Guidance for Industry on Codevelopment of Two or More New Investigational Drugs for Use in Combination; Availability, 35940-35942 [2013-14168]
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35940
Federal Register / Vol. 78, No. 115 / Friday, June 14, 2013 / Notices
FOR FURTHER INFORMATION CONTACT:
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
Food and Drug Administration
[Docket No. FDA–2013–D–0616]
Content of Premarket Submissions for
Management of Cybersecurity in
Medical Devices; Draft Guidance for
Industry and Food and Drug
Administration Staff; Availability
AGENCY:
Food and Drug Administration,
HHS.
mstockstill on DSK4VPTVN1PROD with NOTICES
ACTION:
Notice.
SUMMARY: The Food and Drug
Administration (FDA) is announcing the
availability of the draft guidance
entitled ‘‘Content of Premarket
Submissions for Management of
Cybersecurity in Medical Devices.’’ This
guidance identifies cybersecurity issues
that manufacturers should consider in
preparing premarket submissions for
medical devices in order to maintain
information confidentiality, integrity,
and availability. This draft guidance is
not final nor is it in effect at this time.
DATES: Although you can comment on
any guidance at any time (see 21 CFR
10.115(g)(5)), to ensure that the Agency
considers your comment on this draft
guidance before it begins work on the
final version of the guidance, submit
either electronic or written comments
on the draft guidance by September 12,
2013.
ADDRESSES: Submit written requests for
single copies of the draft guidance
document entitled ‘‘Content of
Premarket Submissions for Management
of Cybersecurity in Medical Devices’’ to
the Division of Small Manufacturers,
International, and Consumer Assistance,
Center for Devices and Radiological
Health, Food and Drug Administration,
10903 New Hampshire Ave., Bldg. 66,
Rm. 4613, Silver Spring, MD 20993–
0002 or the Office of Communication,
Outreach and Development (HFM–40),
1401 Rockville Pike, Suite 200N,
Rockville, MD 20852. Send one selfaddressed adhesive label to assist that
office in processing your request, or fax
your request to 301–847–8149. See the
SUPPLEMENTARY INFORMATION section for
information on electronic access to the
guidance.
Submit electronic comments on the
draft guidance to https://www.
regulations.gov. Submit written
comments to the Division of Dockets
Management (HFA–305), Food and Drug
Administration, 5630 Fishers Lane, Rm.
1061, Rockville, MD 20852. Identify
comments with the docket number
found in brackets in the heading of this
document.
VerDate Mar<15>2010
17:03 Jun 13, 2013
Jkt 229001
Abiy Desta, Center for Devices and
Radiological Health, Food and Drug
Administration, 10903 New Hampshire
Ave., Bldg. 66, Rm. 1682, Silver Spring,
MD 20993–0002, 301–796–0293, Abiy.
Desta@fda.hhs.gov; or Stephen Ripley,
Center for Biologics Evaluation and
Research (HFM–17), Food and Drug
Administration, 1401 Rockville Pike,
Suite 200N, Rockville, MD 20852, 301–
827–6210.
SUPPLEMENTARY INFORMATION:
I. Background
This draft guidance provides
recommendations to consider and
document in FDA medical device
premarket submissions to provide
effective cybersecurity management and
to reduce the risk that device
functionality is intentionally or
unintentionally compromised. The need
for effective cybersecurity to assure
medical device functionality has
become more important with the
increasing use of wireless, Internet- and
network-connected devices and the
frequent electronic exchange of medical
device-related health information.
II. Significance of Guidance
This draft guidance is being issued
consistent with FDA’s good guidance
practices regulation (21 CFR 10.115).
The draft guidance, when finalized, will
represent the Agency’s current thinking
on management of cybersecurity in
medical devices. It does not create or
confer any rights for or on any person
and does not operate to bind FDA or the
public. An alternative approach may be
used if such approach satisfies the
requirements of the applicable statute
and regulations.
III. Electronic Access
Persons interested in obtaining a copy
of the draft guidance may do so by using
the Internet. A search capability for all
Center for Devices and Radiological
Health guidance documents is available
at https://www.fda.gov/MedicalDevices/
DeviceRegulationandGuidance/
GuidanceDocuments/default.htm.
