Guidance Regarding Inspection and Certification of Vessels Under the Maritime Security Program, 13691-13692 [2013-04732]
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Federal Register / Vol. 78, No. 40 / Thursday, February 28, 2013 / Notices
Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 3152,
MSC 7770, Bethesda, MD 20892, 301–435–
1017, tdrgon@csr.nih.gov.
This notice is being published less than 15
days prior to the meeting due to the timing
limitations imposed by the review and
funding cycle.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.306, Comparative Medicine;
93.333, Clinical Research, 93.306, 93.333,
93.337, 93.393–93.396, 93.837–93.844,
93.846–93.878, 93.892, 93.893, National
Institutes of Health, HHS)
Dated: February 22, 2013.
Anna Snouffer,
Deputy Director, Office of Federal Advisory
Committee Policy.
[FR Doc. 2013–04581 Filed 2–27–13; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
Prospective Grant of Exclusive
License: The Development of m971
and m972 Chimeric Antigen Receptors
(CARs) for the Treatment of B Cell
Malignancies
National Institutes of Health,
Public Health Service, HHS.
AGENCY:
ACTION:
Notice.
This is notice, in accordance
with 35 U.S.C. 209(c)(1) and 37 CFR
404.7(a)(1)(i), that the National
Institutes of Health, Department of
Health and Human Services, is
contemplating the grant of an exclusive
license to practice the inventions
embodied in (a) U.S. Patent Application
61/717,960 entitled ‘‘M971 Chimeric
Antigen Receptors’’ [HHS Ref. E–291–
2012/0–US–01], and (b) U.S. Patent
Application 61/042,239 entitled
‘‘Human Monoclonal Antibodies
Specific for CD22’’ [HHS Ref. E–080–
2008/0–US–01], PCT Application PCT/
US2009/124109 entitled ‘‘Human and
Improved Murine Monoclonal
Antibodies Against CD22’’ [HHS Ref. E–
080–2008/0–PCT–02], US patent
application 12/934,214 entitled ‘‘Human
Monoclonal Antibodies Specific for
CD22 ’’ [HHS Ref. E–080–2008/0–US–
03], and all related continuing and
foreign patents/patent applications for
these technology families, to Neomune,
Inc. The patent rights in these
inventions have been assigned to and/or
exclusively licensed to the Government
of the United States of America.
The prospective exclusive license
territory may be worldwide, and the
field of use may be limited to:
mstockstill on DSK4VPTVN1PROD with NOTICES
SUMMARY:
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19:12 Feb 27, 2013
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Treatment of B cell malignancies that
express CD22 on their cell surface using
chimeric antigen receptors which contain the
m971 or m972 antibody binding fragments.
Only written comments and/or
applications for a license which are
received by the NIH Office of
Technology Transfer on or before April
1, 2013 will be considered.
ADDRESSES: Requests for copies of the
patent application, inquiries, comments,
and other materials relating to the
contemplated exclusive evaluation
option license should be directed to:
David A. Lambertson, Ph.D., Senior
Licensing and Patenting Manager, Office
of Technology Transfer, National
Institutes of Health, 6011 Executive
Boulevard, Suite 325, Rockville, MD
20852–3804; Telephone: (301) 435–
4632; Facsimile: (301) 402–0220; Email:
lambertsond@mail.nih.gov.
SUPPLEMENTARY INFORMATION: Chimeric
antigen receptors (CARs) are engineered
cell surface receptors which have been
designed to target immune effector cells
(such as a T cell) to certain cellular
targets. CARs target diseased cells
through antigen-specificity domain
recognizes a protein that is
preferentially expressed on the cells,
and the immune effector cell proceeds
to eradicate the diseased cells. Since
there are a number of cell surface
proteins that are preferentially
expressed on cancer cells, CARs are
potential therapeutic candidates in the
treatment of cancer.
The specific CARs for which this
exclusive license may be granted
comprise a targeting domain which
contains the antibody binding fragments
of the anti-CD22 antibodies m971 and
m972. CD22 is a cell surface protein that
is preferentially expressed on several
types of cancer cells, including
hematological malignancies such as
chronic lymphocytic leukemia (CLL),
acute lymphocytic leukemia (ALL),
hairy cell leukemia (HCL) and nonHodgkin’s lymphoma (NHL). By linking
an anti-CD22 antibody binding fragment
to a CAR, it is possible to selectively kill
the CD22-expressing cancer cells,
leaving non-cancer cells alone. This
results in an effective therapeutic
strategy with fewer side effects than a
non-targeted therapy.
