National Institute of Allergy and Infectious Diseases; Notice of Closed Meeting, 18355 [2013-06803]
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Federal Register / Vol. 78, No. 58 / Tuesday, March 26, 2013 / Notices
• Pre-clinical.
• In vitro data available.
Inventors: Suzanne U. Emerson,
Priyanka Shukla, Hanh T. Nguyen, and
Robert H. Purcell (NIAID).
Publication: Shukla P, et al. Crossspecies infections of cultured cells by
hepatitis E virus and discovery of an
infectious virus-host recombinant. Proc
Natl Acad Sci U S A. 2011 Feb
8;108(6):2438–2443. [PMID 21262830].
Intellectual Property: HHS Reference
No. E–074–2011/2—PCT Application
PCT/US2012/020830 filed 10 Jan 2012.
Licensing Contact: Kevin W. Chang,
Ph.D.; 301–435–5018;
changke@mail.nih.gov.
Collaborative Research Opportunity:
The National Institute of Allergy and
Infectious Diseases is seeking statements
of capability or interest from parties
interested in collaborative research to
further develop, evaluate or
commercialize hepatitis E virus
vaccines. For collaboration
opportunities, please contact Maryann
Puglielli, Ph.D., J.D. at 301–451–6863 or
maryann.puglielli@nih.gov.
srobinson on DSK4SPTVN1PROD with NOTICES
Composite Probes and Use Thereof in
Super Resolution Microscopy
Description of Technology: The
technology is in the field of fluorescence
microscopy. More specifically, the
invention describes and claims the
compo site probes for super resolution
optical techniques using super
resolution via transiently activated
quenchers (STAQ). The compo site
probes include a donor moiety and an
acceptor moiety joined by a linker. The
acceptor moiety, when excited by
incident radiation, is excited to a state
which, for example, absorbs in the
donor emission region, such that the
acceptor moiety in its excited state
quenches at least a portion of the donor
moiety emission. Other transiently
activated quenching mechanisms and
moieties could accomplish the same
task by reducing donor population. Also
disclosed are methods for irradiating a
selected region of a target material
including the compo site probe, wherein
the compo site probe enables improved
resolution by point spread function
modification.
Potential Commercial Applications:
• Ultrafine imaging for biomolecules,
vesicles and organelles, particularly of
living biological samples, in biomedical
research.
• Potential applications in clinical
diagnostics.
• Nanoscopic Lithography—STAQ
compo sites could, in principle, control
polymerization of photoresist masks to
make feature sizes below 20nm.
VerDate Mar<15>2010
19:07 Mar 25, 2013
Jkt 229001
Competitive Advantages: Improved
ultrafine imaging—
• Imaging objects as small as 10 nm.
• Narrow the point spread function.
• STAQ uses less power, making live
cell study practical at theoretically high
resolution.
Development Stage:
• The invention is fully developed.
• Need to build multicolor palette
that can be integrated into a commercial
microscope.
• May need to make certain protein
chimeras and photoinitiators for
validation.
Inventors: Jay R Knutson and Gary L.
Griffiths (NHLBI).
Publications:
1. Doose S, et al. Probing polyproline
structure and dynamics by
photoinduced electron transfer provides
evidence for deviations from a regular
polyproline type II helix. Proc Natl
Acad Sci USA. 2007 Oct
30;104(44):17400–5. [PMID 17956989]
2. Schuler B, et al. Polyproline and
the ‘‘spectroscopic ruler’’ revi sited with
single-molecule fluorescence. Proc Natl
Acad Sci USA. 2005 Feb
22;102(8):2754–9. [PMID 15699337]
3. Best RB, et al. Effect of flexibility
and cis residues in single-molecule
FRET studies of polyproline. Proc Natl
Acad Sci USA. 2007 Nov
27;104(48):18964–9. [PMID 18029448]
4. Sahoo H, et al. A 10–A
spectroscopic ruler applied to short
polyprolines. J Am Chem Soc. 2007 Aug
8;129(31):9762–72. [PMID 17629273]
5. Li L, et al. Achieving lambda/20
resolution by one-color initiation and
deactivation of polymerization. Science.
2009 May 15;324(5929):892–3. [PMID
19359543]
6. Hell SW. Far-field optical
nanoscopy. Science. 2007 May
25;316(5828):1153–8. [PMID 19525330]
7. Masia F, et al. Resonant four-wave
mixing of gold nanoparticles for threedimensional cell microscopy. Opt Lett.
