National Institute of Diabetes and Digestive and Kidney Diseases; Notice of Closed Meetings, 31950-31951 [2013-12530]
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Federal Register / Vol. 78, No. 102 / Tuesday, May 28, 2013 / Notices
novel (CH2) scaffold: identification of
HIV-1 inhibitors. Biochem Biophys Res
Commun. 2009 Sep 18;387(2):387–92.
[PMID 19615335]
5. Wozniak-Knopp G, et al. Stabilisation of
the Fc fragment of human IgG1 by
engineered intradomain disulfide bonds.
PLoS One. 2012;7(1):e30083 [PMID
22272277]
Inventors: Dimiter Dimitrov (NCI) and
Rui Gong (formerly NCI).
Intellectual Property: HHS Reference
No. E–245–2012/0—Research Tool.
Patent protection is not being pursued
for this technology.
Licensing Contact: Sally H. Hu, Ph.D.,
M.B.A.; 301–435–5606;
hus@mail.nih.gov
Collaborative Research Opportunity:
The National Cancer Institute (NCI) is
seeking statements of capability or
interest from parties interested in
collaborative research to further
develop, evaluate or commercialize A
Novel Human Antibody for Deploying
CH2 Based Therapeutics. For
collaboration opportunities, please
contact John D. Hewes, Ph.D. at
hewesj@mail.nih.gov.
mstockstill on DSK4VPTVN1PROD with NOTICES
Methods for Producing Stem Cell-like
Memory T cells for Use in T cell-based
Immunotherapies
Description of Technology: T cells
currently employed for T cell-based
immunotherapies are often senescent,
terminally differentiated cells with poor
proliferate and survival capacity.
Recently, however, NIH scientists
identified and characterized a new
human memory T cell population with
stem cell-like properties. Since these T
cells have limited quantities in vivo, the
scientists have developed methods by
which high numbers of these cells can
be generated ex vivo for use in T cellbased immunotherapies. Specifically,
this technology describes a method for
generating the stem cell-like memory T
cells by stimulating naive T cells in the
presence of inhibitors of GSK-3beta. It
also describes a method for obtaining
the stem cell-like memory T cells by
sorting T cell lymphocytes using flow
cytometry. These stem cell-like memory
T cells display enhanced proliferation
and survival upon transfer, have the
multipotent capacity to generate all
memory and effector T cell subsets and
show increased anti-tumor activity in a
humanized mouse tumor model.
Consequently, the coupling of T cell
receptor or chimeric receptor gene
transfer with this method will enable
the generation of a large number of
memory stem cells with the desired
specificity to effectively treat patients
with cancer and chronic infectious
diseases.
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17:46 May 24, 2013
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Potential Commercial Applications:
• Ex vivo generation of stem cell-like
memory T cells for T cell-based
immunotherapy
• Treatment for patients with cancer
and chronic infectious diseases
Competitive Advantages:
• Enhanced proliferation and survival
upon transfer
• Multipotent capacity to generate all
memory and effector T cell subsets
• Increased anti-tumor actovity
Development Stage:
• Pre-clinical
• In vitro data available
• In vivo data available (animal)
Inventors: Luca Gattinoni (NCI),
Enrico Lugli (NIAID), Mario Roederer
(NIAID), Nicholas Restifo (NCI)
Publications:
1. Gattinoni L, et al. A human T cell memory
subset with stem cell-like properties. Nat
Med. 2011 Sep 18;17(10):1290–7. [PMID
21926977]
2. Gattinoni L, et al. Wnt signaling arrests
effector T cell differentiation and
generates CD8+ memory stem cells. Nat
Med. 2009 Jul;15(7):808–13. [PMID
19525962]
3. Lugli E, et al. Identification, isolation and
in vitro expansion of human and
nonhuman primate T stem cell memory
cells. Nat Protoc. 2013 Jan;8(1):33–42.
[PMID 23222456]
Intellectual Property: HHS Reference
No. E–174–2012/0—PCT Application
No. PCT/US12/053947 filed 06 Sep
2012
Licensing Contact: Whitney Hastings;
301–451–7337; hastingw@mail.nih.gov.
Collaborative Research Opportunity:
The National Cancer Institute is seeking
statements of capability or interest from
parties interested in collaborative
research to further develop, evaluate or
commercialize the use of T memory
stem cells for T cell-based
immunotherapies. For collaboration
opportunities, please contact Luca
Gattinoni at gattinol@mail.nih.gov or
301–451–6914, or Nicholas Restifo at
restifo@nih.gov or 301–496–4904.