Guidance documents are also available
at https://www.regulations.gov or from
the Center for Biologics Evaluation and
Research at https://www.fda.gov/
BiologicsBloodVaccines/Guidance
ComplianceRegulatoryInformation/
default.htm. To receive ‘‘Content of
Premarket Submissions for Management
of Cybersecurity in Medical Devices,’’
you may either send an email request to
dsmica@fda.hhs.gov to receive an
electronic copy of the document or send
a fax request to 301–847–8149 to receive
a hard copy. Please use the document
PO 00000
Frm 00093
Fmt 4703
Sfmt 4703
number 1825 to identify the guidance
you are requesting.
IV. Paperwork Reduction Act of 1995
This draft guidance refers to
previously approved collections of
information found in FDA regulations.
These collections of information are
subject to review by the Office of
Management and Budget (OMB) under
the Paperwork Reduction Act of 1995
(44 U.S.C. 3501–3520). The collections
of information in 21 CFR part 807,
subpart E, have been approved under
OMB control number 0910–0120; the
collections of information in 21 CFR
part 812 have been approved under
OMB control number 0910–0078; the
collections of information in 21 CFR
part 814 have been approved under
OMB control number 0910–0231; the
collections of information in 21 CFR
part 814, subpart H, have been approved
under OMB control number 0910–0332;
and the collections of information in 21
CFR part 820 have been approved under
OMB control number 0910–0073.
V. Comments
Interested persons may submit either
electronic comments regarding this
document to https://www.regulations.gov
or written comments to the Division of
Dockets Management (see ADDRESSES). It
is only necessary to send one set of
comments. Identify comments with the
docket number found in brackets in the
heading of this document. Received
comments may be seen in the Division
of Dockets Management between 9 a.m.
and 4 p.m., Monday through Friday, and
will be posted to the docket at https://
www.regulations.gov.
Dated: June 11, 2013.
Leslie Kux,
Assistant Commissioner for Policy.
[FR Doc. 2013–14167 Filed 6–13–13; 8:45 am]
BILLING CODE 4160–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
Food and Drug Administration
[Docket No. FDA–2010–D–0616]
Guidance for Industry on
Codevelopment of Two or More New
Investigational Drugs for Use in
Combination; Availability
AGENCY:
Food and Drug Administration,
HHS.
ACTION:
Notice.
SUMMARY: The FDA is announcing the
availability of a guidance for industry
entitled ‘‘Codevelopment of Two or
More New Investigational Drugs for Use
E:\FR\FM\14JNN1.SGM
14JNN1
Federal Register / Vol. 78, No. 115 / Friday, June 14, 2013 / Notices
mstockstill on DSK4VPTVN1PROD with NOTICES
in Combination.’’ This guidance is
intended to assist sponsors in the
codevelopment of two or more
investigational drugs that have not been
previously developed for any indication
(i.e., ‘‘new investigational drugs’’) to be
used in combination to treat a disease or
condition. The guidance provides
recommendations and advice on how to
address certain scientific and regulatory
issues that may arise during
codevelopment of two or more new
investigational drugs. It is not intended
to apply to development of
combinations of already approved drugs
or to development of a single new
investigational drug to be used in
combination with an already approved
drug or drugs. The guidance is not
intended to apply to biological products
regulated by the Center for Biologics
Evaluation and Research or medical
devices.
DATES: Submit either electronic or
written comments on Agency guidance
at any time.
ADDRESSES: Submit written requests for
single copies of the guidance to the
Division of Drug Information, Center for
Drug Evaluation and Research, Food
and Drug Administration, 10903 New
Hampshire Ave., Bldg. 51, Rm. 2201,
Silver Spring, MD 20993–0002. Send
one self-addressed adhesive label to
assist that office in processing your
requests. See the SUPPLEMENTARY
INFORMATION section for electronic
access to the draft guidance document.
Submit electronic comments on the
draft guidance to https://www.
regulations.gov. Submit written
comments to the Division of Dockets
Management (HFA–305), Food and Drug
Administration, 5630 Fishers Lane, Rm.
1061, Rockville, MD 20852.
