Findings of Research Misconduct, 76041-76042 [2012-30866]

Download as PDF tkelley on DSK3SPTVN1PROD with Federal Register / Vol. 77, No. 247 / Wednesday, December 26, 2012 / Notices processes, and procedures, that are accountable and transparent, beginning with the per diem methodology to aid in meeting agency missions in an effective and efficient manner at the lowest logical travel cost. Through the review process, the GTAC will address current industry and Federal travel trends and provide advice and make recommendations for improvements to increase travel efficiency and effectiveness, reduce costs, promote sustainability, and incorporate industry best practices. The Committee provides an opportunity for travel industry leaders, and other qualified individuals to offer their expert advice and recommendations to GSA, which among other things, is responsible for the development and implementation of the FTR which prescribes the policies for travel by Federal civilian employees and others authorized to travel at Government expense. 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[FR Doc. 2012–30928 Filed 12–21–12; 8:45 am] BILLING CODE 6820–14–P DEPARTMENT OF HEALTH AND HUMAN SERVICES Office of the Secretary Findings of Research Misconduct Office of the Secretary, HHS. Notice. AGENCY: ACTION: Notice is hereby given that the Office of Research Integrity (ORI) has taken final action in the following case: Terry S. Elton, Ph.D., The Ohio State University: Based on the reports of two investigations conducted by The Ohio State University (OSU) and additional analysis conducted by ORI in its oversight review, ORI found that Dr. Terry S. Elton, Professor, College of Pharmacy and Davis Heart and Lung Research Institute, OSU, engaged in research misconduct in research supported by National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), grants R01 HL048848, R01 HL084498, and P01 HL70294, National Institute of Child Health and Human Development (NICHD), NIH, grant R21 HD058997, National Institute on Aging (NIA), NIH, SUMMARY: PO 00000 Frm 00074 Fmt 4703 Sfmt 4703 76041 grant R01 AG021912, National Institute of Allergy and Infectious Diseases (NIAID), NIH, grant R01 AI39963, and National Eye Institute (NEI), NIH, grant R01 ES012241. ORI found that the Respondent engaged in research misconduct by falsifying and/or fabricating data that were included in 1 R21 HD058997–01, 1 R21 HD058997–01A1, 1 R21 HD058997–01A2, 1 RC1 HL100298–01, and in: 1. Kuhn, D.E., Nuovo, G.J., Terry, A.V. Jr., Martin, M.M., Malana, G.E., Sansom, SE., Pleister, A.P., Beck, W.D., Head, E., Feldman, D.S., & Elton, T.S. ‘‘Chromosome 21derived microRNAs provide an etiological basis for aberrant protein expression in human Down syndrome brains.’’ J Biol Chem 285(2):1529–43, 2010 Jan 8. 2. Kuhn, D.E., Nuovo, G.J., Martin, M.M., Malana, G.E., Pleister, A.P., Jiang, J., Schmittgen, T.D., Terry, A.V. Jr., Gardiner, K., Head, E., Feldman, D.S., & Elton, T.S. ‘‘Human chromosome 21-derived miRNAs are overexpressed in Down syndrome brains and hearts.’’ Biochem Biophys Res Commun 370(3):473–7, 2008 Jun 6. 3. Martin, M.M., Buckenberger, J.A., Jiang, J., Malana, G.E., Knoell, D.L., Feldman, D.S., & Elton, T.S. ‘‘TGF+1 stimulates human AT1 receptor expression in lung fibroblasts by cross talk between the Smad, p38 MAPK, JNK, and PI3K signaling pathways.’’ Am. J. Physiol. Lung Cell. Mol. Physiol. 293(3):L790–9, 2007 Sept. (Retracted: Am. J. Physiol. Lung Cell. Mol. Physiol. 302(7):L719, 2012 Apr.) 4. Martin, M.M., Buckenberger, J.A., Jiang, J., Malana, G.E., Nuovo, G.J., Chotani, M., Feldman, D.S., Schmittgen, T.D., & Elton, T.S. ‘‘The human angiotensin II type 1 receptor +1166 A/C polymorphism attenuates microRNA–155 binding.’’ J Biol Chem 282(33):24262–9, 2007, Aug 17. 5. Martin, M.M., Buckenberger, J.A., Knoell, D.L., Strauch, A.R., & Elton, T.S. ‘‘TGF-beta(1) regulation of human AT1 receptor mRNA splice variants harboring exon 2.’’ Mol Cell Endocrinol 249(1–2):21–31, 2006 Apr 25. 6. Duffy, A.A., Martin, M.M., & Elton, T.S. ‘‘Transcriptional regulation of the AT1 receptor gene in immortalized human trophoblast cells.’’ Biochim. Biophys. Acta. 1680(3):158–70, 2004 Nov 5. E:\FR\FM\26DEN1.SGM 26DEN1 tkelley on DSK3SPTVN1PROD with 76042 Federal Register / Vol. 77, No. 247 / Wednesday, December 26, 2012 / Notices As a result of its investigation, OSU has recommended that all of the above publications be retracted. Specifically, ORI finds that Respondent: • Falsified and/or fabricated Western blots in an NIH grant application in three submissions of the same grant application: fl Figures 4, 7, 11C: 1 R21 HD058997– 01 fl Figures 7B, 7E, 8B: 1 R21 HD058997–01A1 fl Figures 3C, 3F, 6C: 1 R21 HD058997–01A2 and false Western blots were also included in Figure 6 in grant application 1 RC1 HL100298–01. • Falsified and/or fabricated Western blots in eighteen (18) figures and in six (6) published papers. Specifically false and/or fabricated images were included in: fl Figures 2C, 2D, 2F, 3C, 3E, 4G, 5C, 5F: J Biol Chem 285(2):1529–43, 2010 Jan 8 fl Figures 3B, 3C, 3F, 3H, 3I, 3J: Biochem Biophys Res Commun 370(3):473–7, 2008 Jun 6 fl Figures 2, 3, 4B, 5B, 6, 7B, 8A, 9B: Am. J. Physiol. Lung Cell. Mol. Physiol. 