Disease, Disability, and Injury Prevention and Control Special Emphasis Panels (SEP): Initial Review, 22268-22269 [2013-08716]
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Federal Register / Vol. 78, No. 72 / Monday, April 15, 2013 / Notices
and programmed electronic report entry,
which transitioned to the National
Tuberculosis Indicators Project (NTIP), a
secure web-based system for program
evaluation data, in 2010. No other
federal agency collects this type of
national tuberculosis data, and the
Aggregate report of follow-up for
preparation and utilization of these
reports at the local and state levels of
public health jurisdiction. CDC also
provides respondents with technical
support for the NTIP software
(Electronic—100%, Use of Electronic
Signatures—No).
There is no cost to respondents.
contacts of tuberculosis, and Aggregate
report of screening and preventive
therapy for tuberculosis infection are
the only data source about latent
tuberculosis infection for monitoring
national progress toward tuberculosis
elimination with these activities. CDC
provides ongoing assistance in the
ESTIMATED ANNUALIZED BURDEN HOURS
Number of
respondents
Number of
responses per
respondent
Average
burden per
response
(in hours)
Total
burden
hours
Type of respondent
Form name
Data clerks and Program Managers.
Follow-up and Treatment of
Contacts to Tuberculosis
Cases Form.
Follow-up and Treatment of
Contacts to Tuberculosis
Cases Form.
Follow-up and Treatment of
Contacts to Tuberculosis
Cases Form.
Targeted Testing and Treatment for Latent Tuberculosis
Infection.
Targeted Testing and Treatment for Latent Tuberculosis
Infection.
Targeted Testing and Treatment for Latent Tuberculosis
Infection.
100
1 (electronic) .............................
30/60
50
18
1 (manual) ................................
30/60
9
18
1 (manual) ................................
3
54
100
1 (electronic) .............................
30/60
50
18
1 (manual) ................................
30/60
9
18
1 (manual) ................................
3
54
...................................................
........................
...................................................
........................
226
Program Mangers ......................
Data clerks ................................
Data clerks and Program Managers.
Program Mangers ......................
Data clerks ................................
Total ...................................
Ron A. Otten,
Director, Office of Scientific Integrity, Office
of the Associate Director for Science, Office
of the Director, Centers for Disease Control
and Prevention.
[FR Doc. 2013–08730 Filed 4–12–13; 8:45 am]
BILLING CODE 4163–18–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
Centers for Disease Control and
Prevention
sroberts on DSK5SPTVN1PROD with NOTICES
Disease, Disability, and Injury
Prevention and Control Special
Emphasis Panels (SEP): Initial Review
The meeting announced below
concerns Conducting Public Health
Research in Kenya, FOA GH10–003;
Conducting Public Health Research in
Thailand by the Ministry of Public
Health (MOPH), FOA GH11–002;
Conducting Public Health Research in
China, FOA GH12–005; Strengthening
Disease Prevention Research Capacity
for Public Health Action in Guatemala
and the Central American Region, FOA
GH13–001; Detecting Etiologies of
Emerging Infectious Diseases at the
Regional Level—Western Ghat Region of
Karnataka and Kerala, India, FOA
VerDate Mar<15>2010
17:00 Apr 12, 2013
Jkt 229001
GH13–003; Strengthening Surveillance
for Japanese Encephalitis in India, FOA
GH13–004; and Research and Technical
Assistance for Public Health
Interventions in Haiti to Support Postearthquake Reconstruction, Cholera and
HIV/AIDS, FOA GH13–006, initial
review.