The prospective exclusive license will
comply with the terms and conditions
of 35 U.S.C. 209 and 37 CFR 404.7. The
prospective exclusive license may be
granted unless the NIH receives written
evidence and argument that establishes
that the grant of the license would not
be consistent with the requirements of
35 U.S.C. 209 and 37 CFR 404.7 within
DATES:
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13691
thirty (30) days from the date of this
published notice.
Complete applications for a license in
the field of use filed in response to this
notice will be treated as objections to
the grant of the contemplated exclusive
license. Comments and objections
submitted to this notice will not be
made available for public inspection
and, to the extent permitted by law, will
not be released under the Freedom of
Information Act, 5 U.S.C. 552.
Dated: February 22, 2013.
Richard U. Rodriguez,
Director, Division of Technology Development
and Transfer, Office of Technology Transfer,
National Institutes of Health.
[FR Doc. 2013–04585 Filed 2–27–13; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HOMELAND
SECURITY
Coast Guard
[Docket No. USCG–2011–1156]
Guidance Regarding Inspection and
Certification of Vessels Under the
Maritime Security Program
Coast Guard, DHS.
Notice of availability.
AGENCY:
ACTION:
The Coast Guard announces
the availability of Navigation and Vessel
Inspection Circular (NVIC) 01–13,
‘‘Inspection and Certification of Vessels
Under the Maritime Security Program
(MSP).’’ The MSP serves as a means for
establishing a fleet of commercially
viable and militarily useful vessels to
meet national defense as well as other
security requirements. NVIC 01–13 sets
forth the Coast Guard’s policies and
procedures regarding the inspection and
certification of vessels under the MSP.
NVIC 01–13 provides a comprehensive
approach to the MSP inspection process
through the establishment of two levels
of MSP inspection and oversight.
DATES: NVIC 01–13 is effective as of
February 28, 2013.
ADDRESSES: To view the documents
mentioned in this notice, go to https://
www.regulations.gov and use ‘‘USCG–
2012–1156’’ as your search term. Locate
this notice in the search results, and use
the filters on the left side of the page to
locate specific documents by type. If
you do not have access to the Internet,
you may view the docket online by
visiting the Docket Management Facility
in Room W12–140 on the ground floor
of the Department of Transportation
West Building, 1200 New Jersey Avenue
SE., Washington, DC 20590, between 9
a.m. and 5 p.m., Monday through
SUMMARY:
E:\FR\FM\28FEN1.SGM
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13692
Federal Register / Vol. 78, No. 40 / Thursday, February 28, 2013 / Notices
mstockstill on DSK4VPTVN1PROD with NOTICES
Friday, except Federal holidays. We
have an agreement with the Department
of Transportation to use the Docket
Management Facility.
FOR FURTHER INFORMATION CONTACT: If
you have questions on this notice, call
or email Mr. John Hannon, Domestic
Vessels Division, U.S. Coast Guard;
telephone 202–372–1222, email
John.J.Hannon@uscg.mil. If you have
questions on viewing material in the
docket, call Docket Operations at 202–
366–9826.
SUPPLEMENTARY INFORMATION:
Viewing the NVIC and other
documents: To view NVIC 01–13 and
related documents, go to https://
www.regulations.gov, use ‘‘USCG–2011–
1156’’ as your search term, and follow
the instructions in the ADDRESSES
section above.
Background and Purpose
Title VI of the Merchant Marine Act
of 1936, as amended by the Maritime
Security Act of 1996 (MSA) (Pub. L.
104–239), authorized the establishment
of a Maritime Security Fleet under the
Maritime Security Program (MSP). The
MSP serves as a means for establishing
a fleet of commercially viable and
militarily useful vessels to meet national
defense as well as other security
requirements.
The U.S. Maritime Administration
(MARAD) Office of Sealift Support is
the lead governmental office responsible
for administration of the MSP. MARAD,
in coordination with the Department of
Defense, established a program whereby
certain categories of militarily useful
commercial vessels may be designated
for emergency service to carry military
cargo in time of war, national
emergency, or military contingency.