Dated: May 21, 2013.
Richard U. Rodriguez,
Director, Division of Technology Development
and Transfer, Office of Technology Transfer,
National Institutes of Health.
[FR Doc. 2013–12531 Filed 5–24–13; 8:45 am]
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DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
National Institute of Diabetes and
Digestive and Kidney Diseases; Notice
of Closed Meetings
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is
hereby given of the following meetings.
The meetings will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: National Institute of
Diabetes and Digestive and Kidney Diseases
Special Emphasis Panel; Time-Sensitive
Obesity Prevention.
Date: June 24, 2013.
Time: 11:00 a.m. to 12:30 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, Two
Democracy Plaza, 6707 Democracy
Boulevard, Bethesda, MD 20892, (Telephone
Conference Call).
Contact Person: Michele L. Barnard, PhD,
Scientific Review Officer, Review Branch,
DEA, NIDDK, National Institutes of Health,
Room 753, 6707 Democracy Boulevard,
Bethesda, MD 20892–2542, (301) 594–8898,
barnardm@extra.niddk.nih.gov.
Name of Committee: National Institute of
Diabetes and Digestive and Kidney Diseases
Special Emphasis Panel; Close Loop
Technologies.
Date: July 2, 2013.
Time: 11:00 a.m. to 3:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, Two
Democracy Plaza, 6707 Democracy
Boulevard, Bethesda, MD 20892, (Telephone
Conference Call).
Contact Person: Elena Sanovich, PhD,
Scientific Review Officer, Review Branch,
DEA, NIDDK, National Institutes of Health,
Room 750, 6707 Democracy Boulevard,
Bethesda, MD 20892–2542, 301–594–8886,
sanoviche@mail.nih.gov.
Name of Committee: National Institute of
Diabetes and Digestive and Kidney Diseases
Special Emphasis Panel; Advancing Clinical
Research in Primary Glomerular Diseases
(UM1).
Date: July 8, 2013.
Time: 2:00 p.m. to 6:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, Two
Democracy Plaza, 6707 Democracy
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Federal Register / Vol. 78, No. 102 / Tuesday, May 28, 2013 / Notices
Boulevard, Bethesda, MD 20892, (Telephone
Conference Call).
Contact Person: Paul A. Rushing, PhD,
Scientific Review Officer, Review Branch,
DEA, NIDDK, National Institutes of Health,
Room 747, 6707 Democracy Boulevard,
Bethesda, MD 20892–5452, (301) 594–8895,
rushingp@extra.niddk.nih.gov.
Name of Committee: National Institute of
Diabetes and Digestive and Kidney Diseases
Special Emphasis Panel; Causes and
Consequences of Neutrophil Dysfunction in
Early Onset Crohn’s Disease.
Date: July 12, 2013.
Time: 1:00 p.m. to 2:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, Two
Democracy Plaza, 6707 Democracy
Boulevard, Bethesda, MD 20892, (Telephone
Conference Call).
Contact Person: Paul A. Rushing, PhD,
Scientific Review Officer, Review Branch,
DEA, NIDDK, National Institutes of Health,
Room 747, 6707 Democracy Boulevard,
Bethesda, MD 20892–5452, (301) 594–8895,
rushingp@extra.niddk.nih.gov.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.847, Diabetes,
Endocrinology and Metabolic Research;
93.848, Digestive Diseases and Nutrition
Research; 93.849, Kidney Diseases, Urology
and Hematology Research, National Institutes
of Health, HHS).
Dated: May 21, 2013.
David Clary,
Program Analyst, Office of Federal Advisory
Committee Policy.
[FR Doc. 2013–12530 Filed 5–24–13; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
mstockstill on DSK4VPTVN1PROD with NOTICES
Center for Scientific Review; Notice of
Closed Meetings
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is
hereby given of the following meetings.
The meetings will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: Center for Scientific
Review Special Emphasis Panel; Program
Project: Structural Methods to Study
Dynamic Complexes.
Date: June 13–14, 2013.
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Time: 11:00 a.m. to 6:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, 6701
Rockledge Drive, Bethesda, MD 20892,
(Virtual Meeting).
Contact Person: Nuria E Assa-Munt, Ph.D.,
Scientific Review Officer, Center for
Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 4164,
MSC 7806, Bethesda, MD 20892, (301) 451–
1323, assamunu@csr.nih.gov.