Correction: The notice was published
in the Federal Register on April 4, 2013,
Volume 78, Number 65, Pages 20319–
20320. The meeting announced and
matters to be discussed should read as
follows:
Conducting Public Health Research in
Kenya, FOA GH10–003; Conducting
Public Health Research in Thailand by
the Ministry of Public Health (MOPH),
FOA GH11–002; Conducting Public
Health Research in China, FOA GH12–
005; Strengthening Disease Prevention
Research Capacity for Public Health
Action in Guatemala and the Central
American Region, FOA GH13–001;
Detecting Etiologies of Emerging
Infectious Diseases at the Regional
Level—Western Ghat Region of
Karnataka and Kerala, India, FOA
GH13–003; Strengthening Surveillance
for Japanese Encephalitis in India, FOA
GH13–004; and Research and Technical
Assistance for Public Health
Interventions in Haiti to Support Post-
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Fmt 4703
Sfmt 4703
earthquake Reconstruction, Cholera and
HIV/AIDS, FOA GH13–006.
Matters To Be Discussed: The meeting
will include the initial review,
discussion, and evaluation of
applications received in response to
‘‘Conducting Public Health Research in
Kenya, FOA GH10–003; Conducting
Public Health Research in Thailand by
the Ministry of Public Health (MOPH),
FOA GH11–002; Conducting Public
Health Research in China, FOA GH12–
005; Strengthening Disease Prevention
Research Capacity for Public Health
Action in Guatemala and the Central
American Region, FOA GH13–001;
Detecting Etiologies of Emerging
Infectious Diseases at the Regional
Level—Western Ghat Region of
Karnataka and Kerala, India, FOA
GH13–003; Strengthening Surveillance
for Japanese Encephalitis in India, FOA
GH13–004; and Research and Technical
Assistance for Public Health
Interventions in Haiti to Support Postearthquake Reconstruction, Cholera and
HIV/AIDS, FOA GH13–006, initial
review.’’
Contact Person for More Information:
Lata Kumar, Scientific Review Officer,
CGH Science Office, Center for Global
Health, CDC, 1600 Clifton Road, NE.,
E:\FR\FM\15APN1.SGM
15APN1
Federal Register / Vol. 78, No. 72 / Monday, April 15, 2013 / Notices
Mailstop D–69, Atlanta, Georgia 30033,
Telephone (404) 639–7618.
The Director, Management Analysis
and Services Office, has been delegated
the authority to sign Federal Register
notices pertaining to announcements of
meetings and other committee
management activities, for both the
Centers for Disease Control and
Prevention and the Agency for Toxic
Substances and Disease Registry.
Elaine L. Baker,
Director, Management Analysis and Services
Office, Centers for Disease Control and
Prevention.
[FR Doc. 2013–08716 Filed 4–12–13; 8:45 am]
BILLING CODE 4163–18–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
Food and Drug Administration
[Docket No. FDA–2013–D–0369]
International Conference on
Harmonisation; Draft Guidance on M7
Assessment and Control of DNA
Reactive (Mutagenic) Impurities in
Pharmaceuticals To Limit Potential
Carcinogenic Risk; Availability
AGENCY:
Food and Drug Administration,
HHS.
ACTION:
Notice.
The Food and Drug
Administration (FDA) is announcing the
availability of a draft guidance entitled
‘‘M7 Assessment and Control of DNA
Reactive (Mutagenic) Impurities in
Pharmaceuticals to Limit Potential
Carcinogenic Risk.’’ The draft guidance
was prepared under the auspices of the
International Conference on
Harmonisation of Technical
Requirements for Registration of
Pharmaceuticals for Human Use (ICH).
The draft guidance emphasizes
considerations of both safety and quality
risk management in establishing levels
of mutagenic impurities that are
expected to pose negligible carcinogenic
risk. It outlines recommendations for
assessment and control of mutagenic
impurities that reside or are reasonably
expected to reside in a final drug
substance or product, taking into
consideration the intended conditions
of human use. The draft guidance is
intended to provide guidance for new
drug substances and new drug products
during their clinical development and
subsequent applications for marketing.
DATES: Although you can comment on
any guidance at any time (see 21 CFR
10.115 (g)(5)), to ensure that the Agency
considers your comment on this draft
sroberts on DSK5SPTVN1PROD with NOTICES
SUMMARY:
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17:00 Apr 12, 2013
Jkt 229001
guidance before it begins work on the
final version of the guidance, submit
either electronic or written comments
on the draft guidance by June 14, 2013.