Some vessels enrolled in the MSP may
receive a payment as part of their
enrollment. Alternatively, vessels may
enroll in other voluntary sealift support
programs established by MARAD.
Section 53102(e) of Title 46 U.S.C.
established standards for issuance of a
Coast Guard Certificate of Inspection
(COI) to a previously foreign-flagged
vessel transitioning to U.S.-flagged once
eligibility for the MSP has been
established by MARAD and the Coast
Guard. The statute does not specify the
scope or manner of the inspections to be
carried out by the Coast Guard to verify
that MSP vessels fulfill requirements
necessary to receive and maintain a COI.
The purpose of NVIC 01–13 is to
provide the marine industry and Coast
Guard personnel with uniform guidance
regarding the MSP. Vessels that meet
MSP enrollment criteria may obtain a
COI by following the processes outlined
in NVIC 01–13.
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19:12 Feb 27, 2013
Jkt 229001
On January 19, 2012, the Coast Guard
published a notice in the Federal
Register announcing the availability of
a draft NVIC 01–13 and requesting
public comments on the draft (See 77
FR 2741). The Coast Guard recognized
the need to avoid the inconsistent
application of inspection procedures
under the MSP. Accordingly, draft NVIC
01–13 outlined the inspection process
for vessels transitioning from foreignflag to U.S.-flag to obtain initial and
ongoing certification under the MSP. To
promote consistency and
standardization of Coast Guard policies
and procedures, draft NVIC 01–13 set
forth a comprehensive approach to the
MSP inspection process through the
establishment of two levels of MSP
inspection and oversight: (1) MSP
(Regular); and (2) MSP Select. This twolevel approach would enable the Coast
Guard to apply traditional inspection
methods to newly reflagged vessels,
while at the same time apply a less
stringent level of oversight to vessels
that have consistently demonstrated
satisfactory performance and substantial
compliance with applicable rules.
Newly enrolled MSP vessels would
continue to be inspected by the Coast
Guard in a manner similar to traditional
Coast Guard inspections. After a period
of evaluation, MSP vessels would be
eligible to seek enrollment under MSP
Select. MSP Select vessel oversight
would consist of risk-based vessel
examinations, periodic oversight, and
evaluations of Authorized Class Society
(ACS) survey activities.
We received eight public comment
letters in response to the January 19,
2012 Federal Register notice. These
comment letters contained a total of
approximately 60 specific
recommendations, suggestions, and
other comments. We have created a
document that provides a summary of
each comment and the corresponding
Coast Guard response. A copy of this
public comment matrix is available for
viewing in the public docket for this
notice. You may access the docket going
to https://www.regulations.gov, using
‘‘USCG–2011–1156’’ as your search
term, and following the instructions in
the ADDRESSES section above.
The basic framework of draft NVIC
01–13 described above is retained in the
final version. The Coast Guard has made
some changes from the draft version of
NVIC 01–13 to the final version based
on the public comments. A brief
discussion of the most important
changes is provided below. For more
detailed information, please consult the
actual public comment letters and
public comment matrix in the docket.
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Fmt 4703
Sfmt 4703
(1) One commenter requested that we
relax the standards for enrollment into
the MSP Select Program by evaluating
the ship operating company’s regulatory
compliance record over the most recent
5-year period. The commenter suggested
that if the operator is found to be fully
compliant during that period, all of its
vessels should be permitted to enroll in
MSP Select. We disagree. We believe
that a vessel-specific approach is more
appropriate for sufficiently and
effectively evaluating regulatory
compliance. While we disagree with the
commenter’s approach, we have
decided to reduce the performance
verification period from 5 years to 3
years in order to lessen the burden on
vessel operators.
(2) In response to a commenter’s
request, we provided more detail
regarding Marine Inspector
requirements, requisite qualifications,
and duties associated with the MSP. We
have added the requested language in
Sections 2.2.1. and 2.2.2. of NVIC 01–
13.
(3) We received a number of
comments pertaining to engine
automation, the applicability of Engine
International Air Pollution Prevention
(EIAPP) certificates, and the procedures
for underwater survey in lieu of
drydocking (UWILD). In response to
these comments, we provided
additional clarification regarding vessel
automation approval, EIAPP
certification, and UWILD procedures.
