million lb criterion for the HPV Challenge Program, EPA is
requesting their removal from the TSCA section 4(e) Priority Testing
List in this 72nd ITC Report (Ref. 17). The 98 HPV Challenge Program
orphan chemicals being removed from the TSCA section 4(e) Priority
Testing List are listed in Table 3 of this unit. The 50 HPV Challenge
Program orphan chemicals remaining on the TSCA section 4(e) Priority
Testing List are listed in Table 4 of this unit.
Table 3--High Production Volume Challenge Program Orphan Chemicals Being
Removed From the TSCA Section 4(e) Priority Testing List
------------------------------------------------------------------------
CAS No. Chemical name
------------------------------------------------------------------------
77-76-9............. Propane, 2,2-dimethoxy-.
81-07-2............. 1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide.
81-84-5............. 1H,3H-Naphtho[1,8-cd]pyran-1,3-dione.
85-40-5............. 1H-Isoindole-1,3(2H)-dione, 3a,4,7,7a-tetrahydro-.
97-00-7............. Benzene, 1-chloro-2,4-dinitro-.
101-34-8............ 9-Octadecenoic acid, 12-(acetyloxy)-, 1,1',1''-
(1,2,3-propanetriyl) ester,
(9Z,9'Z,9''Z,12R,12'R,12''R)-.
104-93-8............ Benzene, 1-methoxy-4-methyl-.
110-33-8............ Hexanedioic acid, 1,6-dihexyl ester.
111-91-1............ Ethane, 1,1'-[methylenebis(oxy)]bis[2-chloro-.
118-90-1............ Benzoic acid, 2-methyl-.
138-25-0............ 1,3-Benzenedicarboxylic acid, 5-sulfo-, 1,3-
dimethyl ester.
139-40-2............ 1,3,5-Triazine-2,4-diamine, 6-chloro-N2,N4-bis(1-
methylethyl)-.
[[Page 44862]]
140-93-2............ Carbonodithioic acid, O-(1-methylethyl) ester,
sodium salt (1:1).
142-73-4............ Glycine, N-(carboxymethyl)-.
330-54-1............ Urea, N ' -(3,4-dichlorophenyl)-N,N-dimethyl-.
513-74-6............ Carbamodithioic acid, ammonium salt (1:1).
529-33-9............ 1-Naphthalenol, 1,2,3,4-tetrahydro-.
557-61-9............ 1-Octacosanol.
563-72-4............ Ethanedioic acid, calcium salt (1:1).
592-45-0............ 1,4-Hexadiene.
617-94-7............ Benzenemethanol, .alpha.,.alpha.-dimethyl-.
628-13-7............ Pyridine, hydrochloride (1:1).
628-96-6............ 1,2-Ethanediol, 1,2-dinitrate.
645-62-5............ 2-Hexenal, 2-ethyl-.
693-95-8............ Thiazole, 4-methyl-.
756-80-9............ Phosphorodithioic acid, O,O-dimethyl ester.
939-97-9............ Benzaldehyde, 4-(1,1-dimethylethyl)-.
1000-82-4........... Urea, N-(hydroxymethyl)-.
1002-69-3........... Decane, 1-chloro-.
1111-78-0........... Carbamic acid, ammonium salt (1:1).
1445-45-0........... Ethane, 1,1,1-trimethoxy-.
1498-51-7........... Phosphorodichloridic acid, ethyl ester.
1912-24-9........... 1,3,5-Triazine-2,4-diamine, 6-chloro-N2-ethyl-N4-
(1-methylethyl)-.
2152-64-9........... Benzenamine, 4,4'-[[4-(phenylimino)-2,5-
cyclohexadien-1-ylidene]methylene]bis[N-phenyl-,
hydrochloride (1:1).
2524-03-0........... Phosphorochloridothioic acid, O,O-dimethyl ester.
2814-20-2........... 4(3H)-Pyrimidinone, 6-methyl-2-(1-methylethyl)-.
2905-62-6........... Benzoyl chloride, 3,5-dichloro-.