ADDRESSES: Submit written requests for
single copies of the draft guidance to the
Division of Drug Information, Center for
Drug Evaluation and Research, Food
and Drug Administration, 10903 New
Hampshire Ave., Bldg. 51, Rm. 2201,
Silver Spring, MD 20993–0002, or the
Office of Communication, Outreach and
Development (HFM–40), Center for
Biologics Evaluation and Research
(CBER), Food and Drug Administration,
1401 Rockville Pike, suite 200N,
Rockville, MD 20852–1448. Send one
self-addressed adhesive label to assist
the office in processing your requests.
The draft guidance may also be obtained
by mail by calling CBER at 1–800–835–
4709 or 301–827–1800. See the
SUPPLEMENTARY INFORMATION section for
electronic access to the draft guidance
document.
Submit electronic comments on the
draft guidance to https://
www.regulations.gov. Submit written
comments to the Division of Dockets
Management (HFA–305), Food and Drug
Administration, 5630 Fishers Lane, Rm.
1061, Rockville, MD 20852.
FOR FURTHER INFORMATION CONTACT:
Regarding the guidance:
David Jacobson-Kram, Office of New
Drugs, Center for Drug Evaluation and
Research, Food and Drug
Administration, 10903 New
Hampshire Ave., Bldg. 32, Rm. 5299,
Silver Spring, MD 20993–0002, 301–
796–0175.
Regarding the ICH:
Michelle Limoli, International
Programs, Center for Drug Evaluation
and Research, Food and Drug
Administration, 10903 New
Hampshire Ave., Bldg. 51, Rm. 3342,
Silver Spring, MD 20993–0002, 301–
796–8377.
SUPPLEMENTARY INFORMATION:
I. Background
In recent years, many important
initiatives have been undertaken by
regulatory authorities and industry
associations to promote international
harmonization of regulatory
requirements. FDA has participated in
many meetings designed to enhance
harmonization and is committed to
seeking scientifically based harmonized
technical procedures for pharmaceutical
development. One of the goals of
harmonization is to identify and then
reduce differences in technical
requirements for drug development
among regulatory agencies.
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22269
ICH was organized to provide an
opportunity for tripartite harmonization
initiatives to be developed with input
from both regulatory and industry
representatives. FDA also seeks input
from consumer representatives and
others. ICH is concerned with
harmonization of technical
requirements for the registration of
pharmaceutical products among three
regions: The European Union, Japan,
and the United States. The six ICH
sponsors are the European Commission;
the European Federation of
Pharmaceutical Industries Associations;
the Japanese Ministry of Health, Labour,
and Welfare; the Japanese
Pharmaceutical Manufacturers
Association; the Centers for Drug
Evaluation and Research and Biologics
Evaluation and Research, FDA; and the
Pharmaceutical Research and
Manufacturers of America. The ICH
Secretariat, which coordinates the
preparation of documentation, is
provided by the International
Federation of Pharmaceutical
Manufacturers Associations (IFPMA).
The ICH Steering Committee includes
representatives from each of the ICH
sponsors and the IFPMA, as well as
observers from the World Health
Organization, Health Canada, and the
European Free Trade Area.
In February 2013, the ICH Steering
Committee agreed that a draft guidance
entitled ‘‘M7 Assessment and Control of
DNA Reactive (Mutagenic) Impurities in
Pharmaceuticals to Limit Potential
Carcinogenic Risk’’ should be made
available for public comment. The draft
guidance is the product of the M7
Expert Working Group of the ICH.
Comments about this draft will be
considered by FDA and the M7 Expert
Working Group.
The draft guidance provides guidance
on the regulation of genotoxic
impurities in new drug substances and
drug products.
This draft guidance is being issued
consistent with FDA’s good guidance
practices regulation (21 CFR 10.115).
The draft guidance, when finalized, will
represent the Agency’s current thinking
on this topic. It does not create or confer
any rights for or on any person and does
not operate to bind FDA or the public.
An alternative approach may be used if
such approach satisfies the
requirements of the applicable statutes
and regulations.
