National Institute of Diabetes and Digestive and Kidney Diseases; Notice of Closed Meetings, 9401-9402 [2013-02836]
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Federal Register / Vol. 78, No. 27 / Friday, February 8, 2013 / Notices
• Shigella vaccines, therapeutics and
diagnostics.
Competitive Advantages
• Vector is well-characterized.
• Simple manufacturing process.
• Potential low-cost vaccine.
• Oral vaccine—avoids need for
needles.
• Temperature-stable formulation
allows for vaccine distribution without
refrigeration.
Development Stage
• Pre-clinical
• In vitro data available
• In vivo data available (animal)
Inventors: Dennis J. Kopecko and De
Qi Xu (FDA/CBER)
Publication
Xu DQ, et al. Core-linked LPS expression of
Shigella dysenteriae serotype 1 Oantigen in live Salmonella typhi vaccine
vector Ty21a: preclinical evidence of
immunogenicity and protection.
Vaccine. 2007 Aug 14;25(33):6167–75.
[PMID 17629369]
Intellectual Property: HHS Reference
No. E–214–2004/0—
• EP Application No. 05754091.6
filed 24 May 2005
• EP Application No. 12186545.5
filed 24 May 2005
• US Patent No. 8,071,113 issued 06
Dec 2011
• US Patent No. 8,337,831 issued 25
Dec 2012
• US Application No. 13/687,797
filed 28 Nov 2012
Licensing Contact: Peter A. Soukas;
301–435–4646; soukasp@mail.nih.gov
Collaborative Research Opportunity:
The FDA Center for Biologics
Evaluation and Research is seeking
statements of capability or interest from
parties interested in collaborative
research to further develop, evaluate or
commercialize combination typhoidshigellosis oral vaccine. For
collaboration opportunities, please
contact Dr. Dennis J. Kopecko at
dennis.kopecko@fda.hhs.gov or 301–
661–8839.
sroberts on DSK5SPTVN1PROD with NOTICES
Oral Shigellosis Vaccine
Description of Technology: This
application claims a Salmonella typhi
Ty21a construct comprising a Shigella
sonnei O-antigen biosynthetic gene
region inserted into the Salmonella
typhi Ty21a chromosome, where
heterologous Shigella sonnei form 1 Oantigen is stably expressed together with
homologous Salmonella typhi Oantigen. The constructs of this invention
elicit immune protection against
virulent Shigella sonnei challenge, as
well as Salmonella Typhi challenge.
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Also claimed in this application are
methods of recombineering a large
antigenic gene region into a bacterial
chromosome.
Bacillary dysentery and enteric fevers
continue to be important causes of
morbidity in both developed and
developing nations. Shigella cause
greater than one hundred and fifty
million cases of dysentery and enteric
fever occurs in greater than twentyseven million people annually.
Currently, there is no licensed vaccine
to prevent the occurrence of shigellosis.
Increasing multiple resistance in
Shigella commonly thwarts local
therapies.
Potential Commercial Applications
• One component of a multivalent
Shigellosis vaccine under development
• Research tool
Competitive Advantages
• Low cost production
• Lower cost vaccine
• Oral vaccine—no needles required
• Temperature-stable manufacturing
process—avoids need for refrigeration
during vaccine distribution
Development Stage
• Pre-clinical
• In vitro data available
• In vivo data available (animal)
Inventors: Dennis J. Kopecko and
Madushini N. Dharmasena (FDA/CBER)
Publication
Dharmasena MN, et al. Stable Expression of
Shigella sonnei Form I O-Polysaccharide
Genes Recombineered into the
Chromosome of Live Salmonella Oral
Vaccine Vector Ty21a. Int J Med
Microbiol. 2013 (accepted).
Intellectual Property: HHS Reference
No. E–168–2012/0—US Application No.
61/701,939 filed 17 Sep 2012
Licensing Contact: Peter A. Soukas;
301–435–4646; soukasp@mail.nih.gov
Collaborative Research Opportunity:
The FDA Center for Biologics
Evaluation and Research is seeking
statements of capability or interest from
parties interested in collaborative
research to further develop, evaluate or
commercialize oral Shigellosis vaccine.
For collaboration opportunities, please
contact Dr. Dennis J. Kopecko at
dennis.kopecko@fda.hhs.gov or 301–
661–8839.
Dated: February 1, 2013.