2915-53-9........... 2-Butenedioic acid (2Z)-, 1,4-dioctyl ester.
3132-99-8........... Benzaldehyde, 3-bromo-.
3779-63-3........... 1,3,5-Triazine-2,4,6(1H,3H,5H)-trione, 1,3,5-
tris(6-isocyanatohexyl)-.
3965-55-7........... 1,3-Benzenedicarboxylic acid, 5-sulfo-, 1,3-
dimethyl ester, sodium salt (1:1).
4035-89-6........... Imidodicarbonic diamide, N,N ',2-tris(6-
isocyanatohexyl)-.
4316-73-8........... Glycine, N-methyl-, sodium salt (1:1).
5216-25-1........... Benzene, 1-chloro-4-(trichloromethyl)-.
5460-09-3........... 2,7-Naphthalenedisulfonic acid, 4-amino-5-hydroxy-
, sodium salt (1:1).
5915-41-3........... 1,3,5-Triazine-2,4-diamine, 6-chloro-N2-(1,1-
dimethylethyl)-N4-ethyl-.
7795-95-1........... 1-Octanesulfonyl chloride.
10265-69-7.......... Glycine, N-phenyl-, sodium salt (1:1).
13749-94-5.......... Ethanimidothioic acid, N-hydroxy-, methyl ester.
13826-35-2.......... Benzenemethanol, 3-phenoxy-.
17321-47-0.......... Phosphoramidothioic acid, O,O-dimethyl ester.
19438-61-0.......... 1,3-Isobenzofurandione, 5-methyl-.
19525-59-8.......... Glycine, N-phenyl-, potassium salt (1:1).
20068-02-4.......... 2-Butenenitrile, 2-methyl-, (2Z)-.
20227-53-6.......... Phosphorous acid, 2-(1,1-dimethylethyl)-4-[1-[3-
(1,1-dimethylethyl)-4-hydroxyphenyl]-1-
methylethyl]phenyl bis(4-nonylphenyl) ester.
25154-38-5.......... Piperazineethanol.
25168-05-2.......... Benzene, chloromethyl-.
25168-06-3.......... Phenol, (1-methylethyl)-.
25383-99-7.......... Octadecanoic acid, 2-(1-carboxyethoxy)-1-methyl-2-
oxoethyl ester, sodium salt (1:1).
26377-29-7.......... Phosphorodithioic acid, O,O-dimethyl ester, sodium
salt (1:1).
26401-27-4.......... Phosphorous acid, isooctyl diphenyl ester.
27193-28-8.......... Phenol, (1,1,3,3-tetramethylbutyl)-.
30574-97-1.......... 2-Butenenitrile, 2-methyl-, (2E)-.
34689-46-8.......... Phenol, methyl-, sodium salt (1:1).
38185-06-7.......... Benzenesulfonic acid, 4-chloro-3,5-dinitro-,
potassium salt (1:1).
39515-51-0.......... Benzaldehyde, 3-phenoxy-.
40630-63-5.......... 1-Octanesulfonyl fluoride.
40876-98-0.......... Butanedioic acid, 2-oxo-, 1,4-diethyl ester, ion(1-
), sodium (1:1).
51632-16-7.......... Benzene, 1-(bromomethyl)-3-phenoxy-.
52663-57-7.......... Ethanol, 2-butoxy-, sodium salt (1:1).
57693-14-8.......... Chromate(3-), bis[3-(hydroxy-.kappa.O)-4-[2-[2-
(hydroxy-.kappa.O)-1-naphthalenyl] diazenyl-
.kappa.N1]-7-nitro-1-naphthalenesulfonato(3-)]-,
sodium (1:3).
61789-85-3.......... Sulfonic acids, petroleum.
63302-49-8.......... Phosphorochloridous acid, bis(4-nonylphenyl)
ester.
64743-02-8.......... Alkenes, C>10 .alpha.-.
64743-03-9.......... Phenols (petroleum).
65996-83-0.......... Extracts, coal tar oil alk.