FOR FURTHER INFORMATION CONTACT:
Colleen Locicero, Center for Drug
Evaluation and Research, Food and
Drug Administration, Bldg. 22, Rm.
4216, 10903 New Hampshire Ave.,
Silver Spring, MD 20993–0002, 301–
796–1114.
SUPPLEMENTARY INFORMATION:
I. Background
The FDA is announcing the
availability of a guidance for industry
entitled ‘‘Codevelopment of Two or
More New Investigational Drugs for Use
in Combination.’’ The guidance is
intended to assist sponsors in the
codevelopment 1 of two or more
1 The term codevelopment as used in the
guidance refers to the concurrent development of
two or more new investigational drugs that are
intended to be used in combination to treat a
disease or condition. A sponsor may elect to
codevelop two or more new investigational drugs
VerDate Mar<15>2010
17:03 Jun 13, 2013
Jkt 229001
investigational drugs that have not been
previously developed for any indication
(i.e., ‘‘new investigational drugs’’) to be
used in combination to treat a disease or
condition. Recent scientific advances
have increased our understanding of the
pathophysiological processes that
underlie many complex diseases, such
as cancer, cardiovascular disease, and
infectious diseases. This increased
understanding has provided further
impetus to develop therapeutic
approaches that rely primarily or
exclusively on combinations of drugs
directed at multiple therapeutic targets
to improve treatment response and
minimize development of resistance. In
settings in which combination therapy
provides significant therapeutic
advantages, there is growing interest in
the development of combinations of
investigational drugs not previously
developed for any indication.
Because existing developmental and
regulatory pathways focus primarily on
assessment of the safety and
effectiveness of a single new
investigational drug acting alone, or in
combination with an already approved
drug, FDA believes guidance is needed
to assist sponsors in the codevelopment
of two or more new investigational
drugs. This guidance is intended to
describe a high-level, generally
applicable approach. It describes the
criteria for determining when
codevelopment may be an appropriate
option, makes recommendations about
nonclinical and clinical development
strategies, and addresses certain
regulatory process issues. The guidance
is not intended to apply to biological
products regulated by the Center for
Biologics Evaluation and Research or
medical devices.
In the Federal Register of December
15, 2010 (75 FR 78259), FDA announced
the availability of a draft of this
guidance. FDA received a number of
comments, including multiple
comments seeking clarification of the
scope and applicability of the guidance,
the criteria for determining when
codevelopment is appropriate, the
evidentiary expectations for the
individual new investigational drugs
and their use in combination, and the
types of regulatory submissions needed
for codeveloped products. FDA has
carefully considered these comments.
The final guidance clarifies the criteria
for determining when codevelopment is
appropriate and elaborates on strategies
for clinical development of the
individual new investigational drugs
intended to be marketed as individual agents or to
be used in combination as a fixed-combination or
copackaged drug.
PO 00000
Frm 00094
Fmt 4703
Sfmt 4703
35941
and their use in combination. It also
provides a detailed discussion of
considerations for submitting
Investigational New Drug Applications
(INDs) and New Drug Applications
(NDAs) . The final guidance clarifies the
scope of the drugs to which it applies;
it uses the term ‘‘new investigational
drug’’ to refer to drugs that have not
previously been developed for any
indication. We have also revised the
title of the guidance to reflect this term.
This guidance is being issued
consistent with FDA’s good guidance
practices regulation (21 CFR 10.115).
The guidance represents the Agency’s
current thinking on development of two
or more new investigational drugs for
use in combination. It does not create or
confer any rights for or on any person
and does not operate to bind FDA or the
public. An alternative approach may be
used if such approach satisfies the
requirements of the applicable statutes
and regulations.
II. Comments
Interested persons may submit either
electronic comments regarding this
document to https://www.regulations.gov
or written comments to the Division of
Dockets Management (see ADDRESSES). It
is only necessary to send one set of
comments. Identify comments with the
docket number found in brackets in the
heading of this document. Received
comments may be seen in the Division
of Dockets Management between 9 a.m.
and 4 p.m., Monday through Friday, and
will be posted to the docket at https://
www.regulations.gov.