Name of Committee: Center for Scientific
Review Special Emphasis Panel;
Neurodegeneration.
Date: June 13, 2013.
Time: 1:30 p.m. to 2:30 p.m.
Agenda: To review and evaluate grant
applications.
Place: Renaissance Washington DC,
Dupont Circle, 1143 New Hampshire Avenue
NW., Washington, DC 20037.
Contact Person: Laurent Taupenot, Ph.D.,
Scientific Review Officer, Center for
Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 4811,
MSC 7850, Bethesda, MD 20892, 301–435–
1203, taupenol@csr.nih.gov.
Name of Committee: Biobehavioral and
Behavioral Processes Integrated Review
Group; Motor Function, Speech and
Rehabilitation Study Section.
Date: June 24, 2013.
Time: 8:00 a.m. to 6:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: Ritz Carlton Hotel, 1150 22nd Street
NW., Washington, DC 20037.
Contact Person: Biao Tian, Ph.D., Scientific
Review Officer, Center for Scientific Review,
National Institutes of Health, 6701 Rockledge
Drive, Room 3166, MSC 7848, Bethesda, MD
20892, 301–402–4411, tianbi@csr.nih.gov.
Name of Committee: Biobehavioral and
Behavioral Processes Integrated Review
Group; Biobehavioral Mechanisms of
Emotion, Stress and Health Study Section.
Date: June 24, 2013.
Time: 8:00 a.m. to 6:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: The Westin St. Francis, 335 Powell
Street, San Francisco, CA 94102.
Contact Person: Maribeth Champoux,
Ph.D., Scientific Review Officer, Center for
Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 3170,
MSC 7848, Bethesda, MD 20892, (301) 594–
3163, champoum@csr.nih.gov.
Name of Committee: Center for Scientific
Review Special Emphasis Panel;
Fellowships: Oncological Sciences.
Date: June 24–25, 2013.
Time: 8:00 a.m. to 5:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: Embassy Suites at the Chevy Chase
Pavilion, 4300 Military Road NW.,
Washington, DC 20015.
Contact Person: Inese Z Beitins, MD,
Scientific Review Officer, Center for
Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 6152,
MSC 7892, Bethesda, MD 20892, 301–435–
1034, beitinsi@csr.nih.gov.
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Name of Committee: Center for Scientific
Review Special Emphasis Panel; Small
Business Grant Applications: Immunology.
Date: June 24, 2013.
Time: 8:00 a.m. to 6:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: The River Inn, 924 25th Street NW.,
Washington, DC 20037.
Contact Person: Stephen M. Nigida, Ph.D.,
Scientific Review Officer, Center for
Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 4212,
MSC 7812, Bethesda, MD 20892, 301–435–
1222, nigidas@csr.nih.gov.
Name of Committee: Center for Scientific
Review Special Emphasis Panel; Small
Business: Education, Psychology, and
Biology in Health Behavior.
Date: June 24–25, 2013.
Time: 8:00 a.m. to 5:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: Renaissance Mayflower Hotel, 1127
Connecticut Avenue NW., Washington, DC
20036.
Contact Person: John H Newman, Ph.D.,
Scientific Review Officer, Center for
Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 3222,
MSC 7808, Bethesda, MD 20892, (301)267–
9270, newmanjh@csr.nih.gov.
Name of Committee: Brain Disorders and
Clinical Neuroscience Integrated Review
Group; Brain Injury and Neurovascular
Pathologies Study Section.
Date: June 24–25, 2013.
Time: 8:00 a.m. to 5:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: Renaissance Washington DC,
Dupont Circle, 1143 New Hampshire Avenue
NW., Washington, DC 20037.
Contact Person: Alexander Yakovlev,
Ph.D., Scientific Review Officer, Center for
Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 5206,
MSC 7846, Bethesda, MD 20892, 301–435–
1254, yakovleva@csr.nih.gov.
Name of Committee: Center for Scientific
Review Special Emphasis Panel;
Fellowships: Genes, Genomes and Genetics.
Date: June 24, 2013.
Time: 10:00 a.m. to 7:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, 6701
Rockledge Drive, Bethesda, MD 20892.
Contact Person: Marie-Jose Belanger,
Scientific Review Officer, Center for
Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 5181,
MSC, Bethesda, MD 20892, 301–442–9049,
belangerm@csr.nih.gov.
Name of Committee: Center for Scientific
Review Special Emphasis Panel; Motor
Function, Speech and Rehabilitation
Overflow.