293(3):L790–9, 2007 Sept fl Figure 6: J Biol Chem 282(33):24262–9, 2007 Aug 17 fl Figure 6: Mol Cell Endocrinol 249(1– 2):21–31, 2006 Apr 25 fl Figures 5, 6B, 7B, 9B: Biochim. Biophys. Acta 1680(3):158–70, 2004 Nov 5. Dr. Elton has entered into a Voluntary Exclusion Agreement and has voluntarily agreed: (1) To exclude himself from any contracting or subcontracting with any agency of the United States Government and from eligibility or involvement in nonprocurement programs of the United States Government referred to as ‘‘covered transactions’’ pursuant to HHS’ Implementation (2 CFR part 376 et seq.) of OMB Guidelines to Agencies on Govermentwide Debarment and Suspension, 2 CFR part 180 (collectively the ‘‘Debarment Regulations’’) for a period of three (3) years, beginning on November 26, 2012; (2) To exclude himself voluntarily from serving in any advisory capacity to PHS including, but not limited to, service on any PHS advisory committee, board, and/or peer review committee, or as a consultant for a period of three (3) years, beginning on November 26, 2012; and (3) To request that the following publications be retracted: • J Biol Chem 285(2):1529–43, 2010 Jan 8 VerDate Mar<15>2010 06:31 Dec 22, 2012 Jkt 229001 • Biochem Biophys Res Commun 370(3):473–7, 2008 Jun 6 • J Biol Chem 282(33):24262–9, 2007, Aug 17 • Mol Cell Endocrinol 249(1–2):21– 31, 2006 Apr 25 • Biochim. Biophys. Acta. 1680(3):158–70, 2004 Nov 5. FOR FURTHER INFORMATION CONTACT: Director, Office of Research Integrity, 1101 Wootton Parkway, Suite 750, Rockville, MD 20852, (240) 453–8200. John E. Dahlberg, Deputy Director, Office of Research Integrity. [FR Doc. 2012–30866 Filed 12–21–12; 8:45 am] BILLING CODE 4150–31–P DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Meeting of the Presidential Commission for the Study of Bioethical Issues Department of Health and Human Services, Office of the Assistant Secretary for Health, Presidential Commission for the Study of Bioethical Issues. ACTION: Notice of meeting. AGENCY: The Presidential Commission for the Study of Bioethical Issues (the Commission) will conduct its twelfth meeting in January. At this meeting, the Commission will continue discussing topics related to the ethical issues associated with the development of medical countermeasures for children. DATES: The meeting will take place Monday and Tuesday, January 14–15, 2013. SUMMARY: University of Miami Hospital Seminar Center, 1400 NW. 12th Avenue, First Floor, Miami, Florida 33136. Telephone (305) 689– 5511. ADDRESSES: FOR FURTHER INFORMATION CONTACT: Hillary Wicai Viers, Communications Director, Presidential Commission for the Study of Bioethical Issues, 1425 New York Avenue NW., Suite C–100, Washington, DC 20005. Telephone: 202–233–3960. Email: Hillary.Viers@bioethics.gov. Additional information may be obtained at www.bioethics.gov. Pursuant to the Federal Advisory Committee Act of 1972, Public Law 92–463, 5 U.S.C. app. 2, notice is hereby given of the twelfth meeting of the Commission. The meeting will be held from 9 a.m. to approximately 5 p.m. on Monday, January 14, 2013, and from 9 a.m. to approximately 11:45 a.m. on Tuesday, SUPPLEMENTARY INFORMATION: PO 00000 Frm 00075 Fmt 4703 Sfmt 4703 January 15, 2013, in Miami, Fla. The meeting will be open to the public with attendance limited to space available. The meeting will also be webcast at www.bioethics.gov. Under authority of Executive Order 13521, dated November 24, 2009, the President established the Commission. The Commission is an advisory panel of the nation’s leaders in medicine, science, ethics, religion, law, and engineering. The Commission advises the President on bioethical issues arising from advances in biomedicine and related areas of science and technology. The Commission seeks to identify and promote policies and practices that ensure scientific research, health care delivery, and technological innovation are conducted in a socially and ethically responsible manner. The main agenda item for the Commission’s twelfth meeting is to continue discussing topics related to the ethical issues associated with the development of medical countermeasures for children. The draft meeting agenda and other information about the Commission, including information about access to the webcast, will be available at www.bioethics.gov. The Commission welcomes input from anyone wishing to provide public comment on any issue before it. Respectful debate of opposing views and active participation by citizens in public exchange of ideas enhances overall public understanding of the issues at hand and conclusions reached by the Commission. The Commission is particularly interested in receiving comments and questions during the meeting that are responsive to specific sessions. Written comments will be accepted at the registration desk and comment forms will be provided to members of the public in order to write down questions and comments for the Commission as they arise. To accommodate as many individuals as possible, the time for each question or comment may be limited. If the number of individuals wishing to pose a question or make a comment is greater than can reasonably be accommodated during the scheduled meeting, the Commission may make a random selection. Anyone planning to attend the meeting who needs special assistance, such as sign language interpretation or other reasonable accommodations, should notify Esther Yoo by telephone at (202) 233–3960, or email at Esther.Yoo@bioethics.gov in advance of the meeting. The Commission will make every effort to accommodate persons who need special assistance. E:\FR\FM\26DEN1.SGM 26DEN1