III. The Paperwork Reduction Act of
1995
This guidance refers to previously
approved collections of information
found in FDA regulations. These
collections of information are subject to
review by the Office of Management and
Budget (OMB) under the Paperwork
Reduction Act of 1995 (44 U.S.C. 3501–
3520). The collections of information in
21 CFR part 312 have been approved
under OMB control number 0910–0014.
The collections of information in 21
CFR part 314 have been approved under
OMB control number 0910–0001. The
collections of information in 21 CFR
201.56 and 201.57 have been approved
under OMB control number 0910–0572.
The collections of information in 21
CFR 310.305 and 314.80 have been
approved under OMB control number
0910–0230. The collections of
information in 21 CFR 208.20, 208.24,
and 314.70(b) have been approved
under OMB control number 0910–0393.
E:\FR\FM\14JNN1.SGM
14JNN1
35942
Federal Register / Vol. 78, No. 115 / Friday, June 14, 2013 / Notices
IV. Electronic Access
Persons with access to the Internet
may obtain the document at either
https://www.fda.gov/Drugs/Guidance
ComplianceRegulatoryInformation/
Guidances/default.htm or https://
www.regulations.gov.
Dated: June 11, 2013.
Leslie Kux,
Assistant Commissioner for Policy.
[FR Doc. 2013–14168 Filed 6–13–13; 8:45 am]
BILLING CODE 4160–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
Proposed Collection; Comment
Request: Palliative Care:
Conversations Matter Evaluation
SUMMARY: In compliance with the
requirement of Section 3506(c)(2)(A) of
the Paperwork Reduction Act of 1995,
for opportunity for public comment on
proposed data collection projects, the
National Institute of Nursing Research
(NINR), the National Institutes of Health
(NIH) will publish periodic summaries
of proposed projects to be submitted to
the Office of Management and Budget
(OMB) for review and approval.
Written comments and/or suggestions
from the public and affected agencies
are invited on one or more of the
following points: (1) Whether the
proposed collection of information is
necessary for the proper performance of
the function of the agency, including
whether the information will have
practical utility; (2) The accuracy of the
agency’s estimate of the burden of the
proposed collection of information,
including the validity of the
methodology and assumptions used; (3)
Ways to enhance the quality, utility, and
clarity of the information to be
collected; and (4) Ways to minimize the
burden of the collection of information
on those who are to respond, including
the use of appropriate automated,
electronic, mechanical, or other
technological collection techniques or
other forms of information technology.
To obtain a copy of the data collection
plans and instruments, submit
comments in writing, or request more
information on the proposed project,
contact Ms. Adrienne Burroughs, Health
Communications Specialist, Office of
Communications and Public Liaison,
NINR, NIH, Building 31, Room 5B10, 31
Center Drive, Bethesda, MD 20892, or
call non-toll-free number (301) 496–
0256, or Email your request, including
your address to:
adrienne.burroughs@nih.gov.
Comments regarding this information
collection are best assured of having
their full effect if received within 60days of the date of this publication.
Proposed Collection
Palliative Care: Conversations Matter
Evaluation –0925—New—National
Institute of Nursing Research (NINR),
National Institutes of Health (NIH)
Care: Conversations Matter, a pediatric
palliative care campaign to address the
communications challenges faced by
health care providers who recommend
and provide palliative care to pediatric
populations. NINR is launching this
effort to increase the use of palliative
care for children living with serious
illness or life-limiting conditions. The
Palliative Care: Conversations Matter
evaluation will assess the information
and materials being disseminated as
part of the official campaign. Survey
findings will help (1) Determine if the
campaign is effective, relevant, and
useful to health care providers who
recommend and provide palliative care
to pediatric populations; (2) to better
understand the information needs of
health care providers to inform future
campaign efforts; and (3) examine how
effective the campaign materials are in
starting and continuing a pediatric
palliative care conversation and
addressing the communications needs
of health care providers around this
topic.
OMB approval is requested for 3
years. There are no costs to respondents
other than their time. The total
estimated annualized burden hours are
200.