65996-86-3.......... Extract oils (coal), tar base.
65996-87-4.......... Extract residues (coal), tar oil alk.
68081-86-7.......... Phenol, nonyl derivs.
68188-18-1.......... Paraffin oils, chlorosulfonated, saponified.
68309-16-0.......... Fatty acids, tall-oil, 2-(2-hydroxyethoxy)ethyl
esters.
[[Page 44863]]
68608-59-3.......... Ethane, 1,2-dichloro-, manuf. of, by-products
from, distn. lights.
68609-05-2.......... Cyclohexane, oxidized, non-acidic by-products,
distn. lights.
68815-50-9.......... Octadecanoic acid, reaction products with 2-[(2-
aminoethyl)amino]ethanol.
68915-05-9.......... Fatty acids, tall-oil, low-boiling, reaction
products with ammonia-ethanolamine reaction by-
products.
68918-16-1.......... Tar, coal, dried and oxidized.
68937-29-1.......... 1,6-Hexanediol, distn. residues.
68937-69-9.......... Carboxylic acids, C6-18 and C5-15-di-.
68955-37-3.......... Acid chlorides, tallow, hydrogenated.
68987-41-7.......... Benzene, ethylenated.
68987-66-6.......... Ethene, hydrated, by-products from.
68990-65-8.......... Fats and Glyceridic oils, vegetable, reclaimed.
70851-08-0.......... Amides, coco, N-[3-(dimethylamino)propyl],
alkylation products with sodium 3-chloro-2-
hydroxypropanesulfonate.
72854-27-4.......... Tannins, reaction products with sodium bisulfite,
sodium polysulfide and sodium sulfite.
83864-02-2.......... Nickel, bis[(cyano-.kappa.C)triphenylborato(1-)-
kappa.N]bis(hexanedinitrile-.kappa.N,.kappa.N ')-
.
84501-86-0.......... Hexanedioic acid, esters with high-boiling C6-10-
alkene hydroformylation products.
90640-86-1.......... Distillates (coal tar), heavy oils.
125997-20-8......... Phosphoric acid, mixed 3-bromo-2,2-dimethylpropyl
and 2-bromoethyl and 2-chloroethyl esters.
------------------------------------------------------------------------
Table 4--High Production Volume Program Orphan Chemicals Remaining on
the TSCA Section 4(e) Priority Testing List
------------------------------------------------------------------------
CAS No. Chemical name
------------------------------------------------------------------------
94-96-2............. 1,3-Hexanediol, 2-ethyl-.
104-66-5............ Benzene, 1,1'-[1,2-ethanediylbis(oxy)]bis-.
107-39-1............ 1-Pentene, 2,4,4-trimethyl-.
107-40-4............ 2-Pentene, 2,4,4-trimethyl-.
111-85-3............ Octane, 1-chloro-.
121-82-4............ 1,3,5-Triazine, hexahydro-1,3,5-trinitro-.
137-20-2............ Ethanesulfonic acid, 2-[methyl[(9Z)-1-oxo-9-
octadecen-1-yl]amino]-, sodium salt (1:1).
529-34-0............ 1(2H)-Naphthalenone, 3,4-dihydro-.
590-19-2............ 1,2-Butadiene.
598-72-1............ Propanoic acid, 2-bromo-.
1401-55-4........... Tannins.
1738-25-6........... Propanenitrile, 3-(dimethylamino)-.
2210-79-9........... Oxirane, 2-[(2-methylphenoxy)methyl]-.
2372-45-4........... 1-Butanol, sodium salt (1:1).
2409-55-4........... Phenol, 2-(1,1-dimethylethyl)-4-methyl-.
2425-54-9........... Tetradecane, 1-chloro-.
2691-41-0........... 1,3,5,7-Tetrazocine, octahydro-1,3,5,7-tetranitro-
.
3039-83-6........... Ethenesulfonic acid, sodium salt (1:1).
3386-33-2........... Octadecane, 1-chloro-.