Richard U. Rodriguez,
Director, Division of Technology Development
and Transfer, Office of Technology Transfer,
National Institutes of Health.
[FR Doc. 2013–02834 Filed 2–7–13; 8:45 am]
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9401
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
National Institute of Diabetes and
Digestive and Kidney Diseases; Notice
of Closed Meetings
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is
hereby given of the following meetings.
The meetings will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: National Institute of
Diabetes and Digestive and Kidney Diseases
Special Emphasis Panel; Beta-Cell Function
and Cognition.
Date: March 4, 2013.
Time: 3:00 p.m. to 4:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, Two
Democracy Plaza, 6707 Democracy
Boulevard, Bethesda, MD 20892, (Telephone
Conference Call).
Contact Person: Barbara A. Woynarowska,
Ph.D., Scientific Review Officer, Review
Branch, DEA, NIDDK, National Institutes of
Health, Room 754, 6707 Democracy
Boulevard, Bethesda, MD 20892–5452, (301)
402–7172, woynarowskab@niddk.nih.gov.
Name of Committee: National Institute of
Diabetes and Digestive and Kidney Diseases
Special Emphasis Panel; NIDDK R24 SEP.
Date: March 4, 2013.
Time: 12:30 p.m. to 1:30 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institute of Health,
Bethesda, MD 20892, (Telephone Conference
Call).
Contact Person: Xiaodu Guo, MD, Ph.D.,
Scientific Review Officer, Review Branch,
DEA, NIDDK, National Institutes of Health,
Room 761, 6707 Democracy Boulevard,
Bethesda, MD 20892–5452, (301) 594–4719,
guox@extra.niddk.nih.gov.
Name of Committee: National Institute of
Diabetes and Digestive and Kidney Diseases
Special Emphasis Panel; Liver Related
Ancillary Studies.
Date: March 13, 2013
Time: 1:30 p.m. to 3:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, Two
Democracy Plaza, 6707 Democracy
Boulevard, Bethesda, MD 20892, (Telephone
Conference Call).
Contact Person: Paul A. Rushing, Ph.D.,
Scientific Review Officer, Review Branch,
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9402
Federal Register / Vol. 78, No. 27 / Friday, February 8, 2013 / Notices
DEA, NIDDK, National Institutes of Health,
Room 747, 6707 Democracy Boulevard,
Bethesda, MD 20892–5452, (301) 594–8895,
rushingp@extra.niddk.nih.gov.
Name of Committee: National Institute of
Diabetes and Digestive and Kidney Diseases
Special Emphasis Panel; Limited
Competition for the Continuation of Look
AHEAD (Action for Health in Diabetes)
Consortium (U01)-RFA–DK12–502.
Date: March 14, 2013.
Time: 11:00 a.m. to 5:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, Two
Democracy Plaza, 6707 Democracy
Boulevard, Bethesda, MD 20892, (Telephone
Conference Call).
Contact Person: Najma Begum, Ph.D.,
Scientific Review Officer, Review Branch,
DEA, NIDDK, National Institutes of Health,
Room 749, 6707 Democracy Boulevard,
Bethesda, MD 20892–5452, (301) 594–8894,
begumn@niddk.nih.gov.
Name of Committee: National Institute of
Diabetes and Digestive and Kidney Diseases
Special Emphasis Panel; NIDDK Ancillary
Studies.
Date: March 15, 2013.
Time: 10:30 a.m. to 12:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, Two
Democracy Plaza, 6707 Democracy
Boulevard, Bethesda, MD 20892, (Telephone
Conference Call).
Contact Person: Thomas A. Tatham, Ph.D.,
Scientific Review Officer, Review Branch,
DEA, NIDDK, National Institutes of Health,
Room 760, 6707 Democracy Boulevard,
Bethesda, MD 20892–5452, (301) 594–3993,
tathamt@mail.nih.gov.
Name of Committee: National Institute of
Diabetes and Digestive and Kidney Diseases
Special Emphasis Panel; Limited
Competition Acute Kidney Injury.
Date: March 20, 2013.
Time: 11:00 a.m. to 2:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, Two
Democracy Plaza, 6707 Democracy
Boulevard, Bethesda, MD 20892, (Telephone
Conference Call).
Contact Person: Robert Wellner, Ph.D.,
Scientific Review Officer, Review Branch,
DEA, NIDDK, National Institutes of Health,
Room 706, 6707 Democracy Boulevard,
Bethesda, MD 20892–5452, 301–594–4721,
rw175w@nih.gov.