Estimated Annualized Burden Hours
Need and Use of Information
Collection: NINR developed Palliative
TABLE A–12–1—ESTIMATES OF ANNUAL BURDEN HOURS
Number of
respondents
Type of respondents
Frequency of
response
Average
time per
response
(in hours )
Total
burden hours
Physicians ........................................................................................................
Nurses ..............................................................................................................
150
150
2
2
20/60
20/60
100
100
Total ..........................................................................................................
300
........................
........................
200
Dated: June 5, 2013.
Amanda Greene,
Science Evaluation Officer, NINR, National
Institutes of Health.
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
[FR Doc. 2013–14173 Filed 6–13–13; 8:45 am]
National Institute of General Medical
Sciences; Notice of Closed Meetings
mstockstill on DSK4VPTVN1PROD with NOTICES
BILLING CODE 4140–01–P
National Institutes of Health
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is
hereby given of the following meetings.
The meetings will be closed to the
public in accordance with the
provisions set forth in sections
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17:03 Jun 13, 2013
Jkt 229001
PO 00000
Frm 00095
Fmt 4703
Sfmt 4703
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: National Institute of
General Medical Sciences Special Emphasis
Panel; R–13 Conference Grants.
Date: July 9, 2013.
Time: 12:00 p.m. to 5:00 p.m.
E:\FR\FM\14JNN1.SGM
14JNN1
Agencies
[Federal Register Volume 78, Number 115 (Friday, June 14, 2013)]
[Notices]
[Pages 35940-35942]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 2013-14168]
-----------------------------------------------------------------------
DEPARTMENT OF HEALTH AND HUMAN SERVICES
Food and Drug Administration
[Docket No. FDA-2010-D-0616]
Guidance for Industry on Codevelopment of Two or More New
Investigational Drugs for Use in Combination; Availability
AGENCY: Food and Drug Administration, HHS.
ACTION: Notice.
-----------------------------------------------------------------------
SUMMARY: The FDA is announcing the availability of a guidance for
industry entitled ``Codevelopment of Two or More New Investigational
Drugs for Use
[[Page 35941]]
in Combination.'' This guidance is intended to assist sponsors in the
codevelopment of two or more investigational drugs that have not been
previously developed for any indication (i.e., ``new investigational
drugs'') to be used in combination to treat a disease or condition. The
guidance provides recommendations and advice on how to address certain
scientific and regulatory issues that may arise during codevelopment of
two or more new investigational drugs. It is not intended to apply to
development of combinations of already approved drugs or to development
of a single new investigational drug to be used in combination with an
already approved drug or drugs. The guidance is not intended to apply
to biological products regulated by the Center for Biologics Evaluation
and Research or medical devices.
DATES: Submit either electronic or written comments on Agency guidance
at any time.
ADDRESSES: Submit written requests for single copies of the guidance to
the Division of Drug Information, Center for Drug Evaluation and
Research, Food and Drug Administration, 10903 New Hampshire Ave., Bldg.
51, Rm. 2201, Silver Spring, MD 20993-0002. Send one self-addressed
adhesive label to assist that office in processing your requests. See
the SUPPLEMENTARY INFORMATION section for electronic access to the
draft guidance document.
Submit electronic comments on the draft guidance to https://www.regulations.gov. Submit written comments to the Division of Dockets
Management (HFA-305), Food and Drug Administration, 5630 Fishers Lane,
Rm. 1061, Rockville, MD 20852.
FOR FURTHER INFORMATION CONTACT: Colleen Locicero, Center for Drug
Evaluation and Research, Food and Drug Administration, Bldg. 22, Rm.
4216, 10903 New Hampshire Ave., Silver Spring, MD 20993-0002, 301-796-
1114.
SUPPLEMENTARY INFORMATION:
I. Background
The FDA is announcing the availability of a guidance for industry
entitled ``Codevelopment of Two or More New Investigational Drugs for
Use in Combination.'' The guidance is intended to assist sponsors in
the codevelopment \1\ of two or more investigational drugs that have
not been previously developed for any indication (i.e., ``new
investigational drugs'') to be used in combination to treat a disease
or condition. Recent scientific advances have increased our
understanding of the pathophysiological processes that underlie many
complex diseases, such as cancer, cardiovascular disease, and
infectious diseases. This increased understanding has provided further
impetus to develop therapeutic approaches that rely primarily or
exclusively on combinations of drugs directed at multiple therapeutic
targets to improve treatment response and minimize development of
resistance. In settings in which combination therapy provides
significant therapeutic advantages, there is growing interest in the
development of combinations of investigational drugs not previously
developed for any indication.