Agencies

[Federal Register Volume 77, Number 247 (Wednesday, December 26, 2012)]
[Notices]
[Pages 76041-76042]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 2012-30866]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

Office of the Secretary


Findings of Research Misconduct

AGENCY: Office of the Secretary, HHS.

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: Notice is hereby given that the Office of Research Integrity 
(ORI) has taken final action in the following case:
    Terry S. Elton, Ph.D., The Ohio State University: Based on the 
reports of two investigations conducted by The Ohio State University 
(OSU) and additional analysis conducted by ORI in its oversight review, 
ORI found that Dr. Terry S. Elton, Professor, College of Pharmacy and 
Davis Heart and Lung Research Institute, OSU, engaged in research 
misconduct in research supported by National Heart, Lung, and Blood 
Institute (NHLBI), National Institutes of Health (NIH), grants R01 
HL048848, R01 HL084498, and P01 HL70294, National Institute of Child 
Health and Human Development (NICHD), NIH, grant R21 HD058997, National 
Institute on Aging (NIA), NIH, grant R01 AG021912, National Institute 
of Allergy and Infectious Diseases (NIAID), NIH, grant R01 AI39963, and 
National Eye Institute (NEI), NIH, grant R01 ES012241.
    ORI found that the Respondent engaged in research misconduct by 
falsifying and/or fabricating data that were included in 1 R21 
HD058997-01, 1 R21 HD058997-01A1, 1 R21 HD058997-01A2, 1 RC1 HL100298-
01, and in:
1. Kuhn, D.E., Nuovo, G.J., Terry, A.V. Jr., Martin, M.M., Malana, 
G.E., Sansom, SE., Pleister, A.P., Beck, W.D., Head, E., Feldman, D.S., 
& Elton, T.S. ``Chromosome 21-derived microRNAs provide an etiological 
basis for aberrant protein expression in human Down syndrome brains.'' 
J Biol Chem 285(2):1529-43, 2010 Jan 8.
2. Kuhn, D.E., Nuovo, G.J., Martin, M.M., Malana, G.E., Pleister, A.P., 
Jiang, J., Schmittgen, T.D., Terry, A.V. Jr., Gardiner, K., Head, E., 
Feldman, D.S., & Elton, T.S. ``Human chromosome 21-derived miRNAs are 
overexpressed in Down syndrome brains and hearts.'' Biochem Biophys Res 
Commun 370(3):473-7, 2008 Jun 6.
3. Martin, M.M., Buckenberger, J.A., Jiang, J., Malana, G.E., Knoell, 
D.L., Feldman, D.S., & Elton, T.S. ``TGF[szlig]1 stimulates human AT1 
receptor expression in lung fibroblasts by cross talk between the Smad, 
p38 MAPK, JNK, and PI3K signaling pathways.'' Am. J. Physiol. Lung 
Cell. Mol. Physiol. 293(3):L790-9, 2007 Sept. (Retracted: Am. J. 
Physiol. Lung Cell. Mol. Physiol. 302(7):L719, 2012 Apr.)
4. Martin, M.M., Buckenberger, J.A., Jiang, J., Malana, G.E., Nuovo, 
G.J., Chotani, M., Feldman, D.S., Schmittgen, T.D., & Elton, T.S. ``The 
human angiotensin II type 1 receptor +1166 A/C polymorphism attenuates 
microRNA-155 binding.'' J Biol Chem 282(33):24262-9, 2007, Aug 17.
5. Martin, M.M., Buckenberger, J.A., Knoell, D.L., Strauch, A.R., & 
Elton, T.S. ``TGF-beta(1) regulation of human AT1 receptor mRNA splice 
variants harboring exon 2.'' Mol Cell Endocrinol 249(1-2):21-31, 2006 
Apr 25.
6. Duffy, A.A., Martin, M.M., & Elton, T.S. ``Transcriptional 
regulation of the AT1 receptor gene in immortalized human trophoblast 
cells.'' Biochim. Biophys. Acta. 1680(3):158-70, 2004 Nov 5.