Name of Committee: National Institute of
Diabetes and Digestive and Kidney Diseases
Special Emphasis Panel; R24 Collaborative
Interdisciplinary Team Science–3.
Date: March 27, 2013.
Time: 1:30 p.m. to 3:30 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, Two
Democracy Plaza, 6707 Democracy
Boulevard, Bethesda, MD 20892, (Telephone
Conference Call).
Contact Person: Ann A. Jerkins, Ph.D.,
Scientific Review Officer, Review Branch,
DEA, NIDDK, National Institutes Of Health,
VerDate Mar<15>2010
17:23 Feb 07, 2013
Jkt 229001
Room 759, 6707 Democracy Boulevard,
Bethesda, MD 20892–5452, 301–594–2242,
jerkinsa@niddk.nih.gov.
Name of Committee: National Institute of
Diabetes and Digestive and Kidney Diseases
Special Emphasis Panel; R24 Collaborative
Interdisciplinary Team Science–8.
Date: April 1, 2013.
Time: 2:00 p.m. to 3:30 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, Two
Democracy Plaza, 6707 Democracy
Boulevard, Bethesda, MD 20892, (Telephone
Conference Call).
Contact Person: Ann A. Jerkins, Ph.D.,
Scientific Review Officer, Review Branch,
DEA, NIDDK, National Institutes of Health,
Room 759, 6707 Democracy Boulevard,
Bethesda, MD 20892–5452, 301–594–2242,
jerkinsa@niddk.nih.gov.
Name of Committee: National Institute of
Diabetes and Digestive and Kidney Diseases
Special Emphasis Panel; R24 Collaborative
Interdisciplinary Team Science—1.
Date: April 2, 2013.
Time: 2:30 p.m. to 4:30 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, Two
Democracy Plaza, 6707 Democracy
Boulevard, Bethesda, MD 20892, (Telephone
Conference Call).
Contact Person: Ann A. Jerkins, Ph.D.,
Scientific Review Officer, Review Branch,
DEA, NIDDK, National Institutes of Health,
Room 759, 6707 Democracy Boulevard,
Bethesda, MD 20892–5452, 301–594–2242,
jerkinsa@niddk.nih.gov.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.847, Diabetes,
Endocrinology and Metabolic Research;
93.848, Digestive Diseases and Nutrition
Research; 93.849, Kidney Diseases, Urology
and Hematology Research, National Institutes
of Health, HHS)
Dated: February 1, 2013.
David Clary,
Program Analyst, Office of Federal Advisory
Committee Policy.
[FR Doc. 2013–02836 Filed 2–7–13; 8:45 am]
BILLING CODE 4140–01–P
reasonable accommodations, should
notify the Contact Person listed below
in advance of the meeting.
Name of Committee: National Cancer
Institute Director’s Consumer Liaison Group
Date: March 18–19, 2013
Time: 9:00 a.m. to 1:00 p.m.
Agenda: March 18, 2013—Informed
Consent for Genomic Research;March 19,
2013, March 18, 2013In—formed Consent for
Genomic Research;
Place: National Institutes of Health,
Building 31, C Wing, 6th Floor, Conference
Room 10, 31 Center Drive, Bethesda, MD
20892.
Contact Person: Kelli Marciel, Director,
Office of Advocacy Relations, National
Cancer Institute, National Institutes of
Health, 31 Center Drive, Building 31, Room
10A28, Bethesda, MD 20892, 301–594–3194.
Any interested person may file written
comments with the committee by forwarding
the statement to the Contact Person listed on
this notice. The statement should include the
name, address, telephone number and when
applicable, the business or professional
affiliation of the interested person.
In the interest of security, NIH has
instituted stringent procedures for entrance
onto the NIH campus. All visitor vehicles,
including taxicabs, hotel, and airport shuttles
will be inspected before being allowed on
campus. Visitors will be asked to show one
form of identification (for example, a
government-issued photo ID, driver’s license,
or passport) and to state the purpose of their
visit.
Information is also available on the
Institute’s/Center’s home page:
deainfo.nci.nih.gov/advisory/dclg/dclg.htm,
where an agenda and any additional
information for the meeting will be posted
when available.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.392, Cancer Construction;
93.393, Cancer Cause and Prevention
Research; 93.394, Cancer Detection and
Diagnosis Research; 93.395, Cancer
Treatment Research; 93.396, Cancer Biology
Research; 93.397, Cancer CentersSupport;
93.398, Cancer Research Manpower; 93.399,
Cancer Control, National Institutes of Health,
HHS)
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
Dated: February 4, 2013.