Date: June 24, 2013.
Time: 3:00 p.m. to 6:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: Ritz Carlton Hotel, 1150 22nd Street
NW., Washington, DC 20037.
Contact Person: Biao Tian, Ph.D., Scientific
Review Officer, Center for Scientific Review,
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[Federal Register Volume 78, Number 102 (Tuesday, May 28, 2013)]
[Notices]
[Pages 31950-31951]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 2013-12530]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases;
Notice of Closed Meetings
Pursuant to section 10(d) of the Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is hereby given of the following
meetings.
The meetings will be closed to the public in accordance with the
provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5
U.S.C., as amended. The grant applications and the discussions could
disclose confidential trade secrets or commercial property such as
patentable material, and personal information concerning individuals
associated with the grant applications, the disclosure of which would
constitute a clearly unwarranted invasion of personal privacy.
Name of Committee: National Institute of Diabetes and Digestive
and Kidney Diseases Special Emphasis Panel; Time-Sensitive Obesity
Prevention.
Date: June 24, 2013.
Time: 11:00 a.m. to 12:30 p.m.
Agenda: To review and evaluate grant applications.
Place: National Institutes of Health, Two Democracy Plaza, 6707
Democracy Boulevard, Bethesda, MD 20892, (Telephone Conference
Call).
Contact Person: Michele L. Barnard, PhD, Scientific Review
Officer, Review Branch, DEA, NIDDK, National Institutes of Health,
Room 753, 6707 Democracy Boulevard, Bethesda, MD 20892-2542, (301)
594-8898, barnardm@extra.niddk.nih.gov.
Name of Committee: National Institute of Diabetes and Digestive
and Kidney Diseases Special Emphasis Panel; Close Loop Technologies.
Date: July 2, 2013.
Time: 11:00 a.m. to 3:00 p.m.
Agenda: To review and evaluate grant applications.
Place: National Institutes of Health, Two Democracy Plaza, 6707
Democracy Boulevard, Bethesda, MD 20892, (Telephone Conference
Call).
Contact Person: Elena Sanovich, PhD, Scientific Review Officer,
Review Branch, DEA, NIDDK, National Institutes of Health, Room 750,
6707 Democracy Boulevard, Bethesda, MD 20892-2542, 301-594-8886,
sanoviche@mail.nih.gov.
Name of Committee: National Institute of Diabetes and Digestive
and Kidney Diseases Special Emphasis Panel; Advancing Clinical
Research in Primary Glomerular Diseases (UM1).
Date: July 8, 2013.
Time: 2:00 p.m. to 6:00 p.m.
Agenda: To review and evaluate grant applications.
Place: National Institutes of Health, Two Democracy Plaza, 6707
Democracy
[[Page 31951]]
Boulevard, Bethesda, MD 20892, (Telephone Conference Call).
Contact Person: Paul A. Rushing, PhD, Scientific Review Officer,
Review Branch, DEA, NIDDK, National Institutes of Health, Room 747,
6707 Democracy Boulevard, Bethesda, MD 20892-5452, (301) 594-8895,
rushingp@extra.niddk.nih.gov.
Name of Committee: National Institute of Diabetes and Digestive
and Kidney Diseases Special Emphasis Panel; Causes and Consequences
of Neutrophil Dysfunction in Early Onset Crohn's Disease.
Date: July 12, 2013.
Time: 1:00 p.m. to 2:00 p.m.
Agenda: To review and evaluate grant applications.
Place: National Institutes of Health, Two Democracy Plaza, 6707
Democracy Boulevard, Bethesda, MD 20892, (Telephone Conference
Call).
Contact Person: Paul A. Rushing, PhD, Scientific Review Officer,
Review Branch, DEA, NIDDK, National Institutes of Health, Room 747,
6707 Democracy Boulevard, Bethesda, MD 20892-5452, (301) 594-8895,
rushingp@extra.niddk.nih.gov.
(Catalogue of Federal Domestic Assistance Program Nos. 93.847,
Diabetes, Endocrinology and Metabolic Research; 93.848, Digestive
Diseases and Nutrition Research; 93.849, Kidney Diseases, Urology
and Hematology Research, National Institutes of Health, HHS).
Dated: May 21, 2013.
David Clary,
Program Analyst, Office of Federal Advisory Committee Policy.
[FR Doc. 2013-12530 Filed 5-24-13; 8:45 am]
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