This notice is issued under authority
of 5 U.S.C. 552(a), 46 U.S.C. 53102(e),
and Department of Homeland Security
Delegation No. 0170.1(1).
Dated: February 22, 2013.
Paul F. Thomas,
Captain, U.S. Coast Guard, Director,
Inspections and Compliance.
[FR Doc. 2013–04732 Filed 2–27–13; 8:45 am]
BILLING CODE 9110–04–P
DEPARTMENT OF THE INTERIOR
Fish and Wildlife Service
[FWS–R4–R–2012–N154;
FXRS12650400000S3–123–FF04R02000]
Clarks River National Wildlife Refuge,
KY; Final Comprehensive
Conservation Plan/Land Protection
Plan, and Finding of No Significant
Impact for the Environmental
Assessment
Fish and Wildlife Service,
Interior.
ACTION: Notice of availability.
AGENCY:
We, the Fish and Wildlife
Service (Service), announce the
SUMMARY:
E:\FR\FM\28FEN1.SGM
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Agencies
[Federal Register Volume 78, Number 40 (Thursday, February 28, 2013)]
[Notices]
[Pages 13691-13692]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 2013-04732]
=======================================================================
-----------------------------------------------------------------------
DEPARTMENT OF HOMELAND SECURITY
Coast Guard
[Docket No. USCG-2011-1156]
Guidance Regarding Inspection and Certification of Vessels Under
the Maritime Security Program
AGENCY: Coast Guard, DHS.
ACTION: Notice of availability.
-----------------------------------------------------------------------
SUMMARY: The Coast Guard announces the availability of Navigation and
Vessel Inspection Circular (NVIC) 01-13, ``Inspection and Certification
of Vessels Under the Maritime Security Program (MSP).'' The MSP serves
as a means for establishing a fleet of commercially viable and
militarily useful vessels to meet national defense as well as other
security requirements. NVIC 01-13 sets forth the Coast Guard's policies
and procedures regarding the inspection and certification of vessels
under the MSP. NVIC 01-13 provides a comprehensive approach to the MSP
inspection process through the establishment of two levels of MSP
inspection and oversight.
DATES: NVIC 01-13 is effective as of February 28, 2013.
ADDRESSES: To view the documents mentioned in this notice, go to https://www.regulations.gov and use ``USCG-2012-1156'' as your search term.
Locate this notice in the search results, and use the filters on the
left side of the page to locate specific documents by type. If you do
not have access to the Internet, you may view the docket online by
visiting the Docket Management Facility in Room W12-140 on the ground
floor of the Department of Transportation West Building, 1200 New
Jersey Avenue SE., Washington, DC 20590, between 9 a.m. and 5 p.m.,
Monday through
[[Page 13692]]
Friday, except Federal holidays. We have an agreement with the
Department of Transportation to use the Docket Management Facility.
FOR FURTHER INFORMATION CONTACT: If you have questions on this notice,
call or email Mr. John Hannon, Domestic Vessels Division, U.S. Coast
Guard; telephone 202-372-1222, email John.J.Hannon@uscg.mil. If you
have questions on viewing material in the docket, call Docket
Operations at 202-366-9826.
SUPPLEMENTARY INFORMATION:
Viewing the NVIC and other documents: To view NVIC 01-13 and
related documents, go to https://www.regulations.gov, use ``USCG-2011-
1156'' as your search term, and follow the instructions in the
ADDRESSES section above.
Background and Purpose
Title VI of the Merchant Marine Act of 1936, as amended by the
Maritime Security Act of 1996 (MSA) (Pub. L. 104-239), authorized the
establishment of a Maritime Security Fleet under the Maritime Security
Program (MSP). The MSP serves as a means for establishing a fleet of
commercially viable and militarily useful vessels to meet national
defense as well as other security requirements.
The U.S. Maritime Administration (MARAD) Office of Sealift Support
is the lead governmental office responsible for administration of the
MSP. MARAD, in coordination with the Department of Defense, established
a program whereby certain categories of militarily useful commercial
vessels may be designated for emergency service to carry military cargo
in time of war, national emergency, or military contingency. Some
vessels enrolled in the MSP may receive a payment as part of their
enrollment. Alternatively, vessels may enroll in other voluntary
sealift support programs established by MARAD.