Melanie J. Gray,
Program Analyst, Office of Federal Advisory
Committee Policy.
National Institutes of Health
[FR Doc. 2013–02837 Filed 2–7–13; 8:45 am]
National Cancer Institute; Notice of
Meeting
BILLING CODE 4140–01–P
Pursuant to section 10(a) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is
hereby given of a meeting of the
National Cancer Institute Director’s
Consumer Liaison Group.
The meeting will be open to the
public, with attendance limited to space
available. Individuals who plan to
attend and need special assistance, such
as sign language interpretation or other
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
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National Institutes of Health
National Institute on Minority Health
and Health; Disparities Notice of
Meeting
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is
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Agencies
[Federal Register Volume 78, Number 27 (Friday, February 8, 2013)]
[Notices]
[Pages 9401-9402]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 2013-02836]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases;
Notice of Closed Meetings
Pursuant to section 10(d) of the Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is hereby given of the following
meetings.
The meetings will be closed to the public in accordance with the
provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5
U.S.C., as amended. The grant applications and the discussions could
disclose confidential trade secrets or commercial property such as
patentable material, and personal information concerning individuals
associated with the grant applications, the disclosure of which would
constitute a clearly unwarranted invasion of personal privacy.
Name of Committee: National Institute of Diabetes and Digestive
and Kidney Diseases Special Emphasis Panel; Beta-Cell Function and
Cognition.
Date: March 4, 2013.
Time: 3:00 p.m. to 4:00 p.m.
Agenda: To review and evaluate grant applications.
Place: National Institutes of Health, Two Democracy Plaza, 6707
Democracy Boulevard, Bethesda, MD 20892, (Telephone Conference
Call).
Contact Person: Barbara A. Woynarowska, Ph.D., Scientific Review
Officer, Review Branch, DEA, NIDDK, National Institutes of Health,
Room 754, 6707 Democracy Boulevard, Bethesda, MD 20892-5452, (301)
402-7172, woynarowskab@niddk.nih.gov.
Name of Committee: National Institute of Diabetes and Digestive
and Kidney Diseases Special Emphasis Panel; NIDDK R24 SEP.
Date: March 4, 2013.
Time: 12:30 p.m. to 1:30 p.m.
Agenda: To review and evaluate grant applications.
Place: National Institute of Health, Bethesda, MD 20892,
(Telephone Conference Call).
Contact Person: Xiaodu Guo, MD, Ph.D., Scientific Review
Officer, Review Branch, DEA, NIDDK, National Institutes of Health,
Room 761, 6707 Democracy Boulevard, Bethesda, MD 20892-5452, (301)
594-4719, guox@extra.niddk.nih.gov.
Name of Committee: National Institute of Diabetes and Digestive
and Kidney Diseases Special Emphasis Panel; Liver Related Ancillary
Studies.
Date: March 13, 2013
Time: 1:30 p.m. to 3:00 p.m.
Agenda: To review and evaluate grant applications.
Place: National Institutes of Health, Two Democracy Plaza, 6707
Democracy Boulevard, Bethesda, MD 20892, (Telephone Conference
Call).
Contact Person: Paul A. Rushing, Ph.D., Scientific Review
Officer, Review Branch,
[[Page 9402]]
DEA, NIDDK, National Institutes of Health, Room 747, 6707 Democracy
Boulevard, Bethesda, MD 20892-5452, (301) 594-8895,
rushingp@extra.niddk.nih.gov.
Name of Committee: National Institute of Diabetes and Digestive
and Kidney Diseases Special Emphasis Panel; Limited Competition for
the Continuation of Look AHEAD (Action for Health in Diabetes)
Consortium (U01)-RFA-DK12-502.
Date: March 14, 2013.
Time: 11:00 a.m. to 5:00 p.m.
Agenda: To review and evaluate grant applications.
Place: National Institutes of Health, Two Democracy Plaza, 6707
Democracy Boulevard, Bethesda, MD 20892, (Telephone Conference
Call).
Contact Person: Najma Begum, Ph.D., Scientific Review Officer,
Review Branch, DEA, NIDDK, National Institutes of Health, Room 749,
6707 Democracy Boulevard, Bethesda, MD 20892-5452, (301) 594-8894,
begumn@niddk.nih.gov.