2009 Jun 15;34(12):1816–8. [PMID
19529713]
8. Schmidt R, et al. Mitochondrial
cristae revealed with focused light.
Nano Lett. 2009 Jun;9(6):2508–10.
[PMID 19459703]
Intellectual Property: HHS Reference
No. E–253–2009/0—U.S. Patent
Application No. 13/519,737 filed 28 Jun
2012
Licensing Contact: Michael A.
Shmilovich, Esq., CLP; 301–435–5019;
shmilovm@mail.nih.gov
Collaborative Research Opportunity:
The National Heart, Lung and Blood
Institute, Laboratory of Molecular
Biophysics, is also seeking statements of
capability or interest from parties
interested in collaborative partnerships
PO 00000
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18355
to further develop, evaluate, or
commercialize this technology. Please
contact Brian Bailey, Ph.D. at
bbailey@mail.nih.gov for more
information.
Dated: March 18, 2013.
Richard U. Rodriguez,
Director, Division of Technology Development
and Transfer, Office of Technology Transfer,
National Institutes of Health.
[FR Doc. 2013–06836 Filed 3–25–13; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
National Institute of Allergy and
Infectious Diseases; Notice of Closed
Meeting
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is
hereby given of the following meeting.
The meeting will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The contract proposals and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the contract
proposals, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: National Institute of
Allergy and Infectious Diseases Special
Emphasis Panel; Operation of a Facility for
Testing Malaria Vaccine in Human Subjects.
Date: April 19, 2013.
Time: 11:30 a.m. to 5:00 p.m.
Agenda: To review and evaluate contract
proposals.
Place: National Institutes of Health, 6700B
Rockledge Drive, Bethesda, MD 20817,
(Telephone Conference Call).
Contact Person: Jay R. Radke, Ph.D.,
Scientific Review Officer, Scientific Review
Program, Division of Extramural Activities,
National Institutes of Health/NIAID, 6700B
Rockledge Drive, MSC 7616, Bethesda, MD
20892–7616, 301–496–2550,
jay.radke@nih.gov.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.855, Allergy, Immunology,
and Transplantation Research; 93.856,
Microbiology and Infectious Diseases
Research, National Institutes of Health, HHS)
Dated: March 20, 2013.
David Clary,
Program Analyst, Office of Federal Advisory
Committee Policy.
[FR Doc. 2013–06803 Filed 3–25–13; 8:45 am]
BILLING CODE 4140–01–P
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[Federal Register Volume 78, Number 58 (Tuesday, March 26, 2013)]
[Notices]
[Page 18355]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 2013-06803]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
National Institute of Allergy and Infectious Diseases; Notice of
Closed Meeting
Pursuant to section 10(d) of the Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is hereby given of the following
meeting.
The meeting will be closed to the public in accordance with the
provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5
U.S.C., as amended. The contract proposals and the discussions could
disclose confidential trade secrets or commercial property such as
patentable material, and personal information concerning individuals
associated with the contract proposals, the disclosure of which would
constitute a clearly unwarranted invasion of personal privacy.
Name of Committee: National Institute of Allergy and Infectious
Diseases Special Emphasis Panel; Operation of a Facility for Testing
Malaria Vaccine in Human Subjects.
Date: April 19, 2013.
Time: 11:30 a.m. to 5:00 p.m.
Agenda: To review and evaluate contract proposals.
Place: National Institutes of Health, 6700B Rockledge Drive,
Bethesda, MD 20817, (Telephone Conference Call).
Contact Person: Jay R. Radke, Ph.D., Scientific Review Officer,
Scientific Review Program, Division of Extramural Activities,
National Institutes of Health/NIAID, 6700B Rockledge Drive, MSC
7616, Bethesda, MD 20892-7616, 301-496-2550, jay.radke@nih.gov.
(Catalogue of Federal Domestic Assistance Program Nos. 93.855,
Allergy, Immunology, and Transplantation Research; 93.856,
Microbiology and Infectious Diseases Research, National Institutes
of Health, HHS)
Dated: March 20, 2013.
David Clary,
Program Analyst, Office of Federal Advisory Committee Policy.
[FR Doc. 2013-06803 Filed 3-25-13; 8:45 am]
BILLING CODE 4140-01-P