4170-30-3........... 2-Butenal.
4860-03-1........... Hexadecane, 1-chloro-.
8001-58-9........... Creosote.
17103-31-0.......... Urea, sulfate (2:1).
17976-43-1.......... 2,4,6,8,3,5,7-Benzotetraoxatriplumbacycloundecin-
3,5,7-triylidene, 1,9-dihydro-1,9-dioxo-.
21351-39-3.......... Urea, sulfate (1:1).
24794-58-9.......... Formic acid, compd. with 2,2',2''-
nitrilotris[ethanol] (1:1).
26680-54-6.......... 2,5-Furandione, dihydro-3-(octen-1-yl)-.
28908-00-1.......... Benzothiazole, 2-[(chloromethyl)thio]-.
38321-18-5.......... Ethanol, 2-(2-butoxyethoxy)-, sodium salt (1:1).
52184-19-7.......... Phenol, 2,4-bis(1,1-dimethylpropyl)-6-[2-(2-
nitrophenyl)diazenyl]-.
56803-37-3.......... Phosphoric acid, (1,1-dimethylethyl)phenyl
diphenyl ester.
68187-41-7.......... Phosphorodithioic acid, O,O-di-C1-14-alkyl esters.
68187-59-7.......... Coal, anthracite, calcined.
68308-74-7.......... Amides, tall-oil fatty, N,N-di-Me.
68309-27-3.......... Fatty acids, tall-oil, sulfonated, sodium salts.
68441-66-7.......... Decanoic acid, mixed esters with
dipentaerythritol, octanoic acid and valeric
acid.
68515-89-9.......... Barium, carbonate nonylphenol complexes.
68527-22-0.......... Naphtha (petroleum), clay-treated light straight-
run.
68584-25-8.......... Benzenesulfonic acid, C10-16-alkyl derivs.,
compds. with triethanolamine.
68602-81-3.......... Distillates, hydrocarbon resin prodn. higher
boiling.
68649-42-3.......... Phosphorodithioic acid, O,O-di-C1-14-alkyl esters,
zinc salts.
68650-36-2.......... Aromatic hydrocarbons, C8, o-xylene-lean.
68782-97-8.......... Distillates (petroleum), hydrofined lubricating-
oil.
68919-17-5.......... Hydrocarbons, C12-20, catalytic alkylation by-
products.
68953-80-0.......... Benzene, mixed with toluene, dealkylation product.
68955-76-0.......... Aromatic hydrocarbons, C9-16, biphenyl deriv.-
rich.
68990-61-4.......... Tar, coal, high-temp., high-solids.
[[Page 44864]]
70084-98-9.......... Terpenes and Terpenoids, C10-30, distn. residues.
71077-05-9.......... Ethanol, 2,2'-oxybis-, reaction products with
ammonia, morpholine product tower residues.
119345-02-7......... Benzene, 1,1'-oxybis-, tetrapropylene derivs.
------------------------------------------------------------------------
C. Diisocyanates and Related Compounds
At the request of the current EPA member to the ITC, 69
diisocyanates and related compounds were added to the TSCA section 4(e)
Priority Testing List in the ITC's 69th Report. They were added to
obtain numerous data on diisocyanates and related compounds used to
formulate a broad class of polyurethane products (e.g., sealants,
adhesives, etc.) that are intended to further react upon end-use (Ref.
4). The EPA determined that 50 of these diisocyanates and related
compounds were not reported to the EPA's 2006 IUR and 2012 CDR rules.
Since these 50 diisocyanates and related compounds were not reported to
the EPA's 2006 IUR and 2012 CDR rules, EPA is requesting their removal
from the TSCA section 4(e) Priority Testing List in this 72nd ITC
Report (Ref. 17). The 50 diisocyanates and related compounds being
removed from the TSCA section 4(e) Priority Testing List are listed in
Table 5 of this unit. The 19 diisocyanates and related compounds
remaining on the TSCA section 4(e) Priority Testing List are listed in
Table 6 of this unit.