II. Comments
Interested persons may submit either
electronic comments regarding this
document to https://www.regulations.gov
or written comments to the Division of
Dockets Management (see ADDRESSES). It
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Agencies
[Federal Register Volume 78, Number 72 (Monday, April 15, 2013)]
[Notices]
[Pages 22268-22269]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 2013-08716]
-----------------------------------------------------------------------
DEPARTMENT OF HEALTH AND HUMAN SERVICES
Centers for Disease Control and Prevention
Disease, Disability, and Injury Prevention and Control Special
Emphasis Panels (SEP): Initial Review
The meeting announced below concerns Conducting Public Health
Research in Kenya, FOA GH10-003; Conducting Public Health Research in
Thailand by the Ministry of Public Health (MOPH), FOA GH11-002;
Conducting Public Health Research in China, FOA GH12-005; Strengthening
Disease Prevention Research Capacity for Public Health Action in
Guatemala and the Central American Region, FOA GH13-001; Detecting
Etiologies of Emerging Infectious Diseases at the Regional Level--
Western Ghat Region of Karnataka and Kerala, India, FOA GH13-003;
Strengthening Surveillance for Japanese Encephalitis in India, FOA
GH13-004; and Research and Technical Assistance for Public Health
Interventions in Haiti to Support Post-earthquake Reconstruction,
Cholera and HIV/AIDS, FOA GH13-006, initial review.
Correction: The notice was published in the Federal Register on
April 4, 2013, Volume 78, Number 65, Pages 20319-20320. The meeting
announced and matters to be discussed should read as follows:
Conducting Public Health Research in Kenya, FOA GH10-003;
Conducting Public Health Research in Thailand by the Ministry of Public
Health (MOPH), FOA GH11-002; Conducting Public Health Research in
China, FOA GH12-005; Strengthening Disease Prevention Research Capacity
for Public Health Action in Guatemala and the Central American Region,
FOA GH13-001; Detecting Etiologies of Emerging Infectious Diseases at
the Regional Level--Western Ghat Region of Karnataka and Kerala, India,
FOA GH13-003; Strengthening Surveillance for Japanese Encephalitis in
India, FOA GH13-004; and Research and Technical Assistance for Public
Health Interventions in Haiti to Support Post-earthquake
Reconstruction, Cholera and HIV/AIDS, FOA GH13-006.
Matters To Be Discussed: The meeting will include the initial
review, discussion, and evaluation of applications received in response
to ``Conducting Public Health Research in Kenya, FOA GH10-003;
Conducting Public Health Research in Thailand by the Ministry of Public
Health (MOPH), FOA GH11-002; Conducting Public Health Research in
China, FOA GH12-005; Strengthening Disease Prevention Research Capacity
for Public Health Action in Guatemala and the Central American Region,
FOA GH13-001; Detecting Etiologies of Emerging Infectious Diseases at
the Regional Level--Western Ghat Region of Karnataka and Kerala, India,
FOA GH13-003; Strengthening Surveillance for Japanese Encephalitis in
India, FOA GH13-004; and Research and Technical Assistance for Public
Health Interventions in Haiti to Support Post-earthquake
Reconstruction, Cholera and HIV/AIDS, FOA GH13-006, initial review.''
Contact Person for More Information: Lata Kumar, Scientific Review
Officer, CGH Science Office, Center for Global Health, CDC, 1600
Clifton Road, NE.,
[[Page 22269]]
Mailstop D-69, Atlanta, Georgia 30033, Telephone (404) 639-7618.
The Director, Management Analysis and Services Office, has been
delegated the authority to sign Federal Register notices pertaining to
announcements of meetings and other committee management activities,
for both the Centers for Disease Control and Prevention and the Agency
for Toxic Substances and Disease Registry.
Elaine L. Baker,
Director, Management Analysis and Services Office, Centers for Disease
Control and Prevention.
[FR Doc. 2013-08716 Filed 4-12-13; 8:45 am]
BILLING CODE 4163-18-P