Section 53102(e) of Title 46 U.S.C. established standards for
issuance of a Coast Guard Certificate of Inspection (COI) to a
previously foreign-flagged vessel transitioning to U.S.-flagged once
eligibility for the MSP has been established by MARAD and the Coast
Guard. The statute does not specify the scope or manner of the
inspections to be carried out by the Coast Guard to verify that MSP
vessels fulfill requirements necessary to receive and maintain a COI.
The purpose of NVIC 01-13 is to provide the marine industry and
Coast Guard personnel with uniform guidance regarding the MSP. Vessels
that meet MSP enrollment criteria may obtain a COI by following the
processes outlined in NVIC 01-13.
On January 19, 2012, the Coast Guard published a notice in the
Federal Register announcing the availability of a draft NVIC 01-13 and
requesting public comments on the draft (See 77 FR 2741). The Coast
Guard recognized the need to avoid the inconsistent application of
inspection procedures under the MSP. Accordingly, draft NVIC 01-13
outlined the inspection process for vessels transitioning from foreign-
flag to U.S.-flag to obtain initial and ongoing certification under the
MSP. To promote consistency and standardization of Coast Guard policies
and procedures, draft NVIC 01-13 set forth a comprehensive approach to
the MSP inspection process through the establishment of two levels of
MSP inspection and oversight: (1) MSP (Regular); and (2) MSP Select.
This two-level approach would enable the Coast Guard to apply
traditional inspection methods to newly reflagged vessels, while at the
same time apply a less stringent level of oversight to vessels that
have consistently demonstrated satisfactory performance and substantial
compliance with applicable rules. Newly enrolled MSP vessels would
continue to be inspected by the Coast Guard in a manner similar to
traditional Coast Guard inspections. After a period of evaluation, MSP
vessels would be eligible to seek enrollment under MSP Select. MSP
Select vessel oversight would consist of risk-based vessel
examinations, periodic oversight, and evaluations of Authorized Class
Society (ACS) survey activities.
We received eight public comment letters in response to the January
19, 2012 Federal Register notice. These comment letters contained a
total of approximately 60 specific recommendations, suggestions, and
other comments. We have created a document that provides a summary of
each comment and the corresponding Coast Guard response. A copy of this
public comment matrix is available for viewing in the public docket for
this notice. You may access the docket going to https://www.regulations.gov, using ``USCG-2011-1156'' as your search term, and
following the instructions in the ADDRESSES section above.
The basic framework of draft NVIC 01-13 described above is retained
in the final version. The Coast Guard has made some changes from the
draft version of NVIC 01-13 to the final version based on the public
comments. A brief discussion of the most important changes is provided
below. For more detailed information, please consult the actual public
comment letters and public comment matrix in the docket.
(1) One commenter requested that we relax the standards for
enrollment into the MSP Select Program by evaluating the ship operating
company's regulatory compliance record over the most recent 5-year
period. The commenter suggested that if the operator is found to be
fully compliant during that period, all of its vessels should be
permitted to enroll in MSP Select. We disagree. We believe that a
vessel-specific approach is more appropriate for sufficiently and
effectively evaluating regulatory compliance. While we disagree with
the commenter's approach, we have decided to reduce the performance
verification period from 5 years to 3 years in order to lessen the
burden on vessel operators.
(2) In response to a commenter's request, we provided more detail
regarding Marine Inspector requirements, requisite qualifications, and
duties associated with the MSP. We have added the requested language in
Sections 2.2.1. and 2.2.2. of NVIC 01-13.
(3) We received a number of comments pertaining to engine
automation, the applicability of Engine International Air Pollution
Prevention (EIAPP) certificates, and the procedures for underwater
survey in lieu of drydocking (UWILD). In response to these comments, we
provided additional clarification regarding vessel automation approval,
EIAPP certification, and UWILD procedures.
This notice is issued under authority of 5 U.S.C. 552(a), 46 U.S.C.
53102(e), and Department of Homeland Security Delegation No. 0170.1(1).
Dated: February 22, 2013.
Paul F. Thomas,
Captain, U.S. Coast Guard, Director, Inspections and Compliance.
[FR Doc. 2013-04732 Filed 2-27-13; 8:45 am]
BILLING CODE 9110-04-P