Table 5--Fifty Diisocyanates and Related Compounds Being Removed From
the TSCA Section 4(e) Priority Testing List
------------------------------------------------------------------------
CAS No. Chemical name
------------------------------------------------------------------------
104-49-4............ Benzene, 1,4-diisocyanato-.
123-61-5............ Benzene, 1,3-diisocyanato-.
139-25-3............ Benzene, 1,1'-methylenebis[4-isocyanato-3-methyl-.
2422-91-5........... Benzene, 1,1',1''-methylidynetris[4-isocyanato-.
2536-05-2........... Benzene, 1,1'-methylenebis[2-isocyanato-.
3634-83-1........... Benzene, 1,3-bis(isocyanatomethyl)-.
4035-89-6........... Imidodicarbonic diamide, N,N '2-tris(6-
isocyanatohexyl)-.
4128-73-8........... Benzene, 1,1'-oxybis[4-isocyanato-.
7517-76-2........... Cyclohexane, 1,4-diisocyanato-, trans-.
9017-01-0........... Benzene, 1,3-diisocyanatomethyl-, homopolymer; TDI
homopolymer.
9019-85-6........... Benzene, 1,3-diisocyanatomethyl-, trimer.
10347-54-3.......... Cyclohexane, 1,4-bis(isocyanatomethyl)-.
13622-90-7.......... Cyclohexane, 1,1'-methylenebis[4-isocyanato-,
(trans,trans)-.
16325-38-5.......... Benzene, 1,2,4,5-tetrachloro-3,6-
bis(isocyanatomethyl)-.
17589-24-1.......... 1,3-Diazetidine-2,4-dione, 1,3-bis[4-[(4-
isocyanatophenyl)methyl]phenyl]-.
23370-68-5.......... 1,3-Diazetidine-2,4-dione, 1,3-bis[(5-isocyanato-
1,3,3-trimethylcyclohexyl)methyl]-.
25686-28-6.......... Benzene, 1,1'-methylenebis[4-isocyanato-,
homopolymer; MDI homopolymer.
25854-16-4.......... Benzene, bis(isocyanatomethyl)-.
26603-40-7.......... 1,3,5-Triazine-2,4,6(1H,3H,5H)-trione, 1,3,5-
tris(3-isocyanatomethylphenyl)-.
31107-36-5.......... 1,3-Diazetidine-2-one, 1,3-bis[4-[(4-
isocyanatophenyl)methyl]phenyl]-4-[[4-[(4-
isocyanatophenyl)methyl]phenyl]imino]-.
38661-72-2.......... Cyclohexane, 1,3-bis(isocyanatomethyl)-.
42170-25-2.......... Cyclohexane, bis(isocyanatomethyl)-.
50639-37-7.......... 2H-1,3,5-Oxadiazine-2,4,6(3H,5H)-trione, 3,5-bis(6-
isocyanatohexyl)-.
50830-59-6.......... 1,3,4-Thiadiazole, 2-isocyanato-5-
(trifluoromethyl)-, dimer.
51508-06-6.......... 1,3,4-Thiadiazole, 2-(1,1-dimethylethyl)-5-
isocyanato-, dimer.
53880-05-0.......... Cyclohexane, 5-isocyanato-1-(isocyanatomethyl)-
1,3,3-trimethyl-, homopolymer; isophorone
diisocyanate homopolymer.
55525-54-7.......... Urea, N,N '-bis[(5-isocyanato-1,3,3-
trimethylcyclohexyl)methyl]-.
60732-52-7.......... Carbamic acid, N,N'-(3-isocyanatomethylphenyl)-,
C,C '-(oxydi-2,1-ethanediyl) ester.
65087-21-0.......... Carbamic acid, N-[4-[(4-
isocyanatocyclohexyl)methyl]cyclohexyl]-, C,C '-
(oxydi-2,1-ethanediyl) ester.
65104-99-6.......... Imidodicarbonic diamide, 2,2'-[methylenebis(2-
chloro-4,1-phenylene)]bis[N,N '-bis(3-
isocyanatomethylphenyl)-.