[[Page 76042]]

    As a result of its investigation, OSU has recommended that all of 
the above publications be retracted.
    Specifically, ORI finds that Respondent:
     Falsified and/or fabricated Western blots in an NIH grant 
application in three submissions of the same grant application:

[rtrif] Figures 4, 7, 11C: 1 R21 HD058997-01
[rtrif] Figures 7B, 7E, 8B: 1 R21 HD058997-01A1
[rtrif] Figures 3C, 3F, 6C: 1 R21 HD058997-01A2
and false Western blots were also included in Figure 6 in grant 
application 1 RC1 HL100298-01.

     Falsified and/or fabricated Western blots in eighteen (18) 
figures and in six (6) published papers. Specifically false and/or 
fabricated images were included in:

[rtrif] Figures 2C, 2D, 2F, 3C, 3E, 4G, 5C, 5F: J Biol Chem 
285(2):1529-43, 2010 Jan 8
[rtrif] Figures 3B, 3C, 3F, 3H, 3I, 3J: Biochem Biophys Res Commun 
370(3):473-7, 2008 Jun 6
[rtrif] Figures 2, 3, 4B, 5B, 6, 7B, 8A, 9B: Am. J. Physiol. Lung Cell. 
Mol. Physiol. 293(3):L790-9, 2007 Sept
[rtrif] Figure 6: J Biol Chem 282(33):24262-9, 2007 Aug 17
[rtrif] Figure 6: Mol Cell Endocrinol 249(1-2):21-31, 2006 Apr 25
[rtrif] Figures 5, 6B, 7B, 9B: Biochim. Biophys. Acta 1680(3):158-70, 
2004 Nov 5.
    Dr. Elton has entered into a Voluntary Exclusion Agreement and has 
voluntarily agreed:
    (1) To exclude himself from any contracting or subcontracting with 
any agency of the United States Government and from eligibility or 
involvement in nonprocurement programs of the United States Government 
referred to as ``covered transactions'' pursuant to HHS' Implementation 
(2 CFR part 376 et seq.) of OMB Guidelines to Agencies on Govermentwide 
Debarment and Suspension, 2 CFR part 180 (collectively the ``Debarment 
Regulations'') for a period of three (3) years, beginning on November 
26, 2012;
    (2) To exclude himself voluntarily from serving in any advisory 
capacity to PHS including, but not limited to, service on any PHS 
advisory committee, board, and/or peer review committee, or as a 
consultant for a period of three (3) years, beginning on November 26, 
2012; and
    (3) To request that the following publications be retracted:

     J Biol Chem 285(2):1529-43, 2010 Jan 8
     Biochem Biophys Res Commun 370(3):473-7, 2008 Jun 6
     J Biol Chem 282(33):24262-9, 2007, Aug 17
     Mol Cell Endocrinol 249(1-2):21-31, 2006 Apr 25
     Biochim. Biophys. Acta. 1680(3):158-70, 2004 Nov 5.

FOR FURTHER INFORMATION CONTACT: Director, Office of Research 
Integrity, 1101 Wootton Parkway, Suite 750, Rockville, MD 20852, (240) 
453-8200.

John E. Dahlberg,
Deputy Director, Office of Research Integrity.
[FR Doc. 2012-30866 Filed 12-21-12; 8:45 am]
BILLING CODE 4150-31-P
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