---------------------------------------------------------------------------
\1\ The term codevelopment as used in the guidance refers to the
concurrent development of two or more new investigational drugs that
are intended to be used in combination to treat a disease or
condition. A sponsor may elect to codevelop two or more new
investigational drugs intended to be marketed as individual agents
or to be used in combination as a fixed-combination or copackaged
drug.
---------------------------------------------------------------------------
Because existing developmental and regulatory pathways focus
primarily on assessment of the safety and effectiveness of a single new
investigational drug acting alone, or in combination with an already
approved drug, FDA believes guidance is needed to assist sponsors in
the codevelopment of two or more new investigational drugs. This
guidance is intended to describe a high-level, generally applicable
approach. It describes the criteria for determining when codevelopment
may be an appropriate option, makes recommendations about nonclinical
and clinical development strategies, and addresses certain regulatory
process issues. The guidance is not intended to apply to biological
products regulated by the Center for Biologics Evaluation and Research
or medical devices.
In the Federal Register of December 15, 2010 (75 FR 78259), FDA
announced the availability of a draft of this guidance. FDA received a
number of comments, including multiple comments seeking clarification
of the scope and applicability of the guidance, the criteria for
determining when codevelopment is appropriate, the evidentiary
expectations for the individual new investigational drugs and their use
in combination, and the types of regulatory submissions needed for
codeveloped products. FDA has carefully considered these comments. The
final guidance clarifies the criteria for determining when
codevelopment is appropriate and elaborates on strategies for clinical
development of the individual new investigational drugs and their use
in combination. It also provides a detailed discussion of
considerations for submitting Investigational New Drug Applications
(INDs) and New Drug Applications (NDAs) . The final guidance clarifies
the scope of the drugs to which it applies; it uses the term ``new
investigational drug'' to refer to drugs that have not previously been
developed for any indication. We have also revised the title of the
guidance to reflect this term.
This guidance is being issued consistent with FDA's good guidance
practices regulation (21 CFR 10.115). The guidance represents the
Agency's current thinking on development of two or more new
investigational drugs for use in combination. It does not create or
confer any rights for or on any person and does not operate to bind FDA
or the public. An alternative approach may be used if such approach
satisfies the requirements of the applicable statutes and regulations.
II. Comments
Interested persons may submit either electronic comments regarding
this document to https://www.regulations.gov or written comments to the
Division of Dockets Management (see ADDRESSES). It is only necessary to
send one set of comments. Identify comments with the docket number
found in brackets in the heading of this document. Received comments
may be seen in the Division of Dockets Management between 9 a.m. and 4
p.m., Monday through Friday, and will be posted to the docket at https://www.regulations.gov.
III. The Paperwork Reduction Act of 1995
This guidance refers to previously approved collections of
information found in FDA regulations. These collections of information
are subject to review by the Office of Management and Budget (OMB)
under the Paperwork Reduction Act of 1995 (44 U.S.C. 3501-3520). The
collections of information in 21 CFR part 312 have been approved under
OMB control number 0910-0014. The collections of information in 21 CFR
part 314 have been approved under OMB control number 0910-0001. The
collections of information in 21 CFR 201.56 and 201.57 have been
approved under OMB control number 0910-0572. The collections of
information in 21 CFR 310.305 and 314.80 have been approved under OMB
control number 0910-0230. The collections of information in 21 CFR
208.20, 208.24, and 314.70(b) have been approved under OMB control
number 0910-0393.
[[Page 35942]]
IV. Electronic Access
Persons with access to the Internet may obtain the document at
either https://www.fda.gov/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/default.htm or https://www.regulations.gov.
Dated: June 11, 2013.
Leslie Kux,
Assistant Commissioner for Policy.
[FR Doc. 2013-14168 Filed 6-13-13; 8:45 am]
BILLING CODE 4160-01-P