65105-00-2.......... Carbamic acid, N-(3-isocyanatomethylphenyl)-, C,C
'-(1-methyl-1,3-propanediyl) ester.
65105-02-4.......... Carbamic acid, N-(3-isocyanatomethylphenyl)-, C,C
'-(1,4-butanediyl) ester.
67873-91-0.......... 1,3,5-Triazine-2,4,6(1H,3H,5H)-trione, 1,3,5-
tris[(5-isocyanato-1,3,3-
trimethylcyclohexyl)methyl]-.
68083-39-6.......... Benzenamine, N,N '-methanetetraylbis[3-isocyanato-
2,4,6-tris(1-methylethyl)-.
68092-73-9.......... Carbamic acid, N-(3-isocyanatomethylphenyl)-, C,C
'-(1,2-ethanediyl) ester.
68092-74-0.......... Carbamic acid, N-(3-isocyanatomethylphenyl)-, C,C
'-[oxybis(1-methyl-2,1-ethanediyl)] ester.
68133-14-2.......... Carbamic acid, N-(3-isocyanatomethylphenyl)-, C,C
'-[[[(diethoxyphosphinyl)methyl]imino]di-2,1-
ethanediyl] ester.
68310-46-3.......... Hexanoic acid, [[2-ethyl-2-[[[[[5-isocyanato-1(or
5)-
(methoxycarbonyl)pentyl]amino]carbonyl]oxy]methyl
]-1,3-
propanediyl]bis(oxycarbonylimino)]bis[isocyanato-
, 1,1'-dimethyl ester.
68366-14-3.......... Carbamic acid, N-[5-isocyanato-2(or 4)-
methylphenyl]-, C,C '-(1-methyl-1,3-propanediyl)
ester.
68555-56-6.......... 1,3-Diazetidine-2,4-dione, 1,3-bis(4-isocyanato-3-
methylphenyl)-.
68975-84-8.......... Carbamic acid, N-[(5-isocyanato-1,3,3-
trimethylcyclohexyl)methyl]-, C,C '-(oxydi-2,1-
ethanediyl) ester.
69878-18-8.......... Hexanoic acid, 2,6-diisocyanato-, 2-
isocyanatoethyl ester.
70024-76-9.......... Hexatriacontane, diisocyanato-, branched.
70198-24-2.......... Undecane, 1,6,11-triisocyanato-.
71130-76-2.......... Urea, N-(3-isocyanatomethylphenyl)-N '-[[[4-[[[(3-
isocyanatomethylphenyl)amino]carbonyl]amino]pheny
l]methyl]phenyl]-.
71832-70-7.......... Carbamic acid, N-[4-[(4-
isocyanatophenyl)methyl]phenyl]-, C,C '-(oxydi-
2,1-ethanediyl) ester.
[[Page 44865]]
75790-84-0.......... Benzene, 2-isocyanato-4-[(4-
isocyanatophenyl)methyl]-1-methyl-.
75790-87-3.......... Benzene, 1-isocyanato-2-[(4-isocyanatophenyl)thio]-
.
85702-90-5.......... 2,9,11,13-Tetraazanonadecanethioic acid, 19-
isocyanato-11-(6-isocyanatohexyl)-10,12-dioxo-, S-
[3-(trimethoxysilyl)propyl] ester.
106790-31-2......... Benzenamine, 4-isocyanato-N,N-bis(4-
isocyanatophenyl)-2,5-dimethoxy-.
------------------------------------------------------------------------
Table 6--Nineteen Diisocyanates and Related Compounds Remaining on the
TSCA Section 4(e) Priority Testing List
------------------------------------------------------------------------
CAS No. Chemical name
------------------------------------------------------------------------
91-08-7............. Benzene, 1,3-diisocyanato-2-methyl-.
91-97-4............. 1,1'-Biphenyl, 4,4'-diisocyanato-3,3'-dimethyl-.