Name of Committee: National Institute of Diabetes and Digestive
and Kidney Diseases Special Emphasis Panel; NIDDK Ancillary Studies.
Date: March 15, 2013.
Time: 10:30 a.m. to 12:00 p.m.
Agenda: To review and evaluate grant applications.
Place: National Institutes of Health, Two Democracy Plaza, 6707
Democracy Boulevard, Bethesda, MD 20892, (Telephone Conference
Call).
Contact Person: Thomas A. Tatham, Ph.D., Scientific Review
Officer, Review Branch, DEA, NIDDK, National Institutes of Health,
Room 760, 6707 Democracy Boulevard, Bethesda, MD 20892-5452, (301)
594-3993, tathamt@mail.nih.gov.
Name of Committee: National Institute of Diabetes and Digestive
and Kidney Diseases Special Emphasis Panel; Limited Competition
Acute Kidney Injury.
Date: March 20, 2013.
Time: 11:00 a.m. to 2:00 p.m.
Agenda: To review and evaluate grant applications.
Place: National Institutes of Health, Two Democracy Plaza, 6707
Democracy Boulevard, Bethesda, MD 20892, (Telephone Conference
Call).
Contact Person: Robert Wellner, Ph.D., Scientific Review
Officer, Review Branch, DEA, NIDDK, National Institutes of Health,
Room 706, 6707 Democracy Boulevard, Bethesda, MD 20892-5452, 301-
594-4721, rw175w@nih.gov.
Name of Committee: National Institute of Diabetes and Digestive
and Kidney Diseases Special Emphasis Panel; R24 Collaborative
Interdisciplinary Team Science-3.
Date: March 27, 2013.
Time: 1:30 p.m. to 3:30 p.m.
Agenda: To review and evaluate grant applications.
Place: National Institutes of Health, Two Democracy Plaza, 6707
Democracy Boulevard, Bethesda, MD 20892, (Telephone Conference
Call).
Contact Person: Ann A. Jerkins, Ph.D., Scientific Review
Officer, Review Branch, DEA, NIDDK, National Institutes Of Health,
Room 759, 6707 Democracy Boulevard, Bethesda, MD 20892-5452, 301-
594-2242, jerkinsa@niddk.nih.gov.
Name of Committee: National Institute of Diabetes and Digestive
and Kidney Diseases Special Emphasis Panel; R24 Collaborative
Interdisciplinary Team Science-8.
Date: April 1, 2013.
Time: 2:00 p.m. to 3:30 p.m.
Agenda: To review and evaluate grant applications.
Place: National Institutes of Health, Two Democracy Plaza, 6707
Democracy Boulevard, Bethesda, MD 20892, (Telephone Conference
Call).
Contact Person: Ann A. Jerkins, Ph.D., Scientific Review
Officer, Review Branch, DEA, NIDDK, National Institutes of Health,
Room 759, 6707 Democracy Boulevard, Bethesda, MD 20892-5452, 301-
594-2242, jerkinsa@niddk.nih.gov.
Name of Committee: National Institute of Diabetes and Digestive
and Kidney Diseases Special Emphasis Panel; R24 Collaborative
Interdisciplinary Team Science--1.
Date: April 2, 2013.
Time: 2:30 p.m. to 4:30 p.m.
Agenda: To review and evaluate grant applications.
Place: National Institutes of Health, Two Democracy Plaza, 6707
Democracy Boulevard, Bethesda, MD 20892, (Telephone Conference
Call).
Contact Person: Ann A. Jerkins, Ph.D., Scientific Review
Officer, Review Branch, DEA, NIDDK, National Institutes of Health,
Room 759, 6707 Democracy Boulevard, Bethesda, MD 20892-5452, 301-
594-2242, jerkinsa@niddk.nih.gov.
(Catalogue of Federal Domestic Assistance Program Nos. 93.847,
Diabetes, Endocrinology and Metabolic Research; 93.848, Digestive
Diseases and Nutrition Research; 93.849, Kidney Diseases, Urology
and Hematology Research, National Institutes of Health, HHS)
Dated: February 1, 2013.
David Clary,
Program Analyst, Office of Federal Advisory Committee Policy.
[FR Doc. 2013-02836 Filed 2-7-13; 8:45 am]
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