101-68-8............ Benzene, 1,1'-methylenebis[4-isocyanato-.
584-84-9............ Benzene, 2,4-diisocyanato-1-methyl-.
822-06-0............ Hexane, 1,6-diisocyanato-.
2778-42-9........... Benzene, 1,3-bis(1-isocyanato-1-methylethyl)-.
3173-72-6........... Naphthalene, 1,5-diisocyanato-.
3779-63-3........... 1,3,5-Triazine-2,4,6(1H,3H,5H)-trione, 1,3,5-
tris(6-isocyanatohexyl)-.
4098-71-9........... Cyclohexane, 5-isocyanato-1-(isocyanatomethyl)-
1,3,3-trimethyl-.
5124-30-1........... Cyclohexane, 1,1'-methylenebis[4-isocyanato-.
5873-54-1........... Benzene, 1-isocyanato-2-[(4-
isocyanatophenyl)methyl]-.
9016-87-9........... Isocyanic acid, polymethylenepolyphenylene ester.
15646-96-5.......... Hexane, 1,6-diisocyanato-2,4,4-trimethyl-.
16938-22-0.......... Hexane, 1,6-diisocyanato-2,2,4-trimethyl-.
26447-40-5.......... Benzene, 1,1'-methylenebis[isocyanato-.
26471-62-5.......... Benzene, 1,3-diisocyanatomethyl-.
26747-90-0.......... 1,3-Diazetidine-2,4-dione, 1,3-bis(3-
isocyanatomethylphenyl)-.
28182-81-2.......... Hexane, 1,6-diisocyanato-, homopolymer; HDI
homopolymer.
68239-06-5.......... Cyclohexane, 2-heptyl-3,4-bis(9-isocyanatononyl)-1-
pentyl-.
------------------------------------------------------------------------
IV. References
1. ITC. Thirty-Seventh Report of the ITC; Notice. Federal Register
(61 FR 4188, February 2, 1996) (FRL-4991-6). Available at
www.regulations.gov. Docket ID number EPA-HQ-OPPT-2013-0248.
2. ITC. Forty-First Report of the ITC; Notice. Federal Register (63
FR 17658, April 9, 1998) (FRL-5773-5). Available at
www.regulations.gov. Docket ID number EPA-HQ-OPPT-2013-0248.
3. ITC. Sixty-Eighth Report of the ITC; Notice. Federal Register (76
FR 46174, August 1, 2011) (FRL-8879-3). Available at
www.regulations.gov. Docket ID number EPA-HQ-OPPT-2013-0248.
4. ITC. Sixty-Ninth Report of the ITC; Notice. Federal Register (77
FR 30856, May 23, 2012) (FRL-9346-3). Available at
www.regulations.gov. Docket ID number EPA-HQ-OPPT-2013-0248.
5. ITC. Thirty-First Report of the ITC; Notice. Federal Register (58
FR 26898, May 5, 1993) (FRL-4583-4). Available at
www.regulations.gov. Docket ID number EPA-HQ-OPPT-2013-0248.
6. ITC. Thirty-Second Report of the ITC; Notice. Federal Register
(58 FR 38490, July 16, 1993) (FRL-4630-2). Available at
www.regulations.gov. Docket ID number EPA-HQ-OPPT-2013-0248.
7. ITC. Thirty-Fifth Report of the ITC; Notice. Federal Register (59
FR 67596, December 29, 1994) (FRL-4923-2). Available at
www.regulations.gov. Docket ID number EPA-HQ-OPPT-2013-0248.
8. ITC. Thirty-Fourth Report of the ITC; Notice. Federal Register
(59 FR 35720, July 13, 1994) (FRL-4870-4). Available at
www.regulations.gov. Docket ID number EPA-HQ-OPPT-2013-0248.
9. ITC. Thirty-Sixth Report of the ITC; Notice. Federal Register (60
FR 42982, August 17, 1995) (FRL-4965-6). Available at
www.regulations.gov. Docket ID number EPA-HQ-OPPT-2013-0248.
10. ITC. Forty-Fifth Report of the ITC; Notice. Federal Register (65
FR 75544, December 1, 2000) (FRL-6399-5). Available at
www.regulations.gov. Docket ID number EPA-HQ-OPPT-2013-0248.
11. EPA. Proposed Test Rule for In Vitro Dermal Absorption Rate
Testing of Certain Chemicals of Interest to Occupational Safety and
Health Administration; Proposed Rule. Federal Register (64 FR 31074,
June 9, 1999) (FRL-5760-3). Available at www.regulations.gov. Docket
ID number EPA-HQ-OPPT-2013-0248.
12. EPA. In Vitro Dermal Absorption Rate Testing of Certain
Chemicals of Interest to the Occupational Safety and Health
Administration; Final Rule. Federal Register (69 FR 22402, April 26,
2004) (FRL-7312-2). Available at www.regulations.gov. Docket ID
number EPA-HQ-OPPT-2013-0248.
13. ITC. Fifty-Ninth Report of the ITC; Notice. Federal Register (72
FR 2756, January 22, 2007) (FRL 8110-2). Available at
www.regulations.gov. Docket ID number EPA-HQ-OPPT-2013-0248.
14. OSHA. Letter to Dr. John D. Walker, re: OSHA's comments for
removal of 16 chemicals on the TSCA Section 4(e) Priority Testing
List. April 10, 2013. Available at www.regulations.gov. Docket ID
number EPA-HQ-OPPT-2013-0248.
15. ITC. Fifty-Fifth Report of the ITC; Notice. Federal Register (70
FR 7364, February 11, 2005) (FRL-7692-1). Available at
www.regulations.gov. Docket ID number EPA-HQ-OPPT-2013-0248.
16. ITC. Fifty-Sixth Report of the ITC; Notice. Federal Register (70
FR 61520, October 24, 2005) (FRL-7739-9). Available at
www.regulations.gov. Docket ID number EPA-HQ-OPPT-2013-0248.
17. EPA. Memo to Dr. John D. Walker, re: EPA's comments on removal
of 98 High Production Volume (HPV) Challenge Program orphan
chemicals and 50 diisocyants and related compounds from the TSCA
Section 4(e) Priority Testing List. May 8, 2013. Available at
www.regulations.gov. Docket ID number EPA-HQ-OPPT-2013-0248.
[[Page 44866]]
V. The TSCA Interagency Testing Committee
Statutory Organizations With Representatives
Department of Commerce
National Institute of Standards and Technology
Michele Schantz, Member
Jessica Reliner, Alternate
Environmental Protection Agency
Robert W. Jones, Member
John E. Schaeffer, Alternate
National Institute of Environmental Health Sciences
Nigel Walker, Member
Scott Masten, Alternate
National Institute for Occupational Safety and Health
Dennis W. Lynch, Alternate
National Science Foundation
Tyrone D. Mitchell, Member
Occupational Safety and Health Administration
Janet Carter, Member and Chairperson
Thomas Nerad, Alternate
Liaison Organizations With Representatives
Agency for Toxic Substances and Disease Registry
Glenn D. Todd, Member
Consumer Product Safety Commission
Dominique Johnson, Member
Department of Agriculture
Clifford P. Rice, Member
Cathleen J. Hapeman, Alternate
Department of Defense
Laurie E. Roszell, Member
Department of the Interior
Barnett A. Rattner, Member
Food and Drug Administration
Kirk Arvidson, Member
Ronald F. Chanderbhan, Alternate
ITC Staff
John D. Walker, Director
Carol Savage, Administrative Assistant (NOWCC Employee)
TSCA Interagency Testing Committee (7405M), Office of Pollution
Prevention and Toxics, Environmental Protection Agency, 1200
Pennsylvania Ave. NW., Washington, DC 20460-0001; email address:
savage.carol@epa.gov; URL: https://www.epa.gov/oppt/itc.
[FR Doc. 2013-17545 Filed 7-23-13; 8:45 am]
BILLING CODE 